RNA-Induced Silencing Complex
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Subject Areas on Research
- 2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity.
- Argonaute2 suppresses Drosophila fragile X expression preventing neurogenesis and oogenesis defects.
- Derivation and characterization of Dicer- and microRNA-deficient human cells.
- Differential RISC association of endogenous human microRNAs predicts their inhibitory potential.
- Drosophila PIWI associates with chromatin and interacts directly with HP1a.
- Germline AGO2 mutations impair RNA interference and human neurological development.
- Mutational inactivation of herpes simplex virus 1 microRNAs identifies viral mRNA targets and reveals phenotypic effects in culture.
- Nucleotide bias of DCL and AGO in plant anti-virus gene silencing.
- Partial reconstitution of the RNAi response in human cells using Drosophila gene products.
- Reprogramming tumor-associated dendritic cells in vivo using miRNA mimetics triggers protective immunity against ovarian cancer.
- Stem cells: A tale of two kingdoms.
- The role of microRNAs in Epstein-Barr virus latency and lytic reactivation.
- Viruses and microRNAs: RISCy interactions with serious consequences.