Membrane Transport Proteins

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  Subject Areas on Research

  • A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease. 
  • A copper-regulated transporter required for copper acquisition, pigmentation, and specific stages of development in Drosophila melanogaster. 
  • A cross-sectional survey of Plasmodium falciparum pfcrt mutant haplotypes in the Democratic Republic of Congo. 
  • A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing. 
  • A homopolymer polymorphism in the TOMM40 gene contributes to cognitive performance in aging. 
  • A novel nonopioid action of enkephalins: competitive inhibition of the mammalian brain high affinity L-proline transporter. 
  • ABCs of erythroid mitochondrial iron uptake. 
  • APOE ε4-TOMM40 '523 haplotypes and the risk of Alzheimer's disease in older Caucasian and African Americans. 
  • APOE/TOMM40 genetic loci, white matter hyperintensities, and cerebral microbleeds. 
  • Aberrant responses in social interaction of dopamine transporter knockout mice. 
  • Activation state of the M3 muscarinic acetylcholine receptor modulates mammalian odorant receptor signaling. 
  • Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves beta-cell function. 
  • Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels. 
  • Adrenoceptors, uncoupling proteins, and energy expenditure. 
  • African-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles. 
  • Allelic differences in the serotonin transporter-linked polymorphic region in geriatric depression. 
  • Alterations in serotonin transporter expression in brain regions of rats exposed neonatally to chlorpyrifos. 
  • Altered localization of choline transporter sites in the mouse hippocampus after prenatal heroin exposure. 
  • Alzheimer's disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936. 
  • Alzheimer's disease susceptibility genes APOE and TOMM40, and hippocampal volumes in the Lothian birth cohort 1936. 
  • Amino acid permeases require COPII components and the ER resident membrane protein Shr3p for packaging into transport vesicles in vitro. 
  • An animal model of attention deficit hyperactivity disorder. 
  • Androgen stimulation of gross cystic disease fluid protein and carcinoembryonic antigen in patients with metastatic breast carcinoma. 
  • Ankyrin-B is a PI3P effector that promotes polarized α5β1-integrin recycling via recruiting RabGAP1L to early endosomes. 
  • Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter. 
  • Antiproliferative action of dopamine and norepinephrine in neuroblastoma cells expressing the human dopamine transporter. 
  • Application of a molecular marker for surveillance of chloroquine-resistant falciparum malaria. 
  • Approaches to identify monoamine transporter interacting proteins. 
  • Assignment of the creatine transporter gene (SLC6A8) to human chromosome Xq28 telomeric to G6PD. 
  • Association of a Novel Mutation in the Plasmodium falciparum Chloroquine Resistance Transporter With Decreased Piperaquine Sensitivity. 
  • Autoradiographic quantification of neurochemical markers of serotonin, dopamine and opioid systems in rat brain mesolimbic regions following chronic St John's wort treatment. 
  • Basal forebrain moderates the magnitude of task-dependent amygdala functional connectivity. 
  • Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice. 
  • Blood glucose levels and cortical thinning in cognitively normal, middle-aged adults. 
  • Bone histomorphometric and biomechanical abnormalities in mice homozygous for deletion of the dopamine transporter gene. 
  • BtubA-BtubB heterodimer is an essential intermediate in protofilament assembly. 
  • COPII-cargo interactions direct protein sorting into ER-derived transport vesicles. 
  • Catecholamine release and uptake in the mouse prefrontal cortex. 
  • Catecholamine transporters and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity: studies comparing the cloned human noradrenaline and human dopamine transporter. 
  • Cell biology and physiology of the uroepithelium. 
  • Center stage for the serotonin transporter: a gain-of-function polymorphism in persons with obsessive-compulsive disorder. 
  • Central nervous system serotonin function and cardiovascular responses to stress. 
  • Cerebrospinal fluid cortisol concentrations in healthy elderly are affected by both APOE and TOMM40 variants. 
  • Characterization of a putative periplasmic transport system for octopine accumulation encoded by Agrobacterium tumefaciens Ti plasmid pTiA6. 
  • Characterization of the poly-T variant in the TOMM40 gene in diverse populations. 
  • Chlamydia effector proteins and new insights into chlamydial cellular microbiology. 
  • Chlamydial intracellular survival strategies. 
  • Chronic family stress moderates the association between a TOMM40 variant and triglyceride levels in two independent Caucasian samples. 
  • Cloning and functional characterization of a cocaine-sensitive dopamine transporter. 
