Drosophila Proteins

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  Subject Areas on Research

  • A Drosophila CREB/CREM homolog encodes multiple isoforms, including a cyclic AMP-dependent protein kinase-responsive transcriptional activator and antagonist. 
  • A Functionally Conserved Gene Regulatory Network Module Governing Olfactory Neuron Diversity. 
  • A GH3-like domain in reaper is required for mitochondrial localization and induction of IAP degradation. 
  • A bidirectional kinesin motor in live Drosophila embryos. 
  • A case study of the reproducibility of transcriptional reporter cell-based RNAi screens in Drosophila. 
  • A cell-specific nuclear receptor plays essential roles in adrenal and gonadal development. 
  • A chimeric kinesin-1 head/kinesin-5 tail motor switches between diffusive and processive motility. 
  • A collection of cortical crescents: asymmetric protein localization in CNS precursor cells. 
  • A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors. 
  • A contractile actomyosin network linked to adherens junctions by Canoe/afadin helps drive convergent extension. 
  • A decrease in the dose of the lgl tumor suppressor increases life span of Drosophila in stress and is related to the maternal effect. 
  • A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. 
  • A genome-wide RNAi screen reveals multiple regulators of caspase activation. 
  • A human model for multigenic inheritance: phenotypic expression in Hirschsprung disease requires both the RET gene and a new 9q31 locus. 
  • A kinesin motor in a force-producing conformation. 
  • A method to measure myocardial calcium handling in adult Drosophila. 
  • A microtubule-destabilizing kinesin motor regulates spindle length and anchoring in oocytes. 
  • A molecular basis for inositol polyphosphate synthesis in Drosophila melanogaster. 
  • A mutant of the motor protein kinesin that moves in both directions on microtubules. 
  • A neuropeptidergic circuit gates selective escape behavior of Drosophila larvae. 
  • A new trick for Cyclin-Cdk: activation of STAT. 
  • A non-canonical Raf function is required for dorsal-ventral patterning during Drosophila embryogenesis. 
  • A non-canonical start codon in the Drosophila fragile X gene yields two functional isoforms. 
  • A paired-end sequencing strategy to map the complex landscape of transcription initiation. 
  • A point mutation in the microtubule binding region of the Ncd motor protein reduces motor velocity. 
  • A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins. 
  • A role for Pin1 in mammalian germ cell development and spermatogenesis. 
  • A suppressor/enhancer screen in Drosophila reveals a role for wnt-mediated lipid metabolism in primordial germ cell migration. 
  • A systematic analysis of microtubule-destabilizing factors during dendrite pruning in Drosophila. 
  • Abelson kinase (Abl) and RhoGEF2 regulate actin organization during cell constriction in Drosophila. 
  • Accelerated cell cycles enable organ regeneration under developmental time constraints in the Drosophila hindgut. 
  • Actin dynamics: the arp2/3 complex branches out. 
  • Activated armadillo/beta-catenin does not play a general role in cell migration and process extension in Drosophila. 
  • Altered nucleotide-microtubule coupling and increased mechanical output by a kinesin mutant. 
  • An MYH9 human disease model in flies: site-directed mutagenesis of the Drosophila non-muscle myosin II results in hypomorphic alleles with dominant character. 
  • An N-terminal truncation of the ncd motor protein supports diffusional movement of microtubules in motility assays. 
  • An Optogenetic Method to Study Signal Transduction in Intestinal Stem Cell Homeostasis. 
  • Analysis of candidate antagonists of IAP-mediated caspase inhibition using yeast reconstituted with the mammalian Apaf-1-activated apoptosis mechanism. 
  • Anastral spindle assembly: a mathematical model. 
  • Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis. 
  • Apoptosis and NF-kappa B: the FADD connection. 
  • Argonaute2 suppresses Drosophila fragile X expression preventing neurogenesis and oogenesis defects. 
  • Arl2- and Msps-dependent microtubule growth governs asymmetric division. 
  • Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF. 
  • Assembly and dynamics of an anastral:astral spindle: the meiosis II spindle of Drosophila oocytes. 
  • Assembly pathway of the anastral Drosophila oocyte meiosis I spindle. 
  • Asymmetric localization of numb autonomously determines sibling neuron identity in the Drosophila CNS. 
  • Avidity and Cell Uptake of Integrin-Targeting Polypeptide Micelles is Strongly Shape-Dependent. 
  • BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary. 
  • Bacterial Growth Inhibition Screen (BGIS): harnessing recombinant protein toxicity for rapid and unbiased interrogation of protein function. 
  • Balancing different types of actin polymerization at distinct sites: roles for Abelson kinase and Enabled. 
  • Balboa binds to pickpocket in vivo and is required for mechanical nociception in Drosophila larvae. 
