Ubiquitin

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  Subject Areas on Research

  • A Bayesian approach for determining protein side-chain rotamer conformations using unassigned NOE data. 
  • A novel function of VCP (valosin-containing protein; p97) in the control of N-glycosylation of proteins in the endoplasmic reticulum. 
  • A novel role for XIAP in copper homeostasis through regulation of MURR1. 
  • A novel ubiquitin fusion system bypasses the mitochondria and generates biologically active Smac/DIABLO. 
  • A single phenylalanine residue in β-arrestin2 critically regulates its binding to G protein-coupled receptors. 
  • Abi-1 forms an epidermal growth factor-inducible complex with Cbl: role in receptor endocytosis. 
  • Abi3bp is a multifunctional autocrine/paracrine factor that regulates mesenchymal stem cell biology. 
  • Accumulation of Ubiquitin and Sequestosome-1 Implicate Protein Damage in Diacetyl-Induced Cytotoxicity. 
  • Accuracy of SUPREX (stability of unpurified proteins from rates of H/D exchange) and MALDI mass spectrometry-derived protein unfolding free energies determined under non-EX2 exchange conditions. 
  • Activated c-Abl is degraded by the ubiquitin-dependent proteasome pathway. 
  • Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117. 
  • Arabidopsis CAND1, an unmodified CUL1-interacting protein, is involved in multiple developmental pathways controlled by ubiquitin/proteasome-mediated protein Degradation. 
  • Autism genome-wide copy number variation reveals ubiquitin and neuronal genes. 
  • Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression. 
  • BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters. 
  • Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells. 
  • C-Raf antagonizes apoptosis induced by IFN-alpha in human lung cancer cells by phosphorylation and increase of the intracellular content of elongation factor 1A. 
  • Chaperone-mediated 26S proteasome remodeling facilitates free K63 ubiquitin chain production and aggresome clearance. 
  • Characterization of a UBC13 kinase in Plasmodium falciparum. 
  • Characterization of a new family of protein kinases from Arabidopsis containing phosphoinositide 3/4-kinase and ubiquitin-like domains. 
  • Characterization of the ubiquitin-modified proteome regulated by transient forebrain ischemia. 
  • Chemical Regulation of the Protein Quality Control E3 Ubiquitin Ligase C-Terminus of Hsc70 Interacting Protein (CHIP). 
  • Constitutive proteasome-mediated turnover of Bfl-1/A1 and its processing in response to TNF receptor activation in FL5.12 pro-B cells convert it into a prodeath factor. 
  • Convergence of Parkin, PINK1, and α-Synuclein on Stress-induced Mitochondrial Morphological Remodeling. 
  • Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. 
  • Costaining for keratins 8/18 plus ubiquitin improves detection of hepatocyte injury in nonalcoholic fatty liver disease. 
  • Cover Image, Volume 231, Number 10, October 2016. 
  • Detection of β-Arrestin-Mediated G Protein-Coupled Receptor Ubiquitination Using BRET. 
  • Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis. 
  • Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme. 
  • Distinct mechanisms control the stability of the related S-phase cyclins Clb5 and Clb6. 
  • Dopamine and α-synuclein dysfunction in Smad3 null mice. 
  • Dynamic ubiquitination of the mitogen-activated protein kinase kinase (MAPKK) Ste7 determines mitogen-activated protein kinase (MAPK) specificity. 
  • Emi2-mediated inhibition of E2-substrate ubiquitin transfer by the anaphase-promoting complex/cyclosome through a D-box-independent mechanism. 
  • Evolutionarily conserved role of calcineurin in phosphodegron-dependent degradation of phosphodiesterase 4D. 
  • FANCD2 monoubiquitination and activation by hexavalent chromium [Cr(VI)] exposure: activation is not required for repair of Cr(VI)-induced DSBs. 
  • FBW2 targets GCMa to the ubiquitin-proteasome degradation system. 
  • Gateway-compatible tissue-specific vectors for plant transformation. 
  • Gigaxonin glycosylation regulates intermediate filament turnover and may impact giant axonal neuropathy etiology or treatment. 
  • Global transcriptome profile of Cryptococcus neoformans during exposure to hydrogen peroxide induced oxidative stress. 
  • HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. 
  • HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. 
  • HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. 
  • Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication. 
  • Identification of risk and age-at-onset genes on chromosome 1p in Parkinson disease. 
  • Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein. 
  • Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy. 
  • Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2. 
  • Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration. 
  • Inhibitory effect of b-AP15 on the 20S proteasome. 
  • Interaction of the polyglutamine protein ataxin-3 with Rad23 regulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3. 
  • Interferon-Inducible E3 Ligase RNF213 Facilitates Host-Protective Linear and K63-Linked Ubiquitylation of Toxoplasma gondii Parasitophorous Vacuoles. 
  • Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy. 
  • Isoleucine 44 Hydrophobic Patch Controls Toxicity of Unanchored, Linear Ubiquitin Chains through NF-κB Signaling. 
  • Lanthanide-binding tags as versatile protein coexpression probes. 
  • Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration. 
  • MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation. 
  • Mass spectrometry-based thermal shift assay for protein-ligand binding analysis. 
  • Mechanical unfolding of ubiquitin molecules. 
  • Mechanism of ubiquitin activation revealed by the structure of a bacterial MoeB-MoaD complex. 
  • Merlin facilitates ubiquitination and degradation of transactivation-responsive RNA-binding protein. 
  • Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis. 
  • Molecular pathophysiology of Parkinson's disease. 
  • Multiple cell-type-specific elements regulate Myc protein stability. 
  • Murine Irgm Paralogs Regulate Nonredundant Functions To Execute Host Defense to Toxoplasma gondii. 
  • Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I. 
  • NLRP1 - One NLR to guard them all. 
  • Osteopontin induces ubiquitin-dependent degradation of STAT1 in RAW264.7 murine macrophages. 
  • Osteopontin mediates Stat1 degradation to inhibit iNOS transcription in a cecal ligation and puncture model of sepsis. 
  • Osteopontin regulates ubiquitin-dependent degradation of Stat1 in murine mammary epithelial tumor cells. 
  • PACES: Protein sequential assignment by computer-assisted exhaustive search. 
  • Parkin coordinates mitochondrial lipid remodeling to execute mitophagy. 
  • Parkin mediates the degradation-independent ubiquitination of Hsp70. 
  • Phosphorylation of the deubiquitinase USP20 by protein kinase A regulates post-endocytic trafficking of β2 adrenergic receptors to autophagosomes during physiological stress. 
  • Phosphorylation of the platelet-derived growth factor receptor-beta and epidermal growth factor receptor by G protein-coupled receptor kinase-2. Mechanisms for selectivity of desensitization. 
  • Polyubiquitin Chains Linked by Lysine Residue 48 (K48) Selectively Target Oxidized Proteins In Vivo. 
  • Proteasomes activate aggresome disassembly and clearance by producing unanchored ubiquitin chains. 
  • Protein alignment by a coexpressed lanthanide-binding tag for the measurement of residual dipolar couplings. 
  • Protein loop closure using orientational restraints from NMR data. 
  • Protocol for the thermodynamic analysis of some proteins using an H/D exchange- and mass spectrometry-based technique. 
  • Quality control autophagy: a joint effort of ubiquitin, protein deacetylase and actin cytoskeleton. 
  • Reaper is regulated by IAP-mediated ubiquitination. 
  • Receptor regulation: beta-arrestin moves up a notch. 
  • Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes. 
  • Recruiting substrates to cullin 4-dependent ubiquitin ligases by DDB1. 
  • Regulation of V2 vasopressin receptor degradation by agonist-promoted ubiquitination. 
  • Regulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexes. 
  • Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. 
  • Release of ubiquitin-charged Cdc34-S - Ub from the RING domain is essential for ubiquitination of the SCF(Cdc4)-bound substrate Sic1. 
  • Reproductive cytotoxicity is predicted by magnetic resonance microscopy and confirmed by ubiquitin-proteasome immunohistochemistry in a theophylline-induced model of rat testicular and epididymal toxicity. 
