RNA Interference

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  Subject Areas on Research

  • A Multivariate Computational Method to Analyze High-Content RNAi Screening Data. 
  • A RNA interference screen identifies RIP3 as an essential inducer of TNF-induced programmed necrosis. 
  • A case study of the reproducibility of transcriptional reporter cell-based RNAi screens in Drosophila. 
  • A direct HDAC4-MAP kinase crosstalk activates muscle atrophy program. 
  • A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. 
  • A genome-wide RNAi screen reveals multiple regulators of caspase activation. 
  • A kinome RNAi screen identified AMPK as promoting poxvirus entry through the control of actin dynamics. 
  • A loss-of-function RNA interference screen for molecular targets in cancer. 
  • A molecular basis for inositol polyphosphate synthesis in Drosophila melanogaster. 
  • A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53. 
  • A non-canonical RNA degradation pathway suppresses RNAi-dependent epimutations in the human fungal pathogen Mucor circinelloides. 
  • A non-canonical RNAi pathway controls virulence and genome stability in Mucorales. 
  • A novel function of VCP (valosin-containing protein; p97) in the control of N-glycosylation of proteins in the endoplasmic reticulum. 
  • A novel human endogenous retroviral protein inhibits cell-cell fusion. 
  • A novel receptor function for the heat shock protein Grp78: silencing of Grp78 gene expression attenuates alpha2M*-induced signalling. 
  • A novel role for XIAP in copper homeostasis through regulation of MURR1. 
  • A physical interaction network of dengue virus and human proteins. 
  • A role for rat inositol polyphosphate kinases rIPK2 and rIPK1 in inositol pentakisphosphate and inositol hexakisphosphate production in rat-1 cells. 
  • A small molecule inhibitor of alpha4 integrin-dependent cell migration. 
  • A truncated progesterone receptor (PR-M) localizes to the mitochondrion and controls cellular respiration. 
  • AAV exploits subcellular stress associated with inflammation, endoplasmic reticulum expansion, and misfolded proteins in models of cystic fibrosis. 
  • ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory. 
  • ARID1A-mutated ovarian cancers depend on HDAC6 activity. 
  • ATM functions at the peroxisome to induce pexophagy in response to ROS. 
  • Abi3bp regulates cardiac progenitor cell proliferation and differentiation. 
  • Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease. 
  • Activation of Nrf2 Is Required for Normal and ChREBPα-Augmented Glucose-Stimulated β-Cell Proliferation. 
  • Activation of Rap1 promotes prostate cancer metastasis. 
  • Acute ablation of survivin uncovers p53-dependent mitotic checkpoint functions and control of mitochondrial apoptosis. 
  • Adeno-associated virus-mediated ILK gene silencing in the rat NAc core. 
  • Afatinib induces apoptosis in NSCLC without EGFR mutation through Elk-1-mediated suppression of CIP2A. 
  • Agonist-activated glucagon receptors are deubiquitinated at early endosomes by two distinct deubiquitinases to facilitate Rab4a-dependent recycling. 
  • Aldosterone-induced activation of signaling pathways requires activity of angiotensin type 1a receptors. 
  • Alteration of the alkaloid profile in genetically modified tobacco reveals a role of methylenetetrahydrofolate reductase in nicotine N-demethylation. 
  • Alternative Splicing of Rice WRKY62 and WRKY76 Transcription Factor Genes in Pathogen Defense. 
  • An aberrant transcription factor network essential for Wnt signaling and stem cell maintenance in glioblastoma. 
  • An adenovirus vector for efficient RNA interference-mediated suppression of target genes in insulinoma cells and pancreatic islets of langerhans. 
  • An alternative and effective HIV vaccination approach based on inhibition of antigen presentation attenuators in dendritic cells. 
  • An atypical RNA polymerase involved in RNA silencing shares small subunits with RNA polymerase II. 
  • An image-based RNAi screen identifies SH3BP1 as a key effector of Semaphorin 3E-PlexinD1 signaling. 
  • An integrative approach identified genes associated with drug response in gastric cancer. 
  • Analogs of tetrahydroisoquinoline natural products that inhibit cell migration and target galectin-3 outside of its carbohydrate-binding site. 
  • Analysis of tumor environmental response and oncogenic pathway activation identifies distinct basal and luminal features in HER2-related breast tumor subtypes. 
  • Androgens promote prostate cancer cell growth through induction of autophagy. 
  • Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch. 
  • Antifungal drug resistance evoked via RNAi-dependent epimutations. 
  • Antisense inhibitors, ribozymes, and siRNAs. 
  • Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor. 
  • Application of an optimized annotation pipeline to the Cryptococcus deuterogattii genome reveals dynamic primary metabolic gene clusters and genomic impact of RNAi loss. 
  • Applications of RNA interference high-throughput screening technology in cancer biology and virology. 
  • Applications of high-throughput RNA interference screens to problems in cell and developmental biology. 
  • Aptamer-mediated delivery of splice-switching oligonucleotides to the nuclei of cancer cells. 
  • Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology. 
  • Autophagy inhibitor Vacuolin-1 interferes with lipid-based small interference RNA delivery. 
  • Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide. 
  • Aven-dependent activation of ATM following DNA damage. 
  • BPIFB3 Regulates Endoplasmic Reticulum Morphology To Facilitate Flavivirus Replication. 
  • BPIFB6 Regulates Secretory Pathway Trafficking and Enterovirus Replication. 
  • BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function. 
  • Beta-arrestin-mediated localization of smoothened to the primary cilium. 
  • Broad antifungal resistance mediated by RNAi-dependent epimutation in the basal human fungal pathogen Mucor circinelloides. 
  • CCDC62/ERAP75 functions as a coactivator to enhance estrogen receptor beta-mediated transactivation and target gene expression in prostate cancer cells. 
  • CD30 activates both the canonical and alternative NF-kappaB pathways in anaplastic large cell lymphoma cells. 
  • CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1. 
  • CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. 
  • CK1epsilon is required for breast cancers dependent on beta-catenin activity. 
  • CNS myelin wrapping is driven by actin disassembly. 
  • Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin. 
  • Canonical Wnt signaling induces vascular endothelial dysfunction via p66Shc-regulated reactive oxygen species. 
  • Cardiac myocyte p38α kinase regulates angiogenesis via myocyte-endothelial cell cross-talk during stress-induced remodeling in the heart. 
  • Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis. 
  • Cell-internalization SELEX: method for identifying cell-internalizing RNA aptamers for delivering siRNAs to target cells. 
  • Cell-type-specific repression of internal ribosome entry site activity by double-stranded RNA-binding protein 76. 
  • Cellular FLIP Inhibits Myeloid Cell Activation by Suppressing Selective Innate Signaling. 
  • Cellular fatty acid synthase is required for late stages of HIV-1 replication. 
  • Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis. 
  • Ceramide mediates nanovesicle shedding and cell death in response to phosphatidylinositol ether lipid analogs and perifosine. 
  • Chaperone-mediated 26S proteasome remodeling facilitates free K63 ubiquitin chain production and aggresome clearance. 
  • Characterizing the role of RNA silencing components in Cryptococcus neoformans. 
  • Chondrocyte transport and concentration of ascorbic acid is mediated by SVCT2. 
  • Chromatin-associated HMG-17 is a major regulator of homeodomain transcription factor activity modulated by Wnt/beta-catenin signaling. 
  • Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas. 
  • Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors. 
  • Codon bias imposes a targetable limitation on KRAS-driven therapeutic resistance. 
  • Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1. 
  • Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease. 
  • Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation. 
  • Critical issues in delivery of RNAi therapeutics in vivo. 
  • Critical role of the tumor suppressor tuberous sclerosis complex 1 in dendritic cell activation of CD4 T cells by promoting MHC class II expression via IRF4 and CIITA. 
  • Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2. 
  • DEPDC1/LET-99 participates in an evolutionarily conserved pathway for anti-tubulin drug-induced apoptosis. 
  • DNA adducts of decarbamoyl mitomycin C efficiently kill cells without wild-type p53 resulting from proteasome-mediated degradation of checkpoint protein 1. 
  • Deciphering the mechanisms of tumorigenesis in human pancreatic ductal epithelial cells. 
  • Dehydroascorbate transport in human chondrocytes is regulated by hypoxia and is a physiologically relevant source of ascorbic acid in the joint. 
  • Delivery of chemo-sensitizing siRNAs to HER2+-breast cancer cells using RNA aptamers. 
  • Demethylation of H3K27 Is Essential for the Induction of Direct Cardiac Reprogramming by miR Combo. 
  • Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis. 
  • Design and implementation of high-throughput RNAi screens in cultured Drosophila cells. 
  • Destabilization of the VCP-Ufd1-Npl4 complex is associated with decreased levels of ERAD substrates. 
  • Diacetyl induces amphiregulin shedding in pulmonary epithelial cells and in experimental bronchiolitis obliterans. 
  • Differential and complementary effects of glucose and prolactin on islet DNA synthesis and gene expression. 
  • Differential expression of intracellular and secreted osteopontin isoforms by murine macrophages in response to toll-like receptor agonists. 
  • Differentially Expressed miRNAs in Hepatocellular Carcinoma Target Genes in the Genetic Information Processing and Metabolism Pathways. 
  • Diminished acyl-CoA synthetase isoform 4 activity in INS 832/13 cells reduces cellular epoxyeicosatrienoic acid levels and results in impaired glucose-stimulated insulin secretion. 
  • Disruption of lysosome function promotes tumor growth and metastasis in Drosophila. 
  • Distinct properties of cell-type-specific and shared transcription factor binding sites. 
  • Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic β cell fate in response to cytokines. 
  • Do-it-yourself RNAi made easy? 
  • Drosophila genome-wide RNAi screens: are they delivering the promise? 
  • Drug-Resistant Epimutants Exhibit Organ-Specific Stability and Induction during Murine Infections Caused by the Human Fungal Pathogen Mucor circinelloides. 
  • Drug-target identification in Drosophila cells: combining high-throughout RNAi and small-molecule screens. 
  • Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis. 
  • Dynamic loading and redistribution of the Mcm2-7 helicase complex through the cell cycle. 
  • EZH2 regulates the transcription of estrogen-responsive genes through association with REA, an estrogen receptor corepressor. 
  • Efficacy of BET bromodomain inhibition in Kras-mutant non-small cell lung cancer. 
  • Elevated PTH induces endothelial-to-chondrogenic transition in aortic endothelial cells. 
  • Elucidation of the functions of genes central to diterpene metabolism in tobacco trichomes using posttranscriptional gene silencing. 
  • Endoglin Mediates Vascular Maturation by Promoting Vascular Smooth Muscle Cell Migration and Spreading. 
  • Enhancement of Outflow Facility in the Murine Eye by Targeting Selected Tight-Junctions of Schlemm's Canal Endothelia. 
  • Epidermal growth factor receptor signaling promotes metastatic prostate cancer through microRNA-96-mediated downregulation of the tumor suppressor ETV6. 
  • Epigenetic regulation of CD8(+) T-lymphocyte mediated suppression of HIV-1 replication. 
  • Epigenetic regulator BMI1 promotes alveolar rhabdomyosarcoma proliferation and constitutes a novel therapeutic target. 
  • Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer. 
  • Error-prone polyploid mitosis during normal Drosophila development. 
  • Erythropoietin activates mitochondrial biogenesis and couples red cell mass to mitochondrial mass in the heart. 
  • Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation. 
  • Evidence for a pro-proliferative feedback loop in prostate cancer: the role of Epac1 and COX-2-dependent pathways. 
  • Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays. 
  • Exome sequencing reveals recurrent REV3L mutations in cisplatin-resistant squamous cell carcinoma of head and neck. 
  • Expression in aneuploid Drosophila S2 cells. 
  • FBW2 targets GCMa to the ubiquitin-proteasome degradation system. 
  • FKF1 F-box protein mediates cyclic degradation of a repressor of CONSTANS in Arabidopsis 
  • FRA1 promotes squamous cell carcinoma growth and metastasis through distinct AKT and c-Jun dependent mechanisms. 
  • Fatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death. 
  • Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts. 
  • Fine ambient particles induce oxidative stress and metal binding genes in human alveolar macrophages. 
  • FlyRNAi.org--the database of the Drosophila RNAi screening center: 2012 update. 
  • FlyRNAi: the Drosophila RNAi screening center database. 
  • Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents. 
  • G protein-coupled receptor kinase and beta-arrestin-mediated desensitization of the angiotensin II type 1A receptor elucidated by diacylglycerol dynamics. 
