Intercellular Signaling Peptides and Proteins
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Subject Areas on Research
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2010 Nicolas Andry Award: Multipotent adult stem cells from adipose tissue for musculoskeletal tissue engineering.
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Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway.
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Acute ethanol administration downregulates human immunodeficiency virus-1 glycoprotein 120-induced KC and RANTES production by murine Kupffer cells and splenocytes.
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Adeno-associated viral vectors based on serotype 3b use components of the fibroblast growth factor receptor signaling complex for efficient transduction.
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Adiponectin is not altered with exercise training despite enhanced insulin action.
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Amphiregulin-dependent mucous cell metaplasia in a model of nonallergic lung injury.
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An amino-terminal fragment of LCRF, LCRF-(1-35), has the same activity as the natural peptide.
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An essential role for the Glut1 PDZ-binding motif in growth factor regulation of Glut1 degradation and trafficking.
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Angiogenic growth factors in the pathophysiology of a murine model of acute lung injury.
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Anti-neutrophil chemokine preserves alveolar development in hyperoxia-exposed newborn rats.
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Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring.
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Autophagy provides nutrients but can lead to Chop-dependent induction of Bim to sensitize growth factor-deprived cells to apoptosis.
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Beta-catenin and transforming growth factor beta have distinct roles regulating fibroblast cell motility and the induction of collagen lattice contraction.
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Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing.
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Bioactivity of intraduodenally and intravenously infused fragments of luminal cholecystokinin releasing factor (LCRF).
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Bone Marrow Aspirate Concentrate for Bone Healing in Foot and Ankle Surgery.
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C3orf58, a novel paracrine protein, stimulates cardiomyocyte cell-cycle progression through the PI3K-AKT-CDK7 pathway.
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CCK-releasing activity of rat intestinal secretion: effect of atropine and comparison with monitor peptide.
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CCR2 deficiency, dysregulation of Notch signaling, and spontaneous pulmonary arterial hypertension.
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CNS inflammation and bone marrow neuropathy in type 1 diabetes.
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Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors.
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Cholecystokinin cells purified by fluorescence-activated cell sorting respond to monitor peptide with an increase in intracellular calcium.
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Chondrogenesis of adult stem cells from adipose tissue and bone marrow: induction by growth factors and cartilage-derived matrix.
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Chordin and noggin promote organizing centers of forebrain development in the mouse.
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Chronic ethanol intoxication enhances the production of cytokine-induced neutrophil chemoattractant and macrophage inflammatory protein-2 by hepatocytes after human immunodeficiency virus-1 glycoprotein 120 vaccination.
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Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions.
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Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells.
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Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting.
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Controlled differentiation of stem cells.
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Cross-talk between Notch and Hedgehog regulates hepatic stellate cell fate in mice.
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Cytokine profiling using monocytes/macrophages cultured on common biomaterials with a range of surface chemistries.
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Deficiency of Adenosine Deaminase 2 Causes Antibody Deficiency.
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Defining a link with autosomal-dominant polycystic kidney disease in mice with congenitally low expression of Pkd1.
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Dermatologic Features of ADA2 Deficiency in Cutaneous Polyarteritis Nodosa.
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Development of a membrane-anchored chemerin receptor agonist as a novel modulator of allergic airway inflammation and neuropathic pain.
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Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms.
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Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice.
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Distinct requirements for extra-embryonic and embryonic bone morphogenetic protein 4 in the formation of the node and primitive streak and coordination of left-right asymmetry in the mouse.
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Distribution and localization of a novel cholecystokinin-releasing factor in the rat gastrointestinal tract.
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Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.
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Early-onset stroke and vasculopathy associated with mutations in ADA2.
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Education influences the association between genetic variants and refractive error: a meta-analysis of five Singapore studies.
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Effects of the proteasome inhibitor PS-341 on apoptosis and angiogenesis in orthotopic human pancreatic tumor xenografts.
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Elevation of CXCR3-binding chemokines in urine indicates acute renal-allograft dysfunction.
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Endogenous elevation of plasma cholecystokinin does not prevent gallstones.
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Expression of ZIC genes in the development of the chick inner ear and nervous system.
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Expression of three forms of melanoma growth stimulating activity (MGSA)/gro in human retinal pigment epithelial cells.
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Extending the Clinical Phenotype of Adenosine Deaminase 2 Deficiency.
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Fat hormones pull their weight in the CNS.
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Feedback regulation by trypsin: evidence for intraluminal CCK-releasing peptide.
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Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands.
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Glucose metabolism attenuates p53 and Puma-dependent cell death upon growth factor deprivation.
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Granulocyte colony-stimulating factors: finding the right indication.
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Gremlin is overexpressed in lung adenocarcinoma and increases cell growth and proliferation in normal lung cells.
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Growth factors during HCV therapy may be "cost-effective", but are they "effective"?
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Hematopoietic stem cell transplantation rescues the immunologic phenotype and prevents vasculopathy in patients with adenosine deaminase 2 deficiency.
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Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis.
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Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA.
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Hyaluronan fragments synergize with interferon-gamma to induce the C-X-C chemokines mig and interferon-inducible protein-10 in mouse macrophages.
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Hypothesis testing for neural cell growth experiments using a hybrid branching process model.
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IPLEX and the telephone game: the difficulty in separating myth from reality on the internet.
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Imaging genetics of brain longevity and mental wellness: the next frontier?
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Implant healing in experimental animal models of diabetes.
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Increased dietary fat attenuates the anorexic effects of intracerebroventricular injections of MTII.
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Inhibition of constitutive NF-kappa B activity by I kappa B alpha M suppresses tumorigenesis.
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Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance.
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Local Dkk1 crosstalk from breeding ornaments impedes regeneration of injured male zebrafish fins.
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Luminal CCK-releasing factor stimulates CCK release from human intestinal endocrine and STC-1 cells.
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MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
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MGSA/GRO transcription is differentially regulated in normal retinal pigment epithelial and melanoma cells.
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Measurement of novel biomarkers to predict chronic heart failure outcomes and left ventricular remodeling.
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Mechanical stretch is a highly selective regulator of gene expression in human bladder smooth muscle cells.
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Metabolic stress in autophagy and cell death pathways.
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Molecular morphogens. Upside-down ideas vindicated.
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Monitor peptide binding sites are expressed in the rat liver and small intestine.
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Msx1 and Pax3 cooperate to mediate FGF8 and WNT signals during Xenopus neural crest induction.
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Multiple tissue-specific requirements for the BMP antagonist Noggin in development of the mammalian craniofacial skeleton.
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NOTCH-Mediated Maintenance and Expansion of Human Bone Marrow Stromal/Stem Cells: A Technology Designed for Orthopedic Regenerative Medicine.
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NOV (CCN3) regulation in the growth plate and CCN family member expression in cartilage neoplasia.
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Overexpression of receptor tyrosine kinase Axl promotes tumor cell invasion and survival in pancreatic ductal adenocarcinoma.
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Pancreatic secretory trypsin inhibitor I reduces the severity of chronic pancreatitis in mice overexpressing interleukin-1β in the pancreas.
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Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells.
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Paracrine mechanisms of stem cell reparative and regenerative actions in the heart.
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Peutz-Jeghers LKB1 mutants fail to activate GSK-3beta, preventing it from inhibiting Wnt signaling.
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Phase I study of intraperitoneal recombinant human interleukin 12 in patients with Müllerian carcinoma, gastrointestinal primary malignancies, and mesothelioma.
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Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging.
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Plasma adiponectin increases postprandially in obese, but not in lean, subjects.
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Platelets promote pulmonary pull of polys.
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Possible role for vascular cell proliferation in cerebral vasospasm after subarachnoid hemorrhage.
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Preclinical evaluation of ex vivo expanded/activated γδ T cells for immunotherapy of glioblastoma multiforme.
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Progranulin haploinsufficiency causes biphasic social dominance abnormalities in the tube test.
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Prospective of Ras signaling in stem cells.
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Prosurvival function of the granulin-epithelin precursor is important in tumor progression and chemoresponse.
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Protection against chronic pancreatitis and pancreatic fibrosis in mice overexpressing pancreatic secretory trypsin inhibitor.
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Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling.
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Rare and low-frequency coding variants alter human adult height.
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Reciprocal gut microbiota transplants from zebrafish and mice to germ-free recipients reveal host habitat selection.
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Redirecting migration of T cells to chemokine secreted from tumors by genetic modification with CXCR2.
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Regulation of cholecystokinin secretion by intraluminal releasing factors.
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Regulation of connective tissue growth factor expression in the aqueous humor outflow pathway.
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Role of calcium in monitor peptide-stimulated cholecystokinin release from perifused intestinal cells.
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Role of growth factors and thrombopoietic agents in the treatment of chronic hepatitis C.
