Telomere-Binding Proteins
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Subject Areas on Research
- Dependence of the regulation of telomere length on the type of subtelomeric repeat in the yeast Saccharomyces cerevisiae.
- Distinct functions of POT1 at telomeres.
- Distinguishing direct versus indirect transcription factor-DNA interactions.
- Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans.
- Germline mutations in shelterin complex genes are associated with familial glioma.
- Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.
- Inner nuclear envelope proteins SUN1 and SUN2 play a prominent role in the DNA damage response.
- Integrated pathway and epistasis analysis reveals interactive effect of genetic variants at TERF1 and AFAP1L2 loci on melanoma risk.
- KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development.
- Loss of hPot1 function leads to telomere instability and a cut-like phenotype.
- Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis.
- POT1 association with TRF2 regulates telomere length.
- Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1.
- Resequencing Study Confirms That Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis.
- SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice.
- SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice.
- Software for lattice light-sheet imaging of FRET biosensors, illustrated with a new Rap1 biosensor.
- Tethering telomeric double- and single-stranded DNA-binding proteins inhibits telomere elongation.
- The compact chromatin structure of a Ty repeated sequence suppresses recombination hotspot activity in Saccharomyces cerevisiae.
- The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells.
- The tor pathway regulates gene expression by linking nutrient sensing to histone acetylation.
- Utility of telomerase-pot1 fusion protein in vascular tissue engineering.
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Keywords of People
- Gordan, Raluca Mihaela, Associate Professor in Biostatistics & Bioinformatics, Computer Science