Escherichia coli Proteins

• 

  Subject Areas on Research

  • 2.2 Å resolution cryo-EM structure of β-galactosidase in complex with a cell-permeant inhibitor. 
  • A 'Semi-Protected Oligonucleotide Recombination' Assay for DNA Mismatch Repair in vivo Suggests Different Modes of Repair for Lagging Strand Mismatches. 
  • A combination of two antioxidants (an SOD mimic and ascorbate) produces a pro-oxidative effect forcing Escherichia coli to adapt via induction of oxyR regulon. 
  • A flexible statistical model for alignment of label-free proteomics data--incorporating ion mobility and product ion information. 
  • A geometric arrangement algorithm for structure determination of symmetric protein homo-oligomers from NOEs and RDCs. 
  • A human protein with antimutator activity. 
  • A methylation-dependent electrostatic switch controls DNA repair and transcriptional activation by E. coli ada. 
  • A miniaturized technique for assessing protein thermodynamics and function using fast determination of quantitative cysteine reactivity. 
  • A naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype. 
  • A structure-based mechanism for drug binding by multidrug transporters. 
  • A three-dimensional ParF meshwork assembles through the nucleoid to mediate plasmid segregation. 
  • An SOD mimic protects NADP+-dependent isocitrate dehydrogenase against oxidative inactivation. 
  • Assembly and molecular activities of the MutS tetramer. 
  • Assembly dynamics of FtsZ rings in Bacillus subtilis and Escherichia coli and effects of FtsZ-regulating proteins. 
  • Atomic force microscopy captures MutS tetramers initiating DNA mismatch repair. 
  • Atomic force microscopy captures folded ribosome bound nascent chains. 
  • Atomic force microscopy captures the initiation of methyl-directed DNA mismatch repair. 
  • Bacterial Nucleoid Occlusion: Multiple Mechanisms for Preventing Chromosome Bisection During Cell Division. 
  • Bacterial actin homolog ParM: arguments for an apolar, antiparallel double helix. 
  • Bacterial flavohemoglobin: a molecular tool to probe mammalian nitric oxide biology. 
  • Bacterial surface association of heat-labile enterotoxin through lipopolysaccharide after secretion via the general secretory pathway. 
  • Bacteriophage T4 UvsW protein is a helicase involved in recombination, repair and the regulation of DNA replication origins. 
  • Bidirectional excision in methyl-directed mismatch repair. 
  • Biochemical role of the Cryptococcus neoformans ADE2 protein in fungal de novo purine biosynthesis. 
  • Biogenesis, cellular localization, and functional activation of the heat-stable enterotoxin receptor (guanylyl cyclase C). 
  • BtubA-BtubB heterodimer is an essential intermediate in protofilament assembly. 
  • C-terminally truncated derivatives of Escherichia coli Hfq are proficient in riboregulation. 
  • Capturing intrinsic nanomechanics of allostery. 
  • Cell-Specific Chemical Delivery Using a Selective Nitroreductase-Nitroaryl Pair. 
  • Characterization of Escherichia coli MoeB and its involvement in the activation of molybdopterin synthase for the biosynthesis of the molybdenum cofactor. 
  • Circular ribozymes generated in Escherichia coli using group I self-splicing permuted intron-exon sequences. 
  • Computational design of a biologically active enzyme. 
  • Conformational changes of purine repressor DNA-binding domain upon complexation with DNA. 
  • Context-dependent activation kinetics elicited by soluble versus outer membrane vesicle-associated heat-labile enterotoxin. 
  • Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension. 
  • Control of embryonic lung branching morphogenesis by the Rho activator, cytotoxic necrotizing factor 1. 
  • Converting a maltose receptor into a nascent binuclear copper oxygenase by computational design. 
  • Copper shares a piece of the pi. 
  • Critical role of the RpoE stress response pathway in polymyxin resistance of Escherichia coli. 
  • Crystal structure of LacI member, PurR, bound to DNA: minor groove binding by alpha helices. 
  • Crystal structure of activated CheY. Comparison with other activated receiver domains. 
  • Crystal structure of an Escherichia coli Hfq Core (residues 2-69)-DNA complex reveals multifunctional nucleic acid binding sites. 
