Withholding Treatment

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  Subject Areas on Research

  • 'Rationing' health care. Not all definitions are created equal. 
  • Accepting death without artificial nutrition or hydration. 
  • Adaptive leadership: a novel approach for family decision making. 
  • Agency is messy: get used to it. 
  • An economic evaluation of prolonged mechanical ventilation. 
  • Baclofen Toxicity in Kidney Disease. 
  • Beginning a conversation on medical futility in North Carolina. 
  • Braden score may be associated with time to onset of catheter-associated urinary tract infection in high-risk patients: Lessons learned from a root cause analysis tool. 
  • Characterization of Death in Infants With Neonatal Seizures. 
  • Chemotherapy discontinuation processes in a gynecologic oncology population. 
  • Children Exposed to Maltreatment: Assessment and the Role of Psychotropic Medication. 
  • Clinical perspectives on portable do-not-resuscitate orders. 
  • Complexities of defibrillator deactivation. 
  • Continuation versus discontinuation of renin-angiotensin system inhibitors in patients admitted to hospital with COVID-19: a prospective, randomised, open-label trial. 
  • Continuing versus suspending angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: Impact on adverse outcomes in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)--The BRACE CORONA Trial. 
  • Curious Crosses: Injection-Induced Lesions. 
  • Deciding for Others 
  • Deciding to terminate treatment: a practical guide for physicians. 
  • Decision-Making of Patients With Implantable Cardioverter-Defibrillators at End of Life: Family Members' Experiences. 
  • Determining the Association Between End-of-Life Care Resources and Patient Outcomes in Pennsylvania ICUs. 
  • Development and pilot testing of a decision aid for surrogates of patients with prolonged mechanical ventilation. 
  • Discharge Plans for Geriatric Inpatients with Delirium: A Plan to Stop Antipsychotics? 
  • Discharge against medical advice from hospitalizations for substance use disorders: The potential impact of the Affordable Care Act. 
  • Discontinuation and management of direct-acting anticoagulants for emergency procedures. 
  • Discontinuation rates of warfarin versus direct acting oral anticoagulants in US clinical practice: Results from Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II (ORBIT-AF II). 
  • Dual Antiplatelet Therapy Cessation and Adverse Events After Drug-Eluting Stent Implantation in Patients at High Risk for Atherothrombosis (from the PARIS Registry). 
  • Early post-discharge bleeding and antiplatelet therapy discontinuation among acute myocardial infarction patients treated with percutaneous coronary intervention. 
  • Early withdrawal of statin therapy in patients with non-ST-segment elevation myocardial infarction: national registry of myocardial infarction. 
  • Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study. 
  • Effect of Discontinuing vs Continuing Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers on Days Alive and Out of the Hospital in Patients Admitted With COVID-19: A Randomized Clinical Trial. 
  • Efficacy and Safety of Immunosuppression Withdrawal in Pediatric Liver Transplant Recipients: Moving Toward Personalized Management. 
  • Efficacy and safety of three antiretroviral regimens for initial treatment of HIV-1: a randomized clinical trial in diverse multinational settings. 
  • Evaluation of eszopiclone discontinuation after cotherapy with fluoxetine for insomnia with coexisting depression. 
  • Exploring the vagueness of Religion & Spirituality in complex pediatric decision-making: a qualitative study. 
  • From the Johns Hopkins Baby to Baby Miller: what have we learned from four decades of reflection on neonatal cases? 
  • Functional Outcomes Over the First Year After Moderate to Severe Traumatic Brain Injury in the Prospective, Longitudinal TRACK-TBI Study. 
  • Health values of the seriously ill. SUPPORT investigators. 
  • House calls to Cardinal Jackson. 
  • Immunosuppression Withdrawal in Liver Transplant Recipients on Sirolimus. 
  • Impact of a palliative care program on end-of-life care in a neonatal intensive care unit. 
  • Implications of a recurrent in-hospital cardiac arrest on survival and neurological outcomes. 
  • Inference on treatment effects from a randomized clinical trial in the presence of premature treatment discontinuation: the SYNERGY trial. 
  • Influence of beta-blocker continuation or withdrawal on outcomes in patients hospitalized with heart failure: findings from the OPTIMIZE-HF program. 
  • Influence of ethnicity on advance directives and end-of-life decisions. 
  • Initiation, Continuation, or Withdrawal of Angiotensin-Converting Enzyme Inhibitors/Angiotensin Receptor Blockers and Outcomes in Patients Hospitalized With Heart Failure With Reduced Ejection Fraction. 
  • Investigational treatment suspension and enhanced cell-mediated immunity at rebound followed by drug-free remission of simian AIDS. 
  • Is withholding osteoporosis medication after fracture sometimes rational? A comparison of the risk for second fracture versus death. 
  • Life-sustaining therapy. A model for appropriate use. 
  • Managed care: rationing without justice, but not unjustly. 
  • Management of Renin-Angiotensin-Aldosterone System blockade in patients admitted to hospital with confirmed coronavirus disease (COVID-19) infection (The McGill RAAS-COVID- 19): A structured summary of a study protocol for a randomized controlled trial. 
  • Medical Purgatory. 
  • Medical paternalism or legal imperialism: not the only alternatives for handling Saikewicz-type cases. 
  • Minority Patients are Less Likely to Undergo Withdrawal of Care After Spontaneous Intracerebral Hemorrhage. 
