Caloric Restriction

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  Subject Areas on Research

  • A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity. 
  • Aging. It's never too late. 
  • Approaches for quantifying energy intake and %calorie restriction during calorie restriction interventions in humans: the multicenter CALERIE study. 
  • Autophagy as a Therapeutic Target to Enhance Aged Muscle Regeneration. 
  • Body-composition changes in the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE)-2 study: a 2-y randomized controlled trial of calorie restriction in nonobese humans. 
  • Building research in diet and cognition: The BRIDGE randomized controlled trial. 
  • Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial. 
  • Caloric restriction augments radiation efficacy in breast cancer. 
  • Caloric restriction: implications for human cardiometabolic health. 
  • Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. 
  • Calories, carbohydrates, and cancer therapy with radiation: exploiting the five R's through dietary manipulation. 
  • Central and peripheral effects of insulin/IGF-1 signaling in aging and cancer: antidiabetic drugs as geroprotectors and anticarcinogens. 
  • Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis. 
  • Changes in thigh muscle volume predict bone mineral density response to lifestyle therapy in frail, obese older adults. 
  • Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy Phase 2 (CALERIE Phase 2) screening and recruitment: methods and results. 
  • Considering patient diet preference to optimize weight loss: design considerations of a randomized trial investigating the impact of choice. 
  • Date of eclosion modulates longevity: insights across dietary-restriction gradients and female reproduction in the mexfly Anastrepha ludens. 
  • Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice. 
  • Design and conduct of the CALERIE study: comprehensive assessment of the long-term effects of reducing intake of energy. 
  • Development of adherence metrics for caloric restriction interventions. 
  • Diet Shapes Mortality Response to Trauma in Old Tephritid Fruit Flies. 
  • Diet and Exercise for Obese Patients With Heart Failure--Reply. 
  • Diet and neurocognition: review of evidence and methodological considerations. 
  • Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling. 
  • Eating behavior traits of successful weight losers during 12 months of alternate-day fasting: An exploratory analysis of a randomized controlled trial. 
  • Effect of Allowing Choice of Diet on Weight Loss: A Randomized Trial. 
  • Effect of Alternate-Day Fasting on Weight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults: A Randomized Clinical Trial. 
  • Effect of Caloric Restriction or Aerobic Exercise Training on Peak Oxygen Consumption and Quality of Life in Obese Older Patients With Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial. 
  • Effect of Calorie Restriction on Mood, Quality of Life, Sleep, and Sexual Function in Healthy Nonobese Adults: The CALERIE 2 Randomized Clinical Trial. 
  • Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on branched-chain amino acid metabolism. 
  • Effect of Two-Year Caloric Restriction on Bone Metabolism and Bone Mineral Density in Non-Obese Younger Adults: A Randomized Clinical Trial. 
  • Effect of caloric restriction with and without exercise on metabolic intermediates in nonobese men and women. 
  • Effect of calorie restriction on the free-living physical activity levels of nonobese humans: results of three randomized trials. 
  • Effects of 2 years of caloric restriction on oxidative status assessed by urinary F2-isoprostanes: The CALERIE 2 randomized clinical trial. 
  • Effects of Two Years of Calorie Restriction on Aerobic Capacity and Muscle Strength. 
  • Effects of alternate-day fasting or daily calorie restriction on body composition, fat distribution, and circulating adipokines: Secondary analysis of a randomized controlled trial. 
  • Effects of an energy-restricted low-carbohydrate, high unsaturated fat/low saturated fat diet versus a high-carbohydrate, low-fat diet in type 2 diabetes: A 2-year randomized clinical trial. 
  • Effects of comprehensive lifestyle modification on diet, weight, physical fitness, and blood pressure control: 18-month results of a randomized trial. 
  • Effects of phentermine and phenformin on biomarkers of aging in rats. 
  • Effects of the dietary approaches to stop hypertension diet alone and in combination with exercise and caloric restriction on insulin sensitivity and lipids. 
  • Effects of the dietary approaches to stop hypertension diet, exercise, and caloric restriction on neurocognition in overweight adults with high blood pressure. 
  • Efficacy of Commercial Weight-Loss Programs. 
  • Factors associated with choice of a low-fat or low-carbohydrate diet during a behavioral weight loss intervention. 
  • Fat, carbohydrate, and calories in the development of diabetes and obesity in the C57BL/6J mouse. 
  • Gastric bypass surgery restores meal stimulation of the anorexigenic gut hormones glucagon-like peptide-1 and peptide YY independently of caloric restriction. 
  • Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions. 
  • Impact of a Multidomain Intensive Lifestyle Intervention on Complaints About Memory, Problem-Solving, and Decision-Making Abilities: The Action for Health in Diabetes Randomized Controlled Clinical Trial. 
  • Improvement in the Spatial Distribution of Pain, Somatic Symptoms, and Depression After a Weight Loss Intervention. 
  • In reply. 
  • Intermittent fasting vs daily calorie restriction for type 2 diabetes prevention: a review of human findings. 
  • Life-long caloric restriction does not alter the severity of age-related osteoarthritis. 
  • Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms. 
  • Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans. 
  • Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of Aging. 
  • Metabolomics in the study of aging and caloric restriction. 
  • Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors. 
  • Muscle-Specific Overexpression of PGC-1α Does Not Augment Metabolic Improvements in Response to Exercise and Caloric Restriction. 
  • Naïve models of dietary splurges: Beliefs about caloric compensation and weight change following non-habitual overconsumption. 
  • Nutrient restriction and radiation therapy for cancer treatment: when less is more. 
  • Nutrition therapy recommendations for the management of adults with diabetes. 
  • Obesity and insulin resistance: is it due to body fat, energy balance, or gut factors? 
  • Postprandial metabolite profiles reveal differential nutrient handling after bariatric surgery compared with matched caloric restriction. 
  • Predicting support for restricting food marketing to youth. 
  • Predictors of measurement error in energy intake during pregnancy. 
  • Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Responses to Diet Interventions. 
  • Reduction of ovarian and oviductal cancers in calorie-restricted laying chickens. 
  • SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. 
  • SIRT3 regulates mitochondrial protein acetylation and intermediary metabolism. 
  • Safety of two-year caloric restriction in non-obese healthy individuals. 
  • Selectively starving cancer cells through dietary manipulation: methods and clinical implications. 
  • Short term methionine restriction increases hepatic global DNA methylation in adult but not young male C57BL/6J mice. 
  • Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. 
  • Swimming Exercise and Transient Food Deprivation in Caenorhabditis elegans Promote Mitochondrial Maintenance and Protect Against Chemical-Induced Mitotoxicity. 
  • T cell stemness and dysfunction in tumors are triggered by a common mechanism. 
  • The CALERIE Study: design and methods of an innovative 25% caloric restriction intervention. 
  • The impact of exercise training compared to caloric restriction on hepatic and peripheral insulin resistance in obesity. 
  • The long-term effects of lifestyle change on blood pressure: One-year follow-up of the ENCORE study. 
  • The sirtuins, oxidative stress and aging: an emerging link. 
  • Zonisamide for weight loss in obese adults: a randomized controlled trial. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Hirschey, Matthew, Associate Professor, Pharmacology & Cancer Biology
  • Yancy Jr., William Samuel, Associate Professor of Medicine, Medicine, General Internal Medicine