Lower Extremity

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  Subject Areas on Research

  • 2011 ACCF/AHA focused update of the guideline for the management of patients with peripheral artery disease (updating the 2005 guideline): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society for Vascular Medicine, and Society for Vascular Surgery. 
  • 2016 AHA/ACC Guideline on the Management of Patients With Lower Extremity Peripheral Artery Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. 
  • 2016 AHA/ACC Guideline on the Management of Patients With Lower Extremity Peripheral Artery Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. 
  • 2016 AHA/ACC Guideline on the Management of Patients With Lower Extremity Peripheral Artery Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. 
  • 2016 AHA/ACC Guideline on the Management of Patients With Lower Extremity Peripheral Artery Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. 
  • 2016 AHA/ACC Guideline on the Management of Patients with Lower Extremity Peripheral Artery Disease: Executive Summary. 
  • A case of mistaken identity: persistent sciatic artery stenosis as a cause of critical limb ischemia. 
  • A multi-institution experience comparing the clinical and physiologic differences between upper extremity and lower extremity melphalan-based isolated limb infusion. 
  • A retrospective review of lower extremity fracture care in patients with spinal cord injury. 
  • A systematic review of venous stents for iliac and venacaval occlusive disease. 
  • Acetabular Paralabral Cyst: An Unusual Cause of Lower Extremity Pain and Paresthesia. 
  • Acute Limb Ischemia in Peripheral Artery Disease. 
  • Acute Limb Ischemia. 
  • Acute compartment syndrome in lower extremity musculoskeletal trauma. 
  • Altered lower extremity biomechanics following anterior cruciate ligament reconstruction during single-leg and double-leg stop-jump tasks: A bilateral total support moment analysis. 
  • Altered perceptions after upper and lower extremity blocks: an initial investigation. 
  • An expanded series of distal bypass using the distal vein patch technique to improve prosthetic graft performance in critical limb ischemia. 
  • Anatomic runoff score predicts cardiovascular outcomes in patients with lower extremity peripheral artery disease undergoing revascularization. 
  • Anatomic tumor location influences the success of contemporary limb-sparing surgery and radiation among adults with soft tissue sarcomas of the extremities. 
  • Angiographic imaging of the lower extremities with multidetector CT. 
  • Ankle-Brachial Index for Risk Stratification in Patients With Symptomatic Peripheral Artery Disease With and Without Prior Lower Extremity Revascularization: Observations From the EUCLID Trial. 
  • Applying the Keystone Design Perforator Island Flap Concept in a Variety of Anatomic Locations: A Review of 60 Consecutive Cases by a Single Surgeon. 
  • Assessment of vascular contrast and depiction of stenoses in abdominopelvic and lower extremity vasculature: comparison of dual-energy MDCT with digital subtraction angiography. 
  • Association of Health Status Scores With Cardiovascular and Limb Outcomes in Patients With Symptomatic Peripheral Artery Disease: Insights From the EUCLID (Examining Use of Ticagrelor in Symptomatic Peripheral Artery Disease) Trial. 
  • Association of Injury History and Incident Injury in Cadet Basic Military Training. 
  • Association of Meniscal Status, Lower Extremity Alignment, and Body Mass Index With Chondrosis at Revision Anterior Cruciate Ligament Reconstruction. 
  • Beet the Best? 
  • Bilateral symmetry in lower extremity mechanics during stair ascent and descent following a total hip arthroplasty: a one-year longitudinal study. 
  • Bleeding Complications in Lower-Extremity Peripheral Vascular Interventions: Insights From the NCDR PVI Registry. 
  • Body size and lower limb posture during walking in humans. 
  • CT angiography in complex upper extremity reconstruction. 
  • CT angiography of peripheral arterial occlusive disease. 
  • Cardiovascular Outcomes After Lower Extremity Endovascular or Surgical Revascularization: The EUCLID Trial. 
  • Cardiovascular and Limb Outcomes in Patients With Diabetes and Peripheral Artery Disease: The EUCLID Trial. 
  • Characteristics of abdominal vein thrombosis in children and adults. 
  • Characteristics of patients with lower extremity symptoms treated with slump stretching: a case series. 
  • Characterization of a composite injury model of severe lower limb bone and nerve trauma. 
  • Chronic Stroke Outcome Measures for Motor Function Intervention Trials: Expert Panel Recommendations. 
  • Chronic wounds of the lower extremity: a preliminary performance measurement set. 
  • Clinical problem-solving. Undercover and overlooked. 
  • Clinician Specialty, Access to Care, and Outcomes Among Patients with Peripheral Artery Disease. 
  • Clinician-friendly lower extremity physical performance tests in athletes: a systematic review of measurement properties and correlation with injury. Part 2--the tests for the hip, thigh, foot and ankle including the star excursion balance test. 
  • Comparative Effectiveness of Medical Therapy, Supervised Exercise, and Revascularization for Patients With Intermittent Claudication: A Network Meta-analysis. 
  • Comparative effectiveness of endovascular and surgical revascularization for patients with peripheral artery disease and critical limb ischemia: systematic review of revascularization in critical limb ischemia. 
  • Computed Tomography-Based Limb Volume Measurements for Isolated Limb Infusion in Melanoma. 
  • Content Validity of the LIMB-Q: A Patient-Reported Outcome Instrument for Lower Extremity Trauma Patients. 
  • Current Concepts in Lower Extremity Reconstruction. 
  • Current trends in regional therapy for melanoma: lessons learned from 225 regional chemotherapy treatments between 1995 and 2010 at a single institution. 
  • Development of Concise Physical Performance Test Batteries in Young Athletes. 
  • Direct admission versus transfer to a tertiary hospital for definitive management of lower extremity injuries: Systematic review and meta-analysis. 
  • Does knee position at the time of tourniquet inflation affect knee range of motion? 
  • Does the clinical examination predict lower extremity peripheral arterial disease? 
  • Dual vs single antiplatelet therapy in patients with lower extremity peripheral artery disease - A meta-analysis. 
  • Early administration of Fab antivenom resulted in faster limb recovery in copperhead snake envenomation patients. 
  • Early versus delayed amputation in the setting of severe lower extremity trauma. 
  • Effects of dynamic warm-up with and without a weighted vest on lower extremity power performance of high school male athletes. 
  • Effects of telerehabilitation on physical function and disability for stroke patients: a randomized, controlled trial. 
  • Endovascular therapy: is it effective in the diabetic limb? 
  • Endovascular treatment of varicose veins. 
  • Energetic and endurance constraints on great ape quadrupedalism and the benefits of hominin bipedalism. 
  • Engaging Education About Risks of Opioid Use With Patients Before Elective Surgery of the Lower Extremity Did Not Reduce Postoperative Opioid Utilization: A Randomized Controlled Trial. 
  • Epidemiology of Overuse Injuries in Collegiate and High School Athletics in the United States. 
  • Estimating minimal clinically important differences for two scales in patients with chronic traumatic brain injury. 
  • Etiology and outcomes of amputation in patients with peripheral artery disease in the EUCLID trial. 
  • Evaluation and treatment of patients with lower extremity peripheral artery disease: consensus definitions from Peripheral Academic Research Consortium (PARC). 
  • Examining the heterogeneity inexcess risks of coronary heart disease, stroke, dialysis, and lower extremity amputation associated with type 2 diabetes mellitus across demographic subgroups in an Asian population: A population-based matched cohort study. 
  • Factors predicting toxicity and response following isolated limb infusion for melanoma: An international multi-centre study. 
  • Fatigue alters lower extremity kinematics during a single-leg stop-jump task. 
  • First successful lower-extremity transplantation: technique and functional result. 
  • Fractures in myelomeningocele. 
  • Gender and limb differences in temporal gait parameters and gait variability in ankle osteoarthritis. 
  • Genomic modeling of atherosclerosis in peripheral arterial disease and its variant phenotype in patients with diabetes. 
  • Global Vascular Guidelines on the Management of Chronic Limb-Threatening Ischemia. 
  • Graduated compression stockings to treat acute leg pain associated with proximal DVT. A randomised controlled trial. 