  • Modafinil for atypical depression: effects of open-label and double-blind discontinuation treatment. 
  • Modeling survival distribution as a function of time to treatment discontinuation: A dynamic treatment regime approach. 
  • Monitoring liver safety in drug development: the GSK experience. 
  • NCCN Guidelines Insights: Chronic Myeloid Leukemia, Version 1.2017. 
  • North Carolina hospitals' policies on medical futility. 
  • Older age, aggressiveness of care, and survival for seriously ill, hospitalized adults. SUPPORT Investigators. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments. 
  • Outcomes of Preterm Infants following Discussions about Withdrawal or Withholding of Life Support. 
  • Outcomes of discontinuing rivaroxaban compared with warfarin in patients with nonvalvular atrial fibrillation: analysis from the ROCKET AF trial (Rivaroxaban Once-Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation). 
  • Overcoming Resistance - Omission of Radiotherapy for Low-Risk Breast Cancer. 
  • Patient age and decisions to withhold life-sustaining treatments from seriously ill, hospitalized adults. SUPPORT Investigators. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatment. 
  • Patterns and Impact of Dual Antiplatelet Cessation on Cardiovascular Risk After Percutaneous Coronary Intervention in Patients With Acute Coronary Syndromes. 
  • Perceptions of Statin Discontinuation among Patients with Life-Limiting Illness. 
  • Permissive Hypertension and Collateral Revascularization May Allow Avoidance of Cerebrospinal Fluid Drainage in Thoracic Endovascular Aortic Repair. 
  • Phase II study of temozolomide and thalidomide in patients with metastatic melanoma in the brain: high rate of thromboembolic events (CALGB 500102). 
  • Physician-assisted suicide and advance directives concerning life support. 
  • Physicians' legal defensiveness in end-of-life treatment decisions: comparing attitudes and knowledge in states with different laws. 
  • Physicians' quantitative assessments of medical futility. 
  • Predictors of perioperative major bleeding in patients who interrupt warfarin for an elective surgery or procedure: Analysis of the BRIDGE trial. 
  • Premature permanent discontinuation of apixaban or warfarin in patients with atrial fibrillation. 
  • Proliferative lupus nephritis and leukocytoclastic vasculitis during treatment with etanercept. 
  • Prostaglandin E1-Induced Periostitis and Reversibility with Discontinuation. 
  • Quality of Life and Recommendations for Further Care. 
  • Randomized elimination and prolongation of ACE inhibitors and ARBs in coronavirus 2019 (REPLACE COVID) Trial Protocol. 
  • Reasons for warfarin discontinuation in the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF). 
  • Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: implications for eradication. 
  • Recognizing bedside rationing: clear cases and tough calls. 
  • Religious aspects of futile treatment. 
  • Safety and antiviral activity of albinterferon alfa-2b in prior interferon nonresponders with chronic hepatitis C. 
  • Safety and benefit of discontinuing statin therapy in the setting of advanced, life-limiting illness: a randomized clinical trial. 
  • Safety of Early Discontinuation of Antiseizure Medication After Acute Symptomatic Neonatal Seizures. 
  • Semantic and moral debates about hastening death: a survey of bioethicists. 
  • Sex Differences Among Patients With High Risk Receiving Ticagrelor With or Without Aspirin After Percutaneous Coronary Intervention: A Subgroup Analysis of the TWILIGHT Randomized Clinical Trial. 
  • Statistical inference for cancer trials with treatment switching. 
  • Stent Thrombosis and Dual Antiplatelet Therapy Interruption With Everolimus-Eluting Stents: Insights From the Xience V Coronary Stent System Trials. 
  • Surrogates' perceptions about feeding tube placement decisions. 
  • The impact of delirium on withdrawal of life-sustaining treatment after intracerebral hemorrhage. 
  • The limits of proxy decisionmaking for incompetents. 
  • The public's preference for bedside rationing. 
  • The unbearable rightness of bedside rationing. Physician duties in a climate of cost containment. 
  • To die, to sleep: US physicians' religious and other objections to physician-assisted suicide, terminal sedation, and withdrawal of life support. 
  • Tough questions, even harder answers. 
  • Treatment decisions for terminally ill patients: physicians' legal defensiveness and knowledge of medical law. 
  • US Physicians' Opinions about Distinctions between Withdrawing and Withholding Life-Sustaining Treatment. 
  • Unilateral Do Not Resuscitate Orders: Physician Attitudes and Practices. 
  • Validation of a clinician questionnaire to assess reasons for antipsychotic discontinuation and continuation among patients with schizophrenia. 
  • Withdrawal of Life-supporting Treatment in Severe Traumatic Brain Injury. 
  • Withholding anticoagulation after a negative computed tomography pulmonary angiogram as a stand-alone imaging investigation: a prospective management study. 
  • Withholding medical treatment from the severely demented patient. Decisional processes and cost implications. 
  • Withholding or withdrawing life-sustaining treatment in extremely low gestational age neonates. 
  • Withholding versus withdrawing life-sustaining treatment: patient factors and documentation associated with dialysis decisions. 
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  Keywords of People

  • Anderson, Ruth A., Professor Emerita in the School of Nursing, School of Nursing
  • LeBlanc, Thomas William, Associate Professor of Medicine, Duke Cancer Institute
  • O'Connor, Christopher Michael, Adjunct Professor in the Department of Medicine, Medicine, Clinical Pharmacology
  • Zafar, Syed Yousuf, Adjunct Professor in the Department of Medicine, Duke Science & Society