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Subject Areas on Research
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3D cardiac μtissues within a microfluidic device with real-time contractile stress readout.
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A Genetic Cardiomyocyte Ablation Model for the Study of Heart Regeneration in Zebrafish.
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A H(a)rd Way to Adapt in Cardiac Hypertrophy.
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A Regenerative Cardiac Patch Formed by Spray Painting of Biomaterials onto the Heart.
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A Roadmap to Heart Regeneration Through Conserved Mechanisms in Zebrafish and Mammals.
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A biophysical model for cardiac microimpedance measurements.
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A cardiac arrhythmia syndrome caused by loss of ankyrin-B function.
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A dual role for ErbB2 signaling in cardiac trabeculation.
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A high-resolution cardiovascular magnetic resonance diffusion tensor map from ex-vivo C57BL/6 murine hearts.
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A method to replicate the microstructure of heart tissue in vitro using DTMRI-based cell micropatterning.
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A microstructural model of reentry arising from focal breakthrough at sites of source-load mismatch in a central region of slow conduction.
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A mouse model of congenital heart disease: cardiac arrhythmias and atrial septal defect caused by haploinsufficiency of the cardiac transcription factor Csx/Nkx2.5.
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A new activating role for CO in cardiac mitochondrial biogenesis.
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A novel Cbx1, PurB, and Sp3 complex mediates long-term silencing of tissue- and lineage-specific genes.
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A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development.
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A numerical scheme for modeling wavefront propagation on a monolayer of arbitrary geometry.
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A role for Sfrp2 in cardiomyogenesis in vivo.
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A systems genetics approach identifies Trp53inp2 as a link between cardiomyocyte glucose utilization and hypertrophic response.
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A two-current model for the dynamics of cardiac membrane.
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ALLogeneic Heart STem Cells to Achieve Myocardial Regeneration (ALLSTAR) Trial: Rationale and Design.
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AMPK and substrate availability regulate creatine transport in cultured cardiomyocytes.
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AT1 blockade prevents glucose-induced cardiac dysfunction in ventricular myocytes: role of the AT1 receptor and NADPH oxidase.
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Abi3bp regulates cardiac progenitor cell proliferation and differentiation.
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Acceleration of functional reentry by rapid pacing in anisotropic cardiac monolayers: formation of multi-wave functional reentries.
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Action potential and QT prolongation not sufficient to cause Torsade de Pointes: role of action potential triangulation.
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Activation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy.
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Adrenergic CaV1.2 Activation via Rad Phosphorylation Converges at α1C I-II Loop.
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Age-dependent functional crosstalk between cardiac fibroblasts and cardiomyocytes in a 3D engineered cardiac tissue.
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Agonistic angiotensin II type 1 receptor autoantibodies in postpartum women with a history of preeclampsia.
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An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair.
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An essential role of Bmp4 in the atrioventricular septation of the mouse heart.
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An injury-responsive gata4 program shapes the zebrafish cardiac ventricle.
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Analysis of oxygen transport in a diffusion-limited model of engineered heart tissue.
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Analysis of pH gradients resulting from mass transport limitations in engineered heart tissue.
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Analytical model of extracellular potentials in a tissue slab with a finite bath.
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Angiopellosis as an Alternative Mechanism of Cell Extravasation.
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Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes.
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Ankyrin-G and beta2-spectrin collaborate in biogenesis of lateral membrane of human bronchial epithelial cells.
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Ankyrin-G coordinates intercalated disc signaling platform to regulate cardiac excitability in vivo.
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Ankyrin-based patterning of membrane microdomains: new insights into a novel class of cardiovascular diseases.
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BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes.
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BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo.
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Basic and Translational Research in Cardiac Repair and Regeneration: JACC State-of-the-Art Review.
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Being there: cellular targeting of voltage-gated sodium channels in the heart.
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Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes.
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Bone marrow-derived AXL tyrosine kinase promotes mitogenic crosstalk and cardiac allograft vasculopathy.
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Building and re-building the heart by cardiomyocyte proliferation.
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C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling.
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C3orf58, a novel paracrine protein, stimulates cardiomyocyte cell-cycle progression through the PI3K-AKT-CDK7 pathway.
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CRISPR Library Screening in Cultured Cardiomyocytes.
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Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites.
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Calcium Signaling and Cardiac Arrhythmias.
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Calcium dependent CAMTA1 in adult stem cell commitment to a myocardial lineage.
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Calcium signaling regulates ventricular hypertrophy during development independent of contraction or blood flow.
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Calcium-dependent gene regulation in myocyte hypertrophy and remodeling.
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Calmodulin regulation of excitation-contraction coupling in cardiac myocytes.