  • Great saphenous vein stump thrombosis after harvesting for coronary artery bypass graft surgery. 
  • High hemoglobin A1c associated with increased adverse limb events in peripheral arterial disease patients undergoing revascularization. 
  • High mortality risks after major lower extremity amputation in Medicare patients with peripheral artery disease. 
  • How long to treat with antibiotics following amputation in patients with diabetic foot infections? Are the 2012 IDSA DFI guidelines reasonable? 
  • Imaging of the Pelvis and Lower Extremity: Demystifying Uncommon Sources of Pelvic Pain. 
  • Impact of Fluoroscopically Guided Bone Biopsy on Antibiotic Management of Osteomyelitis in the Lower Extremity. 
  • Importance of ultrasound evaluation in the diagnosis of venous insufficiency: guidelines and techniques. 
  • Incidence and risk factors of postoperative neurologic decline after complex adult spinal deformity surgery: results of the Scoli-RISK-1 study. 
  • Increasing Lower Extremity Injury Rates Across the 2009-2010 to 2014-2015 Seasons of National Collegiate Athletic Association Football: An Unintended Consequence of the "Targeting" Rule Used to Prevent Concussions? 
  • Injectable Phosphorescence-based Oxygen Biosensors Identify Post Ischemic Reactive Hyperoxia. 
  • Injury epidemiology of U.S. Army Special Operations forces. 
  • International Multicenter Experience of Isolated Limb Infusion for In-Transit Melanoma Metastases in Octogenarian and Nonagenarian Patients. 
  • Letter by Moris et al Regarding Article, "Ticagrelor Compared With Clopidogrel in Patients With Prior Lower Extremity Revascularization for Peripheral Artery Disease". 
  • Letter by Siasos et al Regarding Article, "Ticagrelor Compared With Clopidogrel in Patients With Prior Lower Extremity Revascularization for Peripheral Artery Disease". 
  • Limb ischemia: cardiovascular diagnosis and management from head to toe. 
  • Long-Term Training with a Brain-Machine Interface-Based Gait Protocol Induces Partial Neurological Recovery in Paraplegic Patients. 
  • Long-term results of endoscopic versus open saphenous vein harvest for lower extremity bypass. 
  • Lower Extremity Motor Function Following Complex Adult Spinal Deformity Surgery: Two-Year Follow-up in the Scoli-RISK-1 Prospective, Multicenter, International Study. 
  • Lower extremity amputation in peripheral artery disease: improving patient outcomes. 
  • Lower extremity neuromuscular recovery following anterior cruciate ligament reconstruction; a 2-week case study. 
  • Lower extremity physical performance, self-reported mobility difficulty, and use of compensatory strategies for mobility by elderly women. 
  • Lower-limb vascular imaging with acoustic radiation force elastography: demonstration of in vivo feasibility. 
  • Magnetic resonance evaluation of peripheral arterial disease. 
  • Major Adverse Limb Events and 1-Year Outcomes After Peripheral Artery Revascularization. 
  • Manual high-dose regional intraoperative thrombolysis of lower extremity emboli after open repair of a ruptured abdominal aortic aneurysm. 
  • Measures of arch height and their relationship to pain and dysfunction in people with lower limb impairments. 
  • Measuring the effect of policy interventions at the population level: some methodological concerns. 
  • Medical management of venous ulcers. 
  • Meta-Analysis of the Role of Intermittent Pneumatic Compression of the Lower Limbs to Prevent Venous Thromboembolism in Critically Ill Patients. 
  • Microvascular Anastomoses Using End-to-End versus End-to-Side Technique in Lower Extremity Free Tissue Transfer. 
  • Midterm follow-up after pharmacomechanical thrombolysis for lower extremity deep venous thrombosis. 
  • Minimally invasive subcutaneous fasciotomy for chronic exertional compartment syndrome of the lower extremity. 
  • Missed opportunities: despite improvement in use of cardioprotective medications among patients with lower-extremity peripheral artery disease, underuse remains. 
  • Morbidity following lower extremity fractures in men with spinal cord injury. 