  • Cloning, gene structure and genomic localization of an orphan transporter from mouse kidney with six alternatively-spliced isoforms. 
  • Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter. 
  • Cloning, pharmacological characterization, and genomic localization of the human creatine transporter. 
  • Cocaine and amphetamine elicit differential effects in rats with a unilateral injection of dopamine transporter antisense oligodeoxynucleotides. 
  • Cocaine self-administration in dopamine-transporter knockout mice. 
  • Comparative expression analysis of the phosphocreatine circuit in extant primates: Implications for human brain evolution. 
  • Concurrent autoreceptor-mediated control of dopamine release and uptake during neurotransmission: an in vivo voltammetric study. 
  • Conservation of a novel vacuolar transporter in Plasmodium species and its central role in chloroquine resistance of P. falciparum. 
  • Construction and destruction of MHC class I in the peptide-loading complex. 
  • Convergent control of serotonin transporter expression by glucocorticoids and cocaine in fetal and neonatal rat brain. 
  • Ctr1 drives intestinal copper absorption and is essential for growth, iron metabolism, and neonatal cardiac function. 
  • Decreased ethanol preference and consumption in dopamine transporter female knock-out mice. 
  • Delineation of discrete domains for substrate, cocaine, and tricyclic antidepressant interactions using chimeric dopamine-norepinephrine transporters. 
  • Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling. 
  • Developmental exposure to terbutaline and chlorpyrifos: pharmacotherapy of preterm labor and an environmental neurotoxicant converge on serotonergic systems in neonatal rat brain regions. 
  • Diet-induced changes in uncoupling proteins in obesity-prone and obesity-resistant strains of mice. 
  • Differences in platelet serotonin transporter sites between African-American tobacco smokers and non-smokers. 
  • Differential psychostimulant-induced activation of neural circuits in dopamine transporter knockout and wild type mice. 
  • Differential quantal release of histamine and 5-hydroxytryptamine from mast cells of vesicular monoamine transporter 2 knockout mice. 
  • Differential regulation of the dopamine D1, D2 and D3 receptor gene expression and changes in the phenotype of the striatal neurons in mice lacking the dopamine transporter. 
  • Differential regulation of tyrosine hydroxylase in the basal ganglia of mice lacking the dopamine transporter. 
  • Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. 
  • Do glucocorticoids contribute to the abnormalities in serotonin transporter expression and function seen in depression? An animal model. 
  • Dopamine genes and ADHD. 
  • Dopamine neuronal transport kinetics and effects of amphetamine. 
  • Dopamine tone regulates D1 receptor trafficking and delivery in striatal neurons in dopamine transporter-deficient mice. 
  • Dopamine transporter expression confers cytotoxicity to low doses of the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium. 
  • Dopamine transporter is required for in vivo MPTP neurotoxicity: evidence from mice lacking the transporter. 
  • Dopamine transporter-dependent and -independent actions of trace amine beta-phenylethylamine. 
  • Dopamine transporters and neuronal injury. 
  • Dystonia with and without deafness is caused by TIMM8A mutation. 
  • Elevated MAL expression is accompanied by promoter hypomethylation and platinum resistance in epithelial ovarian cancer. 
  • Energy metabolism in uncoupling protein 3 gene knockout mice. 
  • Ex Vivo Drug Susceptibility Testing and Molecular Profiling of Clinical Plasmodium falciparum Isolates from Cambodia from 2008 to 2013 Suggest Emerging Piperaquine Resistance. 
  • Expression of mRNA coding for the serotonin transporter in aged vs. young rat brain: differential effects of glucocorticoids. 
  • Expression of mitofusin 2(R94Q) in a transgenic mouse leads to Charcot-Marie-Tooth neuropathy type 2A. 
  • Fasciola hepatica: molecular cloning, nucleotide sequence, and expression of a gene encoding a polypeptide homologous to a Schistosoma mansoni fatty acid-binding protein. 
  • Fetal and adolescent nicotine administration: effects on CNS serotonergic systems. 
  • Fluoxymesterone stimulation of tumor marker secretion in patients with breast carcinoma. 
  • Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1. 
  • Generation and phenotypic analysis of mice lacking all urea transporters. 
  • Genetic studies of quantitative MCI and AD phenotypes in ADNI: Progress, opportunities, and plans. 
  • Genetic variation at a single locus and age of onset for Alzheimer's disease. 
  • Genetics of childhood disorders: XXIV. ADHD, part 8: hyperdopaminergic mice as an animal model of ADHD. 
