Monocarboxylic Acid Transporters
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Subject Areas on Research
- A novel transmembrane transporter encoded by the XPCT gene in Xq13.2.
- Abnormal creatine transport of mutations in monocarboxylate transporter 12 (MCT12) found in patients with age-related cataract can be partially rescued by exogenous chaperone CD147.
- Adaptive Activation of a Stress Response Pathway Improves Learning and Memory Through Gs and β-Arrestin-1-Regulated Lactate Metabolism.
- Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels.
- Altered expression of brain monocarboxylate transporter 1 in models of temporal lobe epilepsy.
- Carbohydrate restriction and lactate transporter inhibition in a mouse xenograft model of human prostate cancer.
- HPV status-independent association of alcohol and tobacco exposure or prior radiation therapy with promoter methylation of FUSSEL18, EBF3, IRX1, and SEPT9, but not SLC5A8, in head and neck squamous cell carcinomas.
- Lactate uptake contributes to the NAD(P)H biphasic response and tissue oxygen response during synaptic stimulation in area CA1 of rat hippocampal slices.
- Monocarboxylate transporter 1 is deficient on microvessels in the human epileptogenic hippocampus.
- Redistribution of monocarboxylate transporter 2 on the surface of astrocytes in the human epileptogenic hippocampus.
- Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice.
- Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis.
- The H+-linked monocarboxylate transporter (MCT1/SLC16A1): a potential therapeutic target for high-risk neuroblastoma.
- Tissue distribution and thyroid hormone effects on mRNA abundance for membrane transporters Mct8, Mct10, and organic anion-transporting polypeptides (Oatps) in a teleost fish.
- Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation.
- Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms.