Potassium Channel Blockers

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  Subject Areas on Research

  • (-)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637): a novel ATP-sensitive potassium channel opener efficacious in suppressing urinary bladder contractions. I. In vitro characterization. 
  • A role for TREK1 in generating the slow afterhyperpolarization in developing starburst amacrine cells. 
  • Antihistamine mepyramine directly inhibits KCNQ/M channel and depolarizes rat superior cervical ganglion neurons. 
  • Aspartate release from rat hippocampal synaptosomes. 
  • Asymmetrical electrically induced injury of rabbit ventricular myocytes. 
  • Basic concepts in cellular cardiac electrophysiology: Part II: Block of ion channels by antiarrhythmic drugs. 
  • Cardiac transient outward potassium current: a pulse chemistry model of frequency-dependent properties. 
  • Cholecystokinin excites interneurons in rat basolateral amygdala. 
  • Defective glycolysis and calcium signaling underlie impaired insulin secretion in a transgenic mouse. 
  • Editorial by concerned physicians: Unintended effect of the orphan drug act on the potential cost of 3,4-diaminopyridine. 
  • Effect of dofetilide on survival in patients with supraventricular arrhythmias. 
  • Effects of U-37883A, a vascular selective KATP+ channel antagonist, in the pulmonary and hindlimb circulation. 
  • Efficacy and safety of the Gardos channel blocker, senicapoc (ICA-17043), in patients with sickle cell anemia. 
  • Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway. 
  • Fluid shear stress induces endothelial transforming growth factor beta-1 transcription and production. Modulation by potassium channel blockade. 
  • Improving the assessment of heart toxicity for all new drugs through translational regulatory science. 
  • Inhibitors of ATP-sensitive potassium channels stimulate intestinal cholecystokinin secretion. 
  • Kv3.1b is a novel component of CNS nodes. 
  • Mortality in patients after a recent myocardial infarction: a randomized, placebo-controlled trial of azimilide using heart rate variability for risk stratification. 
  • NMDA-Receptor-dependent synaptic activation of voltage-dependent calcium channels in basolateral amygdala. 
  • Neocortical disynaptic inhibition requires somatodendritic integration in interneurons. 
  • Population Pharmacokinetics/Pharmacodynamics of 3,4-Diaminopyridine Free Base in Patients With Lambert-Eaton Myasthenia. 
  • Potassium channel blockade amplifies cardiac instability numerical studies of torsades de pointes. 
  • Presynaptic BK channels modulate ethanol-induced enhancement of GABAergic transmission in the rat central amygdala nucleus. 
  • Proarrhythmic response to potassium channel blockade. Numerical studies of polymorphic tachyarrhythmias. 
  • Regulation of cholecystokinin secretion in STC-1 cells by nitric oxide. 
  • Selective inhibition of Kir currents by antihistamines. 
  • Somatostatin receptor subtype 4 couples to the M-current to regulate seizures. 
  • The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K+ channels and activation of Ca2+-activated Cl- channels. 
  • The histone lysine demethylase Kdm6b is required for activity-dependent preconditioning of hippocampal neuronal survival. 
  • The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets. 
  • Validation of the triple timed up-and-go test in Lambert-Eaton myasthenia. 
  • Variability of action potential duration in pharmacologically induced long QT syndrome type 1. 
  • Voltage-gated ion channels in nociceptors: modulation by cGMP. 
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  Keywords of People

  • Starmer, Charles Franklin, Professor Emeritus of Computer Science, Computer Science