RNA-Induced Silencing Complex

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  Subject Areas on Research

  • 2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity. 
  • Argonaute2 suppresses Drosophila fragile X expression preventing neurogenesis and oogenesis defects. 
  • Derivation and characterization of Dicer- and microRNA-deficient human cells. 
  • Differential RISC association of endogenous human microRNAs predicts their inhibitory potential. 
  • Drosophila PIWI associates with chromatin and interacts directly with HP1a. 
  • Germline AGO2 mutations impair RNA interference and human neurological development. 
  • Mutational inactivation of herpes simplex virus 1 microRNAs identifies viral mRNA targets and reveals phenotypic effects in culture. 
  • Nucleotide bias of DCL and AGO in plant anti-virus gene silencing. 
  • Partial reconstitution of the RNAi response in human cells using Drosophila gene products. 
  • Reprogramming tumor-associated dendritic cells in vivo using miRNA mimetics triggers protective immunity against ovarian cancer. 
  • Stem cells: A tale of two kingdoms. 
  • The role of microRNAs in Epstein-Barr virus latency and lytic reactivation. 
  • Viruses and microRNAs: RISCy interactions with serious consequences.