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Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia.
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Cardiac CaV1.2 channels require β subunits for β-adrenergic-mediated modulation but not trafficking.
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Cardiac Stem Cell Patch Integrated with Microengineered Blood Vessels Promotes Cardiomyocyte Proliferation and Neovascularization after Acute Myocardial Infarction.
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Cardiac Stromal Cell Patch Integrated with Engineered Microvessels Improves Recovery from Myocardial Infarction in Rats and Pigs.
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Cardiac Troponin I-Interacting Kinase Affects Cardiomyocyte S-Phase Activity but Not Cardiomyocyte Proliferation.
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Cardiac cell therapy in vitro: reproducible assays for comparing the efficacy of different donor cells.
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Cardiac cell-integrated microneedle patch for treating myocardial infarction.
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Cardiac fibroblast paracrine factors alter impulse conduction and ion channel expression of neonatal rat cardiomyocytes.
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Cardiac gene expression profiling provides evidence for cytokinopathy as a molecular mechanism in Chagas' disease cardiomyopathy.
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Cardiac hypertrophy: role of G protein-coupled receptors.
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Cardiac myocyte p38α kinase regulates angiogenesis via myocyte-endothelial cell cross-talk during stress-induced remodeling in the heart.
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Cardiac progenitors and the embryonic cell cycle.
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Cardiac regenerative capacity and mechanisms.
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Cardiac tissue engineering using stem cells.
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Cardiomyocyte Maturation Requires TLR3 Activated Nuclear Factor Kappa B.
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Cardiomyocyte-Specific Human Bcl2-Associated Anthanogene 3 P209L Expression Induces Mitochondrial Fragmentation, Bcl2-Associated Anthanogene 3 Haploinsufficiency, and Activates p38 Signaling.
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Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues.
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Ccn2a is an injury-induced matricellular factor that promotes cardiac regeneration in zebrafish.
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Cell size and communication: role in structural and electrical development and remodeling of the heart.
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Characterizing functional stem cell-cardiomyocyte interactions.
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Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors.
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Clinical Trial in a Dish: Personalized Stem Cell-Derived Cardiomyocyte Assay Compared With Clinical Trial Results for Two QT-Prolonging Drugs.
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Clinical perspectives on reperfusion injury in acute myocardial infarction.
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Clonal Analysis of the Neonatal Mouse Heart using Nearest Neighbor Modeling.
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Clonally dominant cardiomyocytes direct heart morphogenesis.
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Collision-based spiral acceleration in cardiac media: roles of wavefront curvature and excitable gap.
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Colonizing the heart from the epicardial side.
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Combined acetaldehyde and nicotine exposure depresses cardiac contraction in ventricular myocytes: prevention by folic acid.
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Commentary on selected aspects of cardioprotection.
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Commentary: Cardiosphere-derived exosomes for single-ventricle heart disease: Are some of the parts greater than the whole?
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Commentary: Targeting cytokinesis failure in tetralogy of Fallot: Late to the dance?
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Comparative analysis of media effects on human induced pluripotent stem cell-derived cardiomyocytes in proarrhythmia risk assessment.
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Comparison of various iron chelators and prochelators as protective agents against cardiomyocyte oxidative injury.
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Compensatory hypertrophy induced by ventricular cardiomyocyte-specific COX-2 expression in mice.
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Conditional expression of SV40 T-antigen in mouse cardiomyocytes facilitates an inducible switch from proliferation to differentiation.
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Conditional knockout of Fgf13 in murine hearts increases arrhythmia susceptibility and reveals novel ion channel modulatory roles.
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Conduction block in micropatterned cardiomyocyte cultures replicating the structure of ventricular cross-sections.
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Controlling the structural and functional anisotropy of engineered cardiac tissues.
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Coronary Revascularization During Heart Regeneration Is Regulated by Epicardial and Endocardial Cues and Forms a Scaffold for Cardiomyocyte Repopulation.
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Coupled myovascular expansion directs cardiac growth and regeneration.
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Creatine supplementation reduces doxorubicin-induced cardiomyocellular injury.
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Cultivation in rotating bioreactors promotes maintenance of cardiac myocyte electrophysiology and molecular properties.
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Defects in cardiomyocyte function: role of beta-adrenergic receptor dysfunction.
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Defining Transcription Regulatory Elements in the Human Frataxin Gene: Implications for Gene Therapy.
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Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation.
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Demethylation of H3K27 Is Essential for the Induction of Direct Cardiac Reprogramming by miR Combo.
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Development and cardiac contractility: cardiac troponin T isoforms and cytosolic calcium in rabbit.
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Developmental stage-dependent effects of cardiac fibroblasts on function of stem cell-derived engineered cardiac tissues.
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Differential effect of HERG blocking agents on cardiac electrical alternans in the guinea pig.
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Differentiation of Human Induced Pluripotent Stem Cells into Epicardial-Like Cells.
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Direct Actions of AT1 (Type 1 Angiotensin) Receptors in Cardiomyocytes Do Not Contribute to Cardiac Hypertrophy.
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Direct reprogramming of cardiac fibroblasts to cardiomyocytes using microRNAs.
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Direct visualization of cardiac transcription factories reveals regulatory principles of nuclear architecture during pathological remodeling.
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Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo.
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Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice.
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Distilling complexity to advance cardiac tissue engineering.
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Dual inhibition of beta-adrenergic and angiotensin II receptors by a single antagonist: a functional role for receptor-receptor interaction in vivo.
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Dual-interference-channel quantitative-phase microscopy of live cell dynamics.
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Dynamic culture yields engineered myocardium with near-adult functional output.
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Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function.
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Dynamical mechanism for subcellular alternans in cardiac myocytes.
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Dysregulation of mitochondrial bioenergetics and quality control by HIV-1 Tat in cardiomyocytes.
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Early adaptive chromatin remodeling events precede pathologic phenotypes and are reinforced in the failing heart.
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Effect of resistive barrier location on the relationship between T-wave alternans and cellular repolarization alternans: a 1-D modeling study.
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Efficient fully implicit time integration methods for modeling cardiac dynamics.
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Electrical alternans and hemodynamics in the anesthetized guinea pig can discriminate the cardiac safety of antidepressants.
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Electrical pacing counteracts intrinsic shortening of action potential duration of neonatal rat ventricular cells in culture.
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Electrochemical properties and myocyte interaction of carbon nanotube microelectrodes.
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Electrotonic influences on action potential duration dispersion in small hearts: a simulation study.
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Electrotonic loading of anisotropic cardiac monolayers by unexcitable cells depends on connexin type and expression level.
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Embryonic and neonatal cardiac gene transfer in vivo.
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Emerging Concepts in Paracrine Mechanisms in Regenerative Cardiovascular Medicine and Biology.
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Engineered bacterial voltage-gated sodium channel platform for cardiac gene therapy.
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Engineered cardiac tissue patch maintains structural and electrical properties after epicardial implantation.
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Engineering prokaryotic channels for control of mammalian tissue excitability.
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Engineering skeletal myoblasts: roles of three-dimensional culture and electrical stimulation.
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Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G alpha o* protein.
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Enhanced effect of combining human cardiac stem cells and bone marrow mesenchymal stem cells to reduce infarct size and to restore cardiac function after myocardial infarction.
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Ephrin-Eph signaling as a potential therapeutic target for the treatment of myocardial infarction.
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Epicardial regeneration is guided by cardiac outflow tract and Hedgehog signalling.
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Erythropoietin activates mitochondrial biogenesis and couples red cell mass to mitochondrial mass in the heart.
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Erythropoietin protects cardiac myocytes against anthracycline-induced apoptosis.
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Erythropoietin receptor expression in adult rat cardiomyocytes is associated with an acute cardioprotective effect for recombinant erythropoietin during ischemia-reperfusion injury.
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Exercise alters the regulation of myocardial Na(+)/H(+) exchanger-1 activity.
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Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure.
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FGF12 is a candidate Brugada syndrome locus.
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FGF21-FGFR4 signaling in cardiac myocytes promotes concentric cardiac hypertrophy in mouse models of diabetes.
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FGF23 induces left ventricular hypertrophy.
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FGF23/FGFR4-mediated left ventricular hypertrophy is reversible.
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Feasibility of cardiac microimpedance measurement using multisite interstitial stimulation.
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Feedback-control induced pattern formation in cardiac myocytes: a mathematical modeling study.
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Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts.
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Fibroblast growth factor homologous factors in the heart: a potential locus for cardiac arrhythmias.
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Fibroblast growth factor homologous factors modulate cardiac calcium channels.
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Fibroblast growth factor homologous factors tune arrhythmogenic late NaV1.5 current in calmodulin binding-deficient channels.
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Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration.
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Field stimulation of cardiac fibers with random spatial structure.
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Frame-Hydrogel Methodology for Engineering Highly Functional Cardiac Tissue Constructs.
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Functional cardiac tissue engineering.
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G-Protein-Coupled Receptors in Heart Disease.
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GATA4 and the two sides of gene expression reprogramming.
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GRK2-mediated inhibition of adrenergic and dopaminergic signaling in right ventricular hypertrophy: therapeutic implications in pulmonary hypertension.