  • G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer. 
  • GPR54 is a target for suppression of metastasis in endometrial cancer. 
  • Gene Network Polymorphism Illuminates Loss and Retention of Novel RNAi Silencing Components in the Cryptococcus Pathogenic Species Complex. 
  • Gene Therapy 2017: Progress and Future Directions. 
  • Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand. 
  • Gene silencing using RNA interference in embryonic stem cells. 
  • Genetic Screen Reveals Link between the Maternal Effect Sterile Gene mes-1 and Pseudomonas aeruginosa-induced Neurodegeneration in Caenorhabditis elegans. 
  • Genetic modification of mesenchymal stem cells overexpressing CCR1 increases cell viability, migration, engraftment, and capillary density in the injured myocardium. 
  • Genetic variants at the miR-124 binding site on the cytoskeleton-organizing IQGAP1 gene confer differential predisposition to breast cancer. 
  • Genome-wide analysis of miRNA signature in the APPswe/PS1ΔE9 mouse model of alzheimer's disease. 
  • Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation. 
  • Genome-wide high-resolution mapping of exosome substrates reveals hidden features in the Arabidopsis transcriptome. 
  • Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism. 
  • Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb MuvB/dREAM complex in proliferating cells. 
  • Germline AGO2 mutations impair RNA interference and human neurological development. 
  • HIV-1 incorporation of host-cell-derived glycosphingolipid GM3 allows for capture by mature dendritic cells. 
  • Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells. 
  • Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression. 
  • Heterochromatin and RNAi act independently to ensure genome stability in Mucorales human fungal pathogens. 
  • High LEF1 expression predicts adverse prognosis in chronic lymphocytic leukemia and may be targeted by ethacrynic acid. 
  • High potency silencing by single-stranded boranophosphate siRNA. 
  • High-throughput RNA interference screens in Drosophila tissue culture cells. 
  • High-throughput phenotyping of multicellular organisms: finding the link between genotype and phenotype. 
  • Human Rad9 is required for the activation of S-phase checkpoint and the maintenance of chromosomal stability. 
  • Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development. 
  • Hyperactivated JNK is a therapeutic target in pVHL-deficient renal cell carcinoma. 
  • Hyperphagia and increased fat accumulation in two models of chronic CNS glucagon-like peptide-1 loss of function. 
  • IRF-1 inhibits NF-κB activity, suppresses TRAF2 and cIAP1 and induces breast cancer cell specific growth inhibition. 
  • IRF4 addiction in multiple myeloma. 
  • Identification and Functional Validation of Reciprocal microRNA-mRNA Pairings in African American Prostate Cancer Disparities. 
  • Identification and interaction of multiple genes resulting in DDT resistance in the 91-R strain of Drosophila melanogaster by RNAi approaches. 
  • Identification of a role for beta-catenin in the establishment of a bipolar mitotic spindle. 
  • Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation. 
  • Identification of novel innate immune genes by transcriptional profiling of macrophages stimulated with TLR ligands. 
  • Identification of regulators of germ stem cell enwrapment by its niche in C. elegans. 
  • In vivo identification of regulators of cell invasion across basement membranes. 
  • Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation. 
  • Increasing atmospheric CO2 reduces metabolic and physiological differences between isoprene- and non-isoprene-emitting poplars. 
  • Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor. 
  • Induced cardiomyocyte maturation: Cardiac transcription factors are necessary but not sufficient. 
  • Induction of the ChREBPβ Isoform Is Essential for Glucose-Stimulated β-Cell Proliferation. 
  • Inhibition of Pten deficient Castration Resistant Prostate Cancer by Targeting of the SET - PP2A Signaling axis. 
  • Inhibition of rhabdomyosarcoma cell and tumor growth by targeting specificity protein (Sp) transcription factors. 
  • Inhibition of the Notch-Hey1 axis blocks embryonal rhabdomyosarcoma tumorigenesis. 
  • Integrated detection of natural antisense transcripts using strand-specific RNA sequencing data. 
  • Integrin acts upstream of netrin signaling to regulate formation of the anchor cell's invasive membrane in C. elegans. 
  • Interferon-inducible mechanism of dendritic cell-mediated HIV-1 dissemination is dependent on Siglec-1/CD169. 
  • Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells. 
  • Janus kinase 3-activating mutations identified in natural killer/T-cell lymphoma. 
  • Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling. 
  • Kalirin promotes neointimal hyperplasia by activating Rac in smooth muscle cells. 
  • Katanin p60-like1 promotes microtubule growth and terminal dendrite stability in the larval class IV sensory neurons of Drosophila. 
  • LKB1 reduces ROS-mediated cell damage via activation of p38. 
  • Laminin alpha 2 enables glioblastoma stem cell growth. 
  • Ligation of cancer cell surface GRP78 with antibodies directed against its COOH-terminal domain up-regulates p53 activity and promotes apoptosis. 
  • Ligation of cell surface-associated glucose-regulated protein 78 by receptor-recognized forms of alpha 2-macroglobulin: activation of p21-activated protein kinase-2-dependent signaling in murine peritoneal macrophages. 
  • Liver cancer cells as the model for developing liver-targeted RNAi therapeutics. 
  • Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila. 
  • Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis. 
  • Loss of PTPRM associates with the pathogenic development of colorectal adenoma-carcinoma sequence. 
  • Loss of cell surface TFII-I promotes apoptosis in prostate cancer cells stimulated with activated α₂ -macroglobulin. 
  • Loss-of-Function RNAi Screen to Identify Necrosis-Signaling Molecules. 
  • Loss-of-function genetic tools for animal models: cross-species and cross-platform differences. 
  • MOV10 Provides Antiviral Activity against RNA Viruses by Enhancing RIG-I-MAVS-Independent IFN Induction. 
  • MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells. 
  • Manipulation of OCT4 levels in human embryonic stem cells results in induction of differential cell types. 
  • Matter arising: off-targets and genome-scale RNAi screens in Drosophila. 
  • Mechanisms of specificity in neuronal activity-regulated gene transcription. 
  • Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells. 
  • Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis. 
  • Minimizing the risk of reporting false positives in large-scale RNAi screens. 
  • Mitochondrial Oxidative Phosphorylation Complex Regulates NLRP3 Inflammasome Activation and Predicts Patient Survival in Nasopharyngeal Carcinoma. 
  • Mitochondrial dysfunction in ataxia-telangiectasia. 
  • Mitogen-activated protein kinase phosphatase-1 promotes neovascularization and angiogenic gene expression. 
  • Modulation of PICALM Levels Perturbs Cellular Cholesterol Homeostasis. 
  • Molecular Tools for Carotenogenesis Analysis in the Mucoral Mucor circinelloides. 
  • Monitoring β-secretase activity in living cells with a membrane-anchored FRET probe. 
  • Mortality shifts in Caenorhabditis elegans: remembrance of conditions past. 
  • Mutant IDH1 is required for IDH1 mutated tumor cell growth. 
  • Mycobacterium tuberculosis decreases human macrophage IFN-γ responsiveness through miR-132 and miR-26a. 
  • N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias. 
  • N6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein. 
  • Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor. 
  • Neurabin/protein phosphatase-1 complex regulates dendritic spine morphogenesis and maturation. 
  • Normal spastin gene dosage is specifically required for axon regeneration. 
  • Notch promotes radioresistance of glioma stem cells. 
  • Notch signaling indirectly promotes chondrocyte hypertrophy via regulation of BMP signaling and cell cycle arrest. 
  • Nox4 NADPH oxidase contributes to smooth muscle cell phenotypes associated with unstable atherosclerotic plaques. 
  • Nuclear pore component Nup98 is a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes. 
  • Nucleotide bias of DCL and AGO in plant anti-virus gene silencing. 
  • Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy. 
  • OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection. 
  • Oct4 RNA interference induces trophectoderm differentiation in mouse embryonic stem cells. 
  • Open chromatin mapping identifies transcriptional networks regulating human epididymis epithelial function. 
  • Osteopontin inhibits macrophage nitric oxide synthesis to enhance tumor proliferation. 
  • Osteopontin regulates ubiquitin-dependent degradation of Stat1 in murine mammary epithelial tumor cells. 
  • Overlapping high-resolution copy number alterations in cancer genomes identified putative cancer genes in hepatocellular carcinoma. 
  • Oxygen-coupled redox regulation of the skeletal muscle ryanodine receptor-Ca2+ release channel by NADPH oxidase 4. 
  • PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity. 
  • PLP/DM20 ratio is regulated by hnRNPH and F and a novel G-rich enhancer in oligodendrocytes. 
  • Pairing of competitive and topologically distinct regulatory modules enhances patterned gene expression. 
  • Pathogen virulence factors as molecular probes of basic plant cellular functions. 
  • Pebble/ECT2 RhoGEF negatively regulates the Wingless/Wnt signaling pathway. 
  • Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. 
  • Phytochemical Shift from Condensed Tannins to Flavonoids in Transgenic Betula pendula Decreases Consumption and Growth but Improves Growth Efficiency of Epirrita autumnata Larvae. 
  • Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling. 
  • Plant hormone jasmonate prioritizes defense over growth by interfering with gibberellin signaling cascade 
  • Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. 
  • Pollutant particles induce arginase II in human bronchial epithelial cells. 
  • Poly(A)-binding protein modulates mRNA susceptibility to cap-dependent miRNA-mediated repression. 
  • Post-transcriptional RNA regulons affecting cell cycle and proliferation. 
  • Postsynaptic positioning of endocytic zones and AMPA receptor cycling by physical coupling of dynamin-3 to Homer. 
  • Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis. 
  • Production of highly potent recombinant siRNAs in Escherichia coli. 
  • Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. 
  • Proteomic analysis of mitotic RNA polymerase II reveals novel interactors and association with proteins dysfunctional in disease. 
  • Proteomic dissection of LPS-inducible, PHF8-dependent secretome reveals novel roles of PHF8 in TLR4-induced acute inflammation and T cell proliferation. 
  • Pseudomonas invasion of type I pneumocytes is dependent on the expression and phosphorylation of caveolin-2. 
  • Pyrvinium selectively targets blast phase-chronic myeloid leukemia through inhibition of mitochondrial respiration. 
  • Quantitative analysis of the chromatin proteome in disease reveals remodeling principles and identifies high mobility group protein B2 as a regulator of hypertrophic growth. 
  • Quinocarmycin analog DX-52-1 inhibits cell migration and targets radixin, disrupting interactions of radixin with actin and CD44. 
  • RIP3 Regulates Autophagy and Promotes Coxsackievirus B3 Infection of Intestinal Epithelial Cells. 
  • RNA interference and single particle tracking analysis of hepatitis C virus endocytosis. 
  • RNA interference of human papillomavirus type 18 E6 and E7 induces senescence in HeLa cells. 
  • RNA interference targeting hypoxia inducible factor 1α reduces post-operative adhesions in rats 
  • RNA interference using boranophosphate siRNAs: structure-activity relationships. 
  • RNAi function, diversity, and loss in the fungal kingdom. 
  • RNAi is a critical determinant of centromere evolution in closely related fungi. 
  • RNAi screening in mammalian cells to identify novel host cell molecules involved in the regulation of viral infections. 
  • RNAi-Based Functional Genomics Identifies New Virulence Determinants in Mucormycosis. 
  • Rae1 interaction with NuMA is required for bipolar spindle formation. 
  • Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells. 
  • Reductive TCA cycle metabolism fuels glutamine- and glucose-stimulated insulin secretion. 
  • Regulation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-5 in vascular smooth muscle cells involves the phosphatase Shp2. 
  • RelB/p50 complexes regulate cytokine-induced YKL-40 expression. 
  • Repeated Failure in Reward Pursuit Alters Innate Drosophila Larval Behaviors. 
  • Role of an alternatively spliced form of alphaII-spectrin in localization of connexin 43 in cardiomyocytes and regulation by stress-activated protein kinase. 
  • Role of the Non-Canonical RNAi Pathway in the Antifungal Resistance and Virulence of Mucorales. 
  • Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication. 
  • SHP-1 as a critical regulator of Mycoplasma pneumoniae-induced inflammation in human asthmatic airway epithelial cells. 
  • SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. 
  • Sec5 and Exo84 foster oncogenic ras-mediated tumorigenesis. 
  • Secreted Frizzled-Related Protein 3 (SFRP3) Is Required for Tumorigenesis of PAX3-FOXO1-Positive Alveolar Rhabdomyosarcoma. 
