Zebrafish Proteins

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  Subject Areas on Research

  • A Genetic Cardiomyocyte Ablation Model for the Study of Heart Regeneration in Zebrafish. 
  • A Wnt-CKIvarepsilon-Rap1 pathway regulates gastrulation by modulating SIPA1L1, a Rap GTPase activating protein. 
  • A defect in myoblast fusion underlies Carey-Fineman-Ziter syndrome. 
  • A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development. 
  • A novel missense mutation of Wilms' Tumor 1 causes autosomal dominant FSGS. 
  • A robust and flexible CRISPR/Cas9-based system for neutrophil-specific gene inactivation in zebrafish. 
  • A zebrafish model for the Shwachman-Diamond syndrome (SDS). 
  • AHR2 knockdown prevents PAH-mediated cardiac toxicity and XRE- and ARE-associated gene induction in zebrafish (Danio rerio). 
  • AHR2-Mediated transcriptomic responses underlying the synergistic cardiac developmental toxicity of PAHs. 
  • Agrin is required for posterior development and motor axon outgrowth and branching in embryonic zebrafish. 
  • Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities. 
  • Ambulatory impedance cardiography: a feasibility study. 
  • An injury-responsive gata4 program shapes the zebrafish cardiac ventricle. 
  • Antioxidant responses and NRF2 in synergistic developmental toxicity of PAHs in zebrafish. 
  • Aryl phosphate esters within a major PentaBDE replacement product induce cardiotoxicity in developing zebrafish embryos: potential role of the aryl hydrocarbon receptor. 
  • BMP receptor IA is required in mammalian neural crest cells for development of the cardiac outflow tract and ventricular myocardium. 
  • Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway. 
  • Bmp and Fgf signaling are essential for liver specification in zebrafish. 
  • Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements. 
  • CERKL gene knockout disturbs photoreceptor outer segment phagocytosis and causes rod-cone dystrophy in zebrafish. 
  • Calcium influx through L-type CaV1.2 Ca2+ channels regulates mandibular development. 
  • Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex. 
  • Ccn2a is an injury-induced matricellular factor that promotes cardiac regeneration in zebrafish. 
  • Cellular mechanisms of wingless/Wnt signal transduction. 
  • Ciliogenesis mechanisms mediated by PAK2-ARL13B signaling in brain endothelial cells is responsible for vascular stability. 
  • Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin. 
  • Cloning of zebrafish vsx1: expression of a paired-like homeobox gene during CNS development. 
  • Commensal microbiota stimulate systemic neutrophil migration through induction of serum amyloid A. 
  • Connectomics of the zebrafish's lateral-line neuromast reveals wiring and miswiring in a simple microcircuit. 
  • Conserved roles for Hnf4 family transcription factors in zebrafish development and intestinal function. 
  • Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3. 
  • Coronary Revascularization During Heart Regeneration Is Regulated by Epicardial and Endocardial Cues and Forms a Scaffold for Cardiomyocyte Repopulation. 
  • Cse1l is a negative regulator of CFTR-dependent fluid secretion. 
  • Deletion of the transmembrane protein Prom1b in zebrafish disrupts outer-segment morphogenesis and causes photoreceptor degeneration. 
  • Developmental exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin alters DNA methyltransferase (dnmt) expression in zebrafish (Danio rerio). 
  • Developmentally regulated expression of two members of the Nrarp family in zebrafish. 
  • Distinct roles for luminal acidification in apical protein sorting and trafficking in zebrafish. 
  • Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled. 
  • Drug-Inducible, Cell-Specific Manipulation of Intracellular Calcium in Zebrafish Through Mammalian TRPV1 Expression. 
  • Elucidating the role of plexin D1 in body fat distribution and susceptibility to metabolic disease using a zebrafish model system. 
  • Embryonic expression and steroid regulation of brain aromatase cyp19a1b in zebrafish (Danio rerio). 
  • Embryonic expression of zebrafish MiT family genes tfe3b, tfeb, and tfec. 
  • Endogenous Tagging at the cdh1 Locus for Live Visualization of E-Cadherin Dynamics. 
  • Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways. 
  • Epicardial regeneration is guided by cardiac outflow tract and Hedgehog signalling. 
