Polyubiquitin

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  Subject Areas on Research

  • Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor. 
  • Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling. 
  • Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages. 
  • K63 polyubiquitination is a new modulator of the oxidative stress response. 
  • Mechanical unfolding of ubiquitin molecules. 
  • Polyubiquitin Chains Linked by Lysine Residue 48 (K48) Selectively Target Oxidized Proteins In Vivo. 
  • The mechanical stability of ubiquitin is linkage dependent.