Mechanotransduction, Cellular
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Subject Areas on Research
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"Feeling the force" in reproduction: Mechanotransduction in reproductive processes.
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A precisely defined role for the tip link-associated protein TMIE in the mechanoelectrical transduction channel complex of inner ear hair cells.
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Activation of Piezo1 mechanosensitive ion channel in HEK293T cells by 30 MHz vertically deployed surface acoustic waves.
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Allosteric modulation of β-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch.
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An Internal Dial for Sensitivity and Gain of Rapid Mechanotransduction.
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Analysis of hydrostatic pressure-induced changes in umbrella cell surface area.
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Associations between pressure-pain threshold, symptoms, and radiographic knee and hip osteoarthritis.
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Autophagy and mechanotransduction in outflow pathway cells.
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Biological basis of bone formation, remodeling, and repair-part III: biomechanical forces.
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Bone remodeling as a spatial evolutionary game.
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Calcific Aortic Valve Disease: Part 1--Molecular Pathogenetic Aspects, Hemodynamics, and Adaptive Feedbacks.
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Calponin-3 deficiency augments contractile activity, plasticity, fibrogenic response and Yap/Taz transcriptional activation in lens epithelial cells and explants.
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Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin.
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Cartilage viability and catabolism in the intact porcine knee following transarticular impact loading with and without articular fracture.
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Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis.
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Caveolar and non-Caveolar Caveolin-1 in ocular homeostasis and disease.
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Cell mechanics: dissecting the physical responses of cells to force.
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Cell senescence reduced the mechanotransduction sensitivity of porcine angular aqueous plexus cells to elevation of pressure.
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Characterization of umbilical cord blood-derived late outgrowth endothelial progenitor cells exposed to laminar shear stress.
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Complete canthi removal reveals that forces from the amnioserosa alone are sufficient to drive dorsal closure in Drosophila.
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Control of Skeletal Muscle Cell Growth and Size Through Adhesion GPCRs.
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Control of colonic motility using electrical stimulation to modulate enteric neural activity.
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Dynamic molecular processes mediate cellular mechanotransduction
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Dynamic reciprocity between cells and their microenvironment in reproduction.
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Dynamics and mechanisms of intracellular calcium waves elicited by tandem bubble-induced jetting flow.
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Effect of streptavidin-biotin on endothelial vasoregulation and leukocyte adhesion.
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Elevated intraocular pressure induces Rho GTPase mediated contractile signaling in the trabecular meshwork.
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Endogenous Piezo1 Can Confound Mechanically Activated Channel Identification and Characterization.
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Forces drive basement membrane invasion in Caenorhabditis elegans
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Fragility and mechanosensing in a thermalized cytoskeleton model with forced protein unfolding.
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Frequency-dependent response of the vascular endothelium to pulsatile shear stress.
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Functionality of the TRPV subfamily of TRP ion channels: add mechano-TRP and osmo-TRP to the lexicon!
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Global phosphotyrosinylated protein profile of cell-matrix adhesion complexes of trabecular meshwork cells.
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High-resolution microrheology in the pericellular matrix of prostate cancer cells.
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High-resolution probing of cellular force transmission.
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High-throughput screening for modulators of cellular contractile force.
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How does protein architecture facilitate the transduction of ATP chemical-bond energy into mechanical work? The cases of nitrogenase and ATP binding-cassette proteins.
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Hypertonicity sensing in organum vasculosum lamina terminalis neurons: a mechanical process involving TRPV1 but not TRPV4.
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Inactivation Kinetics and Mechanical Gating of Piezo1 Ion Channels Depend on Subdomains within the Cap.
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Inactivation of Mechanically Activated Piezo1 Ion Channels Is Determined by the C-Terminal Extracellular Domain and the Inner Pore Helix.
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Individual and combined effects of shear stress magnitude and spatial gradient on endothelial cell gene expression
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Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis.
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Localized force application reveals mechanically sensitive domains of Piezo1.
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Loss of stiffness in collagen-rich uterine fibroids after digestion with purified collagenase Clostridium histolyticum.
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Matrix Mechanotransduction via Yes-Associated Protein in Human Lamina Cribrosa Cells in Glaucoma.
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Matrix stiffness regulation of integrin-mediated mechanotransduction during osteogenic differentiation of human mesenchymal stem cells.
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Mechanical Load and Piezo1 Channel Regulated Myosin II Activity in Mouse Lenses.
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Mechanical Signaling and Extracellular Matrix in Uterine Fibroids.
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Mechanical responsiveness of the endothelial cell of Schlemm's canal: scope, variability and its potential role in controlling aqueous humour outflow.
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Mechanical signaling in reproductive tissues: mechanisms and importance.
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Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells.
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Mechanobiology of the meniscus.
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Mechanoelectrical excitation by fluid jets in monolayers of cultured cardiac myocytes.
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Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces.
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Mechanosignaling in bone health, trauma and inflammation.
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Mechanotransduction Mechanisms for Intraventricular Diastolic Vortex Forces and Myocardial Deformations: Part 2.
