Iron-Binding Proteins

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  Subject Areas on Research

  • A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway. 
  • Altered gene expression and DNA damage in peripheral blood cells from Friedreich's ataxia patients: cellular model of pathology. 
  • Analysis of the E399D mutation in SLC11A2. 
  • Borate as a synergistic anion for Marinobacter algicola ferric binding protein, FbpA: a role for boron in iron transport in marine life. 
  • Bordetella pertussis FbpA binds both unchelated iron and iron siderophore complexes. 
  • Cloning, sequencing, and recombinant expression of the porcine inhibitor of carbonic anhydrase: a novel member of the transferrin family. 
  • DMT1 expression is increased in the lungs of hypotransferrinemic mice. 
  • Divalent metal transporter-1 decreases metal-related injury in the lung. 
  • Enhanced mobilization of iron from body stores in malnourished patients during intravenous nutritional support. 
  • Expression of stimulator of Fe transport is not enhanced in Hfe knockout mice. 
  • Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders. 
  • Ga3+ as a mechanistic probe in Fe3+ transport: characterization of Ga3+ interaction with FbpA. 
  • Genes that modify the hemochromatosis phenotype in mice. 
  • Increased leptin levels correlate with thyroid autoantibodies in nonobese males. 
  • Iron homeostasis in the lung. 
  • Iron is hot: an update on the pathophysiology of hemochromatosis. 
  • Iron metabolism in mice with partial frataxin deficiency. 
  • Iron transport across biologic membranes. 
  • Iron uptake and Nramp2/DMT1/DCT1 in human bronchial epithelial cells. 
  • Iron-dependent regulation of the divalent metal ion transporter. 
  • Isolation, purification and characterization of an iron-binding protein from the horseshoe crab (Limulus polyphemus). 
  • Kinetics and mechanism of exogenous anion exchange in FeFbpA-NTA: significance of periplasmic anion lability and anion binding activity of ferric binding protein A. 
  • Kinetics and mechanism of iron release from the bacterial ferric binding protein nFbp: exogenous anion influence and comparison with mammalian transferrin. 
  • Kinetics and mechanism of iron(III) complexation by ferric binding protein: the role of phosphate. 
  • Kinetics of iron release from ferric binding protein (FbpA): mechanistic implications in bacterial periplasm-to-cytosol Fe3+ transport. 
  • Mammalian iron transport: an unexpected link between metal homeostasis and host defense. 
  • Metabolic capacity regulates iron homeostasis in endothelial cells. 
  • Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. 
  • Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. 
  • Periconceptional changes in thyroid function: a longitudinal study. 
  • Progressive mitochondrial protein lysine acetylation and heart failure in a model of Friedreich's ataxia cardiomyopathy. 
  • Role of citrate and phosphate anions in the mechanism of iron(III) sequestration by ferric binding protein: kinetic studies of the formation of the holoprotein of wild-type FbpA and its engineered mutants. 
  • Scara5 is a ferritin receptor mediating non-transferrin iron delivery. 
  • Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver. 
  • TNF, IFN-gamma, and endotoxin increase expression of DMT1 in bronchial epithelial cells. 
  • The G185R mutation disrupts function of the iron transporter Nramp2. 
  • The Nramp2/DMT1 iron transporter is induced in the duodenum of microcytic anemia mk mice but is not properly targeted to the intestinal brush border. 
  • The iron cycle and oxidative stress in the lung. 
  • The iron transporter DMT1.