Pertussis Toxin

• 

  Subject Areas on Research

  • 5-HT1A and histamine H1 receptors in HeLa cells stimulate phosphoinositide hydrolysis and phosphate uptake via distinct G protein pools. 
  • 5-Oxo-eicosanoids and hematopoietic cytokines cooperate in stimulating neutrophil function and the mitogen-activated protein kinase pathway. 
  • A guanine nucleotide regulatory protein controls polyphosphoinositide metabolism, Ca2+ mobilization, and cellular responses to chemoattractants in human monocytes. 
  • A pertussis/choleratoxin-sensitive N protein may mediate chemoattractant receptor signal transduction. 
  • Acidic stimuli activates two distinct pathways in taste receptor cells from rat fungiform papillae. 
  • Actin depolymerization and inhibition of capping induced by pentoxifylline in human lymphocytes and neutrophils. 
  • Activated alpha 2-macroglobulin promotes mitogenesis in rat vascular smooth muscle cells by a mechanism that is independent of growth-factor-carrier activity. 
  • Activation of Gz attenuates Rap1-mediated differentiation of PC12 cells. 
  • Age increases cardiac Galpha(i2) expression, resulting in enhanced coupling to G protein-coupled receptors. 
  • Agonists cause nuclear translocation of phosphatidylinositol 3-kinase gamma. A Gbetagamma-dependent pathway that requires the p110gamma amino terminus. 
  • Analysis of calcium homeostasis in activated human polymorphonuclear leukocytes. Evidence for two distinct mechanisms for lowering cytosolic calcium. 
  • Apolipoprotein E and mimetic peptide initiate a calcium-dependent signaling response in macrophages. 
  • Aspirin inhibits tumor necrosis factoralpha gene expression in murine tissue macrophages. 
  • Baclofen induces spontaneous, rhythmic sharp waves in the rat hippocampal slice. 
  • Beta(2)-adrenergic and several other G protein-coupled receptors in human atrial membranes activate both G(s) and G(i). 
  • Beta-adrenoceptor control of G protein function in the neonate: determinant of desensitization or sensitization. 
  • Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis. 
  • Binding, coupling, and mRNA subtype heterogeneity of alpha 1-adrenergic receptors in cultured human RPE. 
  • Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein. 
  • Chemoattractant receptors activate distinct pathways for chemotaxis and secretion. Role of G-protein usage. 
  • Chemoattractant-induced activation of c-fos gene expression in human monocytes. 
  • Chronic ethanol treatment increases expression of inhibitory G-proteins and reduces adenylylcyclase activity in the central nervous system of two lines of ethanol-sensitive mice. 
  • Constitutively active mutants of the alpha 2-adrenergic receptor. 
  • Coupling of a mutated form of the human beta 2-adrenergic receptor to Gi and Gs. Requirement for multiple cytoplasmic domains in the coupling process. 
  • Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes. 
  • Coupling of the expressed alpha 1B-adrenergic receptor to the phospholipase C pathway in Xenopus oocytes. The role of Go. 
  • Dancing with different partners: protein kinase a phosphorylation of seven membrane-spanning receptors regulates their G protein-coupling specificity. 
  • Depolarization of polymorphonuclear leukocytes by Porphyromonas (Bacteroides) gingivalis 381 in the absence of respiratory burst activation. 
  • Different G(i)-coupled chemoattractant receptors signal qualitatively different functions in human neutrophils. 
  • Differential regulation of cAMP by endogenous versus transfected formylpeptide chemoattractant receptors: implications for Gi-coupled receptor signaling. 
  • Differential regulation of receptor-stimulated cyclic adenosine monophosphate production by polyvalent cations in MC3T3-E1 osteoblasts. 
  • Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity. 
  • Dual coupling of the cloned 5-HT1A receptor to both adenylyl cyclase and phospholipase C is mediated via the same Gi protein. 
  • Dysregulation of dopamine transporters via dopamine D2 autoreceptors triggers anomalous dopamine efflux associated with attention-deficit hyperactivity disorder. 
  • Effect of pertussis toxin on alpha 2-adrenoceptors: decreased formation of the high-affinity state for agonists. 
  • Effector coupling mechanisms of the cloned 5-HT1A receptor. 
  • Effects of interleukin-1 on calcium signaling and the increase of filamentous actin in isolated and in situ articular chondrocytes. 
  • Endogenous RGS proteins attenuate Galpha(i)-mediated lysophosphatidic acid signaling pathways in ovarian cancer cells. 
  • Endothelin activates voltage-dependent Ca2+ current by a G protein-dependent mechanism in rabbit cardiac myocytes. 
  • Endotoxin-mediated synthesis of nitric oxide is dependent on Gq protein signal transduction. 
  • Estrogen receptor transactivation in MCF-7 breast cancer cells by melatonin and growth factors. 
  • Evidence for a second alpha 2-macroglobulin receptor. 
  • Functional expression of human 5-HT1A receptors and differential coupling to second messengers in CHO cells. 
  • G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor. 
  • G protein beta gamma subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of alpha subunits by pertussis toxin but differential interactions with Gs alpha. 
  • G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein. 
  • G protein-coupled receptor internalization signaling is required for cardioprotection in ischemic preconditioning. 
  • G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism. 
  • GRK5 deficiency leads to reduced hippocampal acetylcholine level via impaired presynaptic M2/M4 autoreceptor desensitization. 
  • Granulocyte-macrophage colony-stimulating factor primes neutrophils by activating a pertussis toxin-sensitive G protein not associated with phosphatidylinositol turnover. 
  • Identification of a 43-kilodalton human T lymphocyte membrane protein as a receptor for pertussis toxin. 
  • In vitro effect of chlorpyrifos oxon on muscarinic receptors and adenylate cyclase. 
  • Inhibition of spontaneous beta 2-adrenergic activation rescues beta 1-adrenergic contractile response in cardiomyocytes overexpressing beta 2-adrenoceptor. 
  • Interaction of Bordetella pertussis with mast cells, modulation of cytokine secretion by pertussis toxin. 
  • Intracellular third loop domain of angiotensin II type-2 receptor. Role in mediating signal transduction and cellular function. 
  • Involvement of cAMP-dependent protein kinase in mu-opioid modulation of NMDA-mediated synaptic currents. 
  • Isobutylmethylxanthine stimulates adenylate cyclase by blocking the inhibitory regulatory protein, Gi. 
  • Isolation of GTP-binding proteins from myeloid HL-60 cells. Identification of two pertussis toxin substrates. 
  • Ligation of low-density lipoprotein receptor-related protein with antibodies elevates intracellular calcium and inositol 1,4, 5-trisphosphate in macrophages. 
  • Ligation of the alpha 2-macroglobulin signaling receptor on macrophages induces synthesis of platelet activating factor. 
  • Luteinizing hormone (LH) drives diverse intracellular calcium second messenger signals in isolated porcine ovarian thecal cells: preferential recruitment of intracellular Ca2+ oscillatory cells by higher concentrations of LH. 
  • Maleylated-BSA induces hydrolysis of PIP2, fluxes of Ca2+, NF-kappaB binding, and transcription of the TNF-alpha gene in murine macrophages. 
  • Mechanisms of pertussis toxin-induced myelomonocytic cell adhesion: role of Mac-1(CD11b/CD18) and urokinase receptor (CD87). 
  • Molecular cloning of a novel splice variant of the alpha subunit of the mammalian Go protein. 
  • Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells. 
  • Nicotinamide adenine dinucleotide (NAD) and its metabolites inhibit T lymphocyte proliferation: role of cell surface NAD glycohydrolase and pyrophosphatase activities. 
  • Nucleotide regulatory protein-mediated activation of phospholipase C in human polymorphonuclear leukocytes is disrupted by phorbol esters. 
