Biomimetic Materials

• 

  Subject Areas on Research

  • 4,4'-Unsymmetrically substituted 3,3'-biphenyl alpha helical proteomimetics as potential coactivator binding inhibitors. 
  • A combination of two antioxidants (an SOD mimic and ascorbate) produces a pro-oxidative effect forcing Escherichia coli to adapt via induction of oxyR regulon. 
  • A mechanism-based antioxidant approach for the reduction of skin carcinogenesis. 
  • A tissue-engineered human trabecular meshwork hydrogel for advanced glaucoma disease modeling. 
  • Adhesion properties of catechol-based biodegradable amino acid-based poly(ester urea) copolymers inspired from mussel proteins. 
  • Advances in bioengineered conduits for peripheral nerve regeneration. 
  • An Engineered Biomimetic MPER Peptide Vaccine Induces Weakly HIV Neutralizing Antibodies in Mice. 
  • Angiostatin-like activity of a monoclonal antibody to the catalytic subunit of F1F0 ATP synthase. 
  • Apolipoprotein E COG 133 mimetic peptide improves 5-fluorouracil-induced intestinal mucositis. 
  • Apolipoproteins and apolipoprotein mimetic peptides modulate phagocyte trafficking through chemotactic activity. 
  • Bio-inspired synthesis of hybrid silica nanoparticles templated from elastin-like polypeptide micelles. 
  • Biomimetic Hydrogels with Immobilized EphrinA1 for Therapeutic Angiogenesis 
  • Biomimetic anchors for antifouling and antibacterial polymer brushes on stainless steel 
  • Biomimetic hydrogels with pro-angiogenic properties. 
  • Blocking Interleukin (IL)4- and IL13-Mediated Phosphorylation of STAT6 (Tyr641) Decreases M2 Polarization of Macrophages and Protects Against Macrophage-Mediated Radioresistance of Inflammatory Breast Cancer. 
  • Caddisfly Inspired Phosphorylated Poly(ester urea)-Based Degradable Bone Adhesives. 
  • Cephalopod-inspired design of electro-mechano-chemically responsive elastomers for on-demand fluorescent patterning. 
  • Comparison of real and idealized cetacean flippers. 
  • Complementation of SOD-deficient Escherichia coli by manganese porphyrin mimics of superoxide dismutase activity. 
  • Degradable Adhesives for Surgery and Tissue Engineering. 
  • Detailed mechanism of the autoxidation of N-hydroxyurea catalyzed by a superoxide dismutase mimic Mn(III) porphyrin: formation of the nitrosylated Mn(II) porphyrin as an intermediate. 
  • Development and characterization of a vitreous mimicking material for radiation force imaging. 
  • Directed intermixing in multicomponent self-assembling biomaterials. 
  • Effects of epidermal growth factor on fibroblast migration through biomimetic hydrogels. 
  • Engineering cell-material interfaces for long-term expansion of human pluripotent stem cells. 
  • Environmental Stability of Plasmonic Biosensors Based on Natural versus Artificial Antibody. 
  • Fabrication of 3D Biomimetic Microfluidic Networks in Hydrogels. 
  • HIV-1 antibodies and vaccine antigen selectively interact with lipid domains. 
  • Hazardous chemicals in synthetic turf materials and their bioaccessibility in digestive fluids. 
  • Hierarchically structured bioinspired nanocomposites. 
  • High lipophilicity of meta Mn(III) N-alkylpyridylporphyrin-based superoxide dismutase mimics compensates for their lower antioxidant potency and makes them as effective as ortho analogues in protecting superoxide dismutase-deficient Escherichia coli. 
  • Inhibition of the Staphylococcus aureus sortase transpeptidase SrtA by phosphinic peptidomimetics. 
  • Late administration of Mn porphyrin-based SOD mimic enhances diabetic complications. 
  • Loosely packed self-assembled monolayer of N-hexadecyl-3,6-di(p-mercaptophenylacetylene)carbazole on gold and its application in biomimetic membrane research. 
  • Materials science. Biomimetics and evolution. 
  • Mesenchymal Stem Cell/Red Blood Cell-Inspired Nanoparticle Therapy in Mice with Carbon Tetrachloride-Induced Acute Liver Failure. 
  • Mesoscopic hydrogel molding to control the 3D geometry of bioartificial muscle tissues. 
  • Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(III) N-methoxyalkylpyridylporphyrins. 
  • Mineralized gelatin methacrylate-based matrices induce osteogenic differentiation of human induced pluripotent stem cells. 
  • Multivascular networks and functional intravascular topologies within biocompatible hydrogels. 
  • Nanoparticle Platforms for Antigen-Specific Immune Tolerance. 
  • Peptides from second extracellular loop of C-C chemokine receptor type 5 (CCR5) inhibit diverse strains of HIV-1. 
  • Progress Toward the Clinical Translation of Bioinspired Peptide and Protein Assemblies. 
  • Protein-patterned hydrogels: Customized cell microenvironments. 
  • Radioprotective effects of manganese-containing superoxide dismutase mimics on ataxia-telangiectasia cells. 
  • Recapitulation and Modulation of the Cellular Architecture of a User-Chosen Cell of Interest Using Cell-Derived, Biomimetic Patterning. 
  • Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP(5+), Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma Multiforme. 
  • SOD enzymes and their mimics in cancer: pro vs anti-odixative mode of action-part II. 
  • Superoxide dismutase mimic, MnTE-2-PyP(5+) ameliorates acute and chronic proctitis following focal proton irradiation of the rat rectum. 
  • Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential. 
  • Supramolecular nanomimetics: replication of micelles, viruses, and other naturally occurring nanoscale objects. 
  • Synthetic ECM: Bioactive Synthetic Hydrogels for 3D Tissue Engineering. 
  • Synthetic bone mimetic matrix-mediated in situ bone tissue formation through host cell recruitment. 
  • Synthetic cannabimimetic agents metabolized by carboxylesterases. 
  • The Chemistry of Lyophilized Blood Products. 
  • The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction. 
  • Therapeutic microparticles functionalized with biomimetic cardiac stem cell membranes and secretome. 
  • Thermal stability of the prototypical Mn porphyrin-based superoxide dismutase mimic and potent oxidative-stress redox modulator Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin chloride, MnTE-2-PyP(5+). 
  • Three-dimensional biomimetic patterning in hydrogels to guide cellular organization. 
  • Three-dimensional photolithographic micropatterning: a novel tool to probe the complexities of cell migration. 
  • Tissue engineered bone mimetics to study bone disorders ex vivo: Role of bioinspired materials. 
  • Utilizing Superoxide Dismutase Mimetics to Enhance Radiation Therapy Response While Protecting Normal Tissues. 
  • Vaccination with peptide mimetics of the gp41 prehairpin fusion intermediate yields neutralizing antisera against HIV-1 isolates. 
  • Versatile, Reusable, and Inexpensive Ultrasound Phantom Procedural Trainers. 
  • p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase. 
• 

  Keywords of People

  • Laskowitz, Daniel Todd, Professor of Neurology, Duke Science & Society
  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology