Eukaryotic Initiation Factor-4E

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  Subject Areas on Research

  • 5' UTR m(6)A Promotes Cap-Independent Translation. 
  • Adenovirus inhibition of cellular protein synthesis involves inactivation of cap-binding protein. 
  • Differences in muscle protein synthesis and anabolic signaling in the postabsorptive state and in response to food in 65-80 year old men and women. 
  • Dying glioma cells establish a proangiogenic microenvironment through a caspase 3 dependent mechanism. 
  • Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes. 
  • Identifying mRNA subsets in messenger ribonucleoprotein complexes by using cDNA arrays. 
  • Insulin and diabetes cause reciprocal changes in the association of eIF-4E and PHAS-I in rat skeletal muscle. 
  • MAPK signal-integrating kinase controls cap-independent translation and cell type-specific cytotoxicity of an oncolytic poliovirus. 
  • MNK2 deficiency potentiates β-cell regeneration via translational regulation. 
  • MYC activity mitigates response to rapamycin in prostate cancer through eukaryotic initiation factor 4E-binding protein 1-mediated inhibition of autophagy. 
  • Mnk1 and 2 are dispensable for T cell development and activation but important for the pathogenesis of experimental autoimmune encephalomyelitis. 
  • Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression. 
  • Nox4 mediates TGF-beta1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cells. 
  • Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1. 
  • Phosphorylation of the translational regulator, PHAS-I, by protein kinase CK2. 
  • Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells. 
  • Regulation of eukaryotic initiation factor 4E (eIF4E) phosphorylation by mitogen-activated protein kinase occurs through modulation of Mnk1-eIF4G interaction. 
  • Ribosomal RACK1:Protein Kinase C βII Modulates Intramolecular Interactions between Unstructured Regions of Eukaryotic Initiation Factor 4G (eIF4G) That Control eIF4E and eIF3 Binding. 
  • Structure-Activity Relationship Studies of Mitogen Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 and BCR-ABL1 Inhibitors Targeting Chronic Myeloid Leukemic Cells. 
  • Targeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function. 
  • The eukaryotic translation initiation factor 4E is not modified during the course of vaccinia virus replication. 
  • c-Myc creates an activation loop by transcriptionally repressing its own functional inhibitor, hMad4, in young fibroblasts, a loop lost in replicatively senescent fibroblasts. 
  • eIF4E-phosphorylation-mediated Sox2 upregulation promotes pancreatic tumor cell repopulation after irradiation. 
  • ifet-1 is a broad-scale translational repressor required for normal P granule formation in C. elegans. 
  • p38α mitogen-activated protein kinase depletion and repression of signal transduction to translation machinery by miR-124 and -128 in neurons. 
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  Keywords of People

  • Shinohara, Mari L., Professor of Integrative Immunobiology, Cell Biology