  • Overexpression of the cardiac beta(2)-adrenergic receptor and expression of a beta-adrenergic receptor kinase-1 (betaARK1) inhibitor both increase myocardial contractility but have differential effects on susceptibility to ischemic injury. 
  • Oxidized low density lipoprotein suppresses activation of NF kappa B in macrophages via a pertussis toxin-sensitive signaling mechanism. 
  • Pertussis toxin blocks the effects of alpha 2-agonists and antagonists on locus coeruleus activity in vivo. 
  • Pertussis toxin triggers rapid second messenger production in human T lymphocytes. 
  • Pertussis-toxin-sensitive Galpha subunits selectively bind to C-terminal domain of neuronal GIRK channels: evidence for a heterotrimeric G-protein-channel complex. 
  • Pharmacology of pertussis toxin B-oligomer. 
  • Phosphorylation and calcium influx are not sufficient for the activation of cytosolic phospholipase A2 in U937 cells: requirement for a Gi alpha-type G-protein. 
  • Platelet-activating factor induces tyrosine phosphorylation in human neutrophils. 
  • Potential role for a guanine nucleotide regulatory protein in chemoattractant receptor mediated polyphosphoinositide metabolism, Ca++ mobilization and cellular responses by leukocytes. 
  • Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system. 
  • Ras-dependent activation of fibroblast mitogen-activated protein kinase by 5-HT1A receptor via a G protein beta gamma-subunit-initiated pathway. 
  • Regulation of stably transfected platelet activating factor receptor in RBL-2H3 cells. Role of multiple G proteins and receptor phosphorylation. 
  • Regulation of the G protein Galphai2 by growth and development in fetal airway epithelium. 
  • Role of a guanine nucleotide regulatory protein in the activation of phospholipase C by different chemoattractants. 
  • Secondary lymphoid-tissue chemokine (SLC) stimulates integrin alpha 4 beta 7-mediated adhesion of lymphocytes to mucosal addressin cell adhesion molecule-1 (MAdCAM-1) under flow. 
  • Serine 232 of the alpha(2A)-adrenergic receptor is a protein kinase C-sensitive effector coupling switch. 
  • Short-term sPECAM-Fc treatment ameliorates EAE while chronic use hastens onset of symptoms. 
  • Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins. 
  • Specificity of Gbetagamma signaling depends on Galpha subunit coupling with G-protein-sensitive K(+) channels. 
  • Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. 
  • T cell homeostasis requires G protein-coupled receptor-mediated access to trophic signals that promote growth and inhibit chemotaxis. 
  • The D2-dopamine receptor of anterior pituitary is functionally associated with a pertussis toxin-sensitive guanine nucleotide binding protein. 
  • The Ras-related protein AGS1/RASD1 suppresses cell growth. 
  • The dopamine D2 receptor can directly recruit and activate GRK2 without G protein activation. 
  • The effects of baclofen and pertussis toxin on epileptiform activity induced in the hippocampal slice by magnesium depletion. 
  • The formylpeptide chemoattractant receptor copurifies with a GTP-binding protein containing a distinct 40-kDa pertussis toxin substrate. 
  • The new cardiotonic agent sulmazole is an A1 adenosine receptor antagonist and functionally blocks the inhibitory regulator, Gi. 
  • The regulation of the cGMP-binding cGMP phosphodiesterase by proteins that are immunologically related to gamma subunit of the photoreceptor cGMP phosphodiesterase. 
  • The relationship between low density lipoprotein-related protein/alpha 2-macroglobulin (alpha 2M) receptors and the newly described alpha 2M signaling receptor. 
  • Transgenic mice with cardiac overexpression of alpha1B-adrenergic receptors. In vivo alpha1-adrenergic receptor-mediated regulation of beta-adrenergic signaling. 
  • Tyrosine phosphorylation in human neutrophil. 
  • Unidirectional, heterologous desensitization of the pertussis toxin receptor by the CD3/TCR complex. 
  • beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi. 
  • beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.