Antigens, Nuclear

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  Subject Areas on Research

  • Absence of autoantigen Ku in mature human neutrophils and human promyelocytic leukemia line (HL-60) cells and lymphocytes undergoing apoptosis. 
  • Acute myeloid leukemia ontogeny is defined by distinct somatic mutations. 
  • Antibodies against retroviral proteins and nuclear antigens in a subset of idiopathic CD4+ T lymphocytopenia patients. 
  • Antinuclear antibodies and nuclear antigens in NZB myeloma ascitic fluids. 
  • Application of a unique monoclonal antibody as a marker for nonproliferating subpopulations of cells of some tissue. 
  • Assessment of autoantibodies to meningioma in a population-based study. 
  • B lymphocytes and systemic lupus erythematosus. 
  • Ependymomas: MIB-1 proliferation index and survival. 
  • Genetic variants of the nonhomologous end joining gene LIG4 and severe radiation pneumonitis in nonsmall cell lung cancer patients treated with definitive radiotherapy. 
  • Gliomas of the optic nerve: histological, immunohistochemical (MIB-1 and p53), and MRI analysis. 
  • Haploinsufficiency of the Chromatin Remodeler BPTF Causes Syndromic Developmental and Speech Delay, Postnatal Microcephaly, and Dysmorphic Features. 
  • High-content image informatics of the structural nuclear protein NuMA parses trajectories for stem/progenitor cell lineages and oncogenic transformation. 
  • High-content imaging-based screening of microenvironment-induced changes to stem cells. 
  • March 2000: A 16 year old female with a cerebellar mass. 
  • Murine monoclonal antibodies specific for conserved and non-conserved antigenic determinants of the human and murine Ku autoantigens. 
  • Prediction of response to primary chemotherapy for operable breast cancer. 
  • Prognostic risk factors that identify patients with clinical stage I nonseminomatous germ cell tumors at low risk and high risk for metastasis. 
  • Prognostic value of MIB-1 in advanced ovarian carcinoma as determined using automated immunohistochemistry and quantitative image analysis. 
  • Protein expression of p53, bcl-2, and KI-67 (MIB-1) as prognostic biomarkers in patients with surgically treated, clinically localized prostate cancer. 
  • Rae1 interaction with NuMA is required for bipolar spindle formation. 
  • Sequence divergence of coiled coils--structural rods, myosin filament packing, and the extraordinary conservation of cohesins. 
  • The DNA-binding protein Hdf1p (a putative Ku homologue) is required for maintaining normal telomere length in Saccharomyces cerevisiae. 
  • The glucocorticoid receptor interacting protein 1 (GRIP1) localizes in discrete nuclear foci that associate with ND10 bodies and are enriched in components of the 26S proteasome. 
  • Two serologic markers to monitor the engraftment, growth, and treatment response of human leukemias in severe combined immunodeficient mice. 
  • Use of phage display to identify novel mineralocorticoid receptor-interacting proteins. 
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  Keywords of People

  • Erickson, Harold Paul, James B. Duke Distinguished Professor of Cell Biology, Cell Biology
  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Duke Innovation & Entrepreneurship
  • McLendon, Roger Edwin, Professor of Pathology, Pathology