Virulence Factors

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  Subject Areas on Research

  • A Chlamydia trachomatis strain with a chemically generated amino acid substitution (P370L) in the cthtrA gene shows reduced elementary body production. 
  • A Novel Resistance Pathway for Calcineurin Inhibitors in the Human-Pathogenic Mucorales Mucor circinelloides. 
  • A bacterial virulence protein suppresses host innate immunity to cause plant disease. 
  • A combination of independent transcriptional regulators shapes bacterial virulence gene expression during infection. 
  • A direct link between carbohydrate utilization and virulence in the major human pathogen group A Streptococcus. 
  • A flucytosine-responsive Mbp1/Swi4-like protein, Mbs1, plays pleiotropic roles in antifungal drug resistance, stress response, and virulence of Cryptococcus neoformans. 
  • A glycosylphosphatidylinositol anchor is required for membrane localization but dispensable for cell wall association of chitin deacetylase 2 in Cryptococcus neoformans. 
  • A unique chromosomal rearrangement in the Cryptococcus neoformans var. grubii type strain enhances key phenotypes associated with virulence. 
  • A unique fungal two-component system regulates stress responses, drug sensitivity, sexual development, and virulence of Cryptococcus neoformans. 
  • Activation of MAPK/ERK signaling by Burkholderia pseudomallei cycle inhibiting factor (Cif). 
  • Bacterial-host-cell tethers. 
  • COI1 is a critical component of a receptor for jasmonate and the bacterial virulence factor coronatine. 
  • Caenorhabditis elegans-based screen identifies Salmonella virulence factors required for conserved host-pathogen interactions. 
  • Calcineurin plays key roles in the dimorphic transition and virulence of the human pathogenic zygomycete Mucor circinelloides. 
  • Central Role of the Trehalose Biosynthesis Pathway in the Pathogenesis of Human Fungal Infections: Opportunities and Challenges for Therapeutic Development. 
  • Challenge of Drosophila melanogaster with Cryptococcus neoformans and role of the innate immune response. 
  • Chitosan Biosynthesis and Virulence in the Human Fungal Pathogen Cryptococcus gattii. 
  • Comparative genome analysis of Trichophyton rubrum and related dermatophytes reveals candidate genes involved in infection. 
  • Comparison of Cryptococcus gattii /neoformans Species Complex to Related Genera (Papiliotrema and Naganishia ) Reveal Variances in Virulence Associated Factors and Antifungal Susceptibility. 
  • Connecting virulence pathways to cell-cycle progression in the fungal pathogen Cryptococcus neoformans. 
  • Context-dependent activation kinetics elicited by soluble versus outer membrane vesicle-associated heat-labile enterotoxin. 
  • Coronatine promotes Pseudomonas syringae virulence in plants by activating a signaling cascade that inhibits salicylic acid accumulation. 
  • Cryptococcus neoformans Cda1 and Its Chitin Deacetylase Activity Are Required for Fungal Pathogenesis. 
  • Cryptococcus neoformans hyperfilamentous strain is hypervirulent in a murine model of cryptococcal meningoencephalitis. 
  • Cryptococcus neoformans methionine synthase: expression analysis and requirement for virulence. 
  • Cryptococcus neoformans requires a functional glycolytic pathway for disease but not persistence in the host. 
  • Cryptococcus neoformans virulence gene discovery through insertional mutagenesis. 
  • Cyclic AMP-dependent protein kinase catalytic subunits have divergent roles in virulence factor production in two varieties of the fungal pathogen Cryptococcus neoformans. 
  • Derivatives of plant phenolic compound affect the type III secretion system of Pseudomonas aeruginosa via a GacS-GacA two-component signal transduction system. 
  • Detection of Cytosolic Shigella flexneri via a C-Terminal Triple-Arginine Motif of GBP1 Inhibits Actin-Based Motility. 
  • Development of a vaccine against Staphylococcus aureus invasive infections: Evidence based on human immunity, genetics and bacterial evasion mechanisms. 
  • Differences in antibody levels to H. pylori virulence factors VacA and CagA among African Americans and whites in the Southeast USA. 
  • Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production. 
  • Divergence of protein kinase A catalytic subunits in Cryptococcus neoformans and Cryptococcus gattii illustrates evolutionary reconfiguration of a signaling cascade. 
  • Efficacy and safety of live attenuated persistent and rapidly cleared Mycobacterium tuberculosis vaccine candidates in non-human primates. 
  • Efficacy of compartmental administration of immunotoxin LMB-1 (B3-LysPE38) in a rat model of carcinomatous meningitis. 
  • Efficacy of telavancin in patients with specific types of complicated skin and skin structure infections. 
  • Endosymbiosis: the evil within. 
