Animals, Genetically Modified

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  Subject Areas on Research

  • A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans. 
  • A bidirectional kinesin motor in live Drosophila embryos. 
  • A circuit model for saccadic suppression in the superior colliculus. 
  • A conserved PMK-1/p38 MAPK is required in caenorhabditis elegans tissue-specific immune response to Yersinia pestis infection. 
  • A conserved role of αA-crystallin in the development of the zebrafish embryonic lens. 
  • A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration. 
  • A human CD46 transgenic pig model system for the study of discordant xenotransplantation. 
  • A large-scale functional approach to uncover human genes and pathways in Drosophila. 
  • A method to measure myocardial calcium handling in adult Drosophila. 
  • A non-canonical type 2 immune response coordinates tuberculous granuloma formation and epithelialization. 
  • A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development. 
  • A pathologic study of degeneration of the rod and cone populations of the rhodopsin Pro347Leu transgenic pigs. 
  • A regulatory cascade of three homeobox genes, ceh-10, ttx-3 and ceh-23, controls cell fate specification of a defined interneuron class in C. elegans. 
  • A robust and flexible CRISPR/Cas9-based system for neutrophil-specific gene inactivation in zebrafish. 
  • A single valine residue plays an essential role in peripherin/rds targeting to photoreceptor outer segments. 
  • A small molecule screen identifies a novel compound that induces a homeotic transformation in Hydra. 
  • A suppressor/enhancer screen in Drosophila reveals a role for wnt-mediated lipid metabolism in primordial germ cell migration. 
  • A whole animal chemical screen approach to identify modifiers of intestinal neutrophilic inflammation. 
  • A zebrafish model for the Shwachman-Diamond syndrome (SDS). 
  • ASCL1 represses a SOX9+ neural crest stem-like state in small cell lung cancer. 
  • Activation of direct and indirect pathways of glycogen synthesis by hepatic overexpression of protein targeting to glycogen. 
  • Advancing toxicology research using in vivo high throughput toxicology with small fish models. 
  • Altered light responses of single rod photoreceptors in transgenic pigs expressing P347L or P347S rhodopsin. 
  • An MYH9 human disease model in flies: site-directed mutagenesis of the Drosophila non-muscle myosin II results in hypomorphic alleles with dominant character. 
  • An allele-specific hammerhead ribozyme gene therapy for a porcine model of autosomal dominant retinitis pigmentosa. 
  • An explant technique for high-resolution imaging and manipulation of mycobacterial granulomas. 
  • An injury-responsive gata4 program shapes the zebrafish cardiac ventricle. 
  • Anastral spindle assembly: a mathematical model. 
  • Anchor cell invasion into the vulval epithelium in C. elegans. 
  • Animal model of Sar1b deficiency presents lipid absorption deficits similar to Anderson disease. 
  • Ankyrin-G promotes cyclic nucleotide-gated channel transport to rod photoreceptor sensory cilia. 
  • Apolipoprotein E-mimetics inhibit neurodegeneration and restore cognitive functions in a transgenic Drosophila model of Alzheimer's disease. 
  • Behavioral and circuit basis of sucrose rejection by Drosophila females in a simple decision-making task. 
  • Bidirectional approaches for optogenetic regulation of gene expression in mammalian cells using Arabidopsis cryptochrome 2. 
  • Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements. 
  • CGG repeat-associated translation mediates neurodegeneration in fragile X tremor ataxia syndrome. 
  • CRISPR-Cas9-Guided Genome Engineering in C. elegans. 
  • CRISPR-Cas9-Guided Genome Engineering in Caenorhabditis elegans. 
  • CRL4Mahj E3 ubiquitin ligase promotes neural stem cell reactivation. 
  • Calcitonin driven v-Ha-ras induces multilineage pulmonary epithelial hyperplasias and neoplasms. 
  • Calcium binding by synaptotagmin's C2A domain is an essential element of the electrostatic switch that triggers synchronous synaptic transmission. 
  • Calcium signaling regulates ventricular hypertrophy during development independent of contraction or blood flow. 
  • Cell Invasion In Vivo via Rapid Exocytosis of a Transient Lysosome-Derived Membrane Domain. 
  • Characterization of a male-predominant antisense transcript underexpressed in hybrids of Drosophila pseudoobscura and D. persimilis. 
