Activin Receptors, Type II
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Subject Areas on Research
- A phase Ib study of the combination regorafenib with PF-03446962 in patients with refractory metastatic colorectal cancer (REGAL-1 trial).
- ALK1 regulates the internalization of endoglin and the type III TGF-β receptor.
- ALK1 signalling analysis identifies angiogenesis related genes and reveals disparity between TGF-beta and constitutively active receptor induced gene expression.
- Anaplastic large cell lymphoma associated with breast implants: a report of 13 cases.
- Anaplastic lymphoma kinase (ALK1) immunohistochemistry in diagnostic dermatopathology; an update.
- Arteriovenous malformation.
- Casein kinase 2beta as a novel enhancer of activin-like receptor-1 signaling.
- Endoglin mediates fibronectin/α5β1 integrin and TGF-β pathway crosstalk in endothelial cells.
- Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis.
- Extracellular matrix and Hippo signaling as therapeutic targets of antifibrotic compounds for uterine fibroids.
- Genetic considerations relevant to intracranial hemorrhage and brain arteriovenous malformations.
- Hereditary haemorrhagic telangiectasia: a questionnaire based study to delineate the different phenotypes caused by endoglin and ALK1 mutations.
- Hereditary hemorrhagic telangiectasia: two distinct ENG deletions in one family.
- Human retroviral gag- and gag-pol-like proteins interact with the transforming growth factor-beta receptor activin receptor-like kinase 1.
- Hypoxia-induced inhibin promotes tumor growth and vascular permeability in ovarian cancers.
- Identification of genetic polymorphisms associated with risk for pulmonary hypertension in sickle cell disease.
- Increased tissue perfusion promotes capillary dysplasia in the ALK1-deficient mouse brain following VEGF stimulation.
- Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality.
- Polymorphisms in transforming growth factor-beta-related genes ALK1 and ENG are associated with sporadic brain arteriovenous malformations.
- Predictors of mortality in patients with hereditary hemorrhagic telangiectasia.
- Primary anaplastic large cell lymphoma of the central nervous system: prognostic effect of ALK-1 expression.
- Primary cerebral ALK-1-positive anaplastic large cell lymphoma in a child. Case report and literature review.
- Primary pulmonary hypertension in families with hereditary haemorrhagic telangiectasia.
- Regulation of ALK-1 signaling by the nuclear receptor LXRbeta.
- Regulation of TGF-β receptor hetero-oligomerization and signaling by endoglin.
- SMAD4 mutations found in unselected HHT patients.
- Safety, pharmacokinetics, pharmacodynamics, and antitumor activity of dalantercept, an activin receptor-like kinase-1 ligand trap, in patients with advanced cancer.
- Somatic Mutations in Vascular Malformations of Hereditary Hemorrhagic Telangiectasia Result in Bi-allelic Loss of ENG or ACVRL1.
- TGFβ Superfamily Members Mediate Androgen Deprivation Therapy-Induced Obese Frailty in Male Mice.
- Thoracic endografting in a patient with hereditary hemorrhagic telangiectasia presenting with a descending thoracic aneurysm.
- Utility of modified Rankin Scale for brain vascular malformations in hereditary hemorrhagic telangiectasia.
- Vascular morphogenesis: tales of two syndromes.