  • Behavioral and circuit basis of sucrose rejection by Drosophila females in a simple decision-making task. 
  • Bidirectional power stroke by ncd kinesin. 
  • Binding sites on microtubules of kinesin motors of the same or opposite polarity. 
  • Biochemical analysis of ++Prospero protein during asymmetric cell division: cortical Prospero is highly phosphorylated relative to nuclear Prospero. 
  • Bovine phospholipase C highly homologous to the norpA protein of Drosophila is expressed specifically in cones. 
  • Brain control of blood glucose levels: implications for the pathogenesis of type 2 diabetes. 
  • CDK-Regulated Phase Separation Seeded by Histone Genes Ensures Precise Growth and Function of Histone Locus Bodies. 
  • CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1. 
  • CRL4Mahj E3 ubiquitin ligase promotes neural stem cell reactivation. 
  • Caenorhabditis elegans beta-G spectrin is dispensable for establishment of epithelial polarity, but essential for muscular and neuronal function. 
  • Cardiomyopathy is associated with ribosomal protein gene haplo-insufficiency in Drosophila melanogaster. 
  • Casein kinase I: another cog in the circadian clockworks. 
  • Cell cycle control during early embryogenesis. 
  • Cell cycle: Flies teach an old dogma new tricks. 
  • Cell division requires a direct link between microtubule-bound RacGAP and Anillin in the contractile ring. 
  • Cell patterning in the Drosophila segment: engrailed and wingless antigen distributions in segment polarity mutant embryos. 
  • Cellular mechanisms of wingless/Wnt signal transduction. 
  • Centromere identity in Drosophila is not determined in vivo by replication timing. 
  • Centrosome and spindle function of the Drosophila Ncd microtubule motor visualized in live embryos using Ncd-GFP fusion proteins. 
  • Challenge of Drosophila melanogaster with Cryptococcus neoformans and role of the innate immune response. 
  • Changes in the pattern of adherens junction-associated beta-catenin accompany morphogenesis in the sea urchin embryo. 
  • Characteristics and Treatment Outcomes of Benign Paroxysmal Positional Vertigo in a Cohort of Veterans. 
  • Characterization of a male-predominant antisense transcript underexpressed in hybrids of Drosophila pseudoobscura and D. persimilis. 
  • Characterization of cis-regulatory elements controlling repo transcription in Drosophila melanogaster. 
  • Chromatin Modulatory Proteins and Olfactory Receptor Signaling in the Refinement and Maintenance of Fruitless Expression in Olfactory Receptor Neurons. 
  • Chromatin-based reprogramming of a courtship regulator by concurrent pheromone perception and hormone signaling. 
  • Chromophore-Independent Roles of Opsin Apoproteins in Drosophila Mechanoreceptors. 
  • Chromosome distribution, molecular motors and the claret protein. 
  • Clinical Characteristics, Oral Anticoagulation Patterns, and Outcomes of Medicaid Patients With Atrial Fibrillation: Insights From the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF I) Registry. 
  • Cold temperature improves mobility and survival in Drosophila models of autosomal-dominant hereditary spastic paraplegia (AD-HSP). 
  • Collaborative interactions between MEF-2 and Sp1 in muscle-specific gene regulation. 
  • Combinations of DIPs and Dprs control organization of olfactory receptor neuron terminals in Drosophila. 
  • Combinatorial rules of precursor specification underlying olfactory neuron diversity. 
  • Comparative analysis of behavioral and transcriptional variation underlying CO₂ sensory neuron function and development in Drosophila. 
  • Comprehensive analysis of the chromatin landscape in Drosophila melanogaster. 
  • Concentration and desalting of protein samples for mass spectrometry analysis. 
  • Congenital central hypoventilation syndrome: mutation analysis of the receptor tyrosine kinase RET. 
  • Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2. 
  • Conserved function of Drosophila Fancd2 monoubiquitination in response to double-strand DNA breaks. 
  • Conserved organization of centromeric chromatin in flies and humans. 
  • Control of the postmating behavioral switch in Drosophila females by internal sensory neurons. 
  • Correlating notch signaling with thymocyte maturation. 
  • Coupled oscillators coordinate collective germline growth. 
  • Cytokinesis proteins Tum and Pav have a nuclear role in Wnt regulation. 
  • DNA and RNA topoisomerase activities of Top3β are promoted by mediator protein Tudor domain-containing protein 3. 
  • DNA copy number evolution in Drosophila cell lines. 
  • DSC1 channel-dependent developmental regulation of pyrethroid susceptibility in Drosophila melanogaster. 
  • Decoupling of nucleotide- and microtubule-binding sites in a kinesin mutant. 
  • Decrease in the lgl tumor suppressor dose in Drosophila increases survival and longevity in stress conditions. 