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Screening of 181 Patients With Antibody Deficiency for Deficiency of Adenosine Deaminase 2 Sheds New Light on the Disease in Adulthood.
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Sequential roles of Hedgehog and Wnt signaling in osteoblast development.
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Serum von Willebrand factor, matrix metalloproteinase-9, and vascular endothelial growth factor levels predict the onset of cerebral vasospasm after aneurysmal subarachnoid hemorrhage.
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Sexually dimorphic fin regeneration in zebrafish controlled by androgen/GSK3 signaling.
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Skeletal muscle-specific genetic determinants contribute to the differential strain-dependent effects of hindlimb ischemia in mice.
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Soluble ICAM-1, MCP-1, and MIP-2 protein secretion by rat pleural mesothelial cells following exposure to amosite asbestos.
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Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis.
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Suppression of NF-kappaB-dependent proinflammatory gene expression in human RPE cells by a proteasome inhibitor.
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Synergy between tumor immunotherapy and antiangiogenic therapy.
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TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions.
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Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development.
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Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis.
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Testosterone levels influence mouse fetal Leydig cell progenitors through notch signaling.
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The BMP antagonists Chordin and Noggin have essential but redundant roles in mouse mandibular outgrowth.
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The N- and C-terminal peptides of hIL8/CXCL8 are ligands for hCXCR1 and hCXCR2.
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The class I HDAC inhibitor MGCD0103 induces cell cycle arrest and apoptosis in colon cancer initiating cells by upregulating Dickkopf-1 and non-canonical Wnt signaling.
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The effects of BMP6 overexpression on adipose stem cell chondrogenesis: Interactions with dexamethasone and exogenous growth factors.
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The granulin-epithelin precursor is a steroid-regulated growth factor in endometrial cancer.
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The granulin-epithelin precursor/PC-cell-derived growth factor is a growth factor for epithelial ovarian cancer.
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The granulin-epithelin precursor: a putative new growth factor for ovarian cancer.
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The intestinal glucose-apelin cycle controls carbohydrate absorption in mice.
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The mouse lethal nonagouti (a(x)) mutation deletes the S-adenosylhomocysteine hydrolase (Ahcy) gene.
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The organizer factors Chordin and Noggin are required for mouse forebrain development.
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The role of chordin/Bmp signals in mammalian pharyngeal development and DiGeorge syndrome.
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The vascular NADPH oxidase subunit p47phox is involved in redox-mediated gene expression.
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Three-dimensional culture systems to induce chondrogenesis of adipose-derived stem cells.
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Thymic rejuvenation and aging.
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Tissue engraftment of hypoxic-preconditioned adipose-derived stem cells improves flap viability.
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Transactivation of the epidermal growth factor receptor by angiotensin II in glomerular podocytes.
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Transgenic expression of pancreatic secretory trypsin inhibitor-1 rescues SPINK3-deficient mice and restores a normal pancreatic phenotype.
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Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice.
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USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds.
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Utility of amino-terminal pro-brain natriuretic peptide, galectin-3, and apelin for the evaluation of patients with acute heart failure.
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Vanadium-induced HB-EGF expression in human lung fibroblasts is oxidant dependent and requires MAP kinases.
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Vascular endothelial growth factor expression in pig latissimus dorsi myocutaneous flaps after ischemia reperfusion injury.
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Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4.
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Voluntary running prevents progressive memory decline and increases adult hippocampal neurogenesis and growth factor expression after whole-brain irradiation.
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Wnt pathway activation: new relations and locations.
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Keywords of People
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Abbruzzese, James,
Charles Johnson, M.D. Professor of Medicine,
Medicine, Medical Oncology
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Bejsovec, Amy,
Associate Professor of Biology,
Biology
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Berchuck, Andrew,
James M. Ingram Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
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Choi, Steven Sok,
Associate Professor of Medicine,
Medicine, Gastroenterology
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Gunn, Michael Dee,
Professor of Medicine,
Immunology
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Hilton, Matthew James,
Associate Professor in Orthopaedic Surgery,
Cell Biology
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Hogan, Brigid L. M.,
George Barth Geller Professor,
Cell Biology
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Milano, Carmelo Alessio,
Professor of Surgery,
Surgery, Cardiovascular and Thoracic Surgery
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Premont, Richard Thomas,
Associate Professor in Medicine,
Medicine, Gastroenterology
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Warner, David Samuel,
Distinguished Professor of Anesthesiology, in the School of Medicine,
Neurobiology