  • Genetics of drug-resistant Plasmodium falciparum malaria in the Venezuelan state of Bolivar. 
  • Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans. 
  • Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study. 
  • Glutamatergic modulation of hyperactivity in mice lacking the dopamine transporter. 
  • High affinity choline transporter status in Alzheimer's disease tissue from rapid autopsy. 
  • High affinity copper transport protein in the lizard Podarcis sicula: molecular cloning, functional characterization and expression in somatic tissues, follicular oocytes and eggs. 
  • Human dopamine transporter gene not linked to schizophrenia in multigenerational pedigrees. 
  • Hyperactivity and impaired response habituation in hyperdopaminergic mice. 
  • Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. 
  • Hypertension and impaired glycine handling in mice lacking the orphan transporter XT2. 
  • Identification of a copper transporter family in Arabidopsis thaliana. 
  • Images in neuroscience. A mouse knockout. 
  • Images in neuroscience. Molecular biology, II. A dopamine transporter mouse knockout. 
  • Improving the odorant sensitivity of olfactory receptor-expressing yeast with accessory proteins. 
  • Inactivation of the MAL gene in breast cancer is a common event that predicts benefit from adjuvant chemotherapy. 
  • Inactivation of the dopamine transporter reveals essential roles of dopamine in the control of locomotion, psychostimulant response, and pituitary function. 
  • Increased MPTP neurotoxicity in vesicular monoamine transporter 2 heterozygote knockout mice. 
  • Increased methamphetamine neurotoxicity in heterozygous vesicular monoamine transporter 2 knock-out mice. 
  • Increased rewarding properties of morphine in dopamine-transporter knockout mice. 
  • Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation. 
  • Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. 
  • Influence of serotonin transporter promoter region polymorphisms on hippocampal volumes in late-life depression. 
  • Intracellular Action of a Secreted Peptide Required for Fungal Virulence. 
  • Karyotypic abnormalities create discordance of germline genotype and cancer cell phenotypes. 
  • Knockout of the vesicular monoamine transporter 2 gene results in neonatal death and supersensitivity to cocaine and amphetamine. 
  • Lack of association between autism and SLC25A12. 
  • Levels of cerebrospinal fluid neurofilament light protein in healthy elderly vary as a function of TOMM40 variants. 
  • Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis. 
  • Longitudinal modeling of cognitive aging and the TOMM40 effect. 
  • Loss of autoreceptor functions in mice lacking the dopamine transporter. 
  • Low plasma leptin in response to dietary fat in diabetes- and obesity-prone mice. 
  • MDMA "ecstasy" alters hyperactive and perseverative behaviors in dopamine transporter knockout mice. 
  • Magnetic resonance imaging at microscopic resolution reveals subtle morphological changes in a mouse model of dopaminergic hyperfunction. 
  • Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter. 
  • Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. 
  • Mice lacking the dopamine transporter display altered regulation of distal colonic motility. 
  • Mitofusins 1/2 and ERRalpha expression are increased in human skeletal muscle after physical exercise. 
  • Modeling geriatric depression in animals: biochemical and behavioral effects of olfactory bulbectomy in young versus aged rats. 
  • Molecular characterization of the dopamine transporter. 
  • Molecular determinants of sensitivity to antitumor agents. 
  • Mutations in SLC19A2 cause thiamine-responsive megaloblastic anaemia associated with diabetes mellitus and deafness. 
  • Mutations in the novel mitochondrial protein REEP1 cause hereditary spastic paraplegia type 31. 
  • NADPH oxidase promotes NF-kappaB activation and proliferation in human airway smooth muscle. 
  • Neurobehavioral teratogenicity of sarin in an avian model. 
  • New Genetic Approaches to AD: Lessons from APOE-TOMM40 Phylogenetics. 
  • No association between alleles or genotypes at the dopamine transporter gene and schizophrenia. 
  • No association between polymorphisms in the serotonin transporter gene and susceptibility to cocaine dependence among African-American individuals. 
  • Normal cardiac function in mice with supraphysiological cardiac creatine levels. 
  • Novel loci and pathways significantly associated with longevity. 
  • Oligomerization and trafficking of the human dopamine transporter. Mutational analysis identifies critical domains important for the functional expression of the transporter. 
  • Overexpression of the high affinity choline transporter in cortical regions affected by Alzheimer's disease. Evidence from rapid autopsy studies. 