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Gender-specific patterns of left ventricular and myocyte remodeling following myocardial infarction in mice deficient in the angiotensin II type 1a receptor.
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Gene delivery approaches to heart failure treatment.
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Genetic engineering of somatic cells to study and improve cardiac function.
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Gi alpha 1-mediated cardiac electrophysiological remodeling and arrhythmia in hypertrophic cardiomyopathy.
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Gi-biased β2AR signaling links GRK2 upregulation to heart failure.
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Glycogen-branching enzyme deficiency leads to abnormal cardiac development: novel insights into glycogen storage disease IV.
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HASF (C3orf58) is a novel ligand of the insulin-like growth factor 1 receptor.
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HASF is a stem cell paracrine factor that activates PKC epsilon mediated cytoprotection.
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HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy.
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Hand2 elevates cardiomyocyte production during zebrafish heart development and regeneration.
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Haplo-insufficiency of Bcl2-associated athanogene 3 in mice results in progressive left ventricular dysfunction, β-adrenergic insensitivity, and increased apoptosis.
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Harnessing the Power of Integrated Mitochondrial Biology and Physiology: A Special Report on the NHLBI Mitochondria in Heart Diseases Initiative.
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Heart regeneration in zebrafish.
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Help for the miffed heart.
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Heme Oxygenase-1/Carbon Monoxide System and Embryonic Stem Cell Differentiation and Maturation into Cardiomyocytes.
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Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1.
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High-Resolution Mapping of Chromatin Conformation in Cardiac Myocytes Reveals Structural Remodeling of the Epigenome in Heart Failure.
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High-throughput cardiac safety evaluation and multi-parameter arrhythmia profiling of cardiomyocytes using microelectrode arrays.
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Histologic and electron microscopy findings in myocardium of treated Fabry disease.
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Human Erbb2-induced Erk activity robustly stimulates cycling and functional remodeling of rat and human cardiomyocytes.
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Humanin analog enhances the protective effect of dexrazoxane against doxorubicin-induced cardiotoxicity.
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Hypertrophic preconditioning: short-term tricks for long-term gain.
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Hypoxia decreases creatine uptake in cardiomyocytes, while creatine supplementation enhances HIF activation.
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Hypoxic cell death is reduced by pH buffering in a model of engineered heart tissue.
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Implantation of mouse embryonic stem cell-derived cardiac progenitor cells preserves function of infarcted murine hearts.
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In vitro discovery of novel prokaryotic ion channel candidates for antiarrhythmic gene therapy.
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In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration.
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In vivo proximity labeling identifies cardiomyocyte protein networks during zebrafish heart regeneration.
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Inactivation of the Glucose-Dependent Insulinotropic Polypeptide Receptor Improves Outcomes following Experimental Myocardial Infarction.
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Incorporating histology into a 3D microscopic computer model of myocardium to study propagation at a cellular level.
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Increased interstitial loading reduces the effect of microstructural variations in cardiac tissue.
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Independent requirements for Hedgehog signaling by both the anterior heart field and neural crest cells for outflow tract development.
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Induced cardiomyocyte maturation: Cardiac transcription factors are necessary but not sufficient.
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Induced pluripotent stem cell-derived cardiac progenitors differentiate to cardiomyocytes and form biosynthetic tissues.
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Inducible Fgf13 ablation enhances caveolae-mediated cardioprotection during cardiac pressure overload.
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Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration.
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Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5.
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Inhibition of Wnt6 by Sfrp2 regulates adult cardiac progenitor cell differentiation by differential modulation of Wnt pathways.
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Inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase differentially regulates contractile function in cardiac myocytes from normotensive and spontaneously hypertensive rats: role of Ca2+ regulatory proteins.
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Inhibitor-kappaB kinase-beta regulates LPS-induced TNF-alpha production in cardiac myocytes through modulation of NF-kappaB p65 subunit phosphorylation.
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Inositol 1,4,5-trisphosphate receptor localization and stability in neonatal cardiomyocytes requires interaction with ankyrin-B.
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Insights from molecular signature of in vivo cardiac c-Kit(+) cells following cardiac injury and β-catenin inhibition.
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Interactions between extracellular stimuli and excitation waves in an atrial reentrant loop.
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Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy.
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Isoform specificity among ankyrins. An amphipathic alpha-helix in the divergent regulatory domain of ankyrin-b interacts with the molecular co-chaperone Hdj1/Hsp40.
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Isoform specificity of ankyrin-B: a site in the divergent C-terminal domain is required for intramolecular association.
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JNK activation decreases PP2A regulatory subunit B56alpha expression and mRNA stability and increases AUF1 expression in cardiomyocytes.
