SUMO-1 Protein

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  Subject Areas on Research

  • Cardiovascular biology: heart fails without pump partner. 
  • Cerebral ischemia/stroke and small ubiquitin-like modifier (SUMO) conjugation--a new target for therapeutic intervention? 
  • O-linked β-N-acetylglucosamine modification of proteins is activated in post-ischemic brains of young but not aged mice: Implications for impaired functional recovery from ischemic stress. 
  • Protein interaction analysis of senataxin and the ALS4 L389S mutant yields insights into senataxin post-translational modification and uncovers mutant-specific binding with a brain cytoplasmic RNA-encoded peptide. 
  • Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2. 
  • SUMO proteomics to decipher the SUMO-modified proteome regulated by various diseases. 
  • Small ubiquitin-like modifier 1-3 conjugation [corrected] is activated in human astrocytic brain tumors and is required for glioblastoma cell survival. 
  • Small ubiquitin-like modifier 3-modified proteome regulated by brain ischemia in novel small ubiquitin-like modifier transgenic mice: putative protective proteins/pathways. 
  • Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia. 
  • Transient focal cerebral ischemia induces a dramatic activation of small ubiquitin-like modifier conjugation. 
  • Ubc9 overexpression and SUMO1 deficiency blunt inflammation after intestinal ischemia/reperfusion. 
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  Keywords of People

  • Karhausen, Jorn, Assistant Professor of Anesthesiology, Anesthesiology, Cardiothoracic
  • Warner, David Samuel, Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology