Myocytes, Cardiac

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  Subject Areas on Research

  • 3D cardiac μtissues within a microfluidic device with real-time contractile stress readout. 
  • A biophysical model for cardiac microimpedance measurements. 
  • A cardiac arrhythmia syndrome caused by loss of ankyrin-B function. 
  • A dual role for ErbB2 signaling in cardiac trabeculation. 
  • A high-resolution cardiovascular magnetic resonance diffusion tensor map from ex-vivo C57BL/6 murine hearts. 
  • A method to replicate the microstructure of heart tissue in vitro using DTMRI-based cell micropatterning. 
  • A microstructural model of reentry arising from focal breakthrough at sites of source-load mismatch in a central region of slow conduction. 
  • A new activating role for CO in cardiac mitochondrial biogenesis. 
  • A two-current model for the dynamics of cardiac membrane. 
  • ALLogeneic Heart STem Cells to Achieve Myocardial Regeneration (ALLSTAR) Trial: Rationale and Design. 
  • AMPK and substrate availability regulate creatine transport in cultured cardiomyocytes. 
  • AT1 blockade prevents glucose-induced cardiac dysfunction in ventricular myocytes: role of the AT1 receptor and NADPH oxidase. 
  • Abcc9 is required for the transition to oxidative metabolism in the newborn heart. 
  • Abi3bp regulates cardiac progenitor cell proliferation and differentiation. 
  • Acceleration of functional reentry by rapid pacing in anisotropic cardiac monolayers: formation of multi-wave functional reentries. 
  • Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells. 
  • Age-dependent functional crosstalk between cardiac fibroblasts and cardiomyocytes in a 3D engineered cardiac tissue. 
  • An essential role of Bmp4 in the atrioventricular septation of the mouse heart. 
  • An injury-responsive gata4 program shapes the zebrafish cardiac ventricle. 
  • Analytical model of extracellular potentials in a tissue slab with a finite bath. 
  • Ankyrin-G and beta2-spectrin collaborate in biogenesis of lateral membrane of human bronchial epithelial cells. 
  • Ankyrin-G coordinates intercalated disc signaling platform to regulate cardiac excitability in vivo. 
  • Ankyrin-based patterning of membrane microdomains: new insights into a novel class of cardiovascular diseases. 
  • BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes. 
  • BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo. 
  • Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes. 
  • Biomarker evidence of myocardial cell injury is associated with mortality in acute respiratory distress syndrome. 
  • Building and re-building the heart by cardiomyocyte proliferation. 
  • C3orf58, a novel paracrine protein, stimulates cardiomyocyte cell-cycle progression through the PI3K-AKT-CDK7 pathway. 
  • Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites. 
  • Calcium Signaling and Cardiac Arrhythmias. 
  • Calcium dependent CAMTA1 in adult stem cell commitment to a myocardial lineage. 
  • Calcium signaling regulates ventricular hypertrophy during development independent of contraction or blood flow. 
  • Calcium-dependent gene regulation in myocyte hypertrophy and remodeling. 
  • Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia. 
  • Cardiac cell therapy in vitro: reproducible assays for comparing the efficacy of different donor cells. 
  • Cardiac fibroblast paracrine factors alter impulse conduction and ion channel expression of neonatal rat cardiomyocytes. 
  • Cardiac gene expression profiling provides evidence for cytokinopathy as a molecular mechanism in Chagas' disease cardiomyopathy. 
  • Cardiac hypertrophy: role of G protein-coupled receptors. 
  • Cardiac progenitors and the embryonic cell cycle. 
  • Cardiac regenerative capacity and mechanisms. 
  • Cardiac tissue engineering using stem cells. 
  • Cardiomyocyte-Specific Human Bcl2-Associated Anthanogene 3 P209L Expression Induces Mitochondrial Fragmentation, Bcl2-Associated Anthanogene 3 Haploinsufficiency, and Activates p38 Signaling. 
  • Cardiotoxicity due to cancer therapy. 
  • Cell polarization defects in early heart development. 
  • Cell size and communication: role in structural and electrical development and remodeling of the heart. 
  • Characterizing functional stem cell-cardiomyocyte interactions. 
  • Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors. 
  • Clinical perspectives on reperfusion injury in acute myocardial infarction. 
  • Clonally dominant cardiomyocytes direct heart morphogenesis. 
