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Subject Areas on Research
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A BMP pathway regulates cell fate allocation along the sea urchin animal-vegetal embryonic axis.
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A Wnt-CKIvarepsilon-Rap1 pathway regulates gastrulation by modulating SIPA1L1, a Rap GTPase activating protein.
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A chimeric kinesin-1 head/kinesin-5 tail motor switches between diffusive and processive motility.
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A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition.
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A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis.
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A mouse model of congenital heart disease: cardiac arrhythmias and atrial septal defect caused by haploinsufficiency of the cardiac transcription factor Csx/Nkx2.5.
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A role for Cdc2- and PP2A-mediated regulation of Emi2 in the maintenance of CSF arrest.
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A tarantula-venom peptide antagonizes the TRPA1 nociceptor ion channel by binding to the S1-S4 gating domain.
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A truncated form of fibroblast growth factor receptor 1 inhibits signal transduction by multiple types of fibroblast growth factor receptor.
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Across the meiotic divide - CSF activity in the post-Emi2/XErp1 era.
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Allosteric inhibition of kinesin-5 modulates its processive directional motility.
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Bone morphogenetic proteins in development.
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Cardiac-specific LIM protein FHL2 modifies the hypertrophic response to beta-adrenergic stimulation.
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Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex.
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Cell biology. Enforcing the Greatwall in mitosis.
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Changes in the pattern of adherens junction-associated beta-catenin accompany morphogenesis in the sea urchin embryo.
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Checkpoint signals in grasshopper meiosis are sensitive to microtubule attachment, but tension is still essential.
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Comparison of human and Xenopus GATA-2 promoters.
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Condensin and cohesin display different arm conformations with characteristic hinge angles.
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Conformational studies of the nucleic acid binding sites for Xenopus transcription factor IIIA.
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Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2.
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Control of Emi2 activity and stability through Mos-mediated recruitment of PP2A.
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Crk is required for apoptosis in Xenopus egg extracts.
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Cyclin-binding motifs are essential for the function of p21CIP1.
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DNA replication checkpoint control of Wee1 stability by vertebrate Hsl7.
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Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled.
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Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled.
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Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis.
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Emi2-mediated inhibition of E2-substrate ubiquitin transfer by the anaphase-promoting complex/cyclosome through a D-box-independent mechanism.
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Evidence for the involvement of the Gli gene family in embryonic mouse lung development.
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Features of programmed cell death in intact Xenopus oocytes and early embryos revealed by near-infrared fluorescence and real-time monitoring.
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Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4.
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Identification of a role for beta-catenin in the establishment of a bipolar mitotic spindle.
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Identification of the nuclear localization signal in Xenopus cyclin E and analysis of its role in replication and mitosis.
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Inhibition of the anaphase-promoting complex by the Xnf7 ubiquitin ligase.
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Inhibition of translation and induction of apoptosis by Bunyaviral nonstructural proteins bearing sequence similarity to reaper.
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Load-dependent release limits the processive stepping of the tetrameric Eg5 motor.
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Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication.
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Membrane localization of the kinase which phosphorylates p34cdc2 on threonine 14.
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Metabolic control of Ca2+/calmodulin-dependent protein kinase II (CaMKII)-mediated caspase-2 suppression by the B55β/protein phosphatase 2A (PP2A).
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Microtubule cross-linking triggers the directional motility of kinesin-5.
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Microtubules accelerate the kinase activity of Aurora-B by a reduction in dimensionality.
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Msx1 and Pax3 cooperate to mediate FGF8 and WNT signals during Xenopus neural crest induction.
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Neck-linker length dependence of processive Kinesin-5 motility.
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Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7.
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Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation.
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Nomenclature: vertebrate mediators of TGFbeta family signals.
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Novel retrotransposed imprinted locus identified at human 6p25.
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Nuclear export of mammalian PERIOD proteins.
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Nuclear import of Cdk/cyclin complexes: identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin B1.
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PP1 control of M phase entry exerted through 14-3-3-regulated Cdc25 dephosphorylation.
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PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation.
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Phosphatases driving mitosis: pushing the gas and lifting the brakes.
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Phosphorylation of the cyclin b1 cytoplasmic retention sequence by mitogen-activated protein kinase and Plx.
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Precise regulation of porcupine activity is required for physiological Wnt signaling.
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Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex.
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Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus.
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RCC1, a regulator of mitosis, is essential for DNA replication.
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Rapid identification of protein phosphatase 1-binding proteins by mixed peptide sequencing and data base searching. Characterization of a novel holoenzymic form of protein phosphatase 1.
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Reaper-induced dissociation of a Scythe-sequestered cytochrome c-releasing activity.
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Regulation of apoptosis in Xenopus egg extracts.
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Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A.
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Regulation of casein kinase I epsilon activity by Wnt signaling.
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Requirement of the prolyl isomerase Pin1 for the replication checkpoint.
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Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper.
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Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis.
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Scythe: a novel reaper-binding apoptotic regulator.
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Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway.
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Site-specific casein kinase 1epsilon-dependent phosphorylation of Dishevelled modulates beta-catenin signaling.
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Smad5 induces ventral fates in Xenopus embryo.
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Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11.
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TBX5 is required for embryonic cardiac cell cycle progression.
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Tetramerization and single-stranded DNA binding properties of native and mutated forms of murine mitochondrial single-stranded DNA-binding proteins.
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The CapZ interacting protein Rcsd1 is required for cardiogenesis downstream of Wnt11a in Xenopus laevis.
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The NOTCH1/SNAIL1/MEF2C Pathway Regulates Growth and Self-Renewal in Embryonal Rhabdomyosarcoma.
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The Wnt/JNK signaling target gene alcam is required for embryonic kidney development.
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The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks.
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The effect of monastrol on the processive motility of a dimeric kinesin-5 head/kinesin-1 stalk chimera.
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The mitotic peptidyl-prolyl isomerase, Pin1, interacts with Cdc25 and Plx1.
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The outer segment serves as a default destination for the trafficking of membrane proteins in photoreceptors.
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The vesicular glutamate transporter 1 (xVGlut1) is expressed in discrete regions of the developing Xenopus laevis nervous system.
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Two forms of mitochondrial DNA ligase III are produced in Xenopus laevis oocytes.
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WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification.
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Wee1-regulated apoptosis mediated by the crk adaptor protein in Xenopus egg extracts.
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When the checkpoints have gone: insights into Cdc25 functional activation.
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XMAP215 is a long thin molecule that does not increase microtubule stiffness.
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Xenopus Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity and epithelial integrity.
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