Telomere-Binding Proteins

• 

  Subject Areas on Research

  • Cell cycle regulated phosphorylation of the telomere-associated protein TIN2. 
  • Dependence of the regulation of telomere length on the type of subtelomeric repeat in the yeast Saccharomyces cerevisiae. 
  • Distinct functions of POT1 at telomeres. 
  • Distinguishing direct versus indirect transcription factor-DNA interactions. 
  • Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans. 
  • Germline mutations in shelterin complex genes are associated with familial glioma. 
  • Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer. 
  • Inner nuclear envelope proteins SUN1 and SUN2 play a prominent role in the DNA damage response. 
  • Integrated pathway and epistasis analysis reveals interactive effect of genetic variants at TERF1 and AFAP1L2 loci on melanoma risk. 
  • KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development. 
  • Loss of hPot1 function leads to telomere instability and a cut-like phenotype. 
  • Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis. 
  • POT1 association with TRF2 regulates telomere length. 
  • RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome. 
  • Rap1 acts via multiple mechanisms to position Canoe and adherens junctions and mediate apical-basal polarity establishment. 
  • Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1. 
  • SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice. 
  • SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. 
  • Tethering telomeric double- and single-stranded DNA-binding proteins inhibits telomere elongation. 
  • The compact chromatin structure of a Ty repeated sequence suppresses recombination hotspot activity in Saccharomyces cerevisiae. 
  • The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells. 
  • The tor pathway regulates gene expression by linking nutrient sensing to histone acetylation. 
  • Utility of telomerase-pot1 fusion protein in vascular tissue engineering. 
• 

  Keywords of People

  • Gordan, Raluca Mihaela, Associate Professor in Biostatistics & Bioinformatics, Molecular Genetics and Microbiology