  • Crystal structure of an activated response regulator bound to its target. 
  • Crystal structure of the gephyrin-related molybdenum cofactor biosynthesis protein MogA from Escherichia coli. 
  • Crystal structure of the lactose operon repressor and its complexes with DNA and inducer. 
  • Crystallization and preliminary X-ray analysis of an Escherichia coli purine repressor-hypoxanthine-DNA complex. 
  • Crystallization and preliminary X-ray studies on the co-repressor binding domain of the Escherichia coli purine repressor. 
  • Crystallization of the bifunctional biotin operon repressor. 
  • Cytokines: the future of intranasal vaccine adjuvants. 
  • Cytoskeleton. Evolution in bacteria. 
  • DNA nicks inflicted by restriction endonucleases are repaired by a RecA- and RecB-dependent pathway in Escherichia coli. 
  • Describing Complex Structure-Function Relationships in Biomolecules at Equilibrium. 
  • Detection and characterization of xenon-binding sites in proteins by 129Xe NMR spectroscopy. 
  • Development of novel tumor imaging agents with phage-display combinatorial peptide libraries. 
  • Differential and simultaneous adenosine di- and triphosphate binding by MutS. 
  • Discovery of Thermostable, Fluorescently Responsive Glucose Biosensors by Structure-Assisted Function Extrapolation. 
  • Discovery of a cardiolipin synthase utilizing phosphatidylethanolamine and phosphatidylglycerol as substrates. 
  • Discovery of novel bacterial elongation condensing enzyme inhibitors by virtual screening. 
  • Distinct MutS DNA-binding modes that are differentially modulated by ATP binding and hydrolysis. 
  • Drug detoxification dynamics explain the postantibiotic effect. 
  • Effect of isopropyl-beta-D-thiogalactopyranosid induction of the lac operon on the specificity of spontaneous and doxorubicin-induced mutations in Escherichia coli. 
  • Emergence of extended-spectrum beta-lactamase-producing Escherichia coli in community hospitals throughout North Carolina: a harbinger of a wider problem in the United States? 
  • Endonuclease-independent DNA mismatch repair processes on the lagging strand. 
  • Engineered modular recombinant transporters: application of new platform for targeted radiotherapeutic agents to alpha-particle emitting 211 At. 
  • Enterotoxigenic Escherichia coli secretes active heat-labile enterotoxin via outer membrane vesicles. 
  • Enterotoxigenic Escherichia coli vesicles target toxin delivery into mammalian cells. 
  • Epitope maps of the Escherichia coli heat-labile toxin B subunit for development of a synthetic oral vaccine. 
  • Escherichia coli MoeA and MogA. Function in metal incorporation step of molybdenum cofactor biosynthesis. 
  • Escherichia coli biotin holoenzyme synthetase/bio repressor crystal structure delineates the biotin- and DNA-binding domains. 
  • Escherichia coli global gene expression in urine from women with urinary tract infection. 
  • Escherichia coli purine repressor: key residues for the allosteric transition between active and inactive conformations and for interdomain signaling. 
  • Excision repair reduces doxorubicin-induced genotoxicity. 
  • Expression of a bacterial catalase in a strictly anaerobic methanogen significantly increases tolerance to hydrogen peroxide but not oxygen. 
  • Expression of functional bacterial undecaprenyl pyrophosphate synthase in the yeast rer2{Delta} mutant and CHO cells. 
  • Extracellular secretion of pectate lyase by the Erwinia chrysanthemi out pathway is dependent upon Sec-mediated export across the inner membrane. 
  • Fabrication of a reversible protein array directly from cell lysate using a stimuli-responsive polypeptide. 
  • FimC is a periplasmic PapD-like chaperone that directs assembly of type 1 pili in bacteria. 
  • FimH adhesin of type 1 pili is assembled into a fibrillar tip structure in the Enterobacteriaceae. 
  • Flow linear dichroism and electron microscopic analysis of protein-DNA complexes of a mutant UvrB protein that binds to but cannot kink DNA. 
  • Frameshift intermediates in homopolymer runs are removed efficiently by yeast mismatch repair proteins. 
