Karyopherins

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  Subject Areas on Research

  • An ancient family of human endogenous retroviruses encodes a functional homolog of the HIV-1 Rev protein. 
  • Analysis of cellular factors that mediate nuclear export of RNAs bearing the Mason-Pfizer monkey virus constitutive transport element. 
  • Apoptotic regulation by the Crk adapter protein mediated by interactions with Wee1 and Crm1/exportin. 
  • Combinatorial control of cyclin B1 nuclear trafficking through phosphorylation at multiple sites. 
  • Connections between the processing and nuclear export of mRNA: evidence for an export license? 
  • Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1. 
  • Definition of a consensus transportin-specific nucleocytoplasmic transport signal. 
  • Determination of the functional domain organization of the importin alpha nuclear import factor. 
  • Efficiency, selectivity, and robustness of nucleocytoplasmic transport. 
  • Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. 
  • Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes. 
  • Human immunodeficiency virus: nuclear RNA export unwound. 
  • Identification and functional characterization of a novel nuclear localization signal present in the yeast Nab2 poly(A)+ RNA binding protein. 
  • Inhibition of human immunodeficiency virus Rev and human T-cell leukemia virus Rex function, but not Mason-Pfizer monkey virus constitutive transport element activity, by a mutant human nucleoporin targeted to Crm1. 
  • KPT-330 Prevents Aortic Valve Calcification via a Novel C/EBPβ Signaling Pathway. 
  • Mutational definition of functional domains within the Rev homolog encoded by human endogenous retrovirus K. 
  • Nuclear RNA export. 
  • Nuclear import of Cdk/cyclin complexes: identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin B1. 
  • Nucleocytoplasmic shuttling by protein nuclear import factors. 
  • Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs. 
  • Pharmacodynamic and genomic markers associated with response to the XPO1/CRM1 inhibitor selinexor (KPT-330): A report from the pediatric preclinical testing program. 
  • Reconstitution of nuclear protein export in isolated nuclear envelopes. 
  • Recruitment of the Crm1 nuclear export factor is sufficient to induce cytoplasmic expression of incompletely spliced human immunodeficiency virus mRNAs. 
  • Regulation of the ATM-activator protein Aven by CRM1-dependent nuclear export. 
  • Retroviruses as model systems for the study of nuclear RNA export pathways. 
  • Selinexor for the treatment of patients with previously treated multiple myeloma. 
  • Structural requirements for pre-microRNA binding and nuclear export by Exportin 5. 
  • Suppressor of fused negatively regulates beta-catenin signaling. 
  • The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin beta-dependent nuclear localization signals. 
  • The autophagic protein LC3 translocates to the nucleus and localizes in the nucleolus associated to NUFIP1 in response to cyclic mechanical stress. 
  • The human tap nuclear RNA export factor contains a novel transportin-dependent nuclear localization signal that lacks nuclear export signal function. 
  • The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1. 
  • Two closely related human nuclear export factors utilize entirely distinct export pathways. 
  • Using retroviruses to study the nuclear export of mRNA. 
  • XPO1 expression worsens the prognosis of unfavorable DLBCL that can be effectively targeted by selinexor in the absence of mutant p53. 
  • XPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A.