  • Epigenetic control of intestinal barrier function and inflammation in zebrafish. 
  • Expression of cyp26b1 during zebrafish early development. 
  • Extracellular hyaluronate pressure shaped by cellular tethers drives tissue morphogenesis. 
  • FGF signaling regulates rod photoreceptor cell maintenance and regeneration in zebrafish. 
  • Feedback mechanisms regulate retinoic acid production and degradation in the zebrafish embryo. 
  • Fgf signaling instructs position-dependent growth rate during zebrafish fin regeneration. 
  • Fgf-dependent depletion of microRNA-133 promotes appendage regeneration in zebrafish. 
  • Fgfs control homeostatic regeneration in adult zebrafish fins. 
  • Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration. 
  • Fluoranthene, but not benzo[a]pyrene, interacts with hypoxia resulting in pericardial effusion and lordosis in developing zebrafish. 
  • FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site. 
  • From man to fish: What can Zebrafish tell us about ApoL1 nephropathy? 
  • G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway. 
  • Gene expression changes in developing zebrafish as potential markers for rapid developmental neurotoxicity screening. 
  • Generation and characterization of neurogenin1-GFP transgenic medaka with potential for rapid developmental neurotoxicity screening. 
  • Genetic Reprogramming of Positional Memory in a Regenerating Appendage. 
  • Genetic control of single lumen formation in the zebrafish gut. 
  • Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1. 
  • Glafenine-induced intestinal injury in zebrafish is ameliorated by μ-opioid signaling via enhancement of Atf6-dependent cellular stress responses. 
  • Halogenated carbazoles induce cardiotoxicity in developing zebrafish (Danio rerio) embryos. 
  • Hand2 elevates cardiomyocyte production during zebrafish heart development and regeneration. 
  • Hand2 regulates extracellular matrix remodeling essential for gut-looping morphogenesis in zebrafish. 
  • Haploinsufficiency of the Sin3/HDAC corepressor complex member SIN3B causes a syndromic intellectual disability/autism spectrum disorder. 
  • Heart regeneration in zebrafish. 
  • How the zebrafish gets its stripes. 
  • Hoxb5b acts downstream of retinoic acid signaling in the forelimb field to restrict heart field potential in zebrafish. 
  • Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA. 
  • ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation. 
  • Identification and characterization of a functional zebrafish smrt corepressor (ncor2). 
  • Identification and requirements of enhancers that direct gene expression during zebrafish fin regeneration. 
  • Identification of enhancer regulatory elements that direct epicardial gene expression during zebrafish heart regeneration. 
  • In vivo imaging of tumor-propagating cells, regional tumor heterogeneity, and dynamic cell movements in embryonal rhabdomyosarcoma. 
  • In vivo proximity labeling identifies cardiomyocyte protein networks during zebrafish heart regeneration. 
  • Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration. 
  • Inhibiting the inhibitor: targeting vascular endothelial protein tyrosine phosphatase to promote tumor vascular maturation. 
  • Injury-induced ctgfa directs glial bridging and spinal cord regeneration in zebrafish. 
  • Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation. 
  • Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation. 
  • Intronic cis-regulatory modules mediate tissue-specific and microbial control of angptl4/fiaf transcription. 
  • Knock-in tagging in zebrafish facilitated by insertion into non-coding regions. 
  • Knockdown of AHR1A but not AHR1B exacerbates PAH and PCB-126 toxicity in zebrafish (Danio rerio) embryos. 
  • Knockout of Nr2e3 prevents rod photoreceptor differentiation and leads to selective L-/M-cone photoreceptor degeneration in zebrafish. 
  • L-leucine partially rescues translational and developmental defects associated with zebrafish models of Cornelia de Lange syndrome. 
  • LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. 
  • Ligament versus bone cell identity in the zebrafish hyoid skeleton is regulated by mef2ca. 
  • Live Monitoring of Blastemal Cell Contributions during Appendage Regeneration. 
  • Local Dkk1 crosstalk from breeding ornaments impedes regeneration of injured male zebrafish fins. 
  • Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration. 
  • Lysosome-Rich Enterocytes Mediate Protein Absorption in the Vertebrate Gut. 