  • Degenerative Spondylolisthesis: An Analysis of the Nationwide Inpatient Sample Database. 
  • Deletion of Siah-interacting protein gene in Drosophila causes cardiomyopathy. 
  • Determinants of kinesin motor polarity. 
  • Determinants of molecular motor directionality. 
  • Developmental biology informs cancer: the emerging role of the hedgehog signaling pathway in upper gastrointestinal cancers. 
  • Developmental control of gene copy number by repression of replication initiation and fork progression. 
  • Developmental control of the DNA replication and transcription programs. 
  • Developmental signalling. Sorting out the signals. 
  • Differential effects of TipE and a TipE-homologous protein on modulation of gating properties of sodium channels from Drosophila melanogaster. 
  • Differential requirement for STAT by gain-of-function and wild-type receptor tyrosine kinase Torso in Drosophila. 
  • Dimerized Drosophila myosin VIIa: a processive motor. 
  • Direct ribosomal binding by a cellular inhibitor of translation. 
  • Directionality of wingless protein transport influences epidermal patterning in the Drosophila embryo. 
  • Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. 
  • Disruption of sarcoendoplasmic reticulum calcium ATPase function in Drosophila leads to cardiac dysfunction. 
  • Distinct effects of tafazzin deletion in differentiated and undifferentiated mitochondria. 
  • Distinct modulating effects of TipE-homologs 2-4 on Drosophila sodium channel splice variants. 
  • Distinct responses to reduplicated chromosomes require distinct Mad2 responses. 
  • Distinct roles of the DmNav and DSC1 channels in the action of DDT and pyrethroids. 
  • Division of labor: subsets of dorsal-appendage-forming cells control the shape of the entire tube. 
  • Does phaster mean better? 
  • Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled. 
  • Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin 
  • Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis. 
  • Drosophila CTP synthase regulates collective cell migration by controlling the polarized endocytic cycle. 
  • Drosophila E2f2 promotes the conversion from genomic DNA replication to gene amplification in ovarian follicle cells. 
  • Drosophila ORC localizes to open chromatin and marks sites of cohesin complex loading. 
  • Drosophila PIWI associates with chromatin and interacts directly with HP1a. 
  • Drosophila Subdued is a moonlighting transmembrane protein 16 (TMEM16) that transports ions and phospholipids. 
  • Drosophila Symplekin localizes dynamically to the histone locus body and tricellular junctions. 
  • Drosophila TRPA1 isoforms detect UV light via photochemical production of H2O2. 
  • Drosophila Tcf and Groucho interact to repress Wingless signalling activity. 
  • Drosophila as a model for the identification of genes causing adult human heart disease. 
  • Drosophila betaHeavy-spectrin is essential for development and contributes to specific cell fates in the eye. 
  • Drosophila egg-laying site selection as a system to study simple decision-making processes. 
  • Drosophila follicle cell amplicons as models for metazoan DNA replication: a cyclinE mutant exhibits increased replication fork elongation. 
  • Drosophila homologue of the Rothmund-Thomson syndrome gene: essential function in DNA replication during development. 
  • Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution. 
  • Drosophila p120catenin plays a supporting role in cell adhesion but is not an essential adherens junction component. 
  • Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function. 
  • Drosophila stretchin-MLCK is a novel member of the Titin/Myosin light chain kinase family. 
  • Drosophila, genetic screens, and cardiac function. 
  • Dynamic loading and redistribution of the Mcm2-7 helicase complex through the cell cycle. 
  • Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. 
  • Egg-laying demand induces aversion of UV light in Drosophila females. 
  • Enhancement of the ncdD microtubule motor mutant by mutants of alpha Tub67C. 
  • Evolution in action: giant ankyrins awake. 
  • Evolution of genes and genomes on the Drosophila phylogeny. 
  • Evolution of regeneration and fission in annelids: insights from engrailed- and orthodenticle-class gene expression. 
  • Evolution. Chaperones as buffering agents? 
  • Evolution: spot on (and off). 
  • Evolutionary biology: Genes to make new species. 
  • Evolutionary genetics: gene replacement and the genetics of speciation. 
  • Examination of Endogenous Rotund Expression and Function in Developing Drosophila Olfactory System Using CRISPR-Cas9-Mediated Protein Tagging. 
  • Exploiting codon usage identifies intensity-specific modifiers of Ras/MAPK signaling in vivo. 
  • Expression and functional analysis of Gm114, a putative mammalian ortholog of Drosophila bam. 
  • Expression in aneuploid Drosophila S2 cells. 
  • Expression of nucleotide excision repair genes and the risk for squamous cell carcinoma of the head and neck. 
  • Expression of the blue-light receptor cryptochrome in the human retina. 
  • FIGQY phosphorylation defines discrete populations of L1 cell adhesion molecules at sites of cell-cell contact and in migrating neurons. 
