Glycogen Synthase Kinase 3

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  Subject Areas on Research

  • A Screen for Extracellular Signal-Regulated Kinase-Primed Glycogen Synthase Kinase 3 Substrates Identifies the p53 Inhibitor iASPP. 
  • A beta-arrestin 2 signaling complex mediates lithium action on behavior. 
  • A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1. 
  • A new strategy for studying protein kinase B and its three isoforms. Role of protein kinase B in phosphorylating glycogen synthase kinase-3, tuberin, WNK1, and ATP citrate lyase. 
  • Activation and cross-talk between Akt, NF-kappaB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78. 
  • Activation of messenger-independent protein kinases in wild-type and phorbol ester-resistant EL4 thymoma cells. 
  • Activator protein-1 has an essential role in pancreatic cancer cells and is regulated by a novel Akt-mediated mechanism. 
  • Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an apolipoprotein E receptor/disabled-1/glycogen synthase kinase-3beta cascade. 
  • Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder. 
  • Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling. 
  • Beta-catenin mediates soft tissue contracture in clubfoot. 
  • Cardiac vulnerability to ischemia/reperfusion injury drastically increases in late pregnancy. 
  • Cardiac-specific mindin overexpression attenuates cardiac hypertrophy via blocking AKT/GSK3β and TGF-β1-Smad signalling. 
  • Carteriosulfonic acids A-C, GSK-3beta inhibitors from a Carteriospongia sp. 
  • Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking. 
  • Cytosolic TMEM88 promotes invasion and metastasis in lung cancer cells by binding DVLS. 
  • Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin 
  • Dual kinase-mediated regulation of PITK by CaMKII and GSK3. 
  • Exercise can prevent and reverse the severity of hypertrophic cardiomyopathy. 
  • Fibronectin and beta-catenin act in a regulatory loop in dermal fibroblasts to modulate cutaneous healing. 
  • GSK3 involvement in amylin signaling in isolated rat soleus muscle. 
  • Glucose metabolism attenuates p53 and Puma-dependent cell death upon growth factor deprivation. 
  • Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1. 
  • Glycolysis-dependent histone deacetylase 4 degradation regulates inflammatory cytokine production. 
  • Growth factors regulate beta-catenin-mediated TCF-dependent transcriptional activation in fibroblasts during the proliferative phase of wound healing. 
  • Growth hormone regulates phosphorylation and function of CCAAT/enhancer-binding protein beta by modulating Akt and glycogen synthase kinase-3. 
  • Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication. 
  • Identification of Novel 2,4,5-Trisubstituted Pyrimidines as Potent Dual Inhibitors of Plasmodial Pf GSK3/Pf PK6 with Activity against Blood Stage Parasites In Vitro. 
  • Inactivation of nuclear GSK3β by Ser(389) phosphorylation promotes lymphocyte fitness during DNA double-strand break response. 
  • Inhibiting Glycogen Synthase Kinase-3 Mitigates the Hematopoietic Acute Radiation Syndrome in a Sex- and Strain-dependent Manner in Mice. 
  • Inhibiting glycogen synthase kinase-3 mitigates the hematopoietic acute radiation syndrome in mice. 
  • Intralipid: the new magic bullet in cardioprotection? 
  • Ketamine up-regulates a cluster of intronic miRNAs within the serotonin receptor 2C gene by inhibiting glycogen synthase kinase-3. 
  • Mutations Impairing GSK3-Mediated MAF Phosphorylation Cause Cataract, Deafness, Intellectual Disability, Seizures, and a Down Syndrome-like Facies. 
  • Negative regulation of Armadillo, a Wingless effector in Drosophila. 
  • Okadaic acid mimics the action of insulin in stimulating protein kinase activity in isolated adipocytes. The role of protein phosphatase 2a in attenuation of the signal. 
  • Oxidant-mediated Akt activation in human RPE cells. 
  • Pathogenesis of radiation-induced capsular contracture in tissue expander and implant breast reconstruction. 
  • Peutz-Jeghers LKB1 mutants fail to activate GSK-3beta, preventing it from inhibiting Wnt signaling. 
  • Prolonged beta-catenin stabilization and tcf-dependent transcriptional activation in hyperplastic cutaneous wounds. 
  • Protein kinase CK2 phosphorylates the cell cycle regulatory protein Geminin. 
  • Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. 
  • Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus. 
  • Protein phosphatase 2A: a panoply of enzymes. 
  • Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. 
  • Reelin signals survival through Src-family kinases that inactivate BAD activity. 
  • Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A. 
  • Requirement of dendritic Akt degradation by the ubiquitin-proteasome system for neuronal polarity. 
  • Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency. 
  • Sexually dimorphic fin regeneration in zebrafish controlled by androgen/GSK3 signaling. 
  • Signal integration and gene induction by a functionally distinct STAT3 phosphoform. 
  • Targeting signal transduction pathways in the treatment of mood disorders: recent insights into the relevance of the Wnt pathway. 
  • Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation. 
  • Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits. 
  • The Salmonella Secreted Effector SarA/SteE Mimics Cytokine Receptor Signaling to Activate STAT3. 
  • The effects of brain serotonin deficiency on behavioural disinhibition and anxiety-like behaviour following mild early life stress. 
  • Wnt signalling shows its versatility.