Vesicular Transport Proteins
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Subject Areas on Research
- A conserved sorting-associated protein is mutant in chorea-acanthocytosis.
- A genome-wide association study of intra-ocular pressure suggests a novel association in the gene FAM125B in the TwinsUK cohort.
- A genome-wide visual screen reveals a role for sphingolipids and ergosterol in cell surface delivery in yeast.
- A neuronal Sec1 homolog regulates neurotransmitter release at the squid giant synapse.
- ARFGAP1 plays a central role in coupling COPI cargo sorting with vesicle formation.
- Abl interactor 1 (Abi-1) wave-binding and SNARE domains regulate its nucleocytoplasmic shuttling, lamellipodium localization, and wave-1 levels.
- Activation of RalA is critical for Ras-induced tumorigenesis of human cells.
- Amino acid permeases require COPII components and the ER resident membrane protein Shr3p for packaging into transport vesicles in vitro.
- An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype.
- Association of the missense variant p.Arg203Trp in PACS1 as a cause of intellectual disability and seizures.
- Autoimmunity to munc-18 in Rasmussen's encephalitis.
- Binding of the beta2 adrenergic receptor to N-ethylmaleimide-sensitive factor regulates receptor recycling.
- COPII-cargo interactions direct protein sorting into ER-derived transport vesicles.
- Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis.
- Calcium- and zinc-binding proteins in intracellular transport.
- Collaboration between Distinct Rab Small GTPase Trafficking Circuits Mediates Bacterial Clearance from the Bladder Epithelium.
- Constitutive internalization of the leucine-rich G protein-coupled receptor-5 (LGR5) to the trans-Golgi network.
- Coupling calcium to SNARE-mediated synaptic vesicle fusion.
- Differential regulation of exocytosis by alpha- and beta-SNAPs.
- Disruption of lysosome function promotes tumor growth and metastasis in Drosophila.
- Disruption of syntaxin-mediated protein interactions blocks neurotransmitter secretion.
- Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane.
- Dynamic Glycosylation Governs the Vertebrate COPII Protein Trafficking Pathway.
- Efficient Tor signaling requires a functional class C Vps protein complex in Saccharomyces cerevisiae.
- Endolysosomal membrane trafficking complexes drive nutrient-dependent TORC1 signaling to control cell growth in Saccharomyces cerevisiae.
- Essential roles of class E Vps proteins for sorting into multivesicular bodies in Schizosaccharomyces pombe.
- Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.
- Genome-wide association study of primary open-angle glaucoma in continental and admixed African populations.
- HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes.
- Identification of NSF as a beta-arrestin1-binding protein. Implications for beta2-adrenergic receptor regulation.
- In vivo dynamics of clathrin and its adaptor-dependent recruitment to the actin-based endocytic machinery in yeast.
- Metabolic-stress-induced rearrangement of the 14-3-3ζ interactome promotes autophagy via a ULK1- and AMPK-regulated 14-3-3ζ interaction with phosphorylated Atg9.
- Nuclear translocation of Gln3 in response to nutrient signals requires Golgi-to-endosome trafficking in Saccharomyces cerevisiae.
- PKA/AKAP1 and PP2A/Bβ2 regulate neuronal morphogenesis via Drp1 phosphorylation and mitochondrial bioenergetics.
- Prognostic and predictive blood-based biomarkers in patients with advanced pancreatic cancer: results from CALGB80303 (Alliance).
- Protein kinase-zeta interacts with munc18c: role in GLUT4 trafficking.
- Rabphilin-3A: a multifunctional regulator of synaptic vesicle traffic.
- Recurrent de novo mutations in PACS1 cause defective cranial-neural-crest migration and define a recognizable intellectual-disability syndrome.
- Regulation of neurotransmitter release kinetics by NSF.
- SNAP-mediated protein-protein interactions essential for neurotransmitter release.
- SNARE complex oligomerization by synaphin/complexin is essential for synaptic vesicle exocytosis.
- SNARE proteins and the timing of neurotransmitter release.
- Saccharomyces cerevisiae mutants altered in vacuole function are defective in copper detoxification and iron-responsive gene transcription.
- Schizosaccharomyces pombe Sst4p, a conserved Vps27/Hrs homolog, functions downstream of phosphatidylinositol 3-kinase Pik3p to mediate proper spore formation.
- Sec5 and Exo84 foster oncogenic ras-mediated tumorigenesis.
- Snare protein expression and adenoviral transfection of amphicrine AR42J.
- Sorting nexin homologues are targets of phosphatidylinositol 3-phosphate in sporulation of Schizosaccharomyces pombe.
- Specificity and regulation of a synaptic vesicle docking complex.
- Structures of yeast vesicle trafficking proteins.
- TLR4-mediated expulsion of bacteria from infected bladder epithelial cells.
- The vesicular glutamate transporter 1 (xVGlut1) is expressed in discrete regions of the developing Xenopus laevis nervous system.
- Trafficking of the vesicular acetylcholine transporter in SN56 cells: a dynamin-sensitive step and interaction with the AP-2 adaptor complex.
- WLS retrograde transport to the endoplasmic reticulum during Wnt secretion.
- [Potential role of presenilin 1 in regulation of synaptic function].
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Keywords of People
- Gunn, Michael Dee, Professor of Medicine, Immunology
- Kuehn, Margarethe Joanna, Associate Professor of Biochemistry, Molecular Genetics and Microbiology