  • Fidelity in planar cell polarity signalling. 
  • Fizzy-Related dictates A cell cycle switch during organ repair and tissue growth responses in the Drosophila hindgut. 
  • Forces for morphogenesis investigated with laser microsurgery and quantitative modeling. 
  • Functional analysis of Wingless reveals a link between intercellular ligand transport and dorsal-cell-specific signaling. 
  • Functional conservation of human Spastin in a Drosophila model of autosomal dominant-hereditary spastic paraplegia. 
  • Functional ecdysone receptor is the product of EcR and Ultraspiracle genes. 
  • Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli. 
  • Galactokinase is a novel modifier of calcineurin-induced cardiomyopathy in Drosophila. 
  • Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand. 
  • Gene expression and larval evolution: changing roles of distal-less and orthodenticle in echinoderm larvae. 
  • Gene expression disruptions of organism versus organ in Drosophila species hybrids. 
  • Gene expression divergence recapitulates the developmental hourglass model. 
  • Genes on the wing. 
  • Genetic DISC-section of regeneration in Drosophila. 
  • Genetic analysis demonstrates a direct link between rho signaling and nonmuscle myosin function during Drosophila morphogenesis. 
  • Genetic interaction screens identify a role for hedgehog signaling in Drosophila border cell migration. 
  • Genetic interactions between the RhoA and Stubble-stubbloid loci suggest a role for a type II transmembrane serine protease in intracellular signaling during Drosophila imaginal disc morphogenesis. 
  • Genetics. Enhancing gene regulation. 
  • Genetics. Origin of species in overdrive. 
  • Genome-wide localization of replication factors. 
  • Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb MuvB/dREAM complex in proliferating cells. 
  • Geographic selection in the small heat shock gene complex differentiating populations of Drosophila pseudoobscura. 
  • Germline mutations in glial cell line-derived neurotrophic factor (GDNF) and RET in a Hirschsprung disease patient. 
  • Gp93, the Drosophila GRP94 ortholog, is required for gut epithelial homeostasis and nutrient assimilation-coupled growth control. 
  • H2O2-Sensitive Isoforms of Drosophila melanogaster TRPA1 Act in Bitter-Sensing Gustatory Neurons to Promote Avoidance of UV During Egg-Laying. 
  • HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. 
  • HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. 
  • Haploidy and androgenesis in Drosophila. 
  • Hedgehog signaling patterns mesoderm in the sea urchin. 
  • High Throughput Assay to Examine Egg-Laying Preferences of Individual Drosophila melanogaster. 
  • Highly processive motility is not a general feature of the kinesins. 
  • Human GFRA1: cloning, mapping, genomic structure, and evaluation as a candidate gene for Hirschsprung disease susceptibility. 
  • Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf. 
  • Hybrid neurons in a microRNA mutant are putative evolutionary intermediates in insect CO2 sensory systems. 
  • Identification and interaction of multiple genes resulting in DDT resistance in the 91-R strain of Drosophila melanogaster by RNAi approaches. 
  • Identification of Drosophila neuropeptide receptors by G protein-coupled receptors-beta-arrestin2 interactions. 
  • Identification of E2F target genes that are rate limiting for dE2F1-dependent cell proliferation. 
  • Identification of functional elements and regulatory circuits by Drosophila modENCODE. 
  • Identification of multiple odorant receptors essential for pyrethrum repellency in Drosophila melanogaster. 
  • Identifying Genetic Players in Cell Sheet Morphogenesis Using a Drosophila Deficiency Screen for Genes on Chromosome 2R Involved in Dorsal Closure. 
  • Identifying Key Genetic Regions for Cell Sheet Morphogenesis on Chromosome 2L Using a Drosophila Deficiency Screen in Dorsal Closure. 
  • Immobilized molecular beacons: a new strategy using UV-activated poly(methyl methacrylate) surfaces to provide large fluorescence sensitivities for reporting on molecular association events. 
  • Increased expression of Drosophila tetraspanin, Tsp68C, suppresses the abnormal proliferation of ytr-deficient and Ras/Raf-activated hemocytes. 
  • Inhibition of translation and induction of apoptosis by Bunyaviral nonstructural proteins bearing sequence similarity to reaper. 
  • Inositol phosphate kinase 2 is required for imaginal disc development in Drosophila. 
  • Interorgan regulation of Drosophila intestinal stem cell proliferation by a hybrid organ boundary zone. 
  • Interphase cohesin regulation ensures mitotic fidelity after genome reduplication. 
  • Intracellular trafficking pathways in silver nanoparticle uptake and toxicity in Caenorhabditis elegans. 
  • Ion channels contribute to the regulation of cell sheet forces during Drosophila dorsal closure. 
  • Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled. 
  • Isolation of Vgr-2, a novel member of the transforming growth factor-beta-related gene family. 
  • Katanin p60-like1 promotes microtubule growth and terminal dendrite stability in the larval class IV sensory neurons of Drosophila. 
  • Large introns in relation to alternative splicing and gene evolution: a case study of Drosophila bruno-3. 
  • Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila. 
  • Loss of Drosophila melanogaster p21-activated kinase 3 suppresses defects in synapse structure and function caused by spastin mutations. 
  • LvGroucho and nuclear beta-catenin functionally compete for Tcf binding to influence activation of the endomesoderm gene regulatory network in the sea urchin embryo. 
  • Manipulating the nature of embryonic mitotic waves. 
  • Mature Drosophila meiosis I spindles comprise microtubules of mixed polarity. 
  • Mechanical feedback through E-cadherin promotes direction sensing during collective cell migration. 
  • Mechanisms of olfactory receptor neuron specification in Drosophila. 
  • Mechanosensitive neurons on the internal reproductive tract contribute to egg-laying-induced acetic acid attraction in Drosophila. 
  • Mediation of meiotic and early mitotic chromosome segregation in Drosophila by a protein related to kinesin. 
  • Metabolic regulation of Drosophila apoptosis through inhibitory phosphorylation of Dronc. 
  • Methylation of histone H4 lysine 20 by PR-Set7 ensures the integrity of late replicating sequence domains in Drosophila. 
  • Missense Variants in RHOBTB2 Cause a Developmental and Epileptic Encephalopathy in Humans, and Altered Levels Cause Neurological Defects in Drosophila. 
  • Mitochondrial fusion is regulated by Reaper to modulate Drosophila programmed cell death. 
  • Mitochondrial localization of Reaper to promote inhibitors of apoptosis protein degradation conferred by GH3 domain-lipid interactions. 
  • Molecular characterization and functional expression of the DSC1 channel. 
  • Molecular evolution of X-linked accessory gland proteins in Drosophila pseudoobscura. 
  • Molecular evolution of a Drosophila homolog of human BRCA2. 
  • Molecular morphogens. Upside-down ideas vindicated. 
  • Molecular organization and alternative splicing in zipper, the gene that encodes the Drosophila non-muscle myosin II heavy chain. 
  • Morphogenesis: Shaping Tissues through Extracellular Force Gradients. 
  • Morphogenesis: multitalented GTPases seeking new jobs. 
  • Mutants of the Drosophila ncd microtubule motor protein cause centrosomal and spindle pole defects in mitosis. 
  • Mutants of the microtubule motor protein, nonclaret disjunctional, affect spindle structure and chromosome movement in meiosis and mitosis. 
  • Mutation analysis of the RET receptor tyrosine kinase in Hirschsprung disease. 
  • Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia. 
  • Mutations in Drosophila crinkled/Myosin VIIA disrupt denticle morphogenesis. 
  • Mutations in eukaryotic release factors 1 and 3 act as general nonsense suppressors in Drosophila. 
  • Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein. 
  • Myosin VIIA, important for human auditory function, is necessary for Drosophila auditory organ development. 
  • Myosins motor Miranda. 
  • NMR structure note: solution structure of the core domain of MESD that is essential for proper folding of LRP5/6. 
  • NPAS3 is a trachealess homolog critical for lung development and homeostasis. 
  • Ncd motor binding and transport in the spindle. 
  • Negative regulation of Armadillo, a Wingless effector in Drosophila. 
  • Non-equivalent roles of Drosophila Frizzled and Dfrizzled2 in embryonic wingless signal transduction. 
  • Nonmuscle myosin II generates forces that transmit tension and drive contraction in multiple tissues during dorsal closure. 
  • Normal spastin gene dosage is specifically required for axon regeneration. 
  • Novel sodium channel gene mutations in Blattella germanica reduce the sensitivity of expressed channels to deltamethrin. 
  • Numb antagonizes Notch signaling to specify sibling neuron cell fates. 
  • Overexpression of a Drosophila homolog of apolipoprotein D leads to increased stress resistance and extended lifespan. 
  • PAS is a dimerization domain common to Drosophila period and several transcription factors. 
  • PER protein interactions and temperature compensation of a circadian clock in Drosophila. 
  • Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila. 
  • Partial co-option of the appendage patterning pathway in the development of abdominal appendages in the sepsid fly Themira biloba. 
  • Pebble/ECT2 RhoGEF negatively regulates the Wingless/Wnt signaling pathway. 
  • Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-κB Signaling. 
  • Phosphatases driving mitosis: pushing the gas and lifting the brakes. 
  • Phospholipid membrane composition affects EGF receptor and Notch signaling through effects on endocytosis during Drosophila development. 
