Pluripotent Stem Cells

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  Subject Areas on Research

  • A human pluripotent stem cell platform for assessing developmental neural toxicity screening. 
  • Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues. 
  • Current technology for the derivation of pluripotent stem cell lines from human embryos. 
  • Development of germ cells in the mouse. 
  • Direct Conversion of Human Pluripotent Stem Cells to Osteoblasts With a Small Molecule. 
  • Engineering cell-material interfaces for long-term expansion of human pluripotent stem cells. 
  • Engineering human pluripotent stem cells into a functional skeletal muscle tissue. 
  • Epigenomic comparison reveals activation of "seed" enhancers during transition from naive to primed pluripotency. 
  • Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution. 
  • Functional cardiac tissue engineering. 
  • Gene silencing using RNA interference in embryonic stem cells. 
  • Generation of articular chondrocytes from human pluripotent stem cells. 
  • Genetically Encoded Photoactuators and Photosensors for Characterization and Manipulation of Pluripotent Stem Cells. 
  • Global gene expression profiling reveals similarities and differences among mouse pluripotent stem cells of different origins and strains. 
  • Harnessing developmental plasticity to pattern kidney organoids 
  • Heightened potency of human pluripotent stem cell lines created by transient BMP4 exposure. 
  • Human pluripotent stem cell-derived neural constructs for predicting neural toxicity. 
  • Human pluripotent stem cells decouple respiration from energy production. 
  • Identification of a novel epigenetic regulatory region within the pluripotency associated microRNA cluster, EEmiRC. 
  • In Vitro Tissue-Engineered Skeletal Muscle Models for Studying Muscle Physiology and Disease. 
  • Influence of threonine metabolism on S-adenosylmethionine and histone methylation. 
  • Long-term human pluripotent stem cell self-renewal on synthetic polymer surfaces. 
  • Low-Dose Irradiation Enhances Gene Targeting in Human Pluripotent Stem Cells. 
  • Mineralized gelatin methacrylate-based matrices induce osteogenic differentiation of human induced pluripotent stem cells. 
  • Pluripotent stem cell-derived cardiac tissue patch with advanced structure and function. 
  • Rapid and Efficient Generation of Transgene-Free iPSC from a Small Volume of Cryopreserved Blood. 
  • SFRP2 regulates cardiomyogenic differentiation by inhibiting a positive transcriptional autofeedback loop of Wnt3a. 
  • Summary: present and future challenges for stem cell research. 
  • Testicular teratomas: an intersection of pluripotency, differentiation and cancer biology. 
  • The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency. 
  • The RNA-binding protein DND1 acts sequentially as a negative regulator of pluripotency and a positive regulator of epigenetic modifiers required for germ cell reprogramming. 
  • The cell surface glycosphingolipids SSEA-3 and SSEA-4 are not essential for human ESC pluripotency. 
  • The channel kinase, TRPM7, is required for early embryonic development. 
  • Tumor Suppressors RB1 and CDKN2a Cooperatively Regulate Cell-Cycle Progression and Differentiation During Cardiomyocyte Development and Repair. 
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  Keywords of People

  • Bursac, Nenad, Professor of Biomedical Engineering, Biomedical Engineering
  • Landstrom, Andrew Paul, Associate Professor of Pediatrics, Cell Biology
  • Velkey, John Matthew, Assistant Professor of the Practice of Medical Education in the Department of Cell Biology, Cell Biology