  • Enterotoxigenic Escherichia coli vesicles target toxin delivery into mammalian cells. 
  • Escherichia coli global gene expression in urine from women with urinary tract infection. 
  • Evolution of STEC virulence: Insights from the antipredator activities of Shiga toxin producing E. coli. 
  • Expression of the Salmonella spp. virulence factor SifA in yeast alters Rho1 activity on peroxisomes. 
  • First report of urease activity in the novel systemic fungal pathogen Emergomyces africanus: a comparison with the neurotrope Cryptococcus neoformans. 
  • Functional advantages conferred by extracellular prokaryotic membrane vesicles. 
  • Genome-wide transcriptional analysis of the Arabidopsis thaliana interaction with the plant pathogen Pseudomonas syringae pv. tomato DC3000 and the human pathogen Escherichia coli O157:H7. 
  • Genomic Variation across a Clinical Cryptococcus Population Linked to Disease Outcome. 
  • Genotypic characteristics of Staphylococcus aureus isolates from a multinational trial of complicated skin and skin structure infections. 
  • Identification of ENA1 as a virulence gene of the human pathogenic fungus Cryptococcus neoformans through signature-tagged insertional mutagenesis. 
  • Identification of a regulatory cascade controlling Type III Secretion System 3 gene expression in Burkholderia pseudomallei. 
  • Identification of a two-component fatty acid kinase responsible for host fatty acid incorporation by Staphylococcus aureus. 
  • Immunoinformatics approaches to explore Helicobacter Pylori proteome (Virulence Factors) to design B and T cell multi-epitope subunit vaccine. 
  • Immunotoxins containing Pseudomonas exotoxin that target LeY damage human endothelial cells in an antibody-specific mode: relevance to vascular leak syndrome. 
  • Immunotoxins with increased activity against epidermal growth factor receptor vIII-expressing cells produced by antibody phage display. 
  • Improved antitumor activity of a recombinant anti-Lewis(y) immunotoxin not requiring proteolytic activation. 
  • Influence of vancomycin minimum inhibitory concentration on the outcome of methicillin-susceptible Staphylococcus aureus left-sided infective endocarditis treated with antistaphylococcal β-lactam antibiotics: a prospective cohort study by the International Collaboration on Endocarditis. 
  • Innate immune detection of bacterial virulence factors via the NLRC4 inflammasome. 
  • Innate immunity in plants: an arms race between pattern recognition receptors in plants and effectors in microbial pathogens. 
  • Insights into the Autoproteolytic Processing and Catalytic Mechanism of the Chlamydia trachomatis Virulence-Associated Protease CPAF. 
  • Intracellular Action of a Secreted Peptide Required for Fungal Virulence. 
  • Key Pathogenic Factors in Coronavirus Disease 2019-Associated Coagulopathy and Acute Lung Injury Highlighted in a Patient With Copresentation of Acute Myelocytic Leukemia: A Case Report. 
  • Ligation of low-density lipoprotein receptor-related protein with antibodies elevates intracellular calcium and inositol 1,4, 5-trisphosphate in macrophages. 
  • Live Imaging of Host-Parasite Interactions in a Zebrafish Infection Model Reveals Cryptococcal Determinants of Virulence and Central Nervous System Invasion. 
  • Loss of allergen 1 confers a hypervirulent phenotype that resembles mucoid switch variants of Cryptococcus neoformans. 
  • MTL genotypes, phenotypic switching, and susceptibility profiles of Candida parapsilosis species group compared to Lodderomyces elongisporus. 
  • Metabolic adaptation in Cryptococcus neoformans during early murine pulmonary infection. 
  • Methicillin-susceptible Staphylococcus aureus endocarditis isolates are associated with clonal complex 30 genotype and a distinct repertoire of enterotoxins and adhesins. 
  • Methylthioadenosine Suppresses Salmonella Virulence. 
  • Mucor circinelloides Thrives inside the Phagosome through an Atf-Mediated Germination Pathway. 
  • Multiple activities of the plant pathogen type III effector proteins WtsE and AvrE require WxxxE motifs. 
  • Necroptosis of infiltrated macrophages drives Yersinia pestis dispersal within buboes. 
  • Niche-specific contribution to streptococcal virulence of a MalR-regulated carbohydrate binding protein. 
  • Novel strategies to augment genetically delivered immunotoxin molecular therapy for cancer therapy. 
  • PKC1 is essential for protection against both oxidative and nitrosative stresses, cell integrity, and normal manifestation of virulence factors in the pathogenic fungus Cryptococcus neoformans. 
  • Pathogen virulence factors as molecular probes of basic plant cellular functions. 
  • Perturbation of Staphylococcus aureus gene expression by the enoyl-acyl carrier protein reductase inhibitor AFN-1252. 