  • Phosphorylation and destabilization of human period I clock protein by human casein kinase I epsilon. 
  • Physiology of nitric oxide in skeletal muscle. 
  • Physiology, Development, and Disease Modeling in the Drosophila Excretory System. 
  • Piezo proteins are pore-forming subunits of mechanically activated channels. 
  • Polar Fourier transforms of radially sampled NMR data. 
  • Polyploidization and cell fusion contribute to wound healing in the adult Drosophila epithelium. 
  • Post-transcriptional regulation of myotube elongation and myogenesis by Hoi Polloi. 
  • Posttranslational control of Cdc25 degradation terminates Drosophila's early cell-cycle program. 
  • Preferential re-replication of Drosophila heterochromatin in the absence of geminin. 
  • Preparing Developing Peripheral Olfactory Tissue for Molecular and Immunohistochemical Analysis in Drosophila. 
  • Proliferation of Double-Strand Break-Resistant Polyploid Cells Requires Drosophila FANCD2. 
  • Proper function of the Drosophila trp gene product during pupal development is important for normal visual transduction in the adult. 
  • Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. 
  • Protein phosphatase 2A regulates self-renewal of Drosophila neural stem cells. 
  • Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. 
  • Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins. 
  • Quantifying dorsal closure in three dimensions. 
  • RET cooperates with RB/p53 inactivation in a somatic multi-step model for murine thyroid cancer. 
  • RK2, a glial-specific homeodomain protein required for embryonic nerve cord condensation and viability in Drosophila. 
  • Rab11 helps maintain apical crumbs and adherens junctions in the Drosophila embryonic ectoderm. 
  • RacGap50C negatively regulates wingless pathway activity during Drosophila embryonic development. 
  • Radical alterations in the roles of homeobox genes during echinoderm evolution. 
  • Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans. 
  • Ras promotes cell survival by antagonizing both JNK and Hid signals in the Drosophila eye. 
  • Reaper eliminates IAP proteins through stimulated IAP degradation and generalized translational inhibition. 
  • Reaper is regulated by IAP-mediated ubiquitination. 
  • Reaper-induced apoptosis in a vertebrate system. 
  • Reaper-induced dissociation of a Scythe-sequestered cytochrome c-releasing activity. 
  • Receptor regulation: beta-arrestin moves up a notch. 
  • Reduced expression levels of nucleotide excision repair genes in lung cancer: a case-control analysis. 
  • Reduced life span with heart and muscle dysfunction in Drosophila sarcoglycan mutants. 
  • Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye. 
  • Repeated Failure in Reward Pursuit Alters Innate Drosophila Larval Behaviors. 
  • Requirement for JAK/STAT signaling throughout border cell migration in Drosophila. 
  • Requirement for the vasa RNA helicase in gurken mRNA localization. 
  • Retina-specifically expressed novel subtypes of bovine cyclophilin. 
  • Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper. 
  • Rho1 regulates Drosophila adherens junctions independently of p120ctn. 
  • Rhodopsin maturation antagonized by dominant rhodopsin mutants. 
  • Role for ETS domain transcription factors Pea3/Erm in mouse lung development. 
  • Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses. 
  • Role of the DSC1 channel in regulating neuronal excitability in Drosophila melanogaster: extending nervous system stability under stress. 
  • Rotation of the stalk/neck and one head in a new crystal structure of the kinesin motor protein, Ncd. 
  • SMRTER, a Drosophila nuclear receptor coregulator, reveals that EcR-mediated repression is critical for development. 
  • SOCS36E, a novel Drosophila SOCS protein, suppresses JAK/STAT and EGF-R signalling in the imaginal wing disc. 
  • STING'ing Zika virus in neurons. 
  • Scythe: a novel reaper-binding apoptotic regulator. 
  • Second-site noncomplementation identifies genomic regions required for Drosophila nonmuscle myosin function during morphogenesis. 
  • Segregation at three loci explains familial and population risk in Hirschsprung disease. 
  • Self-Organized Nuclear Positioning Synchronizes the Cell Cycle in Drosophila Embryos. 
  • Sequence variations at I260 and A1731 contribute to persistent currents in Drosophila sodium channels. 
  • Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila. 
  • Seven-up inhibits ultraspiracle-based signaling pathways in vitro and in vivo. 
  • Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. 
  • Signaling activities of the Drosophila wingless gene are separately mutable and appear to be transduced at the cell surface. 
  • Signaling by wingless in Drosophila. 
  • Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury. 
  • Single-target molecule detection with nonbleaching multicolor optical immunolabels. 
  • Size matters (but so does time), and it's OK to be different. 
  • Social Context Enhances Hormonal Modulation of Pheromone Detection in Drosophila. 
  • Social Network Influence on HIV Testing Among Urban Men in Tanzania. 