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Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies.
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Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling.
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Junctophilin-2 is necessary for T-tubule maturation during mouse heart development.
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Keto acid metabolites of branched-chain amino acids inhibit oxidative stress-induced necrosis and attenuate myocardial ischemia-reperfusion injury.
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Klotho and phosphate are modulators of pathologic uremic cardiac remodeling.
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Lack of Thy1 defines a pathogenic fraction of cardiac fibroblasts in heart failure.
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Leukocyte iNOS is required for inflammation and pathological remodeling in ischemic heart failure.
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Lin28a Regulates Pathological Cardiac Hypertrophic Growth Through Pck2-Mediated Enhancement of Anabolic Synthesis.
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Lipid-independent activation of a muscle-specific PKCα splicing variant.
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Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis.
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Loading effect of fibroblast-myocyte coupling on resting potential, impulse propagation, and repolarization: insights from a microstructure model.
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Long-term contractile activity and thyroid hormone supplementation produce engineered rat myocardium with adult-like structure and function.
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MAPK-activated protein kinase-2 in cardiac hypertrophy and cyclooxygenase-2 regulation in heart.
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Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling.
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Mechanical unloading promotes myocardial energy recovery in human heart failure.
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Mechanism-based engineering against anthracycline cardiotoxicity.
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Mechanoelectrical excitation by fluid jets in monolayers of cultured cardiac myocytes.
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Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts.
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Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation.
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Mesenchymal stem cells stimulate protective genetic reprogramming of injured cardiac ventricular myocytes.
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Metallic Nanoislands on Graphene as Highly Sensitive Transducers of Mechanical, Biological, and Optical Signals.
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Metallothionein abrogates GTP cyclohydrolase I inhibition-induced cardiac contractile and morphological defects: role of mitochondrial biogenesis.
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Metallothionein alleviates glutathione depletion-induced oxidative cardiomyopathy in murine hearts.
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Methodologies for Inducing Cardiac Injury and Assaying Regeneration in Adult Zebrafish.
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MicroRNA induced cardiac reprogramming in vivo: evidence for mature cardiac myocytes and improved cardiac function.
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MicroRNA-mediated in vitro and in vivo direct reprogramming of cardiac fibroblasts to cardiomyocytes.
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MicroRNAs and Cardiac Regeneration.
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MicroRNAs targeting the SARS-CoV-2 entry receptor ACE2 in cardiomyocytes.
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Microscopic variations in interstitial and intracellular structure modulate the distribution of conduction delays and block in cardiac tissue with source-load mismatch.
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Mitochondrial dysfunction in human immunodeficiency virus-1 transgenic mouse cardiac myocytes.
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Mitochondrial quality-control dysregulation in conditional HO-1-/- mice.
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Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene.
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Modulation of conduction velocity by nonmyocytes in the low coupling regime.
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Modulation of gene expression in neonatal rat cardiomyocytes by surface modification of polylactide-co-glycolide substrates.
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Modulation of in vivo cardiac function by myocyte-specific nitric oxide synthase-3.
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Modulation of tissue repair by regeneration enhancer elements.
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Multicolor mapping of the cardiomyocyte proliferation dynamics that construct the atrium.
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Multisite interstitial stimulation for cardiac micro-impedance measurements.
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Muscle ring finger-3 protects against diabetic cardiomyopathy induced by a high fat diet.
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Mutation E169K in junctophilin-2 causes atrial fibrillation due to impaired RyR2 stabilization.
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Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice.
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Myocardial NF-κB activation is essential for zebrafish heart regeneration.
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Myocardial protection isn't dead yet.
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Myocardial remodeling is controlled by myocyte-targeted gene regulation of phosphodiesterase type 5.
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Myocardial volume and organization are changed by failure of addition of secondary heart field myocardium to the cardiac outflow tract.
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Na+ channel function, regulation, structure, trafficking and sequestration.
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Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes.
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Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration.
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Nitric oxide regulation of myocardial contractility and calcium cycling: independent impact of neuronal and endothelial nitric oxide synthases.
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Novel anisotropic engineered cardiac tissues: studies of electrical propagation.
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Novel micropatterned cardiac cell cultures with realistic ventricular microstructure.
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Novel--and "neu"--therapeutic possibilities for heart failure.
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Nox1 NADPH oxidase is necessary for late but not early myocardial ischaemic preconditioning.
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Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish.
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Nutrition Modulation of Cardiotoxicity and Anticancer Efficacy Related to Doxorubicin Chemotherapy by Glutamine and ω-3 Polyunsaturated Fatty Acids.
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Optimizing delivery for efficient cardiac reprogramming.
