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Subject Areas on Research
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A TGF-β1 genetic variant at the miRNA187 binding site significantly modifies risk of HPV16-associated oropharyngeal cancer.
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A new EV71 VP3 epitope in norovirus P particle vector displays neutralizing activity and protection in vivo in mice.
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A novel immunocompetent murine tumor model for the evaluation of RCAd-enhanced RDAd transduction efficacy.
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Acute hepatitis due to epstein-barr virus in an immunocompetent patient.
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Adenovirus capsid-display of the retro-oriented human complement inhibitor DAF reduces Ad vector-triggered immune responses in vitro and in vivo.
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Base-pairing potential identified by in vitro selection predicts the kinked RNA backbone observed in the crystal structure of the alfalfa mosaic virus RNA-coat protein complex.
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Calcium signals and calpain-dependent necrosis are essential for release of coxsackievirus B from polarized intestinal epithelial cells.
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Characterization of the Adeno-Associated Virus 1 and 6 Sialic Acid Binding Site.
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Coevolution of Adeno-associated Virus Capsid Antigenicity and Tropism through a Structure-Guided Approach.
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Contributions of E1A to mouse adenovirus type 1 pathogenesis following intranasal inoculation.
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Cross-dressing the virion: the transcapsidation of adeno-associated virus serotypes functionally defines subgroups.
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Design, Synthesis, and Mechanism Study of Benzenesulfonamide-Containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities.
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Design, synthesis and structure-activity relationships of 4-phenyl-1H-1,2,3-triazole phenylalanine derivatives as novel HIV-1 capsid inhibitors with promising antiviral activities.
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Design, synthesis, and antiviral activity of phenylalanine derivatives as HIV-1 capsid inhibitors.
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Determination of the cleavage site of enterovirus 71 VP0 and the effect of this cleavage on viral infectivity and assembly.
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Development of Patient-specific AAV Vectors After Neutralizing Antibody Selection for Enhanced Muscle Gene Transfer.
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Discrete fracture patterns of virus shells reveal mechanical building blocks.
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Dissociation kinetics of the GroEL-gp31 chaperonin complex studied with Förster resonance energy transfer.
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Engineering AAV receptor footprints for gene therapy.
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Enhanced efficacy from gene therapy in Pompe disease using coreceptor blockade.
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Epstein-Barr virus antibodies in whole blood spots: a minimally invasive method for assessing an aspect of cell-mediated immunity.
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Evaluation of recombinant adenovirus vaccines based on glycoprotein D and truncated UL25 against herpes simplex virus type 2 in mice.
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Gangliosides are essential endosomal receptors for quasi-enveloped and naked hepatitis A virus.
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High-level synthesis of biologically active reovirus protein sigma 1 in a mammalian expression vector system.
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Human papillomavirus seropositivity synergizes with MDM2 variants to increase the risk of oral squamous cell carcinoma.
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Immune mechanisms responsible for vaccination against and clearance of mucosal and lymphatic norovirus infection.
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Intra- and inter-subunit disulfide bond formation is nonessential in adeno-associated viral capsids.
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Mapping and Engineering Functional Domains of the Assembly-Activating Protein of Adeno-associated Viruses.
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Mapping the Structural Determinants Required for AAVrh.10 Transport across the Blood-Brain Barrier.
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Mechanisms of bacteriophage inactivation via singlet oxygen generation in UV illuminated fullerol suspensions.
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Modulation of Sialic Acid Dependence Influences the Central Nervous System Transduction Profile of Adeno-associated Viruses.
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Mucosal vaccine targeting improves onset of mucosal and systemic immunity to botulinum neurotoxin A.
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Multiple roles for sialylated glycans in determining the cardiopulmonary tropism of adeno-associated virus 4.
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Nanoindentation studies of full and empty viral capsids and the effects of capsid protein mutations on elasticity and strength.
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Natural variation in HIV-1 protease, Gag p7 and p6, and protease cleavage sites within gag/pol polyproteins: amino acid substitutions in the absence of protease inhibitors in mothers and children infected by human immunodeficiency virus type 1.
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Naturally occurring amino acid polymorphisms in human immunodeficiency virus type 1 (HIV-1) Gag p7(NC) and the C-cleavage site impact Gag-Pol processing by HIV-1 protease.
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Nature of Amorphous Hydrophilic Block Affects Self-Assembly of an Artificial Viral Coat Polypeptide.
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Novel adenovirus vectors 'capsid-displaying' a human complement inhibitor.
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Phage display screening for peptides that inhibit polyglutamine aggregation.
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Phase 1 gene therapy for Duchenne muscular dystrophy using a translational optimized AAV vector.
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Preservation of motor function by inhibition of CD8+ virus peptide-specific T cells in Theiler's virus infection.
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Proteins of purified Epstein-Barr virus.
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Receptor Switching in Newly Evolved Adeno-associated Viruses.
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Replication-attenuated Human Adenoviral Type 4 vectors elicit capsid dependent enhanced innate immune responses that are partially dependent upon interactions with the complement system.
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Resolving Adeno-Associated Viral Particle Diversity With Charge Detection Mass Spectrometry.
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Rotavirus RNA polymerase requires the core shell protein to synthesize the double-stranded RNA genome.
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Single amino acid changes can influence titer, heparin binding, and tissue tropism in different adeno-associated virus serotypes.
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Structurally Mapping Antigenic Epitopes of Adeno-associated Virus 9: Development of Antibody Escape Variants.
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Structure-based high-throughput epitope analysis of hexon proteins in B and C species human adenoviruses (HAdVs).
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Structure-guided evolution of antigenically distinct adeno-associated virus variants for immune evasion.
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Surface loop dynamics in adeno-associated virus capsid assembly.
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Synonymous codon usage analysis of hand, foot and mouth disease viruses: A comparative study on coxsackievirus A6, A10, A16, and enterovirus 71 from 2008 to 2015.
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Systemic gene transfer to skeletal muscle using reengineered AAV vectors.
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The differentiated form of nasopharyngeal carcinoma contains Epstein-Barr virus DNA.
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Turnip yellow mosaic virus as a chemoaddressable bionanoparticle.
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Tyrosine cross-linking reveals interfacial dynamics in adeno-associated viral capsids during infection.