Cation Transport Proteins

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  Subject Areas on Research

  • 3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency. 
  • A Mep2-dependent transcriptional profile links permease function to gene expression during pseudohyphal growth in Saccharomyces cerevisiae. 
  • A comparison of Zn2+- and Ca2+-triggered depolarization of liver mitochondria reveals no evidence of Zn2+-induced permeability transition. 
  • A de novo deafwaddler mutation of Pmca2 arising in ES cells and hitchhiking with a targeted modification of the Pparg gene. 
  • A mouse model of juvenile hemochromatosis. 
  • A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice. 
  • A new face of the Rhesus antigen. 
  • A possible role for TRPV4 receptors in asthma. 
  • A role for the copper transporter Ctr1 in the synergistic interaction between hyperthermia and cisplatin treatment. 
  • A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway. 
  • Abnormal osmotic regulation in trpv4-/- mice. 
  • Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice. 
  • Analysis of the E399D mutation in SLC11A2. 
  • Association of SLC11A1 with tuberculosis and interactions with NOS2A and TLR2 in African-Americans and Caucasians. 
  • Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene. 
  • Brain-derived neurotrophic factor but not vesicular zinc promotes TrkB activation within mossy fibers of mouse hippocampus in vivo. 
  • Cardiac copper deficiency activates a systemic signaling mechanism that communicates with the copper acquisition and storage organs. 
  • Cardiac repolarization: current knowledge, critical gaps, and new approaches to drug development and patient management. 
  • Closing the iron gate. 
  • Coordination of platinum therapeutic agents to met-rich motifs of human copper transport protein1. 
  • Copper is required for oncogenic BRAF signalling and tumorigenesis. 
  • Copper shares a piece of the pi. 
  • Cryo-EM Structures of the Magnesium Channel CorA Reveal Symmetry Break upon Gating. 
  • DMT1 expression is increased in the lungs of hypotransferrinemic mice. 
  • Defective glycosylation and multisystem abnormalities characterize the primary immunodeficiency XMEN disease. 
  • Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice. 
  • Disruption of iron homeostasis in mesothelial cells after talc pleurodesis. 
  • Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic β cell fate in response to cytokines. 
  • Divalent metal transporter-1 decreases metal-related injury in the lung. 
  • Evaluation of SLC11A1 as an inflammatory bowel disease candidate gene. 
  • Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders. 
  • Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse. 
  • Genes that modify the hemochromatosis phenotype in mice. 
  • Genetic variants on chromosome 1q41 influence ocular axial length and high myopia. 
  • Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice. 
  • Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts. 
  • HPV status-independent association of alcohol and tobacco exposure or prior radiation therapy with promoter methylation of FUSSEL18, EBF3, IRX1, and SEPT9, but not SLC5A8, in head and neck squamous cell carcinomas. 
  • Hepcidin expression in human airway epithelial cells is regulated by interferon-γ. 
  • In vitro reconstitution of cortical actin assembly sites in budding yeast. 
  • Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin. 
  • Iron importers Zip8 and Zip14 are expressed in retina and regulated by retinal iron levels. 
  • Iron increases expression of iron-export protein MTP1 in lung cells. 
  • Iron is essential for neuron development and memory function in mouse hippocampus. 
  • Iron is hot: an update on the pathophysiology of hemochromatosis. 
  • Iron transport across biologic membranes. 
  • Iron uptake and Nramp2/DMT1/DCT1 in human bronchial epithelial cells. 
  • Iron-dependent regulation of the divalent metal ion transporter. 
  • Iron-responsive miR-485-3p regulates cellular iron homeostasis by targeting ferroportin. 
  • Kinetics and mechanism of iron release from the bacterial ferric binding protein nFbp: exogenous anion influence and comparison with mammalian transferrin. 
  • Kinetics of iron release from ferric binding protein (FbpA): mechanistic implications in bacterial periplasm-to-cytosol Fe3+ transport. 
  • Kinome screen of ferroptosis reveals a novel role of ATM in regulating iron metabolism. 