  • FtsZ Protofilament Curvature Is the Opposite of Tubulin Rings. 
  • FtsZ at mid-cell is essential in Escherichia coli until the late stage of constriction. 
  • Functional reconstitution and characterization of AqpZ, the E. coli water channel protein. 
  • Functions that Protect Escherichia coli from Tightly Bound DNA-Protein Complexes Created by Mutant EcoRII Methyltransferase. 
  • Functions that protect Escherichia coli from DNA-protein crosslinks. 
  • Genomic Analysis of Multidrug-Resistant Escherichia coli from North Carolina Community Hospitals: Ongoing Circulation of CTX-M-Producing ST131-H30Rx and ST131-H30R1 Strains. 
  • Global folds of proteins with low densities of NOEs using residual dipolar couplings: application to the 370-residue maltodextrin-binding protein. 
  • Global transcriptional and proteomic analysis of the Sig1 heat shock regulon of Deinococcus radiodurans. 
  • Glutamate 350 Plays an Essential Role in Conformational Gating of Long-Range Radical Transport in Escherichia coli Class Ia Ribonucleotide Reductase. 
  • Harnessing Environmental Ca2+ for Extracellular Protein Thermostabilization. 
  • Heat-labile enterotoxin: beyond G(m1) binding. 
  • Heme-copper oxidases use tunneling pathways. 
  • Hfq structure, function and ligand binding. 
  • Hfq: a bacterial Sm-like protein that mediates RNA-RNA interaction. 
  • High resolution AFM topographs of the Escherichia coli water channel aquaporin Z. 
  • Highly selective water channel activity measured by voltage clamp: analysis of planar lipid bilayers reconstituted with purified AqpZ. 
  • HipBA-promoter structures reveal the basis of heritable multidrug tolerance. 
  • Human IAP-like protein regulates programmed cell death downstream of Bcl-xL and cytochrome c. 
  • Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct. 
  • Hydrolytically deficient MutS E694A is defective in the MutL-dependent activation of MutH and in the mismatch-dependent assembly of the MutS.MutL.heteroduplex complex. 
  • Identification and characterization of Escherichia coli DNA helicase II mutants that exhibit increased unwinding efficiency. 
  • Identification of a chloroform-soluble membrane miniprotein in Escherichia coli and its homolog in Salmonella typhimurium. 
  • Identification of cognate ligands for the Escherichia coli phnD protein product and engineering of a reagentless fluorescent biosensor for phosphonates. 
  • Identifying Synaptic Proteins by In Vivo BioID from Mouse Brain. 
  • Importance of the tmRNA system for cell survival when transcription is blocked by DNA-protein cross-links. 
  • In Vivo and in Vitro Synthesis of Phosphatidylglycerol by an Escherichia coli Cardiolipin Synthase. 
  • In vitro assembly studies of FtsZ/tubulin-like proteins (TubZ) from Bacillus plasmids: evidence for a capping mechanism. 
  • In vivo requirement for RecJ, ExoVII, ExoI, and ExoX in methyl-directed mismatch repair. 
  • In-cell NMR spectroscopy in Escherichia coli. 
  • Incision of trivalent chromium [Cr(III)]-induced DNA damage by Bacillus caldotenax UvrABC endonuclease. 
  • Inhibition of DNA helicase II unwinding and ATPase activities by DNA-interacting ligands. Kinetics and specificity. 
  • Initiation of methyl-directed mismatch repair. 
  • Insight into the mechanism of inactivation of ribonucleotide reductase by gemcitabine 5'-diphosphate in the presence or absence of reductant. 
  • Investigating the SecY plug movement at the SecYEG translocation channel. 
  • Investigation of the role of electrostatic charge in activation of the Escherichia coli response regulator CheY. 
  • Involvement of the beta clamp in methyl-directed mismatch repair in vitro. 
  • Involvement of two putative alternative sigma factors in stress response of the radioresistant bacterium Deinococcus radiodurans. 
  • Ion channels: an open and shut case. 
  • Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalpha. 
  • Isolation of SOS constitutive mutants of Escherichia coli. 
  • Lateral density of receptor arrays in the membrane plane influences sensitivity of the E. coli chemotaxis response. 
  • Lessons From the Studies of a CC Bond Forming Radical SAM Enzyme in Molybdenum Cofactor Biosynthesis. 
  • Ligand-induced conformational changes in a thermophilic ribose-binding protein. 
  • Lipopolysaccharide 3-deoxy-D-manno-octulosonic acid (Kdo) core determines bacterial association of secreted toxins. 
  • Local encoding of computationally designed enzyme activity. 
  • Localization of a domain in the FimH adhesin of Escherichia coli type 1 fimbriae capable of receptor recognition and use of a domain-specific antibody to confer protection against experimental urinary tract infection. 
  • Manipulation of ligand binding affinity by exploitation of conformational coupling. 
  • Mapping Hfq-RNA interaction surfaces using tryptophan fluorescence quenching. 
  • MarR family proteins are important regulators of clinically relevant antibiotic resistance. 
  • Mating pair formation homologue TraG is a variable membrane protein essential for contact-independent type IV secretion of chromosomal DNA by Neisseria gonorrhoeae. 
  • Mechanism and inhibition of LpxC: an essential zinc-dependent deacetylase of bacterial lipid A synthesis. 
  • Mechanism by which T7 bacteriophage protein Gp1.2 inhibits Escherichia coli dGTPase. 
  • Mechanism of 5'-directed excision in human mismatch repair. 
  • Mechanism of Rate Acceleration of Radical C-C Bond Formation Reaction by a Radical SAM GTP 3',8-Cyclase. 
  • Mechanism of pyranopterin ring formation in molybdenum cofactor biosynthesis. 
  • Mechanism of ubiquitin activation revealed by the structure of a bacterial MoeB-MoaD complex. 
  • Mechanisms in E. coli and Human Mismatch Repair (Nobel Lecture). 
  • Mechanisms in eukaryotic mismatch repair. 
  • Mechanisms of DNA-mismatch correction. 
  • Mechanistic Investigation of cPMP Synthase in Molybdenum Cofactor Biosynthesis Using an Uncleavable Substrate Analogue. 
  • Membrane Transporters Involved in the Antimicrobial Activities of Pyrithione in Escherichia coli . 
  • MetJ repressor interactions with DNA probed by in-cell NMR. 
  • Methyl-directed mismatch repair is bidirectional. 
  • Mismatch repair proteins MutS and MutL inhibit RecA-catalyzed strand transfer between diverged DNAs. 
  • Mismatch repair proteins and mitotic genome stability. 
  • Mismatch-, MutS-, MutL-, and helicase II-dependent unwinding from the single-strand break of an incised heteroduplex. 
  • Mismatch-containing oligonucleotide duplexes bound by the E. coli mutS-encoded protein. 
  • Modelling regulatory pathways in E. coli from time series expression profiles. 
  • Modulation of MutS ATP hydrolysis by DNA cofactors. 
  • Modulation of bacterial outer membrane vesicle production by envelope structure and content. 
  • Modulation of the binding of signal peptides to lipid bilayers by dipoles near the hydrocarbon-water interface. 
  • Molecular basis for a protein-mediated DNA-bridging mechanism that functions in condensation of the E. coli chromosome. 
  • Molecular mechanism by which the nucleoid occlusion factor, SlmA, keeps cytokinesis in check. 
  • Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB. 
  • Morphology of proteoliposomes reconstituted with purified lac carrier protein from Escherichia coli. 
  • Mucosal and systemic anti-HIV responses in rhesus macaques following combinations of intranasal and parenteral immunizations. 
  • MutS and MutL activate DNA helicase II in a mismatch-dependent manner. 
  • MutS mediates heteroduplex loop formation by a translocation mechanism. 
  • Mutation detection with MutH, MutL, and MutS mismatch repair proteins. 
  • Mutational analysis of potential zinc-binding residues in the active site of the enterococcal D-Ala-D-Ala dipeptidase VanX. 
  • Mutations that Separate the Functions of the Proofreading Subunit of the Escherichia coli Replicase. 
  • NMR solution structure and DNA-binding model of the DNA-binding domain of competence protein A. 
