Fimbriae Proteins
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Subject Areas on Research
- Bacteria-host cell interaction mediated by cellular cholesterol/glycolipid-enriched microdomains.
- Binding of bacteria to mucosal surfaces.
- Co-option of endocytic functions of cellular caveolae by pathogens.
- Contribution of mast cells to bacterial clearance and their proliferation during experimental cystitis induced by type 1 fimbriated E. coli.
- Evaluation of pertussis in U.S. Marine Corps trainees.
- Examination of type IV pilus expression and pilus-associated phenotypes in Kingella kingae clinical isolates.
- Expression of Kingella kingae type IV pili is regulated by sigma54, PilS, and PilR.
- FimC is a periplasmic PapD-like chaperone that directs assembly of type 1 pili in bacteria.
- FimH adhesin of type 1 pili is assembled into a fibrillar tip structure in the Enterobacteriaceae.
- Fimbriae-mediated outer membrane vesicle production and invasion of Porphyromonas gingivalis.
- Genetic, biochemical, and structural studies of biogenesis of adhesive pili in bacteria.
- Immunoglobulin-mediated agglutination of and biofilm formation by Escherichia coli K-12 require the type 1 pilus fiber.
- Internalization of FimH+ Escherichia coli by the human mast cell line (HMC-1 5C6) involves protein kinase C.
- Involvement of cellular caveolae in bacterial entry into mast cells.
- Localization of a domain in the FimH adhesin of Escherichia coli type 1 fimbriae capable of receptor recognition and use of a domain-specific antibody to confer protection against experimental urinary tract infection.
- Lung transplantation for cystic fibrosis patients with Burkholderia cepacia complex. Survival linked to genomovar type.
- Mast cell degranulation induced by type 1 fimbriated Escherichia coli in mice.
- Mast cell modulation of immune responses to bacteria.
- Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha.
- Mast cell modulation of the innate immune response to enterobacterial infection.
- Mast cell phagocytosis of FimH-expressing enterobacteria.
- Mast cells process bacterial Ags through a phagocytic route for class I MHC presentation to T cells.
- Molecular basis for the enterocyte tropism exhibited by Salmonella typhimurium type 1 fimbriae.
- Neutrophil activation by nascent FimH subunits of type 1 fimbriae purified from the periplasm of Escherichia coli.
- Production of TNF-alpha by murine bone marrow derived mast cells activated by the bacterial fimbrial protein, FimH.
- Role of bacterial lectins in urinary tract infections. Molecular mechanisms for diversification of bacterial surface lectins.
- Role of mast cell leukotrienes in neutrophil recruitment and bacterial clearance in infectious peritonitis.
- Six-year molecular analysis of Burkholderia cepacia complex isolates among cystic fibrosis patients at a referral center for lung transplantation.
- Survival of FimH-expressing enterobacteria in macrophages relies on glycolipid traffic.
- The distinct binding specificities exhibited by enterobacterial type 1 fimbriae are determined by their fimbrial shafts.
- The mast cell tumor necrosis factor alpha response to FimH-expressing Escherichia coli is mediated by the glycosylphosphatidylinositol-anchored molecule CD48.
- Type 1 fimbrial shafts of Escherichia coli and Klebsiella pneumoniae influence sugar-binding specificities of their FimH adhesins.