  • SoxNeuro and Shavenbaby act cooperatively to shape denticles in the embryonic epidermis of Drosophila . 
  • Spdeadringer, a sea urchin embryo gene required separately in skeletogenic and oral ectoderm gene regulatory networks. 
  • Spindle dynamics during meiosis in Drosophila oocytes. 
  • Spindle function in yeast: a human motor to the rescue. 
  • Sprinter: a novel transmembrane protein required for Wg secretion and signaling. 
  • Stall encodes an ADAMTS metalloprotease and interacts genetically with Delta in Drosophila ovarian follicle formation. 
  • Stem cells and their niches: integrated units that maintain Drosophila tissues. 
  • Stem cells: A tale of two kingdoms. 
  • Structural and functional domains of the Drosophila ncd microtubule motor protein. 
  • Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein. 
  • Structure-function analysis of Cdc25Twine degradation at the Drosophila maternal-to-zygotic transition. 
  • Structure-function of recombinant Na/H exchanger regulatory factor (NHE-RF). 
  • Studying recombination with high-throughput sequencing: an educational primer for use with "fine-scale heterogeneity in crossover rate in the garnet-scalloped region of the Drosophila melanogaster X chromosome". 
  • Synergistic derepression of gibberellin signaling by removing RGA and GAI function in Arabidopsis thaliana. 
  • Synergistic interaction between two cockroach sodium channel mutations and a tobacco budworm sodium channel mutation in reducing channel sensitivity to a pyrethroid insecticide. 
  • TGF-beta related genes in development. 
  • TOR kinase homologs function in a signal transduction pathway that is conserved from yeast to mammals. 
  • Taste and pheromone perception in mammals and flies. 
  • Temperature-Induced uncoupling of cell cycle regulators. 
  • Temporally regulated nuclear entry of the Drosophila period protein contributes to the circadian clock. 
  • Testing hypotheses for the functions of APC family proteins using null and truncation alleles in Drosophila. 
  • The Arabidopsis RGA gene encodes a transcriptional regulator repressing the gibberellin signal transduction pathway. 
  • The C-terminal 20 Amino Acids of Drosophila Topoisomerase 2 Are Required for Binding to a BRCA1 C Terminus (BRCT) Domain-containing Protein, Mus101, and Fidelity of DNA Segregation. 
  • The DEK oncoprotein is a Su(var) that is essential to heterochromatin integrity. 
  • The DVR gene family in embryonic development. 
  • The Dh gene of Drosophila melanogaster encodes a diuretic peptide that acts through cyclic AMP. 
  • The Drosophila BEAF insulator protein interacts with the polybromo subunit of the PBAP chromatin remodeling complex. 
  • The Drosophila Cadherin Fat regulates tissue size and planar cell polarity through different domains. 
  • The Drosophila Tis11 protein and its effects on mRNA expression in flies. 
  • The Drosophila Translational Control Element (TCE) is required for high-level transcription of many genes that are specifically expressed in testes. 
  • The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction. 
  • The Drosophila claret segregation protein is a minus-end directed motor molecule. 
  • The Drosophila ncd microtubule motor protein is spindle-associated in meiotic and mitotic cells. 
  • The Drosophila protein palmitoylome: characterizing palmitoyl-thioesterases and DHHC palmitoyl-transferases. 
  • The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal. 
  • The Ess1 prolyl isomerase is linked to chromatin remodeling complexes and the general transcription machinery. 
  • The HMG-box transcription factor SoxNeuro acts with Tcf to control Wg/Wnt signaling activity. 
  • The KASH domain protein MSP-300 plays an essential role in nuclear anchoring during Drosophila oogenesis. 
  • The LOV domain family: photoresponsive signaling modules coupled to diverse output domains. 
  • The TOR signal transduction cascade controls cellular differentiation in response to nutrients. 
  • The TOR signaling cascade regulates gene expression in response to nutrients. 
  • The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon. 
  • The deubiquitinating enzyme DUBAI stabilizes DIAP1 to suppress Drosophila apoptosis. 
  • The dishevelled protein is modified by wingless signaling in Drosophila. 
  • The downstream core promoter element, DPE, is conserved from Drosophila to humans and is recognized by TAFII60 of Drosophila. 
  • The effect of Drosophila attP40 background on the glomerular organization of Or47b olfactory receptor neurons. 
  • The effect of monastrol on the processive motility of a dimeric kinesin-5 head/kinesin-1 stalk chimera. 
  • The fruitless gene is required for the proper formation of axonal tracts in the embryonic central nervous system of Drosophila. 
  • The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote. 
  • The homotetrameric kinesin-5 KLP61F preferentially crosslinks microtubules into antiparallel orientations. 
  • The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis. 