  • Requirement of dendritic Akt degradation by the ubiquitin-proteasome system for neuronal polarity. 
  • Reversible protein phosphorylation regulates circadian rhythms. 
  • Ring finger protein 121 is a potent regulator of adeno-associated viral genome transcription. 
  • SCF E3-mediated autoubiquitination negatively regulates activity of Cdc34 E2 but plays a nonessential role in the catalytic cycle in vitro and in vivo. 
  • SRCP1 Conveys Resistance to Polyglutamine Aggregation. 
  • Screen and identification of proteins interacting with ADAM19 cytoplasmic tail. 
  • Selective Autophagy of BES1 Mediated by DSK2 Balances Plant Growth and Survival. 
  • Seven-transmembrane receptors and ubiquitination. 
  • Site-Specific K63 Ubiquitinomics Provides Insights into Translation Regulation under Stress. 
  • Skp2 regulates Myc protein stability and activity. 
  • Smac/Diablo antagonizes ubiquitin ligase activity of inhibitor of apoptosis proteins. 
  • Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin. 
  • Sparsely-sampled, high-resolution 4-D omit spectra for detection and assignment of intermolecular NOEs of protein complexes. 
  • Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa. 
  • Structure of the ubiquitin-binding zinc finger domain of human DNA Y-polymerase eta. 
  • TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth. 
  • TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. 
  • The DNA repair protein, O(6)-methylguanine-DNA methyltransferase is a proteolytic target for the E6 human papillomavirus oncoprotein. 
  • The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing. 
  • The N-Terminal UND Motif of the Arabidopsis U-Box E3 Ligase PUB18 Is Critical for the Negative Regulation of ABA-Mediated Stomatal Movement and Determines Its Ubiquitination Specificity for Exocyst Subunit Exo70B1. 
  • The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1. 
  • The Ubiquitin-Modifying Enzyme A20 Terminates C-Type Lectin Receptor Signals and Is a Suppressor of Host Defense against Systemic Fungal Infection. 
  • The centrosome in human genetic disease. 
  • The cyclophilin-like domain of Ran-binding protein-2 modulates selectively the activity of the ubiquitin-proteasome system and protein biogenesis. 
  • The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. 
  • The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains. 
  • The mechanical stability of ubiquitin is linkage dependent. 
  • The molecular basis of spinocerebellar ataxia type 48 caused by a de novo mutation in the ubiquitin ligase CHIP. 
  • The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor-induced apoptosis. 
  • The protein hSnm1B is stabilized when bound to the telomere-binding protein TRF2. 
  • The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair. 
  • The ubiquitin-conjugating enzyme (E2) Ube2w ubiquitinates the N terminus of substrates. 
  • The unusual UBZ domain of Saccharomyces cerevisiae polymerase η. 
  • Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination. 
  • USP5 Is Dispensable for Monoubiquitin Maintenance in Drosophila. 
  • Ubiquitin recognition by FAAP20 expands the complex interface beyond the canonical UBZ domain. 
  • Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteins. 
  • Ubiquitin-Related Roles of β-Arrestins in Endocytic Trafficking and Signal Transduction. 
  • Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23. 
  • Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin-3. 
  • Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation. 
  • Ubiquitination regulates the neuroprotective function of the deubiquitinase ataxin-3 in vivo. 
  • Ubiquitylated Tax targets and binds the IKK signalosome at the centrosome. 
  • Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms. 
  • Ubiquitylation of p53 by the APC/C inhibitor Trim39. 
  • Ubiquitylation of the transducin betagamma subunit complex. Regulation by phosducin. 
  • Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons. 
  • Unconventional ubiquitin recognition by the ubiquitin-binding motif within the Y family DNA polymerases iota and Rev1. 
  • Uncoupling of Protein Aggregation and Neurodegeneration in a Mouse Amyotrophic Lateral Sclerosis Model. 
  • VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD. 
  • VIAF, a conserved inhibitor of apoptosis (IAP)-interacting factor that modulates caspase activation. 
  • beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1. 
  • {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. 
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  Keywords of People

  • Taylor, Gregory Alan, Professor in Medicine, Integrative Immunobiology