  • Selenium Augments microRNA Directed Reprogramming of Fibroblasts to Cardiomyocytes via Nanog. 
  • Self-assembled Lipid Nanoparticles for Ratiometric Codelivery of Cisplatin and siRNA Targeting XPF to Combat Drug Resistance in Lung Cancer. 
  • Sex-induced silencing defends the genome of Cryptococcus neoformans via RNAi. 
  • Single Cell Chemical Cytometry of Akt Activity in Rheumatoid Arthritis and Normal Fibroblast-like Synoviocytes in Response to Tumor Necrosis Factor α. 
  • Skeletal muscle protein synthesis and the abundance of the mRNA translation initiation repressor PDCD4 are inversely regulated by fasting and refeeding in rats. 
  • Ski inhibits TGF-β/phospho-Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes. 
  • Small ubiquitin-like modifier 1-3 conjugation [corrected] is activated in human astrocytic brain tumors and is required for glioblastoma cell survival. 
  • Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate. 
  • Specific regulation of noncanonical p38alpha activation by Hsp90-Cdc37 chaperone complex in cardiomyocyte. 
  • Specificity of arrestin subtypes in regulating airway smooth muscle G protein-coupled receptor signaling and function. 
  • Stable RNA interference-mediated suppression of cyclophilin A diminishes non-small-cell lung tumor growth in vivo. 
  • Stbd1 is highly elevated in skeletal muscle of Pompe disease mice but suppression of its expression does not affect lysosomal glycogen accumulation. 
  • Stem cell niche exit in C. elegans via orientation and segregation of daughter cells by a cryptic cell outside the niche. 
  • Steroid induction of therapy-resistant cytokeratin-5-positive cells in estrogen receptor-positive breast cancer through a BCL6-dependent mechanism. 
  • Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa. 
  • Structure of the Trypanosoma brucei p22 protein, a cytochrome oxidase subunit II-specific RNA-editing accessory factor. 
  • Suppression of the microRNA pathway by bacterial effector proteins. 
  • Synergistic effects of nelfinavir and bortezomib on proteotoxic death of NSCLC and multiple myeloma cells. 
  • Synthetic lethal analysis of Caenorhabditis elegans posterior embryonic patterning genes identifies conserved genetic interactions. 
  • Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells. 
  • Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. 
  • Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers. 
  • TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death. 
  • TP53 genomic status regulates sensitivity of gastric cancer cells to the histone methylation inhibitor 3-deazaneplanocin A (DZNep). 
  • Targeted suppression of claudin-5 decreases cerebral oedema and improves cognitive outcome following traumatic brain injury. 
  • Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage. 
  • Targeting Id1 and Id3 inhibits peritoneal metastasis of gastric cancer. 
  • Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth. 
  • Targeting the hexosamine biosynthetic pathway and O-linked N-acetylglucosamine cycling for therapeutic and imaging capabilities in diffuse large B-cell lymphoma. 
  • Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis. 
  • The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases. 
  • The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells. 
  • The Hippo Pathway Effector YAP Promotes Ferroptosis via the E3 Ligase SKP2. 
  • The Histone Methyltransferase Ash1l is Required for Epidermal Homeostasis in Mice. 
  • The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer. 
  • The NMDA receptor subunit GluN3A regulates synaptic activity-induced and myocyte enhancer factor 2C (MEF2C)-dependent transcription. 
  • The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells. 
  • The RNAi Mechanism Regulates a New Exonuclease Gene Involved in the Virulence of Mucorales. 
  • The cAMP-activated GTP exchange factor, Epac1 upregulates plasma membrane and nuclear Akt kinase activities in 8-CPT-2-O-Me-cAMP-stimulated macrophages: Gene silencing of the cAMP-activated GTP exchange Epac1 prevents 8-CPT-2-O-Me-cAMP activation of Akt activity in macrophages. 
  • The deubiquitinating enzyme DUBAI stabilizes DIAP1 to suppress Drosophila apoptosis. 
  • The end game of chemical genetics: target identification. 
  • The epidermal growth factor receptor critically regulates endometrial function during early pregnancy. 
  • The exon junction complex component Magoh controls brain size by regulating neural stem cell division. 
  • The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes. 
  • The histone lysine demethylase Kdm6b is required for activity-dependent preconditioning of hippocampal neuronal survival. 