  • Cold temperature improves mobility and survival in Drosophila models of autosomal-dominant hereditary spastic paraplegia (AD-HSP). 
  • Conservation and regeneration of transgenic lines of swine by semen cryopreservation and artificial insemination. 
  • Consistent production of transgenic chickens using replication-deficient retroviral vectors and high-throughput screening procedures. 
  • Construction and detection of fluorescent, germline transgenic zebrafish. 
  • Decreased fibrinolytic activity in porcine-to-primate cardiac xenotransplantation. 
  • Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth. 
  • Differential induction of colitis and gastritis in HLA-B27 transgenic rats selectively colonized with Bacteroides vulgatus or Escherichia coli. 
  • Differential requirements for segment polarity genes in wingless signaling. 
  • Direct In Vivo Manipulation and Imaging of Calcium Transients in Neutrophils Identify a Critical Role for Leading-Edge Calcium Flux. 
  • Directionality of wingless protein transport influences epidermal patterning in the Drosophila embryo. 
  • Discovery of Dual-Stage Malaria Inhibitors with New Targets. 
  • Dissection of genetic pathways in C. elegans. 
  • Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration. 
  • Dmrt1 induces the male pathway in a turtle species with temperature-dependent sex determination. 
  • Drosophila RhoA regulates the cytoskeleton and cell-cell adhesion in the developing epidermis. 
  • Drosophila TFIID binds to a conserved downstream basal promoter element that is present in many TATA-box-deficient promoters. 
  • Drosophila, genetic screens, and cardiac function. 
  • Dual islet transplantation modeling of the instant blood-mediated inflammatory reaction. 
  • Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis. 
  • Early loss of synaptic protein PSD-95 from rod terminals of rhodopsin P347L transgenic porcine retina. 
  • Ectopic myelinating oligodendrocytes in the dorsal spinal cord as a consequence of altered semaphorin 6D signaling inhibit synapse formation. 
  • Ectopic synaptogenesis in the mammalian retina caused by rod photoreceptor-specific mutations. 
  • Egg-laying demand induces aversion of UV light in Drosophila females. 
  • Emergent properties during dorsal closure in Drosophila morphogenesis. 
  • Emerging approaches and technologies in transplantation: the potential game changers. 
  • Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G alpha o* protein. 
  • Enhanced vasorelaxation by overexpression of beta 2-adrenergic receptors in large arteries. 
  • Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways. 
  • Epicardial regeneration is guided by cardiac outflow tract and Hedgehog signalling. 
  • Evidence for polyreactive xenoreactive antibodies in the repertoire of human anti-swine antibodies: the 'next' humoral barrier to xenotransplantation? 
  • Evolution in action: giant ankyrins awake. 
  • Expanding views of presynaptic terminals: new findings from Caenorhabditis elegans. 
  • Explant culture of adult zebrafish hearts for epicardial regeneration studies. 
  • Expression of exogenous protein in the egg white of transgenic chickens. 
  • FGF signaling regulates rod photoreceptor cell maintenance and regeneration in zebrafish. 
  • Facilitative glucose transporter Glut1 is actively excluded from rod outer segments. 
  • Fgf signaling instructs position-dependent growth rate during zebrafish fin regeneration. 
  • Fgfs control homeostatic regeneration in adult zebrafish fins. 
  • Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration. 
  • Flow Cytometry for the Immunotoxicologist. 
  • Forces for morphogenesis investigated with laser microsurgery and quantitative modeling. 
  • From man to fish: What can Zebrafish tell us about ApoL1 nephropathy? 
  • Functional conservation of human Spastin in a Drosophila model of autosomal dominant-hereditary spastic paraplegia. 
  • Functional mapping of neurons that control locomotory behavior in Caenorhabditis elegans. 
  • Functional studies of the carboxy-terminal repeat domain of Drosophila RNA polymerase II in vivo. 
  • GFP-moesin illuminates actin cytoskeleton dynamics in living tissue and demonstrates cell shape changes during morphogenesis in Drosophila. 
  • Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand. 
  • Gene expression markers for Caenorhabditis elegans vulval cells. 
  • Generation and characterization of neurogenin1-GFP transgenic medaka with potential for rapid developmental neurotoxicity screening. 
  • Genetic control of single lumen formation in the zebrafish gut. 
  • Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila. 
  • Genetic interaction screens identify a role for hedgehog signaling in Drosophila border cell migration. 
  • Genetically Modified Salmon and Full Impact Assessment 
  • Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in retinitis pigmentosa. 
  • Genetics of parkin-linked disease. 
  • HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. 
  • HIV-1 infection of renal epithelial cells: 30 years of evidence from transgenic animal models, human studies and in vitro experiments. 
  • Hand2 regulates extracellular matrix remodeling essential for gut-looping morphogenesis in zebrafish. 
  • Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage. 
  • Human Bcl-2 cannot directly inhibit the Caenorhabditis elegans Apaf-1 homologue CED-4, but can interact with EGL-1. 
  • Humoral Reactivity of Renal Transplant-Waitlisted Patients to Cells From GGTA1/CMAH/B4GalNT2, and SLA Class I Knockout Pigs. 
  • Hybrid neurons in a microRNA mutant are putative evolutionary intermediates in insect CO2 sensory systems. 
  • ICLAS Working Group on Harmonization: international guidance concerning the production care and use of genetically-altered animals. 
  • Identification and requirements of enhancers that direct gene expression during zebrafish fin regeneration. 
  • Identification of a motor-to-auditory pathway important for vocal learning. 
  • Identification of enhancer regulatory elements that direct epicardial gene expression during zebrafish heart regeneration. 
  • Imaging and Isolation of Extravasation-Participating Endothelial and Melanoma Cells During Angiopellosis. 
  • Immediate and long-term consequences of vascular toxicity during zebrafish development. 
  • Immunoglobulin gene hypermutation in germinal centers is independent of the RAG-1 V(D)J recombinase. 
  • Immunohistochemical characterization of the hepatic progenitor cell compartment in medaka (Oryzias latipes) following hepatic injury. 
  • In Toto Imaging of Dynamic Osteoblast Behaviors in Regenerating Skeletal Bone. 
  • In Vivo Determination of Mitochondrial Function Using Luciferase-Expressing Caenorhabditis elegans: Contribution of Oxidative Phosphorylation, Glycolysis, and Fatty Acid Oxidation to Toxicant-Induced Dysfunction. 
  • In vivo imaging of tumor-propagating cells, regional tumor heterogeneity, and dynamic cell movements in embryonal rhabdomyosarcoma. 
  • In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration. 
  • In vivo proximity labeling identifies cardiomyocyte protein networks during zebrafish heart regeneration. 
  • Infection-Induced Vascular Permeability Aids Mycobacterial Growth. 
  • Inhibition of protein misfolding/aggregation using polyglutamine binding peptide QBP1 as a therapy for the polyglutamine diseases. 
  • Inhibition stabilization is a widespread property of cortical networks. 
  • Injury-induced ctgfa directs glial bridging and spinal cord regeneration in zebrafish. 
  • Integrin acts upstream of netrin signaling to regulate formation of the anchor cell's invasive membrane in C. elegans. 
  • Intrastromal Gene Therapy Prevents and Reverses Advanced Corneal Clouding in a Canine Model of Mucopolysaccharidosis I. 
  • Ion channels contribute to the regulation of cell sheet forces during Drosophila dorsal closure. 
  • Katanin p60-like1 promotes microtubule growth and terminal dendrite stability in the larval class IV sensory neurons of Drosophila. 
  • Lensectomy and vitrectomy decrease the rate of photoreceptor loss in rhodopsin P347L transgenic pigs. 
  • Letter to the editor in response to: Measuring success in pig to non-human-primate renal xenotransplantation: Systematic review and comparative outcomes analysis of 1051 life sustaining NHP renal allo- and xeno-transplants by Firl and Markmann. 
  • Loss of cftr function leads to pancreatic destruction in larval zebrafish. 
  • MIG-10 (lamellipodin) has netrin-independent functions and is a FOS-1A transcriptional target during anchor cell invasion in C. elegans. 
  • Maintenance of blastemal proliferation by functionally diverse epidermis in regenerating zebrafish fins. 
  • Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans. 
  • Metabolic engineering with recombinant adenoviruses. 
  • Metabolic regulation of Drosophila apoptosis through inhibitory phosphorylation of Dronc. 
  • Metallothionein in the central nervous system: Roles in protection, regeneration and cognition. 
  • Metastatic prostate cancer in a transgenic mouse. 
  • Microbial colonization induces dynamic temporal and spatial patterns of NF-κB activation in the zebrafish digestive tract. 