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Overexpression of TNNI3K, a cardiac-specific MAPKKK, promotes cardiac dysfunction.
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Overexpression of bone morphogenetic protein 10 in myocardium disrupts cardiac postnatal hypertrophic growth.
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Overview of the Alliance for Cellular Signaling.
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PKM1 Exerts Critical Roles in Cardiac Remodeling Under Pressure Overload in the Heart.
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Pacemaker-induced transient asynchrony suppresses heart failure progression.
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Paracrine mechanisms in adult stem cell signaling and therapy.
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Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species.
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Pim1 Kinase Overexpression Enhances ckit+ Cardiac Stem Cell Cardiac Repair Following Myocardial Infarction in Swine.
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Pinning down the CaMKII targets in the L-type Ca(2+) channel: an essential step in defining CaMKII regulation.
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Pluripotent stem cell-derived cardiac tissue patch with advanced structure and function.
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Polymer Microparticles with Defined Surface Chemistry and Topography Mediate the Formation of Stem Cell Aggregates and Cardiomyocyte Function.
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Pompe disease results in a Golgi-based glycosylation deficit in human induced pluripotent stem cell-derived cardiomyocytes.
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Positive Role for a Negative Calcineurin Regulator in Cardiac Hypertrophy.
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Preserved heart function and maintained response to cardiac stresses in a genetic model of cardiomyocyte-targeted deficiency of cyclooxygenase-2.
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Pressure overload selectively up-regulates Ca2+/calmodulin-dependent protein kinase II in vivo.
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Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes.
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Production of Cardiomyocytes by microRNA-Mediated Reprogramming in Optimized Reprogramming Media.
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Quantifying electrical interactions between cardiomyocytes and other cells in micropatterned cell pairs.
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RBFox2-miR-34a-Jph2 axis contributes to cardiac decompensation during heart failure.
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RNA-Mediated Reprogramming of Primary Adult Human Dermal Fibroblasts into c-kit(+) Cardiac Progenitor Cells.
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Rapid fusion between mesenchymal stem cells and cardiomyocytes yields electrically active, non-contractile hybrid cells.
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Reciprocal Regulation of the Cardiac Epigenome by Chromatin Structural Proteins Hmgb and Ctcf: IMPLICATIONS FOR TRANSCRIPTIONAL REGULATION.
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Redirecting cardiac growth mechanisms for therapeutic regeneration.
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Reduced junctional Na+/Ca2+-exchanger activity contributes to sarcoplasmic reticulum Ca2+ leak in junctophilin-2-deficient mice.
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Reflective interferometric chamber for quantitative phase imaging of biological sample dynamics.
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Regulation of cardiac nitric oxide signaling by nuclear β-adrenergic and endothelin receptors.
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Regulation of zebrafish heart regeneration by miR-133.
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Reiterative roles for FGF signaling in the establishment of size and proportion of the zebrafish heart.
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Relation between previous lipid-lowering therapy and infarct size (creatine kinase-MB level) in patients presenting with acute myocardial infarction.
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Relationship between extracellular T-wave height, T-wave alternans amplitude, and tissue action potential alternans: a 1-dimensional computer modeling study.
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Relationship of disease-associated gene expression to cardiac phenotype is buffered by genetic diversity and chromatin regulation.
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Relaxin suppresses atrial fibrillation by reversing fibrosis and myocyte hypertrophy and increasing conduction velocity and sodium current in spontaneously hypertensive rat hearts.
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Rescue of Pressure Overload-Induced Heart Failure by Estrogen Therapy.
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Resolving Heart Regeneration by Replacement Histone Profiling.
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Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration.
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Robust T-tubulation and maturation of cardiomyocytes using tissue-engineered epicardial mimetics.
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Robust adenoviral and adeno-associated viral gene transfer to the in vivo murine heart: application to study of phospholamban physiology.
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Role of 14-3-3-mediated p38 mitogen-activated protein kinase inhibition in cardiac myocyte survival.
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Role of Mitochondrial Oxidative Stress in Glucose Tolerance, Insulin Resistance, and Cardiac Diastolic Dysfunction.
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Role of an alternatively spliced form of alphaII-spectrin in localization of connexin 43 in cardiomyocytes and regulation by stress-activated protein kinase.
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Role of p38alpha MAPK in cardiac apoptosis and remodeling after myocardial infarction.
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Rotenone-Induced 4-HNE Aggresome Formation and Degradation in HL-1 Cardiomyocytes: Role of Autophagy Flux.
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S-Nitrosylation of Sarcomeric Proteins Depresses Myofilament Ca2+)Sensitivity in Intact Cardiomyocytes.
