Amino Acid Transport Systems

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  Subject Areas on Research

  • Amino acid permeases require COPII components and the ER resident membrane protein Shr3p for packaging into transport vesicles in vitro. 
  • Aminoaciduria and altered renal expression of luminal amino acid transporters in mice lacking novel gene collectrin. 
  • COPII-cargo interactions direct protein sorting into ER-derived transport vesicles. 
  • Cell surface polarization during yeast mating. 
  • Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters. 
  • Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells. 
  • Refinement of the PARK3 locus on chromosome 2p13 and the analysis of 14 candidate genes. 
  • Synaptic activation of presynaptic glutamate transporter currents in nerve terminals. 
  • The effect of an amino acid-lowering diet on the rate of melphalan entry into brain and xenotransplanted glioma. 
  • Transport of amino acid-based prodrugs by the Na+- and Cl(-) -coupled amino acid transporter ATB0,+ and expression of the transporter in tissues amenable for drug delivery. 
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  Keywords of People

  • Linardic, Corinne Mary, Associate Professor of Pediatrics, Pharmacology & Cancer Biology