  • Mitochondrial DNA variant in COX1 subunit significantly alters energy metabolism of geographically divergent wild isolates in Caenorhabditis elegans. 
  • Mitogen-activated protein kinases in heart development and diseases. 
  • Model systems for regeneration: Drosophila. 
  • Modified glycan models of pig-to-human xenotransplantation do not enhance the human-anti-pig T cell response. 
  • Molecular biology in cardiology: recent developments and opportunities for clinical applications. 
  • Molecular biology of hypertension. 
  • Monitoring neural activity with bioluminescence during natural behavior. 
  • Multicolor Cell Barcoding Technology for Long-Term Surveillance of Epithelial Regeneration in Zebrafish. 
  • Multicolor mapping of the cardiomyocyte proliferation dynamics that construct the atrium. 
  • Multifocal electroretinogram in rhodopsin P347L transgenic pigs. 
  • Multiple metabolic changes mediate the response of Caenorhabditis elegans to the complex I inhibitor rotenone. 
  • Myocardial NF-κB activation is essential for zebrafish heart regeneration. 
  • Native nonmuscle myosin II stability and light chain binding in Drosophila melanogaster. 
  • Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration. 
  • Neural Circuits Underlying Visually Evoked Escapes in Larval Zebrafish. 
  • Neuroinflammation and α-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease. 
  • Neuronal cell shape and neurite initiation are regulated by the Ndr kinase SAX-1, a member of the Orb6/COT-1/warts serine/threonine kinase family. 
  • Neurophenotyping genetically modified mice for social behavior. 
  • Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease. 
  • Non-equivalent roles of Drosophila Frizzled and Dfrizzled2 in embryonic wingless signal transduction. 
  • Nonmuscle myosin II generates forces that transmit tension and drive contraction in multiple tissues during dorsal closure. 
  • Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats. 
  • Notochord vacuoles are lysosome-related organelles that function in axis and spine morphogenesis. 
  • Optical Imaging of Glucose Uptake and Mitochondrial Membrane Potential to Characterize Her2 Breast Tumor Metabolic Phenotypes. 
  • Optical coherence tomography (OCT) abnormalities in rhodopsin mutant transgenic swine with retinal degeneration. 
  • Overexpression of a Drosophila homolog of apolipoprotein D leads to increased stress resistance and extended lifespan. 
  • Oxidative damage is a potential cause of cone cell death in retinitis pigmentosa. 
  • Phenotypic characterization of transgenic Japanese medaka (Oryzias latipes) that express a red fluorescent protein in hepatocytes. 
  • Phenotypic stability of Pro347Leu rhodopsin transgenic pigs as indicated by photoreceptor cell degeneration. 
  • Phospholipid membrane composition affects EGF receptor and Notch signaling through effects on endocytosis during Drosophila development. 
  • Phosphorylation of FEZ1 by Microtubule Affinity Regulating Kinases regulates its function in presynaptic protein trafficking. 
  • Polyploidization and cell fusion contribute to wound healing in the adult Drosophila epithelium. 
  • Pre-validation of choriogenin H transgenic medaka eleutheroembryos as a quantitative estrogenic activity test method. 
  • Predicting longevity in C. elegans: fertility, mobility and gene expression. 
  • Preservation of myocardial beta-adrenergic receptor signaling delays the development of heart failure after myocardial infarction. 
  • Prevention of acute lung injury in swine: depletion of pulmonary intravascular macrophages using liposomal clodronate. 
  • Prevention of polyglutamine oligomerization and neurodegeneration by the peptide inhibitor QBP1 in Drosophila. 
  • Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes. 
  • Production of transgenic Drosophila. 
  • Projections of Drosophila multidendritic neurons in the central nervous system: links with peripheral dendrite morphology. 
  • Rab11 helps maintain apical crumbs and adherens junctions in the Drosophila embryonic ectoderm. 
  • Ras controls melanocyte expansion during zebrafish fin stripe regeneration. 
  • Real-time imaging of morphogenetic movements in Drosophila using Gal4-UAS-driven expression of GFP fused to the actin-binding domain of moesin. 
  • Recent advances in genome editing and creation of genetically modified pigs. 
  • Recombinant antithrombin: production and role in cardiovascular disorder. 
  • Regeneration Genetics. 
  • Regeneration of amputated zebrafish fin rays from de novo osteoblasts. 
  • Regulated expression of a vitellogenin fusion gene in transgenic nematodes. 
  • Regulation of vitellogenin gene expression in transgenic Caenorhabditis elegans: short sequences required for activation of the vit-2 promoter. 
  • Regulation of zebrafish fin regeneration by vitamin D signaling. 
  • Repeated Failure in Reward Pursuit Alters Innate Drosophila Larval Behaviors. 
  • Resolving Heart Regeneration by Replacement Histone Profiling. 
  • Resolving mechanisms of toxicity while pursuing ecotoxicological relevance? 
  • Restriction of hepatic competence by Fgf signaling. 
  • Retinal ganglion cell genesis requires lakritz, a Zebrafish atonal Homolog. 
  • Retinal rod photoreceptor-specific gene mutation perturbs cone pathway development. 
  • Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration. 
  • Retinoid regulation of the zebrafish cyp26a1 promoter. 
  • Rhodopsin transgenic pigs as a model for human retinitis pigmentosa. 
  • SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation. 
  • SOCS36E, a novel Drosophila SOCS protein, suppresses JAK/STAT and EGF-R signalling in the imaginal wing disc. 
  • SPARC Promotes Cell Invasion In Vivo by Decreasing Type IV Collagen Levels in the Basement Membrane. 
  • Screening for angiogenic inhibitors in zebrafish to evaluate a predictive model for developmental vascular toxicity. 
  • Seven-up inhibits ultraspiracle-based signaling pathways in vitro and in vivo. 
  • Short-term integration of Cdc25 dynamics controls mitotic entry during Drosophila gastrulation. 
  • Signal transduction in cardiac hypertrophy--dissecting compensatory versus pathological pathways utilizing a transgenic approach. 
  • Silencing Porcine CMAH and GGTA1 Genes Significantly Reduces Xenogeneic Consumption of Human Platelets by Porcine Livers. 
  • Silencing porcine genes significantly reduces human-anti-pig cytotoxicity profiles: an alternative to direct complement regulation. 
  • Silencing the porcine iGb3s gene does not affect Galα3Gal levels or measures of anticipated pig-to-human and pig-to-primate acute rejection. 
  • Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart. 
  • Single-cell imaging of T cell immunotherapy responses in vivo. 
  • SoxNeuro and Shavenbaby act cooperatively to shape denticles in the embryonic epidermis of Drosophila . 
  • Specification of epibranchial placodes in zebrafish. 
  • Stem cells and their niches: integrated units that maintain Drosophila tissues. 
  • Strengths and limitations of morphological and behavioral analyses in detecting dopaminergic deficiency in Caenorhabditis elegans. 
  • Stress-activated MAP kinases in cardiac remodeling and heart failure; new insights from transgenic studies. 
  • Structure of the polyisoprenyl-phosphate glycosyltransferase GtrB and insights into the mechanism of catalysis. 
  • Surface acoustic waves enable rotational manipulation of Caenorhabditis elegans. 
  • Swine lungs expressing human complement-regulatory proteins are protected against acute pulmonary dysfunction in a human plasma perfusion model. 
  • TBX5 is required for embryonic cardiac cell cycle progression. 
  • TRPV4 as osmosensor: a transgenic approach. 
  • TRPV4 plays an evolutionary conserved role in the transduction of osmotic and mechanical stimuli in live animals. 
  • TSPO-targeted PET and Optical Probes for the Detection and Localization of Premalignant and Malignant Pancreatic Lesions. 
  • Targeted activation of c-Jun N-terminal kinase in vivo induces restrictive cardiomyopathy and conduction defects. 
  • The Calcineurin-FoxO-MuRF1 signaling pathway regulates myofibril integrity in cardiomyocytes. 
  • The Drosophila Translational Control Element (TCE) is required for high-level transcription of many genes that are specifically expressed in testes. 
  • The GARP Domain of the Rod CNG Channel's β1-Subunit Contains Distinct Sites for Outer Segment Targeting and Connecting to the Photoreceptor Disk Rim. 
  • The KASH domain protein MSP-300 plays an essential role in nuclear anchoring during Drosophila oogenesis. 
  • The Macrophage-Specific Promoter mfap4 Allows Live, Long-Term Analysis of Macrophage Behavior during Mycobacterial Infection in Zebrafish. 
  • The NADH oxidase ENOX1, a critical mediator of endothelial cell radiosensitization, is crucial for vascular development. 
  • The desirable donor pig to eliminate all xenoreactive antigens. 
  • The deubiquitinating enzyme DUBAI stabilizes DIAP1 to suppress Drosophila apoptosis. 
  • The effect of Drosophila attP40 background on the glomerular organization of Or47b olfactory receptor neurons. 
  • The fate of human platelets exposed to porcine renal endothelium: a single-pass model of platelet uptake in domestic and genetically modified porcine organs. 
  • The fruitless gene is required for the proper formation of axonal tracts in the embryonic central nervous system of Drosophila. 
  • The kidney and hypertension: novel insights from transgenic models. 
  • The netrin receptor DCC focuses invadopodia-driven basement membrane transmigration in vivo. 
  • The outer segment serves as a default destination for the trafficking of membrane proteins in photoreceptors. 
  • The role of alpha-synuclein in Parkinson's disease: insights from animal models. 
  • The role of anti-Galalpha1-3Gal antibodies in acute vascular rejection and accommodation of xenografts. 
  • The role of antibodies in acute vascular rejection of pig-to-baboon cardiac transplants. 
  • The role of human CD46 in early xenoislet engraftment in a dual transplant model. 
  • The transcriptional response to oxidative stress during vertebrate development: effects of tert-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin. 
  • Tissue-culture surfaces with mixtures of aminated and fluorinated functional groups. Part 2. Growth and function of transgenic rat insulinoma cells (betaG I/17). 
  • Total particulate matter from cigarette smoke disrupts vascular development in zebrafish brain (Danio rerio). 
  • Transgene expression in zebrafish: A comparison of retroviral-vector and DNA-injection approaches. 
  • Transgenic animals in integrative biology: approaches and interpretations of outcome. 
  • Transgenic animals. New approaches to hypertension research. 
  • Transgenic manipulation of myocardial G protein-coupled receptors and receptor kinases. 
  • Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration. 
  • Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants. 
  • Transplantation of full-thickness retina in the rhodopsin transgenic pig. 
  • UNC-6 (netrin) orients the invasive membrane of the anchor cell in C. elegans. 
  • Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23. 
  • VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations. 
  • Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling. 
  • Varying cecal bacterial loads influences colitis and gastritis in HLA-B27 transgenic rats. 
  • Viral sequences enable efficient and tissue-specific expression of transgenes in Xenopus. 
  • Visualizing Engrafted Human Cancer and Therapy Responses in Immunodeficient Zebrafish. 
  • Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism. 
  • Windows into development: historic, current, and future perspectives on transgenic zebrafish. 
  • Wingless signaling generates pattern through two distinct mechanisms. 
  • Xenotransplantation-the current status and prospects. 
  • ZTF-8 interacts with the 9-1-1 complex and is required for DNA damage response and double-strand break repair in the C. elegans germline. 
  • Zebrafish CYP1A expression in transgenic Caenorhabditis elegans protects from exposures to benzo[a]pyrene and a complex polycyclic aromatic hydrocarbon mixture. 
  • Zebrafish as a neurotoxicological model. 
  • Zebrafish second heart field development relies on progenitor specification in anterior lateral plate mesoderm and nkx2.5 function. 
  • [Investigation of neuroprotective activity of apolipoprotein E peptide mimetic Cog1410 in transgenic lines of Drosophila melanogaster]. 
  • [Studying pathogenesis of Alzheimer's disease in a Drosophila melanogaster model: human APP overexpression in the brain of transgenic flies leads to deficit of the synaptic protein synaptotagmin]. 
  • c-Jun N-terminal kinase activation mediates downregulation of connexin43 in cardiomyocytes. 
  • pH dependence of the Slc4a11-mediated H⁺ conductance is influenced by intracellular lysine residues and modified by disease-linked mutations. 
  • tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration. 
  • zebraflash transgenic lines for in vivo bioluminescence imaging of stem cells and regeneration in adult zebrafish. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Kelsoe, Garnett H., James B. Duke Distinguished Professor of Immunology, Integrative Immunobiology
  • Linardic, Corinne Mary, Associate Professor of Pediatrics, Cell Biology
  • Milano, Carmelo Alessio, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Sunday, Mary Elizabeth Anne, Professor of Pathology, Cell Biology
  • Tsalik, Ephraim, Adjunct Associate Professor in the Department of Medicine, Medicine, Infectious Diseases