Telomeric Repeat Binding Protein 2

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  Subject Areas on Research

  • Distinct functions of POT1 at telomeres. 
  • Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice. 
  • Loss of hPot1 function leads to telomere instability and a cut-like phenotype. 
  • Nucleolar organization, ribosomal DNA array stability, and acrocentric chromosome integrity are linked to telomere function. 
  • POT1 association with TRF2 regulates telomere length. 
  • Putative telomere-recruiting domain in the catalytic subunit of human telomerase. 
  • Telomere dysfunction causes alveolar stem cell failure. 
  • Tethering telomeric double- and single-stranded DNA-binding proteins inhibits telomere elongation. 
  • The protein hSnm1B is stabilized when bound to the telomere-binding protein TRF2. 
  • The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. 
  • hSnm1B is a novel telomere-associated protein.