  • Mortality after lower extremity fractures in men with spinal cord injury. 
  • Muscle force production during bent-knee, bent-hip walking in humans. 
  • Musculoskeletal, biomechanical, and physiological gender differences in the US military. 
  • Natural history of spinopelvic alignment differs from symptomatic deformity of the spine. 
  • Negative pressure wound therapy reduces surgical site infections. 
  • Noncardiac surgery: widening the gap in pulse pressure. 
  • Novel CenterCross and MultiCross devices for the treatment of infrainguinal chronic total occlusions: initial single-centre experience. 
  • Ontogenetic changes in limb postures and their impact on effective limb length in baboons (Papio cynocephalus) 
  • Outcomes of Patients with Critical Limb Ischaemia in the EUCLID Trial. 
  • PLX-PAD Cell Treatment of Critical Limb Ischaemia: Rationale and Design of the PACE Trial. 
  • Patient Radiation Dosage During Lower Extremity Endovascular Intervention. 
  • Performance Goal Criteria for Device Evaluation in Lower Extremity Peripheral Vascular Intervention and the Need for Standardized Data Structure: What Is the Sound of One Hand Clapping? 
  • Perineal and lower extremity reconstruction. 
  • Perioperative Anesthetic Techniques to Reduce Surgical Morbidity After Amputation. 
  • Perioperative Optimization of Geriatric Lower Extremity Bypass in the Era of Increased Performance Accountability. 
  • Peripheral arterial testing before lower extremity amputation among Medicare beneficiaries, 2000 to 2010. 
  • Peripheral artery disease is a coronary heart disease risk equivalent among both men and women: results from a nationwide study. 
  • Pharmacomechanical thrombectomy for treatment of symptomatic lower extremity deep venous thrombosis: safety and feasibility study. 
  • Photoacoustic elastography. 
  • Plasma levels of soluble Tie2 and vascular endothelial growth factor distinguish critical limb ischemia from intermittent claudication in patients with peripheral arterial disease. 
  • Popliteal-to-distal bypass: identifying risk factors associated with limb loss and graft failure. 
  • Population Pharmacokinetics/Pharmacodynamics of 3,4-Diaminopyridine Free Base in Patients With Lambert-Eaton Myasthenia. 
  • Possible incremental benefits of specialized rehabilitation bed units among veterans after lower extremity amputation. 
  • Postoperative Pain Mediates the Association Between Peripheral Nerve Blocks and Postoperative Sleep Following Lower Extremity Arthroplasty. 
  • Postural Stability Under Dual-Task Conditions: Development of a Post-Concussion Assessment for Lower-Extremity Injury Risk. 
  • Predictive factors of regional toxicity and serum creatine phosphokinase levels after isolated limb infusion for melanoma: a multi-institutional analysis. 
  • Preoperative Platelet Count Predicts Lower Extremity Free Flap Thrombosis: A Multi-Institutional Experience. 
  • Prevention of arterial and venous thrombotic events in symptomatic peripheral arterial disease patients after lower extremity revascularization in the VOYAGER PAD trial: Dual anticoagulant/antiplatelet regimen vs antiplatelet therapy alone. 
  • Proceedings from the Society of Interventional Radiology research consensus panel on critical limb ischemia. 
  • Progress in MR imaging of the venous system. 
  • Prostaglandin E1-Induced Periostitis and Reversibility with Discontinuation. 
  • Putting the vascular back into cardiovascular research: ST-segment-elevation myocardial infarction as a blueprint for improving care in patients with acute limb ischemia. 
  • Rationale and design for the Vascular Outcomes study of ASA along with rivaroxaban in endovascular or surgical limb revascularization for peripheral artery disease (VOYAGER PAD). 
  • Reduction in Acute Limb Ischemia With Rivaroxaban Versus Placebo in Peripheral Artery Disease After Lower Extremity Revascularization: Insights From VOYAGER PAD. 
  • Relationship between leg muscle capillary density and peak hyperemic blood flow with endurance capacity in peripheral artery disease. 
  • Relationship of performance on the sensory organization test to landing characteristics. 
  • Reply: Identifying Factors Most Important to Lower Extremity Trauma Patients: Key Concepts from the Development of a Patient-Reported Outcome Instrument for Lower Extremity Trauma, The LIMB-Q. 
  • Report of the Society for Vascular Surgery and the American Venous Forum on the July 20, 2016 meeting of the Medicare Evidence Development and Coverage Advisory Committee panel on lower extremity chronic venous disease. 
  • Research Priorities in Pelvic Venous Disorders in Women: Recommendations from a Multidisciplinary Research Consensus Panel. 
  • Response by Jones et al to Letter Regarding Article, "Ticagrelor Compared With Clopidogrel in Patients With Prior Lower Extremity Revascularization for Peripheral Artery Disease". 
  • Response to Letter to the Editor regarding "Anatomic runoff score predicts cardiovascular outcomes in patients with lower extremity peripheral artery disease undergoing revascularization". 
  • Risk Factors Associated With Infection in Open Fractures of the Upper and Lower Extremities. 
  • Risk factors for early failure of surgical amputations: an analysis of 8,878 isolated lower extremity amputation procedures. 
  • Risk factors for lower extremity amputation among patients with diabetes in Singapore. 
  • Risk factors, transcriptomics, and outcomes of myocardial injury following lower extremity revascularization. 
  • Rivaroxaban and Aspirin in Peripheral Artery Disease Lower Extremity Revascularization: Impact of Concomitant Clopidogrel on Efficacy and Safety. 
  • Rivaroxaban in Peripheral Artery Disease after Revascularization. 
  • Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial. 
  • Safety and Effectiveness of Retrograde Arterial Access for Endovascular Treatment of Critical Limb Ischemia. 
  • Sex-Based Differences in Outcomes Following Peripheral Artery Revascularization: Insights From VOYAGER PAD. 
  • Sex-Specific Risks of Major Cardiovascular and Limb Events in Patients With Symptomatic Peripheral Artery Disease. 
  • Short- and Long-Term Outcomes following Severe Traumatic Lower Extremity Reconstruction: The Value of an Orthoplastic Limb Salvage Center to Racially Underserved Communities. 
  • Sodium-glucose co-transporter-2 inhibitor use and risk of lower-extremity amputation: Evolving questions, evolving answers. 
  • Spatial inequalities of major lower limb amputation rates in Paraná state, Brazil. 
  • Spliced arm vein grafts are a durable conduit for lower extremity bypass. 
  • Standardization of lower extremity quantitative lymphedema measurements and associated patient-reported outcomes in gynecologic cancers. 
  • Strength, flexibility, and balance characteristics of highly proficient golfers. 
  • Survival analysis in amputees based on physical independence grade achievement. 
  • Survival and Causes of Death Among Veterans With Lower Extremity Revascularization With Paclitaxel-Coated Devices: Insights From the Veterans Health Administration. 
  • Takotsubo cardiomyopathy complicating thoracoabdominal aortic aneurysm repair. 
  • Temporal trends and geographic variation of lower-extremity amputation in patients with peripheral artery disease: results from U.S. Medicare 2000-2008. 
  • The Contemporary Safety and Effectiveness of Lower Extremity Bypass Surgery and Peripheral Endovascular Interventions in the Treatment of Symptomatic Peripheral Arterial Disease. 
  • The Current Evidence for Lipid Management in Patients with Lower Extremity Peripheral Artery Disease: What Is the Therapeutic Target? 
  • The Efficacy of Crotalidae Polyvalent Immune Fab (Ovine) Antivenom Versus Placebo Plus Optional Rescue Therapy on Recovery From Copperhead Snake Envenomation: A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial. 
  • The Essential Local Muscle Flaps for Lower Extremity Reconstruction. 
  • The Reconstruction of Lower Extremity Mohs Surgical Wounds With Keystone Fasciocutaneous Flaps: Outcomes From 259 Consecutive Cases. 
  • The Relationship Between BMI and Work-Related Musculoskeletal (MSK) Injury Rates is Modified by Job-Associated Level of MSK Injury Risk. 