  • NMR structure of activated CheY. 
  • Narp and NP1 form heterocomplexes that function in developmental and activity-dependent synaptic plasticity. 
  • New lessons in the regulation of glucose metabolism taught by the glucose 6-phosphatase system. 
  • NlpI-mediated modulation of outer membrane vesicle production through peptidoglycan dynamics in Escherichia coli. 
  • Optimization of a Noncanonical Anti-infective: Interrogation of the Target Binding Pocket for a Small-Molecule Inhibitor of Escherichia coli Polysaccharide Capsule Expression. 
  • Order out of disorder: working cycle of an intrinsically unfolded chaperone. 
  • Orientation of LamB signal peptides in bilayers: influence of lipid probes on peptide binding and interpretation of fluorescence quenching data. 
  • Outer membrane vesicle production by Escherichia coli is independent of membrane instability. 
  • Part III. Analysis of data gaps pertaining to enterotoxigenic Escherichia coli infections in low and medium human development index countries, 1984-2005. 
  • Persistence of structure over fluctuations in biological electron-transfer reactions. 
  • Persisting uropathogenic Escherichia coli lineages show signatures of niche-specific within-host adaptation mediated by mobile genetic elements. 
  • Picomole-scale characterization of protein stability and function by quantitative cysteine reactivity. 
  • Plasticity of lipid-protein interactions in the function and topogenesis of the membrane protein lactose permease from Escherichia coli. 
  • Polyethylene Glycol-conjugated L-asparaginase versus native L-asparaginase in combination with standard agents for children with acute lymphoblastic leukemia in second bone marrow relapse: a Children's Oncology Group Study (POG 8866). 
  • Probing the DNA sequence specificity of Escherichia coli RECA protein. 
  • Probing the domain structure of FtsZ by random truncation and insertion of GFP. 
  • Protection from nitrosative stress: a central role for microbial flavohemoglobin. 
  • Protein loop closure using orientational restraints from NMR data. 
  • Protein secondary structure determination by constrained single-particle cryo-electron tomography. 
  • Purification and mutagenesis of LpxL, the lauroyltransferase of Escherichia coli lipid A biosynthesis. 
  • Purified lac permease and cytochrome o oxidase are functional as monomers. 
  • R73A and H144Q mutants of the yeast mitochondrial cyclophilin Cpr3 exhibit a low prolyl isomerase activity in both peptide and protein-folding assays. 
  • Radical Breakthroughs in Natural Product and Cofactor Biosynthesis. 
  • Rapid assembly dynamics of the Escherichia coli FtsZ-ring demonstrated by fluorescence recovery after photobleaching. 
  • Rapid in vitro assembly dynamics and subunit turnover of FtsZ demonstrated by fluorescence resonance energy transfer. 
  • Recognition of β-strand motifs by RseB is required for σ(E) activity in Escherichia coli. 
  • Reconstitution and functional comparison of purified GlpF and AqpZ, the glycerol and water channels from Escherichia coli. 
  • Reconstitution of contractile FtsZ rings in liposomes. 
  • Reconstitution of protein translocation from detergent-solubilized Escherichia coli inverted vesicles: PrlA protein-deficient vesicles efficiently translocate precursor proteins. 
  • Redundant exonuclease involvement in Escherichia coli methyl-directed mismatch repair. 
  • Release of outer membrane vesicles by Gram-negative bacteria is a novel envelope stress response. 
  • Residues of heat-labile enterotoxin involved in bacterial cell surface binding. 
  • Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs. 
  • Revised structure of the AbrB N-terminal domain unifies a diverse superfamily of putative DNA-binding proteins. 
  • Role of Escherichia coli DNA polymerase I in conferring viability upon the dnaN159 mutant strain. 
  • Role of Pseudomonas aeruginosa dinB-encoded DNA polymerase IV in mutagenesis. 
  • Role of residue 147 in the gene regulatory function of the Escherichia coli purine repressor. 
  • Role of the Hrp pilus in type III protein secretion in Pseudomonas syringae. 
  • Role of unusual P loop ejection and autophosphorylation in HipA-mediated persistence and multidrug tolerance. 
