Caloric Restriction

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  Subject Areas on Research

  • A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity. 
  • Aging. It's never too late. 
  • Body-composition changes in the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE)-2 study: a 2-y randomized controlled trial of calorie restriction in nonobese humans. 
  • Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial. 
  • Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. 
  • Central and peripheral effects of insulin/IGF-1 signaling in aging and cancer: antidiabetic drugs as geroprotectors and anticarcinogens. 
  • Changes in thigh muscle volume predict bone mineral density response to lifestyle therapy in frail, obese older adults. 
  • Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy Phase 2 (CALERIE Phase 2) screening and recruitment: Methods and results 
  • Considering patient diet preference to optimize weight loss: design considerations of a randomized trial investigating the impact of choice. 
  • Date of eclosion modulates longevity: insights across dietary-restriction gradients and female reproduction in the mexfly Anastrepha ludens. 
  • Design and conduct of the CALERIE study: comprehensive assessment of the long-term effects of reducing intake of energy. 
  • Development of adherence metrics for caloric restriction interventions. 
  • Diet Shapes Mortality Response to Trauma in Old Tephritid Fruit Flies. 
  • Diet and Exercise for Obese Patients With Heart Failure--Reply. 
  • Diet and neurocognition: review of evidence and methodological considerations. 
  • Effect of Allowing Choice of Diet on Weight Loss: A Randomized Trial. 
  • Effect of Caloric Restriction or Aerobic Exercise Training on Peak Oxygen Consumption and Quality of Life in Obese Older Patients With Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial. 
  • Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on branched-chain amino acid metabolism. 
  • Effect of Two-Year Caloric Restriction on Bone Metabolism and Bone Mineral Density in Non-Obese Younger Adults: A Randomized Clinical Trial. 
  • Effect of caloric restriction with and without exercise on metabolic intermediates in nonobese men and women. 
  • Effects of comprehensive lifestyle modification on diet, weight, physical fitness, and blood pressure control: 18-month results of a randomized trial. 
  • Effects of phentermine and phenformin on biomarkers of aging in rats. 
  • Effects of the dietary approaches to stop hypertension diet alone and in combination with exercise and caloric restriction on insulin sensitivity and lipids. 
  • Effects of the dietary approaches to stop hypertension diet, exercise, and caloric restriction on neurocognition in overweight adults with high blood pressure. 
  • Efficacy of Commercial Weight-Loss Programs. 
  • Factors associated with choice of a low-fat or low-carbohydrate diet during a behavioral weight loss intervention. 
  • Fat, carbohydrate, and calories in the development of diabetes and obesity in the C57BL/6J mouse. 
  • Gastric bypass surgery restores meal stimulation of the anorexigenic gut hormones glucagon-like peptide-1 and peptide YY independently of caloric restriction. 
  • Life-long caloric restriction does not alter the severity of age-related osteoarthritis. 
  • Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms. 
  • Metabolomics in the study of aging and caloric restriction. 
  • Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors. 
  • Muscle-Specific Overexpression of PGC-1α Does Not Augment Metabolic Improvements in Response to Exercise and Caloric Restriction. 
  • Nutrition therapy recommendations for the management of adults with diabetes. 
  • Obesity and insulin resistance: is it due to body fat, energy balance, or gut factors? 
  • Postprandial metabolite profiles reveal differential nutrient handling after bariatric surgery compared with matched caloric restriction. 
  • Reduction of ovarian and oviductal cancers in calorie-restricted laying chickens. 
  • SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. 
  • Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. 
  • The impact of exercise training compared to caloric restriction on hepatic and peripheral insulin resistance in obesity. 
  • The long-term effects of lifestyle change on blood pressure: One-year follow-up of the ENCORE study. 
  • Zonisamide for weight loss in obese adults: a randomized controlled trial. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Hirschey, Matthew, Associate Professor in Medicine, Pharmacology & Cancer Biology
  • Svetkey, Laura Pat, Professor of Medicine, Medicine
  • Yancy Jr., William Samuel, Associate Professor of Medicine, Medicine, General Internal Medicine