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SARS-CoV-2 Infection Induces Ferroptosis of Sinoatrial Node Pacemaker Cells.
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SCN5A variant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmia.
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SFRP2 regulates cardiomyogenic differentiation by inhibiting a positive transcriptional autofeedback loop of Wnt3a.
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SHP-2 is required for the maintenance of cardiac progenitors.
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SOCE and STIM1 signaling in the heart: Timing and location matter.
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SOCE in the cardiomyocyte: the secret is in the chambers.
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SRC-2 coactivator deficiency decreases functional reserve in response to pressure overload of mouse heart.
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STIM1-Ca2+ signaling in coronary sinus cardiomyocytes contributes to interatrial conduction.
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STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node.
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SUPPORT-1 (Subjects Undergoing PCI and Perioperative Reperfusion Treatment): A Prospective, Randomized Trial of CMX-2043 in Patients Undergoing Elective Percutaneous Coronary Intervention.
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Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair.
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Selective phosphorylation of PKA targets after β-adrenergic receptor stimulation impairs myofilament function in Mybpc3-targeted HCM mouse model.
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Selenium Augments microRNA Directed Reprogramming of Fibroblasts to Cardiomyocytes via Nanog.
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Sex Differences at the Time of Myectomy in Hypertrophic Cardiomyopathy.
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Simulated microgravity produces attenuated baroreflex-mediated pressor, chronotropic, and inotropic responses in mice.
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Single epicardial cell transcriptome sequencing identifies Caveolin 1 as an essential factor in zebrafish heart regeneration.
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Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart.
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Single-detector simultaneous optical mapping of V(m) and [Ca(2+)](i) in cardiac monolayers.
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Size and ionic currents of unexcitable cells coupled to cardiomyocytes distinctly modulate cardiac action potential shape and pacemaking activity in micropatterned cell pairs.
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Socking It to cardiac hypertrophy: STIM1-mediated Ca2+ entry in the cardiomyocyte.
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Spatial profiles of electrical mismatch determine vulnerability to conduction failure across a host-donor cell interface.
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Specific regulation of noncanonical p38alpha activation by Hsp90-Cdc37 chaperone complex in cardiomyocyte.
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Spectral-domain differential interference contrast microscopy.
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Spectral-domain phase microscopy.
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Spectrin- and ankyrin-based membrane domains and the evolution of vertebrates.
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Stoichiometry of Gata4, Mef2c, and Tbx5 influences the efficiency and quality of induced cardiac myocyte reprogramming.
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Structural coupling of cardiomyocytes and noncardiomyocytes: quantitative comparisons using a novel micropatterned cell pair assay.
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Study of unipolar electrogram morphology in a computer model of atrial fibrillation.
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Substrate specificities of g protein-coupled receptor kinase-2 and -3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function.
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Synergistic Efficacy from Gene Therapy with Coreceptor Blockade and a β2-Agonist in Murine Pompe Disease.
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Systems Genetics Approach Identifies Gene Pathways and Adamts2 as Drivers of Isoproterenol-Induced Cardiac Hypertrophy and Cardiomyopathy in Mice.
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Systems proteomics of cardiac chromatin identifies nucleolin as a regulator of growth and cellular plasticity in cardiomyocytes.
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TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling.
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TASK-1 and TASK-3 channels modulate pressure overload-induced cardiac remodeling and dysfunction.
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TRIM35-mediated degradation of nuclear PKM2 destabilizes GATA4/6 and induces P53 in cardiomyocytes to promote heart failure.
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TRM Forum on Computer Simulation and Experimental Assessment of Cardiac Function.
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Targeted anti-IL-1β platelet microparticles for cardiac detoxing and repair.
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Targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer in failing human hearts.
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Targeted expression of calmodulin increases ventricular cardiomyocyte proliferation and deoxyribonucleic acid synthesis during mouse development.
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Temporal activation of c-Jun N-terminal kinase in adult transgenic heart via cre-loxP-mediated DNA recombination.
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The Calcineurin-FoxO-MuRF1 signaling pathway regulates myofibril integrity in cardiomyocytes.
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The PDZ motif of the α1C subunit is not required for surface trafficking and adrenergic modulation of CaV1.2 channel in the heart.
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The chromatin-binding protein Smyd1 restricts adult mammalian heart growth.
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The continuous heart failure spectrum: moving beyond an ejection fraction classification.
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The elusive philosopher's stone in young blood.
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The extracellular matrix protein agrin promotes heart regeneration in mice.
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The glitter of gold: biolistic transfection of fresh adult cardiac myocytes. Focus on "normal targeting of a tagged Kv1.5 channel acutely transfected into fresh adult cardiac myocytes by a biolistic method".
