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Subject Areas on Research
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2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial.
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A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity.
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A Randomized Controlled Trial Evaluating the Relative Effectiveness of the Multiple Traffic Light and Nutri-Score Front of Package Nutrition Labels.
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A cell-nonautonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism.
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A role for ΔFosB in calorie restriction-induced metabolic changes.
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Approaches for quantifying energy intake and %calorie restriction during calorie restriction interventions in humans: the multicenter CALERIE study.
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Association between the FTO rs9939609 single nucleotide polymorphism and dietary adherence during a 2-year caloric restriction intervention: Exploratory analyses from CALERIE™ phase 2.
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Autophagy as a Therapeutic Target to Enhance Aged Muscle Regeneration.
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Body-composition changes in the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE)-2 study: a 2-y randomized controlled trial of calorie restriction in nonobese humans.
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Building research in diet and cognition: The BRIDGE randomized controlled trial.
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Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial.
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Caloric restriction: implications for human cardiometabolic health.
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Calorie restriction alleviates the age-related decrease in neural progenitor cell division in the aging brain.
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Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation.
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Central and peripheral effects of insulin/IGF-1 signaling in aging and cancer: antidiabetic drugs as geroprotectors and anticarcinogens.
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Challenges in defining successful adherence to calorie restriction goals in humans: Results from CALERIE™ 2.
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Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis.
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Changes in body weight, adherence, and appetite during 2 years of calorie restriction: the CALERIE 2 randomized clinical trial.
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Changes in thigh muscle volume predict bone mineral density response to lifestyle therapy in frail, obese older adults.
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Chronic caloric restriction maintains a youthful phosphoproteome in aged skeletal muscle.
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Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy Phase 2 (CALERIE Phase 2) screening and recruitment: methods and results.
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Considering patient diet preference to optimize weight loss: design considerations of a randomized trial investigating the impact of choice.
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Date of eclosion modulates longevity: insights across dietary-restriction gradients and female reproduction in the mexfly Anastrepha ludens.
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Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice.
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Design and conduct of the CALERIE study: comprehensive assessment of the long-term effects of reducing intake of energy.
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Development of adherence metrics for caloric restriction interventions.
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Diet and Exercise for Obese Patients With Heart Failure--Reply.
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Diet and neurocognition: review of evidence and methodological considerations.
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Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling.
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Differential effects of calorie restriction and rapamycin on age-related molecular and functional changes in skeletal muscle.
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Eating behavior traits of successful weight losers during 12 months of alternate-day fasting: An exploratory analysis of a randomized controlled trial.
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Effect of 2 years of calorie restriction on liver biomarkers: results from the CALERIE phase 2 randomized controlled trial.
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Effect of Allowing Choice of Diet on Weight Loss: A Randomized Trial.
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Effect of Alternate-Day Fasting on Weight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults: A Randomized Clinical Trial.
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Effect of Caloric Restriction or Aerobic Exercise Training on Peak Oxygen Consumption and Quality of Life in Obese Older Patients With Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial.
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Effect of Calorie Restriction on Mood, Quality of Life, Sleep, and Sexual Function in Healthy Nonobese Adults: The CALERIE 2 Randomized Clinical Trial.
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Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on branched-chain amino acid metabolism.
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Effect of Two-Year Caloric Restriction on Bone Metabolism and Bone Mineral Density in Non-Obese Younger Adults: A Randomized Clinical Trial.
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Effect of caloric restriction with and without exercise on metabolic intermediates in nonobese men and women.
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Effect of calorie restriction on the free-living physical activity levels of nonobese humans: results of three randomized trials.
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Effect of intermittent fasting on prostate cancer tumor growth in a mouse model.
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Effects of 2 years of caloric restriction on oxidative status assessed by urinary F2-isoprostanes: The CALERIE 2 randomized clinical trial.
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Effects of Two Years of Calorie Restriction on Aerobic Capacity and Muscle Strength.
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Effects of alternate-day fasting or daily calorie restriction on body composition, fat distribution, and circulating adipokines: Secondary analysis of a randomized controlled trial.