  • The Role for Combined Antithrombotic Therapy With Platelet and Coagulation Inhibition After Lower Extremity Revascularization. 
  • The Scoli-RISK 1 results of lower extremity motor function 5 years after complex adult spinal deformity surgery. 
  • The association of anticonvulsant use with fractures in spinal cord injury. 
  • The association of healthcare disparities and patient-specific factors on clinical outcomes in peripheral artery disease. 
  • The association of opioid use with incident lower extremity fractures in spinal cord injury. 
  • The evaluation of casualties from Operation Iraqi Freedom on return to the continental United States from March to June 2003. 
  • The first successful lower extremity transplantation: 6-year follow-up and implications for cortical plasticity. 
  • The keystone fasciocutaneous flap in the reconstruction of lower extremity wounds. 
  • The lower limb and mechanics of walking in Australopithecus sediba. 
  • The role of the built environment in the disablement process. 
  • Thiazide use is associated with reduced risk for incident lower extremity fractures in men with spinal cord injury. 
  • Thick intergluteal cleft and lower extremity plaques. 
  • Thrombus Burden of Deep Vein Thrombosis and Its Association with Thromboprophylaxis and D-Dimer Measurement: Insights from the APEX Trial. 
  • Ticagrelor Compared With Clopidogrel in Patients With Prior Lower Extremity Revascularization for Peripheral Artery Disease. 
  • Ticagrelor in Peripheral Artery Disease Endovascular Revascularization (TI-PAD): Challenges in clinical trial execution. 
  • Total Cardiovascular and Limb Events and the Impact of Polyvascular Disease in Chronic Symptomatic Peripheral Artery Disease. 
  • Total Ischemic Event Reduction With Rivaroxaban After Peripheral Arterial Revascularization in the VOYAGER PAD Trial. 
  • Trajectories of leg strength and gait speed among sedentary older adults: longitudinal pattern of dose response. 
  • Transfemoral amputation following total knee arthroplasty: mortality and functional outcomes. 
  • Trends in movement quality in US Military Academy cadets 2005-17: A JUMP-ACL study. 
  • Trends in multimodal analgesics among end-stage renal disease patients undergoing lower extremity amputation in the US from 2009 to 2018. 
  • Ultrasound for Lower Extremity Deep Venous Thrombosis: Multidisciplinary Recommendations From the Society of Radiologists in Ultrasound Consensus Conference. 
  • Understanding hind limb weight support in chimpanzees with implications for the evolution of primate locomotion. 
  • Unilateral versus bilateral lower extremity motor deficit following complex adult spinal deformity surgery: is there a difference in recovery up to 2-year follow-up? 
  • Unipedal balance is affected by lower extremity joint arthroplasty procedure 1 year following surgery. 
  • Use and 1-year outcomes with conventional and drug-coated balloon angioplasty in patients with lower extremity peripheral artery disease. 
  • Uterine artery embolisation for IVC syndrome and severe lower extremity oedema secondary to IVC compression from massive fibroids. 
  • Validated prediction model for severe groin wound infection after lower extremity revascularization procedures. 
  • Validation of the Brazilian version of the musculoskeletal tumor society rating scale for lower extremity bone sarcoma. 
  • Validation of the triple timed up-and-go test in Lambert-Eaton myasthenia. 
  • Validity of Visual Assessment of Sit to Stand After Hip Fracture. 
  • Why Do Patients Undergoing Extremity Prosthetic Reconstruction for Metastatic Disease Get Readmitted? 
  • Youth Distance Running and Lower Extremity Injury: A Systematic Review. 
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  Keywords of People

  • Attarian, David Edward, Professor of Orthopaedic Surgery, Orthopaedics
  • Curtis, Lesley H., Professor in Population Health Sciences, Medicine, General Internal Medicine
  • Kim, Charles Yoon, Professor of Radiology, Radiology, Interventional Radiology
  • Nielsen, Karen Cristina, Associate Professor of Anesthesiology, Anesthesiology, Ambulatory
  • Olson, Steven Arthur, Goldner Jones Distinguished Professor of Orthopaedic Surgery, Orthopaedics