Symporters

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  Subject Areas on Research

  • A cerebellar learning model of vestibulo-ocular reflex adaptation in wild-type and mutant mice. 
  • A model for optimizing adenoviral delivery in human cancer gene therapy trials. 
  • An efficient targeted radiotherapy/gene therapy strategy utilising human telomerase promoters and radioastatine and harnessing radiation-mediated bystander effects. 
  • Behavioral responses to social stress in noradrenaline transporter knockout mice: effects on social behavior and depression. 
  • Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter. 
  • Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis. 
  • Carbohydrate restriction and lactate transporter inhibition in a mouse xenograft model of human prostate cancer. 
  • Changes in intracellular chloride after oxygen-glucose deprivation of the adult hippocampal slice: effect of diazepam. 
  • Chondrocyte transport and concentration of ascorbic acid is mediated by SVCT2. 
  • Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters. 
  • Comparison of radiohaloanalogues of meta-iodobenzylguanidine (MIBG) for a combined gene- and targeted radiotherapy approach to bladder carcinoma. 
  • Corneal dystrophy mutations R125H and R804H disable SLC4A11 by altering the extracellular pH dependence of the intracellular pK that governs H⁺ (OH^- ) transport. 
  • Decoding the language of epigenetics during neural development is key for understanding development as well as developmental neurotoxicity. 
  • Disrupted Blood-Retina Lysophosphatidylcholine Transport Impairs Photoreceptor Health But Not Visual Signal Transduction. 
  • GENIS: gene expression of sodium iodide symporter for noninvasive imaging of gene therapy vectors and quantification of gene expression in vivo. 
  • Genetic variants in PDSS1 and SLC16A6 of the ketone body metabolic pathway predict cutaneous melanoma-specific survival. 
  • Glucose and lipid effects of the ileal apical sodium-dependent bile acid transporter inhibitor GSK2330672: double-blind randomized trials with type 2 diabetes subjects taking metformin. 
  • Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques. 
  • Higher clearance of micafungin in neonates compared with adults: role of age-dependent micafungin serum binding. 
  • Highly conductive carbon nanotube matrix accelerates developmental chloride extrusion in central nervous system neurons by increased expression of chloride transporter KCC2. 
  • Human trabecular meshwork cell volume regulation. 
  • In vitro cytotoxicity of (211)at-astatide and (131)I-iodide to glioma tumor cells expressing the sodium/iodide symporter. 
  • In vitro investigation of the hepatobiliary disposition mechanisms of the antifungal agent micafungin in humans and rats. 
  • Iodopyridine-for-iodobenzene substitution for use with low molecular weight radiopharmaceuticals: application to m-iodobenzylguanidine. 
  • Localization and interaction of NHERF isoforms in the renal proximal tubule of the mouse. 
  • Mice lacking the norepinephrine transporter are supersensitive to psychostimulants. 
  • Mitochondrial ROS Induced Lysosomal Dysfunction and Autophagy Impairment in an Animal Model of Congenital Hereditary Endothelial Dystrophy. 
  • Morphology of proteoliposomes reconstituted with purified lac carrier protein from Escherichia coli. 
  • Mutual regulation of Src family kinases and the neurotrophin receptor TrkB. 
  • NHERF-1 is required for renal adaptation to a low-phosphate diet. 
  • Neural grafting reverses prenatal drug-induced alterations in hippocampal PKC and related behavioral deficits. 
  • Novel repression of Kcc2 transcription by REST-RE-1 controls developmental switch in neuronal chloride. 
  • Persistent cholinergic presynaptic deficits after neonatal chlorpyrifos exposure. 
  • Plasticity of lipid-protein interactions in the function and topogenesis of the membrane protein lactose permease from Escherichia coli. 
  • Pulmonary alveolar epithelial uptake of S-nitrosothiols is regulated by L-type amino acid transporter. 
  • Purified lac permease and cytochrome o oxidase are functional as monomers. 
  • Reduced Oxidative Phosphorylation and Increased Glycolysis in Human Glaucoma Lamina Cribrosa Cells. 
  • Repurposing cancer drugs identifies kenpaullone which ameliorates pathologic pain in preclinical models via normalization of inhibitory neurotransmission. 
  • Robustness of outcomes in trials evaluating sodium-glucose co-transporter 2 inhibitors for heart failure. 
  • Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity. 
  • Sodium-Glucose Co-Transporter-2 Inhibitor Therapy During Anthracycline Treatment: Is There a Role for Cardioprotection? 
  • Sodium-glucose co-transporter 2 inhibitors as an early, first-line therapy in patients with heart failure and reduced ejection fraction. 
  • Sodium-glucose co-transporter 2 inhibitors for heart failure: clinical trial efficacy and clinical practice effectiveness. 
  • Sodium-iodide symporter (NIS)-mediated accumulation of [(211)At]astatide in NIS-transfected human cancer cells. 
  • TMEM67, TMEM237, and Embigin in Complex With Monocarboxylate Transporter MCT1 Are Unique Components of the Photoreceptor Outer Segment Plasma Membrane. 
  • Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting. 
  • Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. 
  • Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis. 
  • The Time Is Now for Sodium Glucose Co-Transporter 2 Inhibitors for Heart Failure: A Call to Overcome Clinical Inertia. 
  • The cardiac Na+-Ca2+ exchanger binds to the cytoskeletal protein ankyrin. 
  • The effects of ascorbic acid on cartilage metabolism in guinea pig articular cartilage explants. 
  • The molecular identity of the characean OH^- transporter: a candidate related to the SLC4 family of animal pH regulators. 
  • The neural basis of sugar preference. 
  • The role of NHERF-1 in the regulation of renal proximal tubule sodium-hydrogen exchanger 3 and sodium-dependent phosphate cotransporter 2a. 
  • pH dependence of the Slc4a11-mediated H⁺ conductance is influenced by intracellular lysine residues and modified by disease-linked mutations. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute