Vesicular Transport Proteins

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  Subject Areas on Research

  • A conserved sorting-associated protein is mutant in chorea-acanthocytosis. 
  • A genome-wide association study of intra-ocular pressure suggests a novel association in the gene FAM125B in the TwinsUK cohort. 
  • A genome-wide visual screen reveals a role for sphingolipids and ergosterol in cell surface delivery in yeast. 
  • A relatively common homozygous TRAPPC4 splicing variant is associated with an early-infantile neurodegenerative syndrome. 
  • Abl interactor 1 (Abi-1) wave-binding and SNARE domains regulate its nucleocytoplasmic shuttling, lamellipodium localization, and wave-1 levels. 
  • Activation of RalA is critical for Ras-induced tumorigenesis of human cells. 
  • Amino acid permeases require COPII components and the ER resident membrane protein Shr3p for packaging into transport vesicles in vitro. 
  • An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype. 
  • Association of the missense variant p.Arg203Trp in PACS1 as a cause of intellectual disability and seizures. 
  • Autoimmunity to munc-18 in Rasmussen's encephalitis. 
  • Binding of the beta2 adrenergic receptor to N-ethylmaleimide-sensitive factor regulates receptor recycling. 
  • COPII-cargo interactions direct protein sorting into ER-derived transport vesicles. 
  • Collaboration between Distinct Rab Small GTPase Trafficking Circuits Mediates Bacterial Clearance from the Bladder Epithelium. 
  • Constitutive internalization of the leucine-rich G protein-coupled receptor-5 (LGR5) to the trans-Golgi network. 
  • Disruption of lysosome function promotes tumor growth and metastasis in Drosophila. 
  • Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane. 
  • Dynamic Glycosylation Governs the Vertebrate COPII Protein Trafficking Pathway. 
  • Efficient Tor signaling requires a functional class C Vps protein complex in Saccharomyces cerevisiae. 
  • Endolysosomal membrane trafficking complexes drive nutrient-dependent TORC1 signaling to control cell growth in Saccharomyces cerevisiae. 
  • Essential roles of class E Vps proteins for sorting into multivesicular bodies in Schizosaccharomyces pombe. 
  • Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels. 
  • Genome-wide association study of primary open-angle glaucoma in continental and admixed African populations. 
  • HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes. 
  • Identification of NSF as a beta-arrestin1-binding protein. Implications for beta2-adrenergic receptor regulation. 
  • In vivo dynamics of clathrin and its adaptor-dependent recruitment to the actin-based endocytic machinery in yeast. 
  • Metabolic-stress-induced rearrangement of the 14-3-3ζ interactome promotes autophagy via a ULK1- and AMPK-regulated 14-3-3ζ interaction with phosphorylated Atg9. 
  • Multiple Surface Regions on the Niemann-Pick C2 Protein Facilitate Intracellular Cholesterol Transport. 
  • Nuclear translocation of Gln3 in response to nutrient signals requires Golgi-to-endosome trafficking in Saccharomyces cerevisiae. 
  • Prognostic and predictive blood-based biomarkers in patients with advanced pancreatic cancer: results from CALGB80303 (Alliance). 
  • Protein kinase-zeta interacts with munc18c: role in GLUT4 trafficking. 
  • Role of Arf-like proteins (Arl1 and Arl2) of Mucor circinelloides in virulence and antifungal susceptibility. 
  • Schizosaccharomyces pombe Sst4p, a conserved Vps27/Hrs homolog, functions downstream of phosphatidylinositol 3-kinase Pik3p to mediate proper spore formation. 
  • Sec5 and Exo84 foster oncogenic ras-mediated tumorigenesis. 
  • Selective inhibition of protein secretion by abrogating receptor-coat interactions during ER export. 
  • Snare protein expression and adenoviral transfection of amphicrine AR42J. 
  • Sorting nexin homologues are targets of phosphatidylinositol 3-phosphate in sporulation of Schizosaccharomyces pombe. 
  • Specificity and regulation of a synaptic vesicle docking complex. 
  • Structures of yeast vesicle trafficking proteins. 
  • TLR4-mediated expulsion of bacteria from infected bladder epithelial cells. 
  • The integrity of a cholesterol-binding pocket in Niemann-Pick C2 protein is necessary to control lysosome cholesterol levels. 
  • The vesicular glutamate transporter 1 (xVGlut1) is expressed in discrete regions of the developing Xenopus laevis nervous system. 
  • WLS retrograde transport to the endoplasmic reticulum during Wnt secretion. 
  • [Potential role of presenilin 1 in regulation of synaptic function]. 
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  Keywords of People

  • Gunn, Michael Dee, Professor of Medicine, Immunology
  • Kuehn, Margarethe Joanna, Associate Professor of Biochemistry, Molecular Genetics and Microbiology