  • Permanent, sex-selective effects of prenatal or adolescent nicotine exposure, separately or sequentially, in rat brain regions: indices of cholinergic and serotonergic synaptic function, cell signaling, and neural cell number and size at 6 months of age. 
  • Persistent nuclear factor-kappa B activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production. 
  • Phenotypic and genotypic evaluation of fluconazole resistance in vaginal Candida strains isolated from HIV-infected women from Brazil. 
  • Plasma membrane monoamine transporters: structure, regulation and function. 
  • Plasma membrane transporters of serotonin, dopamine, and norepinephrine mediate serotonin accumulation in atypical locations in the developing brain of monoamine oxidase A knock-outs. 
  • Pleiotropy and allelic heterogeneity in the TOMM40-APOE genomic region related to clinical and metabolic features of hepatitis C infection. 
  • Polymorphism in the TOMM40 gene modifies the risk of developing sporadic inclusion body myositis and the age of onset of symptoms. 
  • Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine. 
  • Predicting treatment-outcome in cocaine dependence from admission urine drug screen and peripheral serotonergic measures. 
  • Prenatal nicotine alters the developmental neurotoxicity of postnatal chlorpyrifos directed toward cholinergic systems: better, worse, or just "different?". 
  • Prenatal nicotine exposure alters the response to nicotine administration in adolescence: effects on cholinergic systems during exposure and withdrawal. 
  • Prepulse inhibition deficits and perseverative motor patterns in dopamine transporter knock-out mice: differential effects of D1 and D2 receptor antagonists. 
  • Profound neuronal plasticity in response to inactivation of the dopamine transporter. 
  • Programming of brainstem serotonin transporter development by prenatal glucocorticoids. 
  • Purified lac permease and cytochrome o oxidase are functional as monomers. 
  • Quantitation of response to therapy in patients with metastatic breast carcinoma by serial analysis of plasma gross cystic disease fluid protein and carcinoembryonic antigen. 
  • RTP family members induce functional expression of mammalian odorant receptors. 
  • Re-evaluation of the role of the dopamine transporter in dopamine system homeostasis. 
  • Receptor-transporting protein 1 short (RTP1S) mediates translocation and activation of odorant receptors by acting through multiple steps. 
  • Regression of atherosclerosis in monkeys reduces vascular superoxide levels. 
  • Regulation of the uncoupling protein-2 gene in INS-1 beta-cells by oleic acid. 
  • Regulators of pseudohyphal differentiation in Saccharomyces cerevisiae identified through multicopy suppressor analysis in ammonium permease mutant strains. 
  • Relationship between serotonin transporter gene polymorphisms and platelet serotonin transporter sites among African-American cocaine-dependent individuals and healthy volunteers. 
  • Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels. 
  • Return of chloroquine antimalarial efficacy in Malawi. 
  • Return of chloroquine-susceptible falciparum malaria in Malawi was a reexpansion of diverse susceptible parasites. 
  • Return of widespread chloroquine-sensitive Plasmodium falciparum to Malawi. 
  • Reversal of P-glycoprotein expressed in Escherichia coli leaky mutant by ascorbic acid. 
  • Role of UTB urea transporters in the urine concentrating mechanism of the rat kidney. 
  • Role of dopamine transporter in methamphetamine-induced neurotoxicity: evidence from mice lacking the transporter. 
  • Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity. 
  • Seasonal variations in the binding of [3H]paroxetine to the platelet serotonin transporter sites in African-American cocaine-dependent patients and healthy volunteers. 
  • Serotonergic systems targeted by developmental exposure to chlorpyrifos: effects during different critical periods. 
  • Serotonin transporter expression in rat brain regions and blood platelets: aging and glucocorticoid effects. 
  • Serotonin transporter gene polymorphism and antidepressant response. 
  • Serotonin transporter polymorphisms and measures of impulsivity, aggression, and sensation seeking among African-American cocaine-dependent individuals. 
  • Serotonin-related gene polymorphisms and central nervous system serotonin function. 
  • Short-term adolescent nicotine exposure has immediate and persistent effects on cholinergic systems: critical periods, patterns of exposure, dose thresholds. 
  • Specificity of the type II secretion systems of enterotoxigenic Escherichia coli and Vibrio cholerae for heat-labile enterotoxin and cholera toxin. 
  • Structural analysis of a periplasmic binding protein in the tripartite ATP-independent transporter family reveals a tetrameric assembly that may have a role in ligand transport. 
  • Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters. 
  • Synergism of accessory factors in functional expression of mammalian odorant receptors. 