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Mechanotransduction mechanisms for intraventricular diastolic vortex forces and myocardial deformations: part 1.
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Modeling the adaptive permeability response of porcine iliac arteries to acute changes in mural shear
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Molecular mechanisms of TRPV4-mediated neural signaling.
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Molecular-Scale Tools for Studying Mechanotransduction.
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Nonlinear osmotic properties of the cell nucleus.
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Normal and shear stresses influence the spatial distribution of intracellular adhesion molecule-1 expression in human umbilical vein endothelial cells exposed to sudden expansion flow.
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Optimal pulse length of insonification for Piezo1 activation and intracellular calcium response.
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Physical exosome:exosome interactions.
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Physics of mechanotransduction by Piezo ion channels.
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Physiologic pulsatile flow bioreactor conditioning of poly(ethylene glycol)-based tissue engineered vascular grafts.
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Piezo proteins are pore-forming subunits of mechanically activated channels.
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Piezo1 acts upstream of TRPV4 to induce pathological changes in endothelial cells due to shear stress.
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Piezo1 channels mediate trabecular meshwork mechanotransduction and promote aqueous fluid outflow.
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Piezo1 ion channels inherently function as independent mechanotransducers.
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Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis.
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Predicting auditory tone-in-noise detection performance: the effects of neural variability.
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Pressure-sensing Piezo1: the eyes have it.
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Prestress in the extracellular matrix sensitizes latent TGF-β1 for activation.
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Primary cilia and the reciprocal activation of AKT and SMAD2/3 regulate stretch-induced autophagy in trabecular meshwork cells.
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Primary human chondrocyte extracellular matrix formation and phenotype maintenance using RGD-derivatized PEGDM hydrogels possessing a continuous Young's modulus gradient.
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Regulation of chondrocytic gene expression by biomechanical signals.
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Role of Piezo Channels in Joint Health and Injury.
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Role of TRPV ion channels in sensory transduction of osmotic stimuli in mammals.
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Role of aquaporin-1 in trabecular meshwork cell homeostasis during mechanical strain.
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Round versus flat: bone cell morphology, elasticity, and mechanosensing.
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Selective role for TRPV4 ion channels in visceral sensory pathways.
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Shear Stress in Schlemm's Canal as a Sensor of Intraocular Pressure.
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Site-specific effects of compression on macromolecular diffusion in articular cartilage.
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Sodium channels and mammalian sensory mechanotransduction.
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Statistical hemodynamics: a tool for evaluating the effect of fluid dynamic forces on vascular biology in vivo.
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Sweet neurons inhibit texture discrimination by signaling TMC-expressing mechanosensitive neurons in Drosophila.
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Synergistic effect of shear stress and streptavidin-biotin on the expression of endothelial vasodilator and cytoskeleton genes.
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TGF-β regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion.
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TRPC1 channels are critical for hypertrophic signaling in the heart.
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TRPV channels' role in osmotransduction and mechanotransduction.
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TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading.
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The detection and role of molecular tension in focal adhesion dynamics.
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The ocular pulse decreases aqueous humor outflow resistance by stimulating nitric oxide production.
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The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells.
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The role of F-actin and myosin in epithelial cell rheology.
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The role of epigenetics in the endothelial cell shear stress response and atherosclerosis
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The role of extracellular matrix elasticity and composition in regulating the nucleus pulposus cell phenotype in the intervertebral disc: a narrative review.
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Touch, Tension, and Transduction - The Function and Regulation of Piezo Ion Channels.
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Towards a Dynamic Understanding of Cadherin-Based Mechanobiology.
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Transduction of Repetitive Mechanical Stimuli by Piezo1 and Piezo2 Ion Channels.
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Transient Receptor Potential Vanilloid 4 and Serum Glucocorticoid-regulated Kinase 1 Are Critical Mediators of Lung Injury in Overventilated Mice In Vivo.
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Transient receptor potential vanilloid 4: The sixth sense of the musculoskeletal system?
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TrkB-Shc Signaling Protects against Hippocampal Injury Following Status Epilepticus.
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Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart Injury.
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Type VI Collagen Regulates Pericellular Matrix Properties, Chondrocyte Swelling, and Mechanotransduction in Mouse Articular Cartilage.
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Upregulation of forces and morphogenic asymmetries in dorsal closure during Drosophila development.
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Vertebrate Lonesome Kinase Regulated Extracellular Matrix Protein Phosphorylation, Cell Shape, and Adhesion in Trabecular Meshwork Cells.
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Visualizing mechanosensory endings of TrkC-expressing neurons in HS3ST-2-hPLAP mice.
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Keywords of People
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Hoffman, Brenton D.,
James L. and Elizabeth M. Vincent Associate Professor of Biomedical Engineering,
Biomedical Engineering
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Huettel, Lisa Gresham,
Edmund T. Pratt, Jr. School Professor of the Practice of Electrical and Computer Engineering,
Electrical and Computer Engineering
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Zhong, Pei,
Professor in the Department of Mechanical Engineering and Materials Science,
Thomas Lord Department of Mechanical Engineering and Materials Science