  • Saccharomyces cerevisiae MutLalpha is a mismatch repair endonuclease. 
  • Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines. 
  • Serologic differentiation between antitoxin responses to infection with Vibrio cholerae and enterotoxin-producing Escherichia coli. 
  • SlmA forms a higher-order structure on DNA that inhibits cytokinetic Z-ring formation over the nucleoid. 
  • Specificity of the type II secretion systems of enterotoxigenic Escherichia coli and Vibrio cholerae for heat-labile enterotoxin and cholera toxin. 
  • Structural analysis of the purine repressor, an Escherichia coli DNA-binding protein. 
  • Structural and Functional Analyses Reveal Insights into the Molecular Properties of the Escherichia coli Z Ring Stabilizing Protein, ZapC. 
  • Structural basis for ADP-mediated transcriptional regulation by P1 and P7 ParA. 
  • Structural basis for the differential regulation of DNA by the methionine repressor MetJ. 
  • Structural basis of pilus subunit recognition by the PapD chaperone. 
  • Structural comparison of the free and DNA-bound forms of the purine repressor DNA-binding domain. 
  • Structural determinants for signal sequence function in the mammalian endoplasmic reticulum. 
  • Structural evidence that the P/Q domain of ZipA is an unstructured, flexible tether between the membrane and the C-terminal FtsZ-binding domain. 
  • Structural insights into inhibition of lipid I production in bacterial cell wall synthesis. 
  • Structure and function of the UvrB protein. 
  • Structure of Escherichia coli Hfq bound to polyriboadenylate RNA. 
  • Structure of the Z Ring-associated Protein, ZapD, Bound to the C-terminal Domain of the Tubulin-like Protein, FtsZ, Suggests Mechanism of Z Ring Stabilization through FtsZ Cross-linking. 
  • Structure of the water channel AqpZ from Escherichia coli revealed by electron crystallography. 
  • Structure of β-galactosidase at 3.2-Å resolution obtained by cryo-electron microscopy. 
  • Structure-based redesign of corepressor specificity of the Escherichia coli purine repressor by substitution of residue 190. 
  • Structures of ParB bound to DNA reveal mechanism of partition complex formation. 
  • Structures of the Escherichia coli transcription activator and regulator of diauxie, XylR: an AraC DNA-binding family member with a LacI/GalR ligand-binding domain. 
  • Structures of the bacterial ribosome in classical and hybrid states of tRNA binding. 
  • Structures of the nucleoid occlusion protein SlmA bound to DNA and the C-terminal domain of the cytoskeletal protein FtsZ. 
  • Substrate Selectivity of Lysophospholipid Transporter LplT Involved in Membrane Phospholipid Remodeling in Escherichia coli. 
  • Substrate spectrum of human excinuclease: repair of abasic sites, methylated bases, mismatches, and bulky adducts. 
  • SulA inhibits assembly of FtsZ by a simple sequestration mechanism. 
  • Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold. 
  • Synthetic effect between envelope stress and lack of outer membrane vesicle production in Escherichia coli. 
  • Temporal control of self-organized pattern formation without morphogen gradients in bacteria. 
  • The 3.7 A projection map of the glycerol facilitator GlpF: a variant of the aquaporin tetramer. 
  • The 6.9-A structure of GlpF: a basis for homology modeling of the glycerol channel from Escherichia coli. 
  • The C-terminal linker of Escherichia coli FtsZ functions as an intrinsically disordered peptide. 
  • The Escherichia coli subtilase cytotoxin A subunit specifically cleaves cell-surface GRP78 protein and abolishes COOH-terminal-dependent signaling. 
  • The FtsZ protofilament and attachment of ZipA--structural constraints on the FtsZ power stroke. 
  • The Mechanism of HdeA Unfolding and Chaperone Activation. 
  • The MutL ATPase is required for mismatch repair. 
  • The RNase P associated with HeLa cell mitochondria contains an essential RNA component identical in sequence to that of the nuclear RNase P. 
  • The X-ray structure of the PurR-guanine-purF operator complex reveals the contributions of complementary electrostatic surfaces and a water-mediated hydrogen bond to corepressor specificity and binding affinity. 
