Myocytes, Smooth Muscle

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  Subject Areas on Research

  • A Tissue Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome Using Human iPSC-derived Smooth Muscle Cells. 
  • A device to study the effects of stretch gradients on cell behavior. 
  • A differential role for endocytosis in receptor-mediated activation of Nox1. 
  • A novel role for primary cilia in airway remodeling. 
  • A possible role for TRPV4 receptors in asthma. 
  • Activation of NADPH oxidase 1 increases intracellular calcium and migration of smooth muscle cells. 
  • Adhesion and function of human endothelial cells co-cultured on smooth muscle cells. 
  • Aldosterone increases oxidant stress to impair guanylyl cyclase activity by cysteinyl thiol oxidation in vascular smooth muscle cells. 
  • Aldosterone-induced activation of signaling pathways requires activity of angiotensin type 1a receptors. 
  • Allergic inflammation induces a persistent mechanistic switch in thromboxane-mediated airway constriction in the mouse. 
  • An oxidized extracellular oxidation-reduction state increases Nox1 expression and proliferation in vascular smooth muscle cells via epidermal growth factor receptor activation. 
  • Angiotensin II type 1A receptors in vascular smooth muscle cells do not influence aortic remodeling in hypertension. 
  • Arterial gene transfer of the TGF-beta signalling protein Smad3 induces adaptive remodelling following angioplasty: a role for CTGF. 
  • Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration. 
  • Biomechanical effects of flow and coculture on human aortic and cord blood-derived endothelial cells. 
  • Biomimetic hydrogels with pro-angiogenic properties. 
  • Blood pressure homeostasis is maintained by a P311-TGF-β axis. 
  • Blood pressure-associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding. 
  • Canonical transient receptor potential 3 channels activate NF-κB to mediate allergic airway disease via PKC-α/IκB-α and calcineurin/IκB-β pathways. 
  • Cell cycle-dependent regulation of smooth muscle cell activation. 
  • Comparison of mixed and lamellar coculture spatial arrangements for tissue engineering capillary networks in vitro. 
  • Covalently immobilized gradients of bFGF on hydrogel scaffolds for directed cell migration. 
  • Covalently immobilized platelet-derived growth factor-BB promotes angiogenesis in biomimetic poly(ethylene glycol) hydrogels. 
  • Cytokine activation of nuclear factor kappa B in vascular smooth muscle cells requires signaling endosomes containing Nox1 and ClC-3. 
  • Direct-contact co-culture between smooth muscle and endothelial cells inhibits TNF-alpha-mediated endothelial cell activation. 
  • Distinct function of estrogen receptor α in smooth muscle and fibroblast cells in prostate development. 
  • Distribution of shear stress over smooth muscle cells in deformable arterial wall. 
  • Drebrin regulates angiotensin II-induced aortic remodelling. 
  • Dynamics of smooth muscle cell deadhesion from thermosensitive hydroxybutyl chitosan. 
  • Effect of the shape and configuration of smooth muscle cells on the diffusion of ATP through the arterial wall. 
  • Effects of plasminogen activator inhibitor-1-specific RNA aptamers on cell adhesion, motility, and tube formation. 
  • Electrical stimulation of gut motility guided by an in silico model. 
  • Endoglin Mediates Vascular Maturation by Promoting Vascular Smooth Muscle Cell Migration and Spreading. 
  • Endothelial Bmp4 is induced during arterial remodeling: effects on smooth muscle cell migration and proliferation. 
  • Epigenetic regulation of COL15A1 in smooth muscle cell replicative aging and atherosclerosis. 
  • Evaluation of Poly (Carbonate-Urethane) Urea (PCUU) Scaffolds for Urinary Bladder Tissue Engineering. 
  • Fetal-derived adrenomedullin mediates the innate immune milieu of the placenta. 
  • Fibroblast growth factor 23 is not associated with and does not induce arterial calcification. 
  • Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor. 
  • G-Protein-Coupled Receptors in Heart Disease. 
  • Giant Intracardiac Smooth-Muscle Cell Tumor Presenting as Superior Vena Cava Syndrome. 
  • Graft-extrinsic cells predominate in vein graft arterialization. 
  • High-dose, but not low-dose, aspirin impairs anticontractile effect of ticagrelor following ADP stimulation in rat tail artery smooth muscle cells. 
  • High-throughput screening for modulators of cellular contractile force. 
  • Human arteries engineered in vitro. 
  • Human immunodeficiency virus (HIV) infects human arterial smooth muscle cells in vivo and in vitro: implications for the pathogenesis of HIV-mediated vascular disease. 
  • Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation. 
  • Increased expression of Nox1 in neointimal smooth muscle cells promotes activation of matrix metalloproteinase-9. 
  • Increased vascular smooth muscle contractility in TRPC6-/- mice. 
  • Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor. 
  • Inhibition of EGFR signaling abrogates smooth muscle proliferation resulting from sustained distension of the urinary bladder. 
  • Intracellular calcium transients are necessary for platelet-derived growth factor but not extracellular matrix protein-induced vascular smooth muscle cell migration. 
  • Kalirin promotes neointimal hyperplasia by activating Rac in smooth muscle cells. 
  • Kruppel-like factor 15 is critical for vascular inflammation. 
  • Laminar shear stress stimulates vascular smooth muscle cell apoptosis via the Akt pathway. 
  • Magnetoactive sponges for dynamic control of microfluidic flow patterns in microphysiological systems. 
  • Mechanical stretch is a highly selective regulator of gene expression in human bladder smooth muscle cells. 
  • MicroRNA-145 restores contractile vascular smooth muscle phenotype and coronary collateral growth in the metabolic syndrome. 
  • Mitochondrial GLUT10 facilitates dehydroascorbic acid import and protects cells against oxidative stress: mechanistic insight into arterial tortuosity syndrome. 
  • Nitric oxide-generating hydrogels inhibit neointima formation. 
  • Novel heparanase-inhibiting antibody reduces neointima formation. 
  • Nox1 transactivation of epidermal growth factor receptor promotes N-cadherin shedding and smooth muscle cell migration. 
  • Nox4 NADPH oxidase contributes to smooth muscle cell phenotypes associated with unstable atherosclerotic plaques. 
  • Nox4 mediates TGF-beta1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cells. 
  • Orchestrating Airway Smooth Muscle Cell Migration: GMFγ Phosphorylation Is the Key. 
  • Overexpression of G protein-coupled receptor kinase-2 in smooth muscle cells reduces neointimal hyperplasia. 
  • Phosphorylation of Nox1 regulates association with NoxA1 activation domain. 
  • Physiologic pulsatile flow bioreactor conditioning of poly(ethylene glycol)-based tissue engineered vascular grafts. 
  • Porcine endothelial cells cocultured with smooth muscle cells became procoagulant in vitro. 
  • Preparing for the first breath: genetic and cellular mechanisms in lung development. 
  • Rapid identification of cell-specific, internalizing RNA aptamers with bioinformatics analyses of a cell-based aptamer selection. 
  • Readily available tissue-engineered vascular grafts. 
  • Redox Activation of Nox1 (NADPH Oxidase 1) Involves an Intermolecular Disulfide Bond Between Protein Disulfide Isomerase and p47phox in Vascular Smooth Muscle Cells. 
  • Regulation of endotoxin-induced proinflammatory activation in human coronary artery cells: expression of functional membrane-bound CD14 by human coronary artery smooth muscle cells. 
  • Relevance and safety of telomerase for human tissue engineering. 
  • Smooth Muscle Cell-targeted RNA Aptamer Inhibits Neointimal Formation. 
  • Smooth muscle cell signal transduction: implications of vascular biology for vascular surgeons. 
  • Statins and nitric oxide donors affect thrombospondin 1-induced chemotaxis. 
  • Stem cell factor and c-kit are expressed by and may affect vascular SMCs through an autocrine pathway. 
  • Study of gastric fluid induced cytokine and chemokine expression in airway smooth muscle cells and airway remodeling. 
  • Targeted HAS2 Expression Lessens Airway Responsiveness in Chronic Murine Allergic Airway Disease. 
  • The Actin-Binding Protein Drebrin Inhibits Neointimal Hyperplasia. 
  • The effect of enzymatically degradable poly(ethylene glycol) hydrogels on smooth muscle cell phenotype. 
  • The effects of nicotine on vascular smooth muscle cell chemotaxis induced by thrombospondin-1 and fibronectin. 
  • The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome. 
  • The study of wall deformation and flow distribution with transmural pressure by three-dimensional model of thoracic aorta wall. 
  • The use of micropatterning to control smooth muscle myosin heavy chain expression and limit the response to transforming growth factor β1 in vascular smooth muscle cells. 
  • Three linked vasculopathic processes characterize Kawasaki disease: a light and transmission electron microscopic study. 
  • Thromboxane receptors in smooth muscle promote hypertension, vascular remodeling, and sudden death. 
  • Transdifferentiation of human endothelial progenitors into smooth muscle cells. 
  • Type I collagen synergistically enhances PDGF-induced smooth muscle cell proliferation through pp60src-dependent crosstalk between the alpha2beta1 integrin and PDGFbeta receptor. 
  • USP20 (Ubiquitin-Specific Protease 20) Inhibits TNF (Tumor Necrosis Factor)-Triggered Smooth Muscle Cell Inflammation and Attenuates Atherosclerosis. 
  • Upregulation of osmo-mechanosensitive TRPV4 channel facilitates chronic hypoxia-induced myogenic tone and pulmonary hypertension. 
  • Val-ala-pro-gly, an elastin-derived non-integrin ligand: smooth muscle cell adhesion and specificity. 
  • Vascular Type 1A Angiotensin II Receptors Control BP by Regulating Renal Blood Flow and Urinary Sodium Excretion. 
  • Vascular smooth muscle cell migration induced by domains of thrombospondin-1 is differentially regulated. 
  • Vascular type 1 angiotensin receptors control blood pressure by augmenting peripheral vascular resistance in female mice. 
  • {beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation. 
  • β-Arrestin regulation of myosin light chain phosphorylation promotes AT1aR-mediated cell contraction and migration.