Karyopherins
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Subject Areas on Research
- An ancient family of human endogenous retroviruses encodes a functional homolog of the HIV-1 Rev protein.
- Analysis of cellular factors that mediate nuclear export of RNAs bearing the Mason-Pfizer monkey virus constitutive transport element.
- Apoptotic regulation by the Crk adapter protein mediated by interactions with Wee1 and Crm1/exportin.
- Combinatorial control of cyclin B1 nuclear trafficking through phosphorylation at multiple sites.
- Connections between the processing and nuclear export of mRNA: evidence for an export license?
- Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1.
- Definition of a consensus transportin-specific nucleocytoplasmic transport signal.
- Determination of the functional domain organization of the importin alpha nuclear import factor.
- Efficiency, selectivity, and robustness of nucleocytoplasmic transport.
- Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs.
- Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes.
- Human immunodeficiency virus: nuclear RNA export unwound.
- Identification and functional characterization of a novel nuclear localization signal present in the yeast Nab2 poly(A)+ RNA binding protein.
- Inhibition of human immunodeficiency virus Rev and human T-cell leukemia virus Rex function, but not Mason-Pfizer monkey virus constitutive transport element activity, by a mutant human nucleoporin targeted to Crm1.
- KPT-330 Prevents Aortic Valve Calcification via a Novel C/EBPβ Signaling Pathway.
- Mutational definition of functional domains within the Rev homolog encoded by human endogenous retrovirus K.
- Nuclear RNA export.
- Nuclear import of Cdk/cyclin complexes: identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin B1.
- Nucleocytoplasmic shuttling by protein nuclear import factors.
- Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs.
- Pharmacodynamic and genomic markers associated with response to the XPO1/CRM1 inhibitor selinexor (KPT-330): A report from the pediatric preclinical testing program.
- Reconstitution of nuclear protein export in isolated nuclear envelopes.
- Recruitment of the Crm1 nuclear export factor is sufficient to induce cytoplasmic expression of incompletely spliced human immunodeficiency virus mRNAs.
- Regulation of the ATM-activator protein Aven by CRM1-dependent nuclear export.
- Retroviruses as model systems for the study of nuclear RNA export pathways.
- Selinexor for the treatment of patients with previously treated multiple myeloma.
- Structural requirements for pre-microRNA binding and nuclear export by Exportin 5.
- Suppressor of fused negatively regulates beta-catenin signaling.
- The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin beta-dependent nuclear localization signals.
- The autophagic protein LC3 translocates to the nucleus and localizes in the nucleolus associated to NUFIP1 in response to cyclic mechanical stress.
- The human tap nuclear RNA export factor contains a novel transportin-dependent nuclear localization signal that lacks nuclear export signal function.
- The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.
- Two closely related human nuclear export factors utilize entirely distinct export pathways.
- Using retroviruses to study the nuclear export of mRNA.
- XPO1 expression worsens the prognosis of unfavorable DLBCL that can be effectively targeted by selinexor in the absence of mutant p53.
- XPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A.