  • Lung injury after ozone exposure is iron dependent. 
  • Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans. 
  • Mammalian iron transport: an unexpected link between metal homeostasis and host defense. 
  • Metabolic capacity regulates iron homeostasis in endothelial cells. 
  • Metal transporters and disease. 
  • Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. 
  • Mining copper transport genes. 
  • Model Peptide Studies Reveal a Mixed Histidine-Methionine Cu(I) Binding Site at the N-Terminus of Human Copper Transporter 1. 
  • Model peptides provide new insights into the role of histidine residues as potential ligands in human cellular copper acquisition via Ctr1. 
  • Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. 
  • Multiple different missense mutations in the pore region of HERG in patients with long QT syndrome. 
  • Multiple horizontal gene transfers of ammonium transporters/ammonia permeases from prokaryotes to eukaryotes: toward a new functional and evolutionary classification. 
  • Mutational analysis of ATP7B and genotype-phenotype correlation in Japanese with Wilson's disease. 
  • Novel gene functions required for melanization of the human pathogen Cryptococcus neoformans. 
  • Novel missense mutation in the cyclic nucleotide-binding domain of HERG causes long QT syndrome. 
  • Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. 
  • Obesity and diabetes genetic variants associated with gestational weight gain. 
  • Oxidant generation promotes iron sequestration in BEAS-2B cells exposed to asbestos. 
  • PINA is essential for growth and positively influences NIMA function in Aspergillus nidulans. 
  • Pathology of inherited manganese transporter deficiency. 
  • Peptidylglycine α-amidating monooxygenase heterozygosity alters brain copper handling with region specificity. 
  • Phorbol esters induce differentiation in a pre-B-lymphocyte cell line by enhancing Na+/H+ exchange. 
  • Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. 
  • Pseudohyphal growth of Cryptococcus neoformans is a reversible dimorphic transition in response to ammonium that requires Amt1 and Amt2 ammonium permeases. 
  • Regulators of pseudohyphal differentiation in Saccharomyces cerevisiae identified through multicopy suppressor analysis in ammonium permease mutant strains. 
  • Sequence proximity between Cu(II) and Cu(I) binding sites of human copper transporter 1 model peptides defines reactivity with ascorbate and O2. 
  • Sequestration of mitochondrial iron by silica particle initiates a biological effect. 
  • Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver. 
  • Syndrome of hepatic cirrhosis, dystonia, polycythemia, and hypermanganesemia caused by mutations in SLC30A10, a manganese transporter in man. 
  • TNF, IFN-gamma, and endotoxin increase expression of DMT1 in bronchial epithelial cells. 
  • TRPV4 plays an evolutionary conserved role in the transduction of osmotic and mechanical stimuli in live animals. 
  • The G185R mutation disrupts function of the iron transporter Nramp2. 
  • The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae. 
  • The N-terminal 14-mer model peptide of human Ctr1 can collect Cu(ii) from albumin. Implications for copper uptake by Ctr1. 
  • The Nramp2/DMT1 iron transporter is induced in the duodenum of microcytic anemia mk mice but is not properly targeted to the intestinal brush border. 
  • The influence of the synergistic anion on iron chelation by ferric binding protein, a bacterial transferrin. 
  • The ins and outs of iron homeostasis. 
  • The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. 
  • The iron transporter DMT1. 
  • The oral ferroportin inhibitor vamifeport improves hemodynamics in a mouse model of sickle cell disease. 
  • Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant: a 14-cohort meta-analysis. 
  • Vesicular zinc promotes presynaptic and inhibits postsynaptic long-term potentiation of mossy fiber-CA3 synapse. 
  • ZIP4 is a novel diagnostic and prognostic marker in human pancreatic cancer: a systemic comparison between EUS-FNA and surgical specimens. 
  • Zinc transporter ZIP7 is a novel determinant of ferroptosis. 
  • hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands. 
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  Keywords of People

  • Lee, Walter T, Professor of Head and Neck Surgery & Communication Sciences, Radiation Oncology