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Effects of an energy-restricted low-carbohydrate, high unsaturated fat/low saturated fat diet versus a high-carbohydrate, low-fat diet in type 2 diabetes: A 2-year randomized clinical trial.
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Effects of caloric restriction on human physiological, psychological, and behavioral outcomes: highlights from CALERIE phase 2.
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Effects of comprehensive lifestyle modification on diet, weight, physical fitness, and blood pressure control: 18-month results of a randomized trial.
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Effects of phentermine and phenformin on biomarkers of aging in rats.
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Effects of the dietary approaches to stop hypertension diet alone and in combination with exercise and caloric restriction on insulin sensitivity and lipids.
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Effects of the dietary approaches to stop hypertension diet, exercise, and caloric restriction on neurocognition in overweight adults with high blood pressure.
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Efficacy of Commercial Weight-Loss Programs.
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Epigenome-wide Association Study Analysis of Calorie Restriction in Humans, CALERIETM Trial Analysis.
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Factors associated with choice of a low-fat or low-carbohydrate diet during a behavioral weight loss intervention.
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Fat, carbohydrate, and calories in the development of diabetes and obesity in the C57BL/6J mouse.
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Gastric bypass surgery restores meal stimulation of the anorexigenic gut hormones glucagon-like peptide-1 and peptide YY independently of caloric restriction.
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Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions.
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Intermittent fasting vs daily calorie restriction for type 2 diabetes prevention: a review of human findings.
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Life-long caloric restriction does not alter the severity of age-related osteoarthritis.
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Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans.
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Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of Aging.
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Metabolomics in the study of aging and caloric restriction.
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Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors.
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Muscle-Specific Overexpression of PGC-1α Does Not Augment Metabolic Improvements in Response to Exercise and Caloric Restriction.
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Naïve models of dietary splurges: Beliefs about caloric compensation and weight change following non-habitual overconsumption.
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Nutrition therapy recommendations for the management of adults with diabetes.
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Nutritional basis of type 2 diabetes remission.
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Nutritional quality of calorie restricted diets in the CALERIE™ 1 trial.
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Obesity and insulin resistance: is it due to body fat, energy balance, or gut factors?
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Postprandial metabolite profiles reveal differential nutrient handling after bariatric surgery compared with matched caloric restriction.
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Predicting support for restricting food marketing to youth.
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Predictors of measurement error in energy intake during pregnancy.
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Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Responses to Diet Interventions.
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Pten-null tumors cohabiting the same lung display differential AKT activation and sensitivity to dietary restriction.
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Rationale and Design for a Higher (Dairy) Protein Weight Loss Intervention That Promotes Muscle Quality and Bone Health in Older Adults with Obesity: A Randomized, Controlled Pilot Study.
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Reduction of ovarian and oviductal cancers in calorie-restricted laying chickens.
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SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation.
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SIRT3 regulates mitochondrial protein acetylation and intermediary metabolism.
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Safety of two-year caloric restriction in non-obese healthy individuals.
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Short term methionine restriction increases hepatic global DNA methylation in adult but not young male C57BL/6J mice.
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Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor.
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Swimming Exercise and Transient Food Deprivation in Caenorhabditis elegans Promote Mitochondrial Maintenance and Protect Against Chemical-Induced Mitotoxicity.
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T cell stemness and dysfunction in tumors are triggered by a common mechanism.
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The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction.
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The CALERIE Study: design and methods of an innovative 25% caloric restriction intervention.
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The impact of exercise training compared to caloric restriction on hepatic and peripheral insulin resistance in obesity.
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The long-term effects of lifestyle change on blood pressure: One-year follow-up of the ENCORE study.
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The sirtuins, oxidative stress and aging: an emerging link.
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Therapy for heart failure with preserved ejection fraction: current status, unique challenges, and future directions.
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Zonisamide for weight loss in obese adults: a randomized controlled trial.
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Keywords of People
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Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
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Hirschey, Matthew,
Associate Professor of Medicine,
Cell Biology
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Yancy Jr., William Samuel,
Professor of Medicine,
Medicine, General Internal Medicine