  • Collision-based spiral acceleration in cardiac media: roles of wavefront curvature and excitable gap. 
  • Colonizing the heart from the epicardial side. 
  • Combined acetaldehyde and nicotine exposure depresses cardiac contraction in ventricular myocytes: prevention by folic acid. 
  • Comparison of various iron chelators and prochelators as protective agents against cardiomyocyte oxidative injury. 
  • Computational modeling of cardiac fibroblasts and fibrosis. 
  • Conditional expression of SV40 T-antigen in mouse cardiomyocytes facilitates an inducible switch from proliferation to differentiation. 
  • Conditional knockout of Fgf13 in murine hearts increases arrhythmia susceptibility and reveals novel ion channel modulatory roles. 
  • Conduction block in micropatterned cardiomyocyte cultures replicating the structure of ventricular cross-sections. 
  • Controlling the structural and functional anisotropy of engineered cardiac tissues. 
  • Cultivation in rotating bioreactors promotes maintenance of cardiac myocyte electrophysiology and molecular properties. 
  • Defects in cardiomyocyte function: role of beta-adrenergic receptor dysfunction. 
  • Demethylation of H3K27 Is Essential for the Induction of Direct Cardiac Reprogramming by miR Combo. 
  • Development and cardiac contractility: cardiac troponin T isoforms and cytosolic calcium in rabbit. 
  • Differential effect of HERG blocking agents on cardiac electrical alternans in the guinea pig. 
  • Direct reprogramming of cardiac fibroblasts to cardiomyocytes using microRNAs. 
  • Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo. 
  • Distilling complexity to advance cardiac tissue engineering. 
  • Dual inhibition of beta-adrenergic and angiotensin II receptors by a single antagonist: a functional role for receptor-receptor interaction in vivo. 
  • Dynamic culture yields engineered myocardium with near-adult functional output. 
  • Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function. 
  • Dynamical mechanism for subcellular alternans in cardiac myocytes. 
  • Dysautonomia due to reduced cholinergic neurotransmission causes cardiac remodeling and heart failure. 
  • Dysregulation of mitochondrial bioenergetics and quality control by HIV-1 Tat in cardiomyocytes. 
  • Effect of resistive barrier location on the relationship between T-wave alternans and cellular repolarization alternans: a 1-D modeling study. 
  • Efficient fully implicit time integration methods for modeling cardiac dynamics. 
  • Electrical alternans and hemodynamics in the anesthetized guinea pig can discriminate the cardiac safety of antidepressants. 
  • Electrical pacing counteracts intrinsic shortening of action potential duration of neonatal rat ventricular cells in culture. 
  • Electrotonic influences on action potential duration dispersion in small hearts: a simulation study. 
  • Electrotonic loading of anisotropic cardiac monolayers by unexcitable cells depends on connexin type and expression level. 
  • Emerging Concepts in Paracrine Mechanisms in Regenerative Cardiovascular Medicine and Biology. 
  • Emerging biomarkers in heart failure. 
  • Engineering skeletal myoblasts: roles of three-dimensional culture and electrical stimulation. 
  • Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G alpha o* protein. 
  • Epicardial regeneration is guided by cardiac outflow tract and Hedgehog signalling. 
  • Erythropoietin activates mitochondrial biogenesis and couples red cell mass to mitochondrial mass in the heart. 
  • Erythropoietin protects cardiac myocytes against anthracycline-induced apoptosis. 
  • Erythropoietin receptor expression in adult rat cardiomyocytes is associated with an acute cardioprotective effect for recombinant erythropoietin during ischemia-reperfusion injury. 
  • FGF12 is a candidate Brugada syndrome locus. 
  • FGF23 induces left ventricular hypertrophy. 
  • Feasibility of cardiac microimpedance measurement using multisite interstitial stimulation. 
  • Feedback-control induced pattern formation in cardiac myocytes: a mathematical modeling study. 
  • Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts. 
  • Fibroblast growth factor homologous factors in the heart: a potential locus for cardiac arrhythmias. 
  • Fibroblast growth factor homologous factors modulate cardiac calcium channels. 
  • Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration. 
  • Functional cardiac tissue engineering. 
  • GATA4 and the two sides of gene expression reprogramming. 
  • GRK2-mediated inhibition of adrenergic and dopaminergic signaling in right ventricular hypertrophy: therapeutic implications in pulmonary hypertension. 