  • The aquaporin sidedness revisited. 
  • The backbone structure of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein is essentially identical to its mesophilic E. coli homolog. 
  • The beta sliding clamp binds to multiple sites within MutL and MutS. 
  • The crystal structure of Escherichia coli MoeA and its relationship to the multifunctional protein gephyrin. 
  • The crystal structure of the Escherichia coli MobA protein provides insight into molybdopterin guanine dinucleotide biosynthesis. 
  • The effects of Ca(2+) binding on the conformation of calbindin D(28K): a nuclear magnetic resonance and microelectrospray mass spectrometry study. 
  • The epsilon subunit of DNA polymerase III Is involved in the nalidixic acid-induced SOS response in Escherichia coli. 
  • The filamentous bacteriophage assembly proteins require the bacterial SecA protein for correct localization to the membrane. 
  • The gene coding for the Hrp pilus structural protein is required for type III secretion of Hrp and Avr proteins in Pseudomonas syringae pv. tomato. 
  • The phospholipid-repair system LplT/Aas in Gram-negative bacteria protects the bacterial membrane envelope from host phospholipase A2 attack. 
  • The proximity-labeling technique BioID identifies sorting nexin 6 as a member of the insulin-like growth factor 1 (IGF1)-IGF1 receptor pathway. 
  • The rational design of allosteric interactions in a monomeric protein and its applications to the construction of biosensors. 
  • The role of lysine 55 in determining the specificity of the purine repressor for its operators through minor groove interactions. 
  • The symmetrical structure of structural maintenance of chromosomes (SMC) and MukB proteins: long, antiparallel coiled coils, folded at a flexible hinge. 
  • Thermodynamic analysis of a molecular chaperone binding to unfolded protein substrates. 
  • Thermodynamic analysis of ligand-induced changes in protein thermal unfolding applied to high-throughput determination of ligand affinities with extrinsic fluorescent dyes. 
  • Thermodynamic analysis of subunit interactions in Escherichia coli molybdopterin synthase. 
  • Thermodynamic evaluation of binding interactions in the methionine repressor system of Escherichia coli using isothermal titration calorimetry. 
  • Three phosphatidylglycerol-phosphate phosphatases in the inner membrane of Escherichia coli. 
  • Tn5-mediated bleomycin resistance in Escherichia coli requires the expression of host genes. 
  • Uncoupling of nucleotide hydrolysis and polymerization in the ParA protein superfamily disrupts DNA segregation dynamics. 
  • Uridine-based inhibitors as new leads for antibiotics targeting Escherichia coli LpxC. 
  • Use of dominant-negative HrpA mutants to dissect Hrp pilus assembly and type III secretion in Pseudomonas syringae pv. tomato. 
  • Using fluorine nuclear magnetic resonance to probe changes in the structure and dynamics of membrane-active peptides interacting with lipid bilayers. 
  • Visualization of secreted Hrp and Avr proteins along the Hrp pilus during type III secretion in Erwinia amylovora and Pseudomonas syringae. 
  • Visualizing conformation transitions of the Lipid II flippase MurJ. 
  • Water-Mediated Carbon-Oxygen Hydrogen Bonding Facilitates S-Adenosylmethionine Recognition in the Reactivation Domain of Cobalamin-Dependent Methionine Synthase. 
  • Whole genome re-sequencing to identify suppressor mutations of mutant and foreign Escherichia coli FtsZ. 
  • YbiV from Escherichia coli K12 is a HAD phosphatase. 
  • ZipA and FtsA* stabilize FtsZ-GDP miniring structures. 
  • [Vesicular flow in epithelial cells: physiopathologic importance of two multiligand receptors]. 
  • hMutSalpha- and hMutLalpha-dependent phosphorylation of p53 in response to DNA methylator damage. 
• 

  Keywords of People

  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Guan, Ziqiang, Research Professor in Biochemistry, Biochemistry
  • Kuehn, Margarethe Joanna, Associate Professor of Biochemistry, Cell Biology
  • Patz Jr., Edward F., James and Alice Chen Distinguished Professor of Radiology, Pathology