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Subject Areas on Research
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5-HT1A and histamine H1 receptors in HeLa cells stimulate phosphoinositide hydrolysis and phosphate uptake via distinct G protein pools.
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5-Oxo-eicosanoids and hematopoietic cytokines cooperate in stimulating neutrophil function and the mitogen-activated protein kinase pathway.
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A guanine nucleotide regulatory protein controls polyphosphoinositide metabolism, Ca2+ mobilization, and cellular responses to chemoattractants in human monocytes.
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A pertussis/choleratoxin-sensitive N protein may mediate chemoattractant receptor signal transduction.
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Acidic stimuli activates two distinct pathways in taste receptor cells from rat fungiform papillae.
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Actin depolymerization and inhibition of capping induced by pentoxifylline in human lymphocytes and neutrophils.
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Activated alpha 2-macroglobulin promotes mitogenesis in rat vascular smooth muscle cells by a mechanism that is independent of growth-factor-carrier activity.
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Activation of Gz attenuates Rap1-mediated differentiation of PC12 cells.
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Age increases cardiac Galpha(i2) expression, resulting in enhanced coupling to G protein-coupled receptors.
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Agonists cause nuclear translocation of phosphatidylinositol 3-kinase gamma. A Gbetagamma-dependent pathway that requires the p110gamma amino terminus.
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Analysis of calcium homeostasis in activated human polymorphonuclear leukocytes. Evidence for two distinct mechanisms for lowering cytosolic calcium.
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Apolipoprotein E and mimetic peptide initiate a calcium-dependent signaling response in macrophages.
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Aspirin inhibits tumor necrosis factoralpha gene expression in murine tissue macrophages.
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Baclofen induces spontaneous, rhythmic sharp waves in the rat hippocampal slice.
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Beta(2)-adrenergic and several other G protein-coupled receptors in human atrial membranes activate both G(s) and G(i).
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Beta-adrenoceptor control of G protein function in the neonate: determinant of desensitization or sensitization.
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Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis.
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Binding, coupling, and mRNA subtype heterogeneity of alpha 1-adrenergic receptors in cultured human RPE.
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Bradykinin stimulation of inositol polyphosphate production in porcine aortic endothelial cells.
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Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein.
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Chemoattractant receptors activate distinct pathways for chemotaxis and secretion. Role of G-protein usage.
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Chemoattractant-induced activation of c-fos gene expression in human monocytes.
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Chronic ethanol treatment increases expression of inhibitory G-proteins and reduces adenylylcyclase activity in the central nervous system of two lines of ethanol-sensitive mice.
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Constitutively active mutants of the alpha 2-adrenergic receptor.
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Coupling of a mutated form of the human beta 2-adrenergic receptor to Gi and Gs. Requirement for multiple cytoplasmic domains in the coupling process.
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Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes.
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Coupling of the expressed alpha 1B-adrenergic receptor to the phospholipase C pathway in Xenopus oocytes. The role of Go.
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Dancing with different partners: protein kinase a phosphorylation of seven membrane-spanning receptors regulates their G protein-coupling specificity.
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Depolarization of polymorphonuclear leukocytes by Porphyromonas (Bacteroides) gingivalis 381 in the absence of respiratory burst activation.
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Different G(i)-coupled chemoattractant receptors signal qualitatively different functions in human neutrophils.
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Differential regulation of cAMP by endogenous versus transfected formylpeptide chemoattractant receptors: implications for Gi-coupled receptor signaling.
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Differential regulation of receptor-stimulated cyclic adenosine monophosphate production by polyvalent cations in MC3T3-E1 osteoblasts.
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Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity.
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Dual coupling of the cloned 5-HT1A receptor to both adenylyl cyclase and phospholipase C is mediated via the same Gi protein.
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Dysregulation of dopamine transporters via dopamine D2 autoreceptors triggers anomalous dopamine efflux associated with attention-deficit hyperactivity disorder.
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Effect of pertussis toxin on alpha 2-adrenoceptors: decreased formation of the high-affinity state for agonists.
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Effector coupling mechanisms of the cloned 5-HT1A receptor.
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Effects of interleukin-1 on calcium signaling and the increase of filamentous actin in isolated and in situ articular chondrocytes.
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Endogenous RGS proteins attenuate Galpha(i)-mediated lysophosphatidic acid signaling pathways in ovarian cancer cells.
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Endothelin activates voltage-dependent Ca2+ current by a G protein-dependent mechanism in rabbit cardiac myocytes.
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Endotoxin-mediated synthesis of nitric oxide is dependent on Gq protein signal transduction.
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Estrogen receptor transactivation in MCF-7 breast cancer cells by melatonin and growth factors.
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Evidence for a second alpha 2-macroglobulin receptor.
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Functional characterization of alpha1-adrenergic receptors in experimental vein grafts.
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Functional expression of human 5-HT1A receptors and differential coupling to second messengers in CHO cells.
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G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor.
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G protein beta gamma subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of alpha subunits by pertussis toxin but differential interactions with Gs alpha.
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G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.
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G protein-coupled receptor internalization signaling is required for cardioprotection in ischemic preconditioning.
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G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism.
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GRK5 deficiency leads to reduced hippocampal acetylcholine level via impaired presynaptic M2/M4 autoreceptor desensitization.
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Granulocyte-macrophage colony-stimulating factor primes neutrophils by activating a pertussis toxin-sensitive G protein not associated with phosphatidylinositol turnover.
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Identification of a 43-kilodalton human T lymphocyte membrane protein as a receptor for pertussis toxin.
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In vitro effect of chlorpyrifos oxon on muscarinic receptors and adenylate cyclase.
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Inhibition of spontaneous beta 2-adrenergic activation rescues beta 1-adrenergic contractile response in cardiomyocytes overexpressing beta 2-adrenoceptor.
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Interaction of Bordetella pertussis with mast cells, modulation of cytokine secretion by pertussis toxin.
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Intracellular third loop domain of angiotensin II type-2 receptor. Role in mediating signal transduction and cellular function.
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Involvement of cAMP-dependent protein kinase in mu-opioid modulation of NMDA-mediated synaptic currents.
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Isobutylmethylxanthine stimulates adenylate cyclase by blocking the inhibitory regulatory protein, Gi.
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Isolation of GTP-binding proteins from myeloid HL-60 cells. Identification of two pertussis toxin substrates.
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Ligation of low-density lipoprotein receptor-related protein with antibodies elevates intracellular calcium and inositol 1,4, 5-trisphosphate in macrophages.
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Ligation of the alpha 2-macroglobulin signaling receptor on macrophages induces synthesis of platelet activating factor.
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Luteinizing hormone (LH) drives diverse intracellular calcium second messenger signals in isolated porcine ovarian thecal cells: preferential recruitment of intracellular Ca2+ oscillatory cells by higher concentrations of LH.
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Maleylated-BSA induces hydrolysis of PIP2, fluxes of Ca2+, NF-kappaB binding, and transcription of the TNF-alpha gene in murine macrophages.
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Mechanisms of pertussis toxin-induced myelomonocytic cell adhesion: role of Mac-1(CD11b/CD18) and urokinase receptor (CD87).
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Modulation of basal L-type Ca2+ current by adenosine in ferret isolated right ventricular myocytes.
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Molecular cloning of a novel splice variant of the alpha subunit of the mammalian Go protein.
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Morphological and functional characterization of beta TC-6 cells--an insulin-secreting cell line derived from transgenic mice.
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Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells.
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Nicotinamide adenine dinucleotide (NAD) and its metabolites inhibit T lymphocyte proliferation: role of cell surface NAD glycohydrolase and pyrophosphatase activities.
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Nucleotide regulatory protein-mediated activation of phospholipase C in human polymorphonuclear leukocytes is disrupted by phorbol esters.
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Overexpression of the cardiac beta(2)-adrenergic receptor and expression of a beta-adrenergic receptor kinase-1 (betaARK1) inhibitor both increase myocardial contractility but have differential effects on susceptibility to ischemic injury.
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Oxidized low density lipoprotein suppresses activation of NF kappa B in macrophages via a pertussis toxin-sensitive signaling mechanism.
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Pertussis toxin attenuates platelet-activating factor-induced pulmonary hemodynamic alterations in pigs.
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Pertussis toxin blocks the effects of alpha 2-agonists and antagonists on locus coeruleus activity in vivo.
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Pertussis toxin triggers rapid second messenger production in human T lymphocytes.
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Pertussis-toxin-sensitive Galpha subunits selectively bind to C-terminal domain of neuronal GIRK channels: evidence for a heterotrimeric G-protein-channel complex.
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Pharmacology of pertussis toxin B-oligomer.
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Phosphorylation and calcium influx are not sufficient for the activation of cytosolic phospholipase A2 in U937 cells: requirement for a Gi alpha-type G-protein.
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Platelet-activating factor induces tyrosine phosphorylation in human neutrophils.
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Potential role for a guanine nucleotide regulatory protein in chemoattractant receptor mediated polyphosphoinositide metabolism, Ca++ mobilization and cellular responses by leukocytes.
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Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system.
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Ras-dependent activation of fibroblast mitogen-activated protein kinase by 5-HT1A receptor via a G protein beta gamma-subunit-initiated pathway.
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Receptor-evoked Cl- current in Xenopus oocytes is mediated through a beta-type phospholipase C. Cloning of a new form of the enzyme.
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Regulation of stably transfected platelet activating factor receptor in RBL-2H3 cells. Role of multiple G proteins and receptor phosphorylation.
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Regulation of the G protein Galphai2 by growth and development in fetal airway epithelium.
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Role of a guanine nucleotide regulatory protein in the activation of phospholipase C by different chemoattractants.
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Secondary lymphoid-tissue chemokine (SLC) stimulates integrin alpha 4 beta 7-mediated adhesion of lymphocytes to mucosal addressin cell adhesion molecule-1 (MAdCAM-1) under flow.
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Serine 232 of the alpha(2A)-adrenergic receptor is a protein kinase C-sensitive effector coupling switch.
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Short-term sPECAM-Fc treatment ameliorates EAE while chronic use hastens onset of symptoms.
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Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins.
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Specificity of Gbetagamma signaling depends on Galpha subunit coupling with G-protein-sensitive K(+) channels.
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Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.
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T cell homeostasis requires G protein-coupled receptor-mediated access to trophic signals that promote growth and inhibit chemotaxis.
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The D2-dopamine receptor of anterior pituitary is functionally associated with a pertussis toxin-sensitive guanine nucleotide binding protein.
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The Ras-related protein AGS1/RASD1 suppresses cell growth.
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The dopamine D2 receptor can directly recruit and activate GRK2 without G protein activation.
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The effects of baclofen and pertussis toxin on epileptiform activity induced in the hippocampal slice by magnesium depletion.
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The formylpeptide chemoattractant receptor copurifies with a GTP-binding protein containing a distinct 40-kDa pertussis toxin substrate.
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The new cardiotonic agent sulmazole is an A1 adenosine receptor antagonist and functionally blocks the inhibitory regulator, Gi.
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The regulation of the cGMP-binding cGMP phosphodiesterase by proteins that are immunologically related to gamma subunit of the photoreceptor cGMP phosphodiesterase.
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The relationship between low density lipoprotein-related protein/alpha 2-macroglobulin (alpha 2M) receptors and the newly described alpha 2M signaling receptor.
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Transgenic mice with cardiac overexpression of alpha1B-adrenergic receptors. In vivo alpha1-adrenergic receptor-mediated regulation of beta-adrenergic signaling.
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Tyrosine phosphorylation in human neutrophil.
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Unidirectional, heterologous desensitization of the pertussis toxin receptor by the CD3/TCR complex.
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beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi.
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beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.