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The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy.
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The nuclear receptor RORα protects against angiotensin II-induced cardiac hypertrophy and heart failure.
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The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion.
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The role of Sfrp and DKK proteins in cardiomyocyte development.
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The role of cytoprotective cytokines in cardiac ischemia/reperfusion injury.
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The serine/threonine-protein kinase/endoribonuclease IRE1α protects the heart against pressure overload-induced heart failure.
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The small molecule Chicago Sky Blue promotes heart repair following myocardial infarction in mice.
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The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction.
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The variability of the electrical properties of the pulmonary veins.
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Therapy with Cardiomyocytes Derived from Pluripotent Cells in Chronic Chagasic Cardiomyopathy.
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Thiazolidinediones, peripheral oedema and congestive heart failure: what is the evidence?
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Tissue-engineered 3-dimensional (3D) microenvironment enhances the direct reprogramming of fibroblasts into cardiomyocytes by microRNAs.
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Tissue-engineered cardiac patch for advanced functional maturation of human ESC-derived cardiomyocytes.
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Titin truncations lead to impaired cardiomyocyte autophagy and mitochondrial function in vivo.
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Tp53 Suppression Promotes Cardiomyocyte Proliferation during Zebrafish Heart Regeneration.
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Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming.
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Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration.
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Transplantation of embryonic stem cells into the infarcted mouse heart: formation of multiple cell types.
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Treatment with the 3-ketoacyl-CoA thiolase inhibitor trimetazidine does not exacerbate whole-body insulin resistance in obese mice.
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Triiodothyronine and dexamethasone alter potassium channel expression and promote electrophysiological maturation of human-induced pluripotent stem cell-derived cardiomyocytes.
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Troglitazone stimulates beta-arrestin-dependent cardiomyocyte contractility via the angiotensin II type 1A receptor.
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Tumor Suppressors RB1 and CDKN2a Cooperatively Regulate Cell-Cycle Progression and Differentiation During Cardiomyocyte Development and Repair.
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Untangle a Broken Heart via Janus Kinase 1.
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Usefulness of frequent arrhythmias after epicardial recanalization in anterior wall acute myocardial infarction as a marker of cellular injury leading to poor recovery of left ventricular function.
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Using a gene-switch transgenic approach to dissect distinct roles of MAP kinases in heart failure.
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VDAC2 as a novel target for heart failure: Ca2+ at the sarcomere, mitochondria and SR.
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Vegfaa instructs cardiac muscle hyperplasia in adult zebrafish.
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Viability assessment by delayed enhancement cardiovascular magnetic resonance: will low-dose dobutamine dull the shine?
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Vitamin D Stimulates Cardiomyocyte Proliferation and Controls Organ Size and Regeneration in Zebrafish.
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WIPI1 is a conserved mediator of right ventricular failure.
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What happens when cardiac Na channels lose their function? 1--numerical studies of the vulnerable period in tissue expressing mutant channels.
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X-linked inhibitor of apoptosis protein-mediated attenuation of apoptosis, using a novel cardiac-enhanced adeno-associated viral vector.
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YAP: The nexus between metabolism and cardiac remodeling.
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hapln1 Defines an Epicardial Cell Subpopulation Required for Cardiomyocyte Expansion During Heart Morphogenesis and Regeneration.
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microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential.
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p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes.
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p38 MAP kinase mediates inflammatory cytokine induction in cardiomyocytes and extracellular matrix remodeling in heart.
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p38 MAP kinases in the heart.
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p38 Mitogen-activated protein kinase regulates chamber-specific perinatal growth in heart.
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α1-Syntrophin Variant Identified in Drug-Induced Long QT Syndrome Increases Late Sodium Current.
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β-Adrenergic receptor antagonists ameliorate myocyte T-tubule remodeling following myocardial infarction.
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β-Arrestin-Biased Allosteric Modulator Potentiates Carvedilol-Stimulated β Adrenergic Receptor Cardioprotection.
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Keywords of People
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Bennett, Vann,
George Barth Geller Distinguished Professor of Molecular Biology,
Duke Cancer Institute
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Bursac, Nenad,
Professor of Biomedical Engineering,
Biomedical Engineering
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Henriquez, Craig S.,
Professor of Biomedical Engineering,
Biomedical Engineering
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Milano, Carmelo Alessio,
Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery,
Surgery, Cardiovascular and Thoracic Surgery
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Pitt, Geoffrey Stuart,
Adjunct Professor in the Department of Medicine,
Medicine, Cardiology
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Starmer, Charles Franklin,
Professor Emeritus of Computer Science,
Computer Science