Xenopus Proteins

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  Subject Areas on Research

  • A BMP pathway regulates cell fate allocation along the sea urchin animal-vegetal embryonic axis. 
  • A Wnt-CKIvarepsilon-Rap1 pathway regulates gastrulation by modulating SIPA1L1, a Rap GTPase activating protein. 
  • A chimeric kinesin-1 head/kinesin-5 tail motor switches between diffusive and processive motility. 
  • A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition. 
  • A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis. 
  • A mouse model of congenital heart disease: cardiac arrhythmias and atrial septal defect caused by haploinsufficiency of the cardiac transcription factor Csx/Nkx2.5. 
  • A role for Cdc2- and PP2A-mediated regulation of Emi2 in the maintenance of CSF arrest. 
  • A tarantula-venom peptide antagonizes the TRPA1 nociceptor ion channel by binding to the S1-S4 gating domain. 
  • A truncated form of fibroblast growth factor receptor 1 inhibits signal transduction by multiple types of fibroblast growth factor receptor. 
  • Across the meiotic divide - CSF activity in the post-Emi2/XErp1 era. 
  • Allosteric inhibition of kinesin-5 modulates its processive directional motility. 
  • Bone morphogenetic proteins in development. 
  • Cardiac-specific LIM protein FHL2 modifies the hypertrophic response to beta-adrenergic stimulation. 
  • Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex. 
  • Cell biology. Enforcing the Greatwall in mitosis. 
  • Changes in the pattern of adherens junction-associated beta-catenin accompany morphogenesis in the sea urchin embryo. 
  • Checkpoint signals in grasshopper meiosis are sensitive to microtubule attachment, but tension is still essential. 
  • Comparison of human and Xenopus GATA-2 promoters. 
  • Condensin and cohesin display different arm conformations with characteristic hinge angles. 
  • Conformational studies of the nucleic acid binding sites for Xenopus transcription factor IIIA. 
  • Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2. 
  • Control of Emi2 activity and stability through Mos-mediated recruitment of PP2A. 
  • Crk is required for apoptosis in Xenopus egg extracts. 
  • Cyclin-binding motifs are essential for the function of p21CIP1. 
  • DNA replication checkpoint control of Wee1 stability by vertebrate Hsl7. 
  • Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled. 
  • Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled. 
  • Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis. 
  • Emi2-mediated inhibition of E2-substrate ubiquitin transfer by the anaphase-promoting complex/cyclosome through a D-box-independent mechanism. 
  • Evidence for the involvement of the Gli gene family in embryonic mouse lung development. 
  • Features of programmed cell death in intact Xenopus oocytes and early embryos revealed by near-infrared fluorescence and real-time monitoring. 
  • Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4. 
  • Identification of a role for beta-catenin in the establishment of a bipolar mitotic spindle. 
  • Identification of the nuclear localization signal in Xenopus cyclin E and analysis of its role in replication and mitosis. 
  • Inhibition of the anaphase-promoting complex by the Xnf7 ubiquitin ligase. 
  • Inhibition of translation and induction of apoptosis by Bunyaviral nonstructural proteins bearing sequence similarity to reaper. 
  • Load-dependent release limits the processive stepping of the tetrameric Eg5 motor. 
  • Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication. 
  • Membrane localization of the kinase which phosphorylates p34cdc2 on threonine 14. 
  • Metabolic control of Ca2+/calmodulin-dependent protein kinase II (CaMKII)-mediated caspase-2 suppression by the B55β/protein phosphatase 2A (PP2A). 
  • Microtubule cross-linking triggers the directional motility of kinesin-5. 
  • Microtubules accelerate the kinase activity of Aurora-B by a reduction in dimensionality. 
  • Msx1 and Pax3 cooperate to mediate FGF8 and WNT signals during Xenopus neural crest induction. 
  • Neck-linker length dependence of processive Kinesin-5 motility. 
  • Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7. 
  • Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation. 
  • Nomenclature: vertebrate mediators of TGFbeta family signals. 
  • Novel retrotransposed imprinted locus identified at human 6p25. 
  • Nuclear export of mammalian PERIOD proteins. 
  • Nuclear import of Cdk/cyclin complexes: identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin B1. 
  • PP1 control of M phase entry exerted through 14-3-3-regulated Cdc25 dephosphorylation. 
  • PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation. 
  • Phosphatases driving mitosis: pushing the gas and lifting the brakes. 
  • Phosphorylation of the cyclin b1 cytoplasmic retention sequence by mitogen-activated protein kinase and Plx. 
  • Precise regulation of porcupine activity is required for physiological Wnt signaling. 
  • Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. 
  • Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus. 
  • RCC1, a regulator of mitosis, is essential for DNA replication. 
  • Rapid identification of protein phosphatase 1-binding proteins by mixed peptide sequencing and data base searching. Characterization of a novel holoenzymic form of protein phosphatase 1. 
  • Reaper-induced dissociation of a Scythe-sequestered cytochrome c-releasing activity. 
  • Regulation of apoptosis in Xenopus egg extracts. 
  • Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A. 
  • Regulation of casein kinase I epsilon activity by Wnt signaling. 
  • Requirement of the prolyl isomerase Pin1 for the replication checkpoint. 
  • Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper. 
  • Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis. 
  • Scythe: a novel reaper-binding apoptotic regulator. 
  • Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway. 
  • Site-specific casein kinase 1epsilon-dependent phosphorylation of Dishevelled modulates beta-catenin signaling. 
  • Smad5 induces ventral fates in Xenopus embryo. 
  • Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11. 
  • TBX5 is required for embryonic cardiac cell cycle progression. 
  • Tetramerization and single-stranded DNA binding properties of native and mutated forms of murine mitochondrial single-stranded DNA-binding proteins. 
  • The CapZ interacting protein Rcsd1 is required for cardiogenesis downstream of Wnt11a in Xenopus laevis. 
  • The NOTCH1/SNAIL1/MEF2C Pathway Regulates Growth and Self-Renewal in Embryonal Rhabdomyosarcoma. 
  • The Wnt/JNK signaling target gene alcam is required for embryonic kidney development. 
  • The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks. 
  • The effect of monastrol on the processive motility of a dimeric kinesin-5 head/kinesin-1 stalk chimera. 
  • The mitotic peptidyl-prolyl isomerase, Pin1, interacts with Cdc25 and Plx1. 
  • The outer segment serves as a default destination for the trafficking of membrane proteins in photoreceptors. 
  • The vesicular glutamate transporter 1 (xVGlut1) is expressed in discrete regions of the developing Xenopus laevis nervous system. 
  • Two forms of mitochondrial DNA ligase III are produced in Xenopus laevis oocytes. 
  • WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification. 
  • Wee1-regulated apoptosis mediated by the crk adaptor protein in Xenopus egg extracts. 
  • When the checkpoints have gone: insights into Cdc25 functional activation. 
  • XMAP215 is a long thin molecule that does not increase microtubule stiffness. 
  • Xenopus Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity and epithelial integrity. 
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  Keywords of People

  • Erickson, Harold Paul, James B. Duke Distinguished Professor of Cell Biology, Cell Biology
  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor for Research in Molecular Biology, Cell Biology