Sodium Channel Blockers

• 

  Subject Areas on Research

  • A circuit model for saccadic suppression in the superior colliculus. 
  • Alternative splicing of an insect sodium channel gene generates pharmacologically distinct sodium channels. 
  • An alanine in segment 3 of domain III (IIIS3) of the cockroach sodium channel contributes to the low pyrethroid sensitivity of an alternative splice variant. 
  • An in vitro study of horizontal connections in the intermediate layer of the superior colliculus. 
  • Analysis of the action of lidocaine on insect sodium channels. 
  • Ankyrin-G coordinates intercalated disc signaling platform to regulate cardiac excitability in vivo. 
  • Antiepileptic drugs prevent seizures in hyperbaric oxygen: A novel model of epileptiform activity. 
  • Basic concepts in cellular cardiac electrophysiology: Part II: Block of ion channels by antiarrhythmic drugs. 
  • Block of wild-type and inactivation-deficient cardiac sodium channels IFM/QQQ stably expressed in mammalian cells. 
  • Cholecystokinin excites interneurons in rat basolateral amygdala. 
  • Computer-aided Discovery of a New Nav1.7 Inhibitor for Treatment of Pain and Itch. 
  • Discovery of a Novel Series of Tricyclic Oxadiazine 4a-Methyl Esters Based on Indoxacarb as Potential Sodium Channel Blocker/Modulator Insecticides. 
  • Improving the assessment of heart toxicity for all new drugs through translational regulatory science. 
  • Increased Antiseizure Effectiveness with Tiagabine Combined with Sodium Channel Antagonists in Mice Exposed to Hyperbaric Oxygen. 
  • Iron accumulation in bronchial epithelial cells is dependent on concurrent sodium transport. 
  • Ischemic modulation of vulnerable period and the effects of pharmacological treatment of ischemia-induced arrhythmias: a simulation study. 
  • Molecular Mechanism of Action and Selectivity of Sodium Ch annel Blocker Insecticides. 
  • Molecular basis of differential sensitivity of insect sodium channels to DCJW, a bioactive metabolite of the oxadiazine insecticide indoxacarb. 
  • Molecular characterization and functional expression of the DSC1 channel. 
  • Molecular determinants on the insect sodium channel for the specific action of type II pyrethroid insecticides. 
  • Mutations in the transmembrane helix S6 of domain IV confer cockroach sodium channel resistance to sodium channel blocker insecticides and local anesthetics. 
  • Na+ channel function, regulation, structure, trafficking and sequestration. 
  • Neocortical disynaptic inhibition requires somatodendritic integration in interneurons. 
  • Neural origin of evoked potentials during thalamic deep brain stimulation. 
  • Nociceptors are interleukin-1beta sensors. 
  • Open Na+ channel blockade: multiple rest states revealed by channel interactions with disopyramide and quinidine. 
  • Pharmacologically defined components of the normal porcine multifocal ERG. 
  • Potassium channel blockade amplifies cardiac instability numerical studies of torsades de pointes. 
  • Ranolazine in patients with incomplete revascularisation after percutaneous coronary intervention (RIVER-PCI): a multicentre, randomised, double-blind, placebo-controlled trial. 
  • Ranolazine reduces atrial fibrillatory wave frequency. 
  • Relationship Between Optimism and Outcomes in Patients With Chronic Angina Pectoris. 
  • Relationship between structure and sodium channel blockade by lidocaine and its amino-alkyl derivatives. 
  • Rescue of Methyl-CpG Binding Protein 2 Dysfunction-induced Defects in Newborn Neurons by Pentobarbital. 
  • Reversible inactivation of macaque frontal eye field. 
  • Role of the sixth transmembrane segment of domain IV of the cockroach sodium channel in the action of sodium channel blocker insecticides. 
  • Sodium channel NaV1.3 is important for enterochromaffin cell excitability and serotonin release. 
  • The Receptor Site and Mechanism of Action of Sodium Channel Blocker Insecticides. 
  • The role of inactivation in open-channel block of the sodium channel: studies with inactivation-deficient mutant channels. 
  • Thrombospondin-4 contributes to spinal sensitization and neuropathic pain states. 
  • Transcriptional and functional profiles of voltage-gated Na(+) channels in injured and non-injured DRG neurons in the SNI model of neuropathic pain. 
  • Two novel sodium channel mutations associated with resistance to indoxacarb and metaflumizone in the diamondback moth, Plutella xylostella. 
  • Use of Antiarrhythmic Medications in Medicare Part D Patients With an Implantable Cardioverter-Defibrillator and Ventricular Tachycardia. 
  • Use of bulleyaconitine A as an adjuvant for prolonged cutaneous analgesia in the rat. 
  • Voltage-gated ion channels in nociceptors: modulation by cGMP. 
  • What happens when cardiac Na channel function is compromised? 2. Numerical studies of the vulnerable period in tissue altered by drugs. 
  • κ-Opioid receptors in the central amygdala regulate ethanol actions at presynaptic GABAergic sites. 
• 

  Keywords of People

  • Starmer, Charles Franklin, Professor Emeritus of Computer Science, Computer Science