  • The prospero transcription factor is asymmetrically localized to the cell cortex during neuroblast mitosis in Drosophila. 
  • The role of HOM-C genes in segmental transformations: reexamination of the Drosophila Sex combs reduced embryonic phenotype. 
  • The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. 
  • The strength and periodicity of D. melanogaster circadian rhythms are differentially affected by alterations in period gene expression. 
  • Thermosensory and nonthermosensory isoforms of Drosophila melanogaster TRPA1 reveal heat-sensor domains of a thermoTRP Channel. 
  • Tissue Sculpting by Fibrils. 
  • Toll-like receptor 4 (TLR4)-deficient murine macrophage cell line as an in vitro assay system to show TLR4-independent signaling of Bacteroides fragilis lipopolysaccharide. 
  • Transcriptional Timers Regulating Mitosis in Early Drosophila Embryos. 
  • Transcriptional profiling of olfactory system development identifies distal antenna as a regulator of subset of neuronal fates. 
  • Transcriptional repressor functions of Drosophila E2F1 and E2F2 cooperate to inhibit genomic DNA synthesis in ovarian follicle cells. 
  • Tum/RacGAP50C provides a critical link between anaphase microtubules and the assembly of the contractile ring in Drosophila melanogaster. 
  • Two chemosensory receptors together mediate carbon dioxide detection in Drosophila. 
  • Two-dimensional tracking of ncd motility by back focal plane interferometry. 
  • USP5 Is Dispensable for Monoubiquitin Maintenance in Drosophila. 
  • Ubiquitination regulates the neuroprotective function of the deubiquitinase ataxin-3 in vivo. 
  • Ultrabithorax function in butterfly wings and the evolution of insect wing patterns. 
  • Unveiling the secrets to her heart. 
  • Use of time-lapse imaging and dominant negative receptors to dissect the steroid receptor control of neuronal remodeling in Drosophila. 
  • Using Bcr-Abl to examine mechanisms by which abl kinase regulates morphogenesis in Drosophila. 
  • VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations. 
  • Variability on the dot chromosome in the Drosophila simulans clade. 
  • Visualization of replication initiation and elongation in Drosophila. 
  • Waiting for two mutations: with applications to regulatory sequence evolution and the limits of Darwinian evolution. 
  • Waves of Cdk1 Activity in S Phase Synchronize the Cell Cycle in Drosophila Embryos. 
  • Wingless Signaling: A Genetic Journey from Morphogenesis to Metastasis. 
  • Wingless signaling generates pattern through two distinct mechanisms. 
  • Wingless signaling: an axin to grind. 
  • Wnt signaling in development, disease and translational medicine. 
  • Wnt signaling: an embarrassment of receptors. 
  • Wnt signalling shows its versatility. 
  • Working strokes by single molecules of the kinesin-related microtubule motor ncd. 
  • X-ray crystal structure of the yeast Kar3 motor domain complexed with Mg.ADP to 2.3 A resolution. 
  • Yantar, a conserved arginine-rich protein is involved in Drosophila hemocyte development. 
  • Zinc finger binding motifs do not explain recombination rate variation within or between species of Drosophila. 
  • [Protein transduction domain peptide mediates delivery to the brain via the blood-brain barrier in Drosophila]. 
  • bullwinkle is required for epithelial morphogenesis during Drosophila oogenesis. 
  • cis-Proline-mediated Ser(P)5 dephosphorylation by the RNA polymerase II C-terminal domain phosphatase Ssu72. 
  • crinkled reveals a new role for Wingless signaling in Drosophila denticle formation. 
  • dishevelled and armadillo act in the wingless signalling pathway in Drosophila. 
  • mirror controls planar polarity and equator formation through repression of fringe expression and through control of cell affinities. 
  • mirror encodes a novel PBX-class homeoprotein that functions in the definition of the dorsal-ventral border in the Drosophila eye. 
  • neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions. 
  • speck, First Identified in Drosophila melanogaster in 1910, Is Encoded by the Arylalkalamine N-Acetyltransferase (AANAT1) Gene. 
  • zipper Nonmuscle myosin-II functions downstream of PS2 integrin in Drosophila myogenesis and is necessary for myofibril formation. 
  • ¹H, ¹³C and ¹⁵N backbone and side-chain resonance assignments of Drosophila melanogaster Ssu72. 
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  Keywords of People

  • Bejsovec, Amy, Associate Professor of Biology, Biology
  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Ciofani, Maria, Associate Professor of Integrative Immunobiology, Cell Biology
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Gordan, Raluca Mihaela, Associate Professor in Biostatistics & Bioinformatics, Computer Science
  • Hartemink, Alexander J., Professor in the Department of Computer Science, Biology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
  • Wray, Gregory Allan, Professor of Biology, Evolutionary Anthropology