Mechanotransduction, Cellular

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  Subject Areas on Research

  • "Feeling the force" in reproduction: Mechanotransduction in reproductive processes. 
  • A precisely defined role for the tip link-associated protein TMIE in the mechanoelectrical transduction channel complex of inner ear hair cells. 
  • Activation of Piezo1 mechanosensitive ion channel in HEK293T cells by 30 MHz vertically deployed surface acoustic waves. 
  • Allosteric modulation of β-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch. 
  • An Internal Dial for Sensitivity and Gain of Rapid Mechanotransduction. 
  • Analysis of hydrostatic pressure-induced changes in umbrella cell surface area. 
  • Associations between pressure-pain threshold, symptoms, and radiographic knee and hip osteoarthritis. 
  • Autophagy and mechanotransduction in outflow pathway cells. 
  • Biological basis of bone formation, remodeling, and repair-part III: biomechanical forces. 
  • Bone remodeling as a spatial evolutionary game. 
  • Calcific Aortic Valve Disease: Part 1--Molecular Pathogenetic Aspects, Hemodynamics, and Adaptive Feedbacks. 
  • Calponin-3 deficiency augments contractile activity, plasticity, fibrogenic response and Yap/Taz transcriptional activation in lens epithelial cells and explants. 
  • Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin. 
  • Cartilage viability and catabolism in the intact porcine knee following transarticular impact loading with and without articular fracture. 
  • Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis. 
  • Caveolar and non-Caveolar Caveolin-1 in ocular homeostasis and disease. 
  • Cell mechanics: dissecting the physical responses of cells to force. 
  • Cell senescence reduced the mechanotransduction sensitivity of porcine angular aqueous plexus cells to elevation of pressure. 
  • Characterization of umbilical cord blood-derived late outgrowth endothelial progenitor cells exposed to laminar shear stress. 
  • Complete canthi removal reveals that forces from the amnioserosa alone are sufficient to drive dorsal closure in Drosophila. 
  • Control of Skeletal Muscle Cell Growth and Size Through Adhesion GPCRs. 
  • Control of colonic motility using electrical stimulation to modulate enteric neural activity. 
  • Dynamic molecular processes mediate cellular mechanotransduction 
  • Dynamic reciprocity between cells and their microenvironment in reproduction. 
  • Dynamics and mechanisms of intracellular calcium waves elicited by tandem bubble-induced jetting flow. 
  • Effect of streptavidin-biotin on endothelial vasoregulation and leukocyte adhesion. 
  • Elevated intraocular pressure induces Rho GTPase mediated contractile signaling in the trabecular meshwork. 
  • Endogenous Piezo1 Can Confound Mechanically Activated Channel Identification and Characterization. 
  • Forces drive basement membrane invasion in Caenorhabditis elegans . 
  • Fragility and mechanosensing in a thermalized cytoskeleton model with forced protein unfolding. 
  • Frequency-dependent response of the vascular endothelium to pulsatile shear stress. 
  • Functionality of the TRPV subfamily of TRP ion channels: add mechano-TRP and osmo-TRP to the lexicon! 
  • Global phosphotyrosinylated protein profile of cell-matrix adhesion complexes of trabecular meshwork cells. 
  • High-resolution microrheology in the pericellular matrix of prostate cancer cells. 
  • High-resolution probing of cellular force transmission. 
  • High-throughput screening for modulators of cellular contractile force. 
  • How does protein architecture facilitate the transduction of ATP chemical-bond energy into mechanical work? The cases of nitrogenase and ATP binding-cassette proteins. 
  • Hypertonicity sensing in organum vasculosum lamina terminalis neurons: a mechanical process involving TRPV1 but not TRPV4. 
  • Inactivation Kinetics and Mechanical Gating of Piezo1 Ion Channels Depend on Subdomains within the Cap. 
  • Inactivation of Mechanically Activated Piezo1 Ion Channels Is Determined by the C-Terminal Extracellular Domain and the Inner Pore Helix. 
  • Individual and combined effects of shear stress magnitude and spatial gradient on endothelial cell gene expression 
  • Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis. 
  • Localized force application reveals mechanically sensitive domains of Piezo1. 
  • Loss of stiffness in collagen-rich uterine fibroids after digestion with purified collagenase Clostridium histolyticum. 
  • Matrix Mechanotransduction via Yes-Associated Protein in Human Lamina Cribrosa Cells in Glaucoma. 
  • Matrix stiffness regulation of integrin-mediated mechanotransduction during osteogenic differentiation of human mesenchymal stem cells. 
  • Mechanical Load and Piezo1 Channel Regulated Myosin II Activity in Mouse Lenses. 
  • Mechanical Signaling and Extracellular Matrix in Uterine Fibroids. 
  • Mechanical responsiveness of the endothelial cell of Schlemm's canal: scope, variability and its potential role in controlling aqueous humour outflow. 
  • Mechanical signaling in reproductive tissues: mechanisms and importance. 
  • Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells. 
  • Mechanobiology of the meniscus. 
  • Mechanoelectrical excitation by fluid jets in monolayers of cultured cardiac myocytes. 
  • Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces. 
  • Mechanosignaling in bone health, trauma and inflammation. 