  • Maintenance of blastemal proliferation by functionally diverse epidermis in regenerating zebrafish fins. 
  • Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight. 
  • Methodologies for Inducing Cardiac Injury and Assaying Regeneration in Adult Zebrafish. 
  • Microarray gene expression profiling during the segmentation phase of zebrafish development. 
  • Microbial colonization induces dynamic temporal and spatial patterns of NF-κB activation in the zebrafish digestive tract. 
  • Microbiota regulate intestinal epithelial gene expression by suppressing the transcription factor Hepatocyte nuclear factor 4 alpha. 
  • Modulation of tissue repair by regeneration enhancer elements. 
  • Mps1 defines a proximal blastemal proliferative compartment essential for zebrafish fin regeneration. 
  • Mutations in NCAPG2 Cause a Severe Neurodevelopmental Syndrome that Expands the Phenotypic Spectrum of Condensinopathies. 
  • Mutations in fam20b and xylt1 reveal that cartilage matrix controls timing of endochondral ossification by inhibiting chondrocyte maturation. 
  • Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS. 
  • Myocardium and BMP signaling are required for endocardial differentiation. 
  • Neurobehavioral effects of 1,2-propanediol in zebrafish (Danio rerio). 
  • Neuronal regulation of the spatial patterning of neurogenesis. 
  • Notochord vacuoles absorb compressive bone growth during zebrafish spine formation. 
  • Notochord vacuoles are lysosome-related organelles that function in axis and spine morphogenesis. 
  • Notochordal Signals Establish Phylogenetic Identity of the Teleost Spine. 
  • Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish. 
  • Nuclear beta-catenin-dependent Wnt8 signaling in vegetal cells of the early sea urchin embryo regulates gastrulation and differentiation of endoderm and mesodermal cell lineages. 
  • Nuclear phosphatase PPM1G in cellular survival and neural development. 
  • Oesophageal and sternohyal muscle fibres are novel Pax3-dependent migratory somite derivatives essential for ingestion. 
  • Ontogeny and nutritional control of adipogenesis in zebrafish (Danio rerio). 
  • Otx but not Mitf transcription factors are required for zebrafish retinal pigment epithelium development. 
  • PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation. 
  • Phenotypic regulation of the sphingosine 1-phosphate receptor miles apart by G protein-coupled receptor kinase 2. 
  • Phosphorylation of Threonine 794 on Tie1 by Rac1/PAK1 Reveals a Novel Angiogenesis Regulatory Pathway. 
  • Positional cloning of a temperature-sensitive mutant emmental reveals a role for sly1 during cell proliferation in zebrafish fin regeneration. 
  • Potentiation of P2RX7 as a host-directed strategy for control of mycobacterial infection. 
  • Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes. 
  • Propranolol inhibits cavernous vascular malformations by β1 adrenergic receptor antagonism in animal models. 
  • Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus. 
  • Protein phosphatase 2A: a panoply of enzymes. 
  • Public funding of understanding nature. 
  • Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. 
  • RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro. 
  • Ras controls melanocyte expansion during zebrafish fin stripe regeneration. 
  • Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A. 
  • Regulation of casein kinase I epsilon activity by Wnt signaling. 
  • Regulation of intrahepatic biliary duct morphogenesis by Claudin 15-like b. 
  • Regulation of zebrafish fin regeneration by vitamin D signaling. 
  • Restriction of hepatic competence by Fgf signaling. 
  • Retinal ganglion cell genesis requires lakritz, a Zebrafish atonal Homolog. 
  • Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration. 
  • Retinoic acid-mediated gene expression in transgenic reporter zebrafish. 
  • Retinoid regulation of the zebrafish cyp26a1 promoter. 
  • Self-organization of apical membrane protein sorting in epithelial cells. 
  • Sequence and expression of zebrafish foxc1a and foxc1b, encoding conserved forkhead/winged helix transcription factors. 
  • Sexually dimorphic fin regeneration in zebrafish controlled by androgen/GSK3 signaling. 
  • Single continuous lumen formation in the zebrafish gut is mediated by smoothened-dependent tissue remodeling. 
  • Single epicardial cell transcriptome sequencing identifies Caveolin 1 as an essential factor in zebrafish heart regeneration. 
  • Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart. 
  • Single-cell imaging of T cell immunotherapy responses in vivo. 
  • Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase. 
  • Specification of epibranchial placodes in zebrafish. 
  • Stac3 is a component of the excitation-contraction coupling machinery and mutated in Native American myopathy. 
  • Staggered cell-intrinsic timing of ath5 expression underlies the wave of ganglion cell neurogenesis in the zebrafish retina. 
  • Steroid-sensitive nephrotic syndrome candidate gene CLVS1 regulates podocyte oxidative stress and endocytosis. 
  • Suppressor of fused negatively regulates beta-catenin signaling. 
  • Synergistic induction of AHR regulated genes in developmental toxicity from co-exposure to two model PAHs in zebrafish. 
  • Systems proteomics of cardiac chromatin identifies nucleolin as a regulator of growth and cellular plasticity in cardiomyocytes. 
  • The Calcineurin-FoxO-MuRF1 signaling pathway regulates myofibril integrity in cardiomyocytes. 
  • The Macrophage-Specific Promoter mfap4 Allows Live, Long-Term Analysis of Macrophage Behavior during Mycobacterial Infection in Zebrafish. 
  • The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells. 
  • The actin nucleator Cordon-bleu is required for development of motile cilia in zebrafish. 
  • The case for thyroid disruption in early life stage exposures to thiram in zebrafish (Danio rerio). 
  • The feelgood mutation in zebrafish dysregulates COPII-dependent secretion of select extracellular matrix proteins in skeletal morphogenesis. 
  • The forkhead transcription factor FoxI1 remains bound to condensed mitotic chromosomes and stably remodels chromatin structure. 
  • The role of alpha7 and alpha4beta2 nicotinic receptors in the nicotine-induced anxiolytic effect in zebrafish. 
  • The transcriptional response to oxidative stress during vertebrate development: effects of tert-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin. 
  • The winged helix transcription factor Foxc1a is essential for somitogenesis in zebrafish. 
  • Tp53 Suppression Promotes Cardiomyocyte Proliferation during Zebrafish Heart Regeneration. 
  • Transcriptional components of anteroposterior positional information during zebrafish fin regeneration. 
  • Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights. 
  • Transient laminin beta 1a Induction Defines the Wound Epidermis during Zebrafish Fin Regeneration. 
  • Transient requirement for ganglion cells during assembly of retinal synaptic layers. 
  • Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration. 
  • Tuberculous granuloma induction via interaction of a bacterial secreted protein with host epithelium. 
  • Vegfaa instructs cardiac muscle hyperplasia in adult zebrafish. 
  • Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel. 
  • Vitamin D Stimulates Cardiomyocyte Proliferation and Controls Organ Size and Regeneration in Zebrafish. 
  • Voltage-gated sodium channel scn8a is required for innervation and regeneration of amputated adult zebrafish fins. 
  • Wnt signaling: an embarrassment of receptors. 
  • Wnt signalling shows its versatility. 
  • Wnt/PCP controls spreading of Wnt/β-catenin signals by cytonemes in vertebrates. 
  • Zebrafish Locomotor Responses Reveal Irritant Effects of Fine Particulate Matter Extracts and a Role for TRPA1. 
  • Zebrafish Posterior Lateral Line primordium migration requires interactions between a superficial sheath of motile cells and the skin. 
  • Zebrafish Transcription Factor ORFeome for Gene Discovery and Regulatory Network Elucidation. 
  • Zebrafish as a model for apolipoprotein biology: comprehensive expression analysis and a role for ApoA-IV in regulating food intake. 
  • Zebrafish cardiotoxicity: the effects of CYP1A inhibition and AHR2 knockdown following exposure to weak aryl hydrocarbon receptor agonists. 
  • Zebrafish have an ethanol-inducible hepatic 4-nitrophenol hydroxylase that is not CYP2E1-like. 
  • Zebrafish second heart field development relies on progenitor specification in anterior lateral plate mesoderm and nkx2.5 function. 
  • hapln1 Defines an Epicardial Cell Subpopulation Required for Cardiomyocyte Expansion During Heart Morphogenesis and Regeneration. 
  • tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration. 
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  Keywords of People

  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology