S-Nitrosothiols

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  Subject Areas on Research

  • A Multiplex Enzymatic Machinery for Cellular Protein S-nitrosylation. 
  • A central role for S-nitrosylation in apoptosis. 
  • A genetic analysis of nitrosative stress. 
  • A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans. 
  • A nitric oxide processing defect of red blood cells created by hypoxia: deficiency of S-nitrosohemoglobin in pulmonary hypertension. 
  • A protein microarray-based analysis of S-nitrosylation. 
  • A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. 
  • Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation. 
  • An S-nitrosothiol (SNO) synthase function of hemoglobin that utilizes nitrite as a substrate. 
  • Antagonists of the system L neutral amino acid transporter (LAT) promote endothelial adhesivity of human red blood cells. 
  • Antiplatelet properties of protein S-nitrosothiols derived from nitric oxide and endothelium-derived relaxing factor. 
  • Ascaris haemoglobin is a nitric oxide-activated 'deoxygenase'. 
  • Assays for S-nitrosothiols and S-nitrosylated proteins and mechanistic insights into cardioprotection. 
  • Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient. 
  • Bronchodilator S-nitrosothiol deficiency in asthmatic respiratory failure. 
  • Calcium regulates S-nitrosylation, denitrosylation, and activity of tissue transglutaminase. 
  • Concerted nitric oxide/oxygen delivery by hemoglobin. 
  • Convergence of G protein-coupled receptor and S-nitrosylation signaling determines the outcome to cardiac ischemic injury. 
  • Detection of protein S-nitrosylation with the biotin-switch technique. 
  • Direct methods for detection of protein S-nitrosylation. 
  • Editorial for "Methods for analysis of nitric oxide signalling by S-nitrosylation". 
  • Endogenous S-nitrosothiols protect against myocardial injury. 
  • Endogenous protein S-Nitrosylation in E. coli: regulation by OxyR. 
  • Endotoxin-mediated nitric oxide synthesis inhibits IL-1beta gene transcription in ANA-1 murine macrophages. 
  • Enzymatic mechanisms regulating protein S-nitrosylation: implications in health and disease. 
  • Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock. 
  • Evolution of adverse changes in stored RBCs. 
  • Export by red blood cells of nitric oxide bioactivity. 
  • Fas-induced caspase denitrosylation. 
  • Hemoglobin conformation couples erythrocyte S-nitrosothiol content to O2 gradients. 
  • Hemoglobin βCys93 is essential for cardiovascular function and integrated response to hypoxia. 
  • Hemoglobin, nitric oxide and molecular mechanisms of hypoxic vasodilation. 
  • Host S-nitrosylation inhibits clostridial small molecule-activated glucosylating toxins. 
  • How do red blood cells cause hypoxic vasodilation? The SNO-hemoglobin paradigm. 
  • Identification of S-nitrosylated proteins in endotoxin-stimulated RAW264.7 murine macrophages. 
  • Identification of S-nitrosylated targets of thioredoxin using a quantitative proteomic approach. 
  • In vivo transfer of nitric oxide between a plasma protein-bound reservoir and low molecular weight thiols. 
  • Inhibition of NF-kappa B by S-nitrosylation. 
  • Methodologies for the characterization, identification and quantification of S-nitrosylated proteins. 
  • Molecular recognition of S-nitrosothiol substrate by its cognate protein denitrosylase. 
  • NO forms an adduct with serum albumin that has endothelium-derived relaxing factor-like properties. 
  • Nitric oxide in the central nervous system. 
  • Nitric oxide modulates HIV-1 replication. 
  • Nitric oxide-generating hydrogels inhibit neointima formation. 
  • Nitrosative stress-induced apoptosis through inhibition of NF-kappa B. 
  • Nitrosative stress: activation of the transcription factor OxyR. 
  • Nitrosative stress: metabolic pathway involving the flavohemoglobin. 
  • Nitrosonium-catalyzed decomposition of s-nitrosothiols in solution: a theoretical and experimental study. 
  • Protection from experimental asthma by an endogenous bronchodilator. 
  • Protection from lipopolysaccharide-induced lung injury by augmentation of airway S-nitrosothiols. 
  • Protein denitrosylation: enzymatic mechanisms and cellular functions. 
  • Proteomic analysis of S-nitrosylation and denitrosylation by resin-assisted capture. 
  • Reactions between nitric oxide and haemoglobin under physiological conditions. 
  • Redox pioneer: Professor Stuart A. Lipton. 
  • Regulated protein denitrosylation by cytosolic and mitochondrial thioredoxins. 
  • Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2. 
  • Regulation of mitochondrial processes by protein S-nitrosylation. 
  • Regulation of protein tyrosine phosphatase 1B in intact cells by S-nitrosothiols. 
  • Relaxation of human bronchial smooth muscle by S-nitrosothiols in vitro. 
  • Responses of normal and sickle cell hemoglobin to S-nitroscysteine: implications for therapeutic applications of NO in treatment of sickle cell disease. 
  • RhoA inactivation by S-nitrosylation regulates vascular smooth muscle contractive signaling. 
  • Role of circulating S-nitrosothiols in control of blood pressure. 
  • S-N dissociation energies of S-nitrosothiols: on the origins of nitrosothiol decomposition rates. 
  • S-Nitrosylation of Sarcomeric Proteins Depresses Myofilament Ca2+)Sensitivity in Intact Cardiomyocytes. 
  • S-nitrosoglutathione inhibits alpha1-adrenergic receptor-mediated vasoconstriction and ligand binding in pulmonary artery. 
  • S-nitrosohemoglobin deficiency: a mechanism for loss of physiological activity in banked blood. 
  • S-nitrosothiol repletion by an inhaled gas regulates pulmonary function. 
  • S-nitrosothiol signaling in respiratory biology. 
  • S-nitrosothiol signaling regulates liver development and improves outcome following toxic liver injury. 
  • S-nitrosothiols and the S-nitrosoproteome of the cardiovascular system. 
  • S-nitrosothiols and the bioregulatory actions of nitrogen oxides through reactions with thiol groups. 
  • S-nitrosylating agents: a novel class of compounds that increase cystic fibrosis transmembrane conductance regulator expression and maturation in epithelial cells. 
  • S-nitrosylation drives cell senescence and aging in mammals by controlling mitochondrial dynamics and mitophagy. 
  • S-nitrosylation in cardiovascular signaling. 
  • S-nitrosylation of beta-arrestin regulates beta-adrenergic receptor trafficking. 
  • S-nitrosylation: physiological regulation of NF-kappaB. 
  • S-nitrosylation: spectrum and specificity. 
  • Solid-phase capture for the detection and relative quantification of S-nitrosoproteins by mass spectrometry. 
  • The relaxant properties in guinea pig airways of S-nitrosothiols. 
  • Transport rather than diffusion-dependent route for nitric oxide gas activity in alveolar epithelium. 
  • Transpulmonary flux of S-nitrosothiols and pulmonary vasodilation during nitric oxide inhalation: role of transport. 
  • Treatment-related biomarkers in pulmonary hypertension. 
  • Umbilical arterial S-nitrosothiols in stressed newborns: role in perinatal circulatory transition.