  • Gender-specific patterns of left ventricular and myocyte remodeling following myocardial infarction in mice deficient in the angiotensin II type 1a receptor. 
  • Genetic engineering of somatic cells to study and improve cardiac function. 
  • Glycogen-branching enzyme deficiency leads to abnormal cardiac development: novel insights into glycogen storage disease IV. 
  • HASF (C3orf58) is a novel ligand of the insulin-like growth factor 1 receptor. 
  • HASF is a stem cell paracrine factor that activates PKC epsilon mediated cytoprotection. 
  • Hand2 elevates cardiomyocyte production during zebrafish heart development and regeneration. 
  • Harnessing the Power of Integrated Mitochondrial Biology and Physiology: A Special Report on the NHLBI Mitochondria in Heart Diseases Initiative. 
  • Heart regeneration in zebrafish. 
  • Help for the miffed heart. 
  • Heme Oxygenase-1/Carbon Monoxide System and Embryonic Stem Cell Differentiation and Maturation into Cardiomyocytes. 
  • Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1. 
  • Histologic and electron microscopy findings in myocardium of treated Fabry disease. 
  • Hypoxia decreases creatine uptake in cardiomyocytes, while creatine supplementation enhances HIF activation. 
  • Implantation of mouse embryonic stem cell-derived cardiac progenitor cells preserves function of infarcted murine hearts. 
  • In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration. 
  • Increased interstitial loading reduces the effect of microstructural variations in cardiac tissue. 
  • Induced pluripotent stem cell-derived cardiac progenitors differentiate to cardiomyocytes and form biosynthetic tissues. 
  • Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5. 
  • Inhibition of Wnt6 by Sfrp2 regulates adult cardiac progenitor cell differentiation by differential modulation of Wnt pathways. 
  • Inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase differentially regulates contractile function in cardiac myocytes from normotensive and spontaneously hypertensive rats: role of Ca2+ regulatory proteins. 
  • Inhibitor-kappaB kinase-beta regulates LPS-induced TNF-alpha production in cardiac myocytes through modulation of NF-kappaB p65 subunit phosphorylation. 
  • Inositol 1,4,5-trisphosphate receptor localization and stability in neonatal cardiomyocytes requires interaction with ankyrin-B. 
  • Interactions between extracellular stimuli and excitation waves in an atrial reentrant loop. 
  • Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy. 
  • Isoform specificity among ankyrins. An amphipathic alpha-helix in the divergent regulatory domain of ankyrin-b interacts with the molecular co-chaperone Hdj1/Hsp40. 
  • Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling. 
  • Junctophilin-2 is necessary for T-tubule maturation during mouse heart development. 
  • Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis. 
  • Leukocyte iNOS is required for inflammation and pathological remodeling in ischemic heart failure. 
  • Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis. 
  • Loading effect of fibroblast-myocyte coupling on resting potential, impulse propagation, and repolarization: insights from a microstructure model. 
  • Mechanical unloading promotes myocardial energy recovery in human heart failure. 
  • Mechanoelectrical excitation by fluid jets in monolayers of cultured cardiac myocytes. 
  • Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. 
  • Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation. 
  • Mesenchymal stem cells stimulate protective genetic reprogramming of injured cardiac ventricular myocytes. 
  • Metallic Nanoislands on Graphene as Highly Sensitive Transducers of Mechanical, Biological, and Optical Signals. 
  • Metallothionein abrogates GTP cyclohydrolase I inhibition-induced cardiac contractile and morphological defects: role of mitochondrial biogenesis. 
  • Metallothionein alleviates glutathione depletion-induced oxidative cardiomyopathy in murine hearts. 
  • Methodologies for Inducing Cardiac Injury and Assaying Regeneration in Adult Zebrafish. 
  • MicroRNA induced cardiac reprogramming in vivo: evidence for mature cardiac myocytes and improved cardiac function. 
  • MicroRNA-mediated in vitro and in vivo direct reprogramming of cardiac fibroblasts to cardiomyocytes. 
  • MicroRNAs and Cardiac Regeneration. 
  • Microscopic variations in interstitial and intracellular structure modulate the distribution of conduction delays and block in cardiac tissue with source-load mismatch. 
  • Modulation of conduction velocity by nonmyocytes in the low coupling regime. 
  • Modulation of tissue repair by regeneration enhancer elements. 
  • Molecular Mechanisms Linking Autonomic Dysfunction and Impaired Cardiac Contractility in Critical Illness. 
  • Multicolor mapping of the cardiomyocyte proliferation dynamics that construct the atrium. 
  • Muscle ring finger-3 protects against diabetic cardiomyopathy induced by a high fat diet. 
  • Mutation E169K in junctophilin-2 causes atrial fibrillation due to impaired RyR2 stabilization. 
  • Myocardial NF-κB activation is essential for zebrafish heart regeneration. 
  • Myocardial protection isn't dead yet. 
  • Myocardial volume and organization are changed by failure of addition of secondary heart field myocardium to the cardiac outflow tract. 
  • Na+ channel function, regulation, structure, trafficking and sequestration. 
  • Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes. 
  • Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration. 
  • Novel anisotropic engineered cardiac tissues: studies of electrical propagation. 
  • Novel micropatterned cardiac cell cultures with realistic ventricular microstructure. 
  • Novel--and "neu"--therapeutic possibilities for heart failure. 
  • Nox1 NADPH oxidase is necessary for late but not early myocardial ischaemic preconditioning. 
  • Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish. 
  • Nutrition Modulation of Cardiotoxicity and Anticancer Efficacy Related to Doxorubicin Chemotherapy by Glutamine and ω-3 Polyunsaturated Fatty Acids. 
  • Overexpression of TNNI3K, a cardiac-specific MAPKKK, promotes cardiac dysfunction. 
  • Overview of the Alliance for Cellular Signaling. 
  • Pacemaker-induced transient asynchrony suppresses heart failure progression. 
  • Paracrine mechanisms in adult stem cell signaling and therapy. 
  • Pathophysiology of the cardiorenal syndromes: executive summary from the eleventh consensus conference of the Acute Dialysis Quality Initiative (ADQI). 
  • Physiological Implications of Myocardial Scar Structure. 
  • Pinning down the CaMKII targets in the L-type Ca(2+) channel: an essential step in defining CaMKII regulation. 
  • Pluripotent stem cell-derived cardiac tissue patch with advanced structure and function. 
  • Pompe disease results in a Golgi-based glycosylation deficit in human induced pluripotent stem cell-derived cardiomyocytes. 
  • Pressure overload selectively up-regulates Ca2+/calmodulin-dependent protein kinase II in vivo. 
  • Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes. 
  • Quantifying electrical interactions between cardiomyocytes and other cells in micropatterned cell pairs. 
  • RNA-Mediated Reprogramming of Primary Adult Human Dermal Fibroblasts into c-kit(+) Cardiac Progenitor Cells. 
  • Rapid fusion between mesenchymal stem cells and cardiomyocytes yields electrically active, non-contractile hybrid cells. 
  • Rate-dependent propagation of cardiac action potentials in a one-dimensional fiber. 
  • Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin. 
  • Redirecting cardiac growth mechanisms for therapeutic regeneration. 
  • Reduced junctional Na+/Ca2+-exchanger activity contributes to sarcoplasmic reticulum Ca2+ leak in junctophilin-2-deficient mice. 
  • Reduction of cardiomyocyte S-nitrosylation by S-nitrosoglutathione reductase protects against sepsis-induced myocardial depression. 
  • Reflective interferometric chamber for quantitative phase imaging of biological sample dynamics. 
  • Regulation of cardiac nitric oxide signaling by nuclear β-adrenergic and endothelin receptors. 
  • Regulation of zebrafish heart regeneration by miR-133. 
  • Reiterative roles for FGF signaling in the establishment of size and proportion of the zebrafish heart. 
  • Relationship between extracellular T-wave height, T-wave alternans amplitude, and tissue action potential alternans: a 1-dimensional computer modeling study. 
  • Relaxin suppresses atrial fibrillation by reversing fibrosis and myocyte hypertrophy and increasing conduction velocity and sodium current in spontaneously hypertensive rat hearts. 
  • Relaxin suppresses atrial fibrillation in aged rats by reversing fibrosis and upregulating Na+ channels. 
  • Resolving Heart Regeneration by Replacement Histone Profiling. 
  • Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration. 
  • Robust T-tubulation and maturation of cardiomyocytes using tissue-engineered epicardial mimetics. 
  • S-Nitrosylation of Calcium-Handling Proteins in Cardiac Adrenergic Signaling and Hypertrophy. 
  • S-Nitrosylation of Sarcomeric Proteins Depresses Myofilament Ca2+)Sensitivity in Intact Cardiomyocytes. 
  • SCN5A variant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmia. 
  • SFRP2 regulates cardiomyogenic differentiation by inhibiting a positive transcriptional autofeedback loop of Wnt3a. 
  • SHP-2 is required for the maintenance of cardiac progenitors. 
  • SRC-2 coactivator deficiency decreases functional reserve in response to pressure overload of mouse heart. 
  • STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node. 
  • Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair. 
  • Selenium Augments microRNA Directed Reprogramming of Fibroblasts to Cardiomyocytes via Nanog. 
  • Simulated microgravity produces attenuated baroreflex-mediated pressor, chronotropic, and inotropic responses in mice. 
  • Single epicardial cell transcriptome sequencing identifies Caveolin 1 as an essential factor in zebrafish heart regeneration. 
  • Single-detector simultaneous optical mapping of V(m) and [Ca(2+)](i) in cardiac monolayers. 
  • Size and ionic currents of unexcitable cells coupled to cardiomyocytes distinctly modulate cardiac action potential shape and pacemaking activity in micropatterned cell pairs. 
  • Spatial profiles of electrical mismatch determine vulnerability to conduction failure across a host-donor cell interface. 
  • Spectral-domain differential interference contrast microscopy. 
  • Spectral-domain phase microscopy. 
  • Spectrin- and ankyrin-based membrane domains and the evolution of vertebrates. 
  • Stoichiometry of Gata4, Mef2c, and Tbx5 influences the efficiency and quality of induced cardiac myocyte reprogramming. 
  • Structural coupling of cardiomyocytes and noncardiomyocytes: quantitative comparisons using a novel micropatterned cell pair assay. 
  • Substrate specificities of g protein-coupled receptor kinase-2 and -3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function. 
  • Synergistic Efficacy from Gene Therapy with Coreceptor Blockade and a β2-Agonist in Murine Pompe Disease. 
  • Targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer in failing human hearts. 
  • Targeted expression of calmodulin increases ventricular cardiomyocyte proliferation and deoxyribonucleic acid synthesis during mouse development. 
  • The PDZ motif of the α1C subunit is not required for surface trafficking and adrenergic modulation of CaV1.2 channel in the heart. 
  • The biology of ST2: the International ST2 Consensus Panel. 
  • The extracellular matrix protein agrin promotes heart regeneration in mice. 
  • The glitter of gold: biolistic transfection of fresh adult cardiac myocytes. Focus on "normal targeting of a tagged Kv1.5 channel acutely transfected into fresh adult cardiac myocytes by a biolistic method". 
  • The neural crest in cardiac congenital anomalies. 
  • The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion. 
  • Tissue-engineered cardiac patch for advanced functional maturation of human ESC-derived cardiomyocytes. 
  • Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming. 
  • Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration. 
  • Treatment with the 3-ketoacyl-CoA thiolase inhibitor trimetazidine does not exacerbate whole-body insulin resistance in obese mice. 
  • Troglitazone stimulates beta-arrestin-dependent cardiomyocyte contractility via the angiotensin II type 1A receptor. 
  • Usefulness of frequent arrhythmias after epicardial recanalization in anterior wall acute myocardial infarction as a marker of cellular injury leading to poor recovery of left ventricular function. 
  • Viability assessment by delayed enhancement cardiovascular magnetic resonance: will low-dose dobutamine dull the shine? 
  • What happens when cardiac Na channels lose their function? 1--numerical studies of the vulnerable period in tissue expressing mutant channels. 
  • X-linked inhibitor of apoptosis protein-mediated attenuation of apoptosis, using a novel cardiac-enhanced adeno-associated viral vector. 
  • α1-Syntrophin Variant Identified in Drug-Induced Long QT Syndrome Increases Late Sodium Current. 
  • β-Adrenergic receptor antagonists ameliorate myocyte T-tubule remodeling following myocardial infarction. 
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  Keywords of People

  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Bursac, Nenad, Professor of Biomedical Engineering, Biomedical Engineering
  • Henriquez, Craig S., Professor of Biomedical Engineering, Pratt School of Engineering
  • Milano, Carmelo Alessio, Professor of Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
  • Starmer, Charles Franklin, Professor Emeritus of Computer Science, Computer Science