  • The homeodomain protein PAL-1 specifies a lineage-specific regulatory network in the C. elegans embryo. 
  • The human oncoprotein and chromatin architectural factor DEK counteracts DNA replication stress. 
  • The oncogenic microRNA miR-21 promotes regulated necrosis in mice. 
  • The role of Grp 78 in alpha 2-macroglobulin-induced signal transduction. Evidence from RNA interference that the low density lipoprotein receptor-related protein is associated with, but not necessary for, GRP 78-mediated signal transduction. 
  • The role of IFN-alpha and nitric oxide in the release of HMGB1 by RAW 264.7 cells stimulated with polyinosinic-polycytidylic acid or lipopolysaccharide. 
  • The role of MTJ-1 in cell surface translocation of GRP78, a receptor for alpha 2-macroglobulin-dependent signaling. 
  • The small heat shock protein alpha B-crystallin is a novel inhibitor of TRAIL-induced apoptosis that suppresses the activation of caspase-3. 
  • The uric acid transporter SLC2A9 is a direct target gene of the tumor suppressor p53 contributing to antioxidant defense. 
  • Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling. 
  • Thermosensory and nonthermosensory isoforms of Drosophila melanogaster TRPA1 reveal heat-sensor domains of a thermoTRP Channel. 
  • Thyroid Hormone Stimulation of Autophagy Is Essential for Mitochondrial Biogenesis and Activity in Skeletal Muscle. 
  • Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy. 
  • Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression. 
  • Transcription factor TFII-I causes transcriptional upregulation of GRP78 synthesis in prostate cancer cells. 
  • Transgene induced co-suppression during vegetative growth in Cryptococcus neoformans. 
  • Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia. 
  • Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons. 
  • Uncontrolled transposition following RNAi loss causes hypermutation and antifungal drug resistance in clinical isolates of Cryptococcus neoformans. 
  • Unexpected role of clathrin adaptor AP-1 in MHC-dependent positive selection of T cells. 
  • Upregulation of AKT1 protein expression in forskolin-stimulated macrophage: evidence from ChIP analysis that CREB binds to and activates the AKT1 promoter. 
  • Upstream regulatory role for XIAP in receptor-mediated apoptosis. 
  • Use of retrovirus expression of interfering RNA to determine the contribution of activated K-Ras and ras effector expression to human tumor cell growth. 
  • VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD. 
  • VIAF, a conserved inhibitor of apoptosis (IAP)-interacting factor that modulates caspase activation. 
  • Versatility of borane nucleic acids mimics for coding, decoding and modulating genetic information. 
  • Vertebrate Lonesome Kinase Regulated Extracellular Matrix Protein Phosphorylation, Cell Shape, and Adhesion in Trabecular Meshwork Cells. 
  • Vitamin D analogs differentially control antimicrobial peptide/"alarmin" expression in psoriasis. 
  • WLS retrograde transport to the endoplasmic reticulum during Wnt secretion. 
  • WNT11 expression is induced by estrogen-related receptor alpha and beta-catenin and acts in an autocrine manner to increase cancer cell migration. 
  • WRN helicase is a synthetic lethal target in microsatellite unstable cancers. 
  • Who owns the genome? 
  • beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. 
  • beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha. 
  • miR-27b shapes the presynaptic transcriptome and influences neurotransmission by silencing the polycomb group protein Bmi1. 
  • siRNA-based approaches in cancer therapy. 
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  Keywords of People

  • Freemark, Michael Scott, Robert C. Atkins, M.D. and Veronica Atkins Distinguished Professor of Pediatrics, in the School of Medicine, Pediatrics, Endocrinology
  • Huang, Linfeng, Associate Professor of Biology at Duke Kunshan University, DKU Faculty
  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Perez Arques, Carlos, Postdoctoral Associate, Molecular Genetics and Microbiology
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
  • Shinohara, Mari L., Professor of Integrative Immunobiology, Cell Biology
  • Velkey, John Matthew, Assistant Professor of the Practice of Medical Education in the Department of Cell Biology, Cell Biology
  • Yadav, Vikas, Postdoctoral Associate, Molecular Genetics and Microbiology
  • Zhong, Xiaoping, Professor of Pediatrics, Integrative Immunobiology