  • Mechanotransduction Mechanisms for Intraventricular Diastolic Vortex Forces and Myocardial Deformations: Part 2. 
  • Mechanotransduction mechanisms for intraventricular diastolic vortex forces and myocardial deformations: part 1. 
  • Modeling the adaptive permeability response of porcine iliac arteries to acute changes in mural shear 
  • Molecular mechanisms of TRPV4-mediated neural signaling. 
  • Molecular-Scale Tools for Studying Mechanotransduction. 
  • Nonlinear osmotic properties of the cell nucleus. 
  • Normal and shear stresses influence the spatial distribution of intracellular adhesion molecule-1 expression in human umbilical vein endothelial cells exposed to sudden expansion flow. 
  • Optimal pulse length of insonification for Piezo1 activation and intracellular calcium response. 
  • Physical exosome:exosome interactions. 
  • Physics of mechanotransduction by Piezo ion channels. 
  • Physiologic pulsatile flow bioreactor conditioning of poly(ethylene glycol)-based tissue engineered vascular grafts. 
  • Piezo proteins are pore-forming subunits of mechanically activated channels. 
  • Piezo1 acts upstream of TRPV4 to induce pathological changes in endothelial cells due to shear stress. 
  • Piezo1 channels mediate trabecular meshwork mechanotransduction and promote aqueous fluid outflow. 
  • Piezo1 ion channels inherently function as independent mechanotransducers. 
  • Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis. 
  • Predicting auditory tone-in-noise detection performance: the effects of neural variability. 
  • Pressure-sensing Piezo1: the eyes have it. 
  • Prestress in the extracellular matrix sensitizes latent TGF-β1 for activation. 
  • Primary cilia and the reciprocal activation of AKT and SMAD2/3 regulate stretch-induced autophagy in trabecular meshwork cells. 
  • Primary human chondrocyte extracellular matrix formation and phenotype maintenance using RGD-derivatized PEGDM hydrogels possessing a continuous Young's modulus gradient. 
  • Regulation of chondrocytic gene expression by biomechanical signals. 
  • Role of Piezo Channels in Joint Health and Injury. 
  • Role of TRPV ion channels in sensory transduction of osmotic stimuli in mammals. 
  • Role of aquaporin-1 in trabecular meshwork cell homeostasis during mechanical strain. 
  • Round versus flat: bone cell morphology, elasticity, and mechanosensing. 
  • Selective role for TRPV4 ion channels in visceral sensory pathways. 
  • Shear Stress in Schlemm's Canal as a Sensor of Intraocular Pressure. 
  • Site-specific effects of compression on macromolecular diffusion in articular cartilage. 
  • Sodium channels and mammalian sensory mechanotransduction. 
  • Statistical hemodynamics: a tool for evaluating the effect of fluid dynamic forces on vascular biology in vivo. 
  • Sweet neurons inhibit texture discrimination by signaling TMC-expressing mechanosensitive neurons in Drosophila. 
  • Synergistic effect of shear stress and streptavidin-biotin on the expression of endothelial vasodilator and cytoskeleton genes. 
  • TGF-β regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion. 
  • TRPC1 channels are critical for hypertrophic signaling in the heart. 
  • TRPV channels' role in osmotransduction and mechanotransduction. 
  • TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading. 
  • The detection and role of molecular tension in focal adhesion dynamics. 
  • The ocular pulse decreases aqueous humor outflow resistance by stimulating nitric oxide production. 
  • The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells. 
  • The role of F-actin and myosin in epithelial cell rheology. 
  • The role of epigenetics in the endothelial cell shear stress response and atherosclerosis 
  • The role of extracellular matrix elasticity and composition in regulating the nucleus pulposus cell phenotype in the intervertebral disc: a narrative review. 
  • Touch, Tension, and Transduction - The Function and Regulation of Piezo Ion Channels. 
  • Towards a Dynamic Understanding of Cadherin-Based Mechanobiology. 
  • Transduction of Repetitive Mechanical Stimuli by Piezo1 and Piezo2 Ion Channels. 
  • Transient Receptor Potential Vanilloid 4 and Serum Glucocorticoid-regulated Kinase 1 Are Critical Mediators of Lung Injury in Overventilated Mice In Vivo. 
  • Transient receptor potential vanilloid 4: The sixth sense of the musculoskeletal system? 
  • TrkB-Shc Signaling Protects against Hippocampal Injury Following Status Epilepticus. 
  • Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart Injury. 
  • Type VI Collagen Regulates Pericellular Matrix Properties, Chondrocyte Swelling, and Mechanotransduction in Mouse Articular Cartilage. 
  • Upregulation of forces and morphogenic asymmetries in dorsal closure during Drosophila development. 
  • Vertebrate Lonesome Kinase Regulated Extracellular Matrix Protein Phosphorylation, Cell Shape, and Adhesion in Trabecular Meshwork Cells. 
  • Visualizing mechanosensory endings of TrkC-expressing neurons in HS3ST-2-hPLAP mice. 
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  Keywords of People

  • Hoffman, Brenton D., James L. and Elizabeth M. Vincent Associate Professor of Biomedical Engineering, Biomedical Engineering
  • Huettel, Lisa Gresham, Edmund T. Pratt, Jr. School Professor of the Practice of Electrical and Computer Engineering, Electrical and Computer Engineering
  • Zhong, Pei, Professor in the Department of Mechanical Engineering and Materials Science, Thomas Lord Department of Mechanical Engineering and Materials Science