Activin Receptors, Type I
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Subject Areas on Research
- ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis.
- ACVR1/JAK1/JAK2 inhibitor momelotinib reverses transfusion dependency and suppresses hepcidin in myelofibrosis phase 2 trial.
- Assignment of human transforming growth factor-beta type I and type III receptor genes (TGFBR1 and TGFBR3) to 9q33-q34 and 1p32-p33, respectively.
- Bmp and Fgf signaling are essential for liver specification in zebrafish.
- CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis.
- FKBP12 is not required for the modulation of transforming growth factor beta receptor I signaling activity in embryonic fibroblasts and thymocytes.
- Functional roles for the cytoplasmic domain of the type III transforming growth factor beta receptor in regulating transforming growth factor beta signaling.
- Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways.
- Hereditary haemorrhagic telangiectasia: a questionnaire based study to delineate the different phenotypes caused by endoglin and ALK1 mutations.
- Human retroviral gag- and gag-pol-like proteins interact with the transforming growth factor-beta receptor activin receptor-like kinase 1.
- Increased tissue perfusion promotes capillary dysplasia in the ALK1-deficient mouse brain following VEGF stimulation.
- Mechanisms of neuroprotection against ischemic insult by stress-inducible phosphoprotein-1/prion protein complex.
- Ontogeny and localization of TGF-beta type I receptor expression during lung development.
- PPARgamma agonists prevent TGFbeta1/Smad3-signaling in human hepatic stellate cells.
- Polymorphisms in transforming growth factor-beta-related genes ALK1 and ENG are associated with sporadic brain arteriovenous malformations.
- Primary anaplastic large cell lymphoma of the central nervous system: prognostic effect of ALK-1 expression.
- Primary pulmonary hypertension in families with hereditary haemorrhagic telangiectasia.
- Reduced expression of transforming growth factor beta type I receptor contributes to the malignancy of human colon carcinoma cells.
- Regulation of ALK-1 signaling by the nuclear receptor LXRbeta.
- SB-431542, a small molecule transforming growth factor-beta-receptor antagonist, inhibits human glioma cell line proliferation and motility.
- Tumor-specific efficacy of transforming growth factor-beta RI inhibition in Eker rats.
- Vascular morphogenesis: tales of two syndromes.