  • Synthesis and biological evaluation of pentacyclo[5.4.0.0(2,6).0(3,10).0(5,9)]undecane derivatives as potential therapeutic agents in Parkinson's disease. 
  • Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers. 
  • TGF-β-induced stromal CYR61 promotes resistance to gemcitabine in pancreatic ductal adenocarcinoma through downregulation of the nucleoside transporters hENT1 and hCNT3. 
  • TOMM40 alterations in Alzheimer's disease over a 2-year follow-up period. 
  • TOMM40 and APOE: Requirements for replication studies of association with age of disease onset and enrichment of a clinical trial. 
  • TOMM40'523 variant and cognitive decline in older persons with APOE ε3/3 genotype. 
  • The Alu neurodegeneration hypothesis: A primate-specific mechanism for neuronal transcription noise, mitochondrial dysfunction, and manifestation of neurodegenerative disease. 
  • The Alzheimer's associated 5' region of the SORL1 gene cis regulates SORL1 transcripts expression. 
  • The Arabidopsis copper transporter COPT1 functions in root elongation and pollen development. 
  • The Haemophilus influenzae hFbpABC Fe3+ transporter: analysis of the membrane permease and development of a gallium-based screen for mutants. 
  • The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae. 
  • The NH(2)-terminus of norepinephrine transporter contains a basolateral localization signal for epithelial cells. 
  • The TOMM40 poly-T rs10524523 variant is associated with cognitive performance among non-demented elderly with type 2 diabetes. 
  • The alterations in CNS serotonergic mechanisms caused by neonatal chlorpyrifos exposure are permanent. 
  • The cis-regulatory effect of an Alzheimer's disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes. 
  • The dopamine transporter. The cloned target site of parkinsonism-inducing toxins and of drugs of abuse. 
  • The dopamine transporter: a crucial component regulating dopamine transmission. 
  • The effect of TOMM40 poly-T length on gray matter volume and cognition in middle-aged persons with APOE ε3/ε3 genotype. 
  • The filamentous bacteriophage assembly proteins require the bacterial SecA protein for correct localization to the membrane. 
  • The final touches make perfect the peptide-MHC class I repertoire. 
  • The genetic determinants of smoking. 
  • The human olfactory transcriptome. 
  • The importance of being connected. 
  • The mitochondrial 2-oxoglutarate carrier is part of a metabolic pathway that mediates glucose- and glutamine-stimulated insulin secretion. 
  • The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion. 
  • The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter. 
  • The sea urchin embryo as a model for mammalian developmental neurotoxicity: ontogenesis of the high-affinity choline transporter and its role in cholinergic trophic activity. 
  • The selective serotonin-2A receptor antagonist M100907 reverses behavioral deficits in dopamine transporter knockout mice. 
  • The vesicular glutamate transporter 1 (xVGlut1) is expressed in discrete regions of the developing Xenopus laevis nervous system. 
  • Trafficking of mammalian chemosensory receptors by receptor-transporting proteins. 
  • Trafficking of the vesicular acetylcholine transporter in SN56 cells: a dynamin-sensitive step and interaction with the AP-2 adaptor complex. 
  • Transcriptional regulation of the mouse uncoupling protein-2 gene. Double E-box motif is required for peroxisome proliferator-activated receptor-gamma-dependent activation. 
  • Translocase of outer mitochondrial membrane 40 homolog (TOMM40) poly-T length modulates lorazepam-related cognitive toxicity in healthy APOE ε4-negative elderly. 
  • Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. 
  • Understanding the genetics of APOE and TOMM40 and role of mitochondrial structure and function in clinical pharmacology of Alzheimer's disease. 
  • VNTR polymorphism for the human dopamine transporter gene (DAT1). 
  • Variation of human amygdala response during threatening stimuli as a function of 5'HTTLPR genotype and personality style. 
  • Whole exome sequencing and functional studies identify an intronic mutation in TRAPPC2 that causes SEDT. 
  • [Behavioral, cellular and molecular consequences of the dopamine transporter gene inactivation]. 
  • [Pharmacological modulation of dopaminergic transmission in the rat striatum in vivo]. 
  • [Serotonin transporter gene polymorphism and factors influencing mental and physical health in aging]. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Kuehn, Margarethe Joanna, Associate Professor of Biochemistry, Molecular Genetics and Microbiology
  • MacFall, James R., Adjunct Professor in the Department of Radiology, Radiology
  • Wray, Gregory Allan, Professor of Biology, Evolutionary Anthropology