  • Plakoglobin and High-Mobility Group Box 1 Mediate Intestinal Epithelial Cell Apoptosis Induced by Clostridioides difficile TcdB. 
  • Plant stomata function in innate immunity against bacterial invasion. 
  • Population genomics and the evolution of virulence in the fungal pathogen Cryptococcus neoformans. 
  • Presence of genes encoding panton-valentine leukocidin is not the primary determinant of outcome in patients with hospital-acquired pneumonia due to Staphylococcus aureus. 
  • Production and quality control assessment of a GLP-grade immunotoxin, D2C7-(scdsFv)-PE38KDEL, for a phase I/II clinical trial. 
  • Programmed Cell Death in the Evolutionary Race against Bacterial Virulence Factors. 
  • Protein selection and export via outer membrane vesicles. 
  • Pseudomonas exotoxin A mutants. Replacement of surface exposed residues in domain II with cysteine residues that can be modified with polyethylene glycol in a site-specific manner. 
  • RNAi-Based Functional Genomics Identifies New Virulence Determinants in Mucormycosis. 
  • Reassessing the role of the secreted protease CPAF in Chlamydia trachomatis infection through genetic approaches. 
  • Receptor-associated protein binding blocks ubiquitinylation of the low density lipoprotein receptor-related protein. 
  • Recombinant anti-podoplanin (NZ-1) immunotoxin for the treatment of malignant brain tumors. 
  • Recombinant immunotoxin containing a disulfide-stabilized Fv directed at erbB2 that does not require proteolytic activation. 
  • Regional treatment of epidermal growth factor receptor vIII-expressing neoplastic meningitis with a single-chain immunotoxin, MR-1. 
  • Relationship between Vancomycin MIC and Virulence Gene Expression in Clonal Complexes of Methicillin-Susceptible Staphylococcus aureus Strains Isolated from Left-Sided Endocarditis. 
  • Risk factors for hematogenous complications of intravascular catheter-associated Staphylococcus aureus bacteremia. 
  • Signalling pathways in the pathogenesis of Cryptococcus. 
  • Ssk2 mitogen-activated protein kinase kinase kinase governs divergent patterns of the stress-activated Hog1 signaling pathway in Cryptococcus neoformans. 
  • Staphylococcal surgical site infections. 
  • Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management. 
  • Stomatal Defense a Decade Later. 
  • Structural Basis for Virulence Activation of Francisella tularensis. 
  • Structure of the Francisella response regulator QseB receiver domain, and characterization of QseB inhibition by antibiofilm 2-aminoimidazole-based compounds. 
  • Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus. 
  • Systematic functional profiling of transcription factor networks in Cryptococcus neoformans. 
  • The Chlamydia protease CPAF regulates host and bacterial proteins to maintain pathogen vacuole integrity and promote virulence. 
  • The Listeria monocytogenes PASTA Kinase PrkA and Its Substrate YvcK Are Required for Cell Wall Homeostasis, Metabolism, and Virulence. 
  • The Monothiol Glutaredoxin Grx4 Regulates Iron Homeostasis and Virulence in Cryptococcus neoformans. 
  • The core and accessory genomes of Burkholderia pseudomallei: implications for human melioidosis. 
  • The extracellular vesicle generation paradox: a bacterial point of view. 
  • The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans. 
  • The role of Aspartyl aminopeptidase (Ape4) in Cryptococcus neoformans virulence and authophagy. 
  • The virulence factor urease and its unexplored role in the metabolism of Cryptococcus neoformans. 
  • Toxoplasma gondii Parasitophorous Vacuole Membrane-Associated Dense Granule Proteins Orchestrate Chronic Infection and GRA12 Underpins Resistance to Host Gamma Interferon. 
  • Tuberculous granuloma induction via interaction of a bacterial secreted protein with host epithelium. 
  • Understanding Mucor circinelloides pathogenesis by comparative genomics and phenotypical studies. 
  • Variation in Leishmania chemokine suppression driven by diversification of the GP63 virulence factor. 
  • Variation in chromosome copy number influences the virulence of Cryptococcus neoformans and occurs in isolates from AIDS patients. 
  • Virulence and immunomodulatory roles of bacterial outer membrane vesicles. 
  • Virulence factors identified by Cryptococcus neoformans mutant screen differentially modulate lung immune responses and brain dissemination. 
  • Virulence mechanisms and Cryptococcus neoformans pathogenesis. 
  • Virulence of endemic nonpigmented northern Australian Staphylococcus aureus clone (clonal complex 75, S. argenteus) is not augmented by staphyloxanthin. 
  • Yersinia pestis kills Caenorhabditis elegans by a biofilm-independent process that involves novel virulence factors. 
  • YopM puts caspase-1 on ice. 
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  Keywords of People

  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering