Proteomics

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  Subject Areas on Research

  • A "best-in-class" systemic biomarker predictor of clinically relevant knee osteoarthritis structural and pain progression. 
  • A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation. 
  • A Comparative Study of Serum Exosome Isolation Using Differential Ultracentrifugation and Three Commercial Reagents. 
  • A Genome-Wide Association Study of 2304 Extreme Longevity Cases Identifies Novel Longevity Variants. 
  • A Genoproteomic Approach to Detect Peptide Markers of Bacterial Respiratory Pathogens. 
  • A Modified Nucleoside 6-Thio-2'-Deoxyguanosine Exhibits Antitumor Activity in Gliomas. 
  • A Multidimensional Bioinformatic Platform for the Study of Human Response to Surgery. 
  • A Novel Proteomics Approach to Identify Serum and Urinary Biomarkers and Pathways that Associate with Lower Urinary Tract Symptoms in Men and Women: Pilot Results of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Study. 
  • A Quantitative Global Proteomics Approach Identifies Candidate Urinary Biomarkers That Correlate With Intraductal Papillary Mucinous Neoplasm Dysplasia. 
  • A Roadmap for the Human Oral and Craniofacial Cell Atlas. 
  • A biotin switch-based proteomics approach identifies 14-3-3ζ as a target of Sirt1 in the metabolic regulation of caspase-2. 
  • A chemical glycoproteomics platform reveals O-GlcNAcylation of mitochondrial voltage-dependent anion channel 2. 
  • A flexible statistical model for alignment of label-free proteomics data--incorporating ion mobility and product ion information. 
  • A functional proteomics approach to signal transduction. 
  • A gel-free MS-based quantitative proteomic approach accurately measures cytochrome P450 protein concentrations in human liver microsomes. 
  • A genomic- and proteomic-based hypothesis on the eclectic effects of systemic interleukin-2 administration in the context of melanoma-specific immunization. 
  • A highly selective Hsp90 affinity chromatography resin with a cleavable linker. 
  • A mass spectrometry-based proteomic approach to study Marek's Disease Virus gene expression. 
  • A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death. 
  • A protein microarray-based analysis of S-nitrosylation. 
  • A proteogenomic survey of the Medicago truncatula genome. 
  • A proteomic analysis of human cilia: identification of novel components. 
  • A proteomic approach for dissecting H-Ras signaling networks in NIH/3T3 mouse embryonic fibroblast cells. 
  • A proteomic approach for unraveling the oncogenic H-Ras protein networks in NIH/3T3 mouse embryonic fibroblast cells. 
  • A proteomic surrogate for cardiovascular outcomes that is sensitive to multiple mechanisms of change in risk. 
  • A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis. 
  • A reference tissue atlas for the human kidney. 
  • A serum proteomic approach to gauging the state of remission in Wegener's granulomatosis. 
  • APOE4 Copy Number-Dependent Proteomic Changes in the Cerebrospinal Fluid. 
  • Ablation of Sirtuin5 in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload. 
  • Accentuation of differentially expressed proteins using phage technology. 
  • Acetylation goes global: the emergence of acetylation biology. 
  • Act globally, think locally: systems biology addresses the PDZ domain. 
  • Action potential-coupled Rho GTPase signaling drives presynaptic plasticity. 
  • Adaptive Responses of Pseudomonas aeruginosa to Treatment with Antibiotics. 
  • Alpha-2 macroglobulin in Alzheimer's disease: a marker of neuronal injury through the RCAN1 pathway. 
  • An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target. 
  • An integrated clinico-metabolomic model improves prediction of death in sepsis. 
  • An unbiased evaluation of CK2 inhibitors by chemoproteomics: characterization of inhibitor effects on CK2 and identification of novel inhibitor targets. 
  • Analysis of copper-induced protein precipitation across the E. coli proteome. 
  • Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. 
  • Analysis of the glycoproteome of Toxoplasma gondii using lectin affinity chromatography and tandem mass spectrometry. 
  • Application of a label-free, gel-free quantitative proteomics method for ecotoxicological studies of small fish species. 
  • Application of chemoproteomics to drug discovery: identification of a clinical candidate targeting hsp90. 
  • Application of proteomic marker ensembles to subcellular organelle identification. 
  • Aspirin exposure reveals novel genes associated with platelet function and cardiovascular events. 
  • Association of Circulating Proteins with Death or Lung Transplant in Patients with Idiopathic Pulmonary Fibrosis in the IPF-PRO Registry Cohort. 
  • Association of calcineurin with the COPI protein Sec28 and the COPII protein Sec13 revealed by quantitative proteomics. 
  • Autoantibody biomarkers identified by proteomics methods distinguish ovarian cancer from non-ovarian cancer with various CA-125 levels. 
  • Automated, reproducible, titania-based phosphopeptide enrichment strategy for label-free quantitative phosphoproteomics. 
  • Automation and low-cost proteomics for characterization of the protein corona: experimental methods for big data. 
  • Autotaxin-lysophosphatidic acid axis is a novel molecular target for lowering intraocular pressure. 
  • Beta2-adrenergic receptor lysosomal trafficking is regulated by ubiquitination of lysyl residues in two distinct receptor domains. 
  • BiPS, a photocleavable, isotopically coded, fluorescent cross-linker for structural proteomics. 
  • Bioinformatic challenges in targeted proteomics. 
  • Biomarkers and proteomic analysis of osteoarthritis. 
  • Biomarkers for amyotrophic lateral sclerosis. 
  • Biomarkers of Diabetic Retinopathy. 
  • CLN5 and CLN8 protein association with ceramide synthase: biochemical and proteomic approaches. 
  • Calcineurin Targets Involved in Stress Survival and Fungal Virulence. 
  • Can binimetinib, encorafenib and masitinib be more efficacious than currently available mutation-based targeted therapies for melanoma treatment? 
  • Carbonylation of adipose proteins in obesity and insulin resistance: identification of adipocyte fatty acid-binding protein as a cellular target of 4-hydroxynonenal. 
  • Cardiac rupture after myocardial infarction: new insights from murine models. 
  • Cardiovascular Disease: Impact of Biomarkers, Proteomics, and Genomics. 
  • Cartilage matrix remodelling differs by disease state and joint type. 
  • Cascaded Multi-view Canonical Correlation (CaMCCo) for Early Diagnosis of Alzheimer's Disease via Fusion of Clinical, Imaging and Omic Features. 
  • Cathelicidin-related antimicrobial peptide mediates skeletal muscle degeneration caused by injury and Duchenne muscular dystrophy in mice. 
  • Cellular fatty acid synthase is required for late stages of HIV-1 replication. 
  • Cerebrospinal fluid proteomics in children during induction for acute lymphoblastic leukemia: A pilot study. 
  • Changes in the Adult GluN2B Associated Proteome following Adolescent Intermittent Ethanol Exposure. 
  • Characterization of serum proteins associated with IL28B genotype among patients with chronic hepatitis C. 
  • Characterization of the Saccharomyces cerevisiae ATP-Interactome using the iTRAQ-SPROX Technique. 
  • Characterization of the ubiquitin-modified proteome regulated by transient forebrain ischemia. 
  • Chemical Denaturation and Protein Precipitation Approach for Discovery and Quantitation of Protein-Drug Interactions. 
  • Chemico-genetic discovery of astrocytic control of inhibition in vivo. 
  • Chemo-Selection Strategy for Limited Proteolysis Experiments on the Proteomic Scale. 
  • Chemoproteomic characterization of protein kinase inhibitors using immobilized ATP. 
  • Chlamydia trachomatis Infection Leads to Defined Alterations to the Lipid Droplet Proteome in Epithelial Cells. 
  • Chronic caloric restriction maintains a youthful phosphoproteome in aged skeletal muscle. 
  • Clinical Decision Making: Integrating Advances in the Molecular Understanding of Spine Tumors. 
  • Clinical and economic evaluation of a proteomic biomarker preterm birth risk predictor: cost-effectiveness modeling of prenatal interventions applied to predicted higher-risk pregnancies within a large and diverse cohort. 
  • Clinical decisions surrounding genomic and proteomic testing among United States veterans treated for lung cancer within the Veterans Health Administration. 
  • Co-Clinical Imaging Resource Program (CIRP): Bridging the Translational Divide to Advance Precision Medicine. 
  • Combining MALDI-FTMS and bioinformatics for rapid peptidomic comparisons. 
  • Comparative Analysis of Mass-Spectrometry-Based Proteomic Methods for Protein Target Discovery Using a One-Pot Approach. 
  • Comparative genome-wide screening identifies a conserved doxorubicin repair network that is diploid specific in Saccharomyces cerevisiae. 
  • Comparative proteomic analysis of differentially expressed proteins in β-aminobutyric acid enhanced Arabidopsis thaliana tolerance to simulated acid rain. 
  • Comparative proteomic analysis of proteins in response to simulated acid rain in Arabidopsis. 
  • Comparative proteomic characterization of articular cartilage tissue from normal donors and patients with osteoarthritis. 
  • Complexities associated with the molecular and proteomic identification of Paecilomyces species in the clinical mycology laboratory. 
  • Comprehensive Proteomic and Metabolomic Signatures of Nontypeable Haemophilus influenzae-Induced Acute Otitis Media Reveal Bacterial Aerobic Respiration in an Immunosuppressed Environment. 
  • Comprehensive molecular portraits of human breast tumours. 
  • Concentration and composition of the protein corona as a function of incubation time and serum concentration: an automated approach to the protein corona. 
  • Constrained selected reaction monitoring: quantification of selected post-translational modifications and protein isoforms. 
  • DYT-TOR1A subcellular proteomics reveals selective vulnerability of the nuclear proteome to cell stress. 
  • De novo engineering of intracellular condensates using artificial disordered proteins. 
  • Delineating signal transduction pathways in smooth muscle through focused proteomics. 
  • Design and application of a data-independent precursor and product ion repository. 
  • Detecting Cardiovascular Protein-Protein Interactions by Proximity Proteomics. 
  • Direct tandem mass spectrometry reveals limitations in protein profiling experiments for plasma biomarker discovery. 
  • Discovering the landscape of protein modifications. 
  • Discovery and verification of protein differences between Er positive/Her2/neu negative breast tumor tissue and matched adjacent normal breast tissue. 
  • Discovery of Tamoxifen and N-Desmethyl Tamoxifen Protein Targets in MCF-7 Cells Using Large-Scale Protein Folding and Stability Measurements. 
  • Discovery of biomarker candidates for coronary artery disease from an APOE-knock out mouse model using iTRAQ-based multiplex quantitative proteomics. 
  • Discovery of proteins related to coronary artery disease using industrial-scale proteomics analysis of pooled plasma. 
  • Discovery of the Xenon-Protein Interactome Using Large-Scale Measurements of Protein Folding and Stability. 
  • Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors. 
  • Elucidating structural and molecular mechanisms of β-arrestin-biased agonism at GPCRs via MS-based proteomics. 
  • Elucidating the Molecular Composition of Cartilage by Proteomics. 
  • Endothelial cell antibodies associated with novel targets and increased rejection. 
  • Ethanol metabolism modifies hepatic protein acylation in mice. 
  • Evaluation of serum protein profiling by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry for the detection of prostate cancer: I. Assessment of platform reproducibility. 
  • Experimental design of time series data for learning from dynamic Bayesian networks. 
  • Exploiting the complementary nature of LC/MALDI/MS/MS and LC/ESI/MS/MS for increased proteome coverage. 
  • Exploring the mechanism of Physcomitrella patens desiccation tolerance through a proteomic strategy. 
  • Expression of ectopic heat shock protein 90 in male and female primary afferent nociceptors regulates inflammatory pain. 
  • Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinases. 
  • Extracellular trafficking of myocilin in human trabecular meshwork cells. 
  • Extracellular vesicles from endometriosis patients are characterized by a unique miRNA-lncRNA signature. 
  • Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure. 
  • False-positive rate determination of protein target discovery using a covalent modification- and mass spectrometry-based proteomics platform. 
  • Fimbriae-mediated outer membrane vesicle production and invasion of Porphyromonas gingivalis. 
  • Finding diagnostic biomarkers in proteomic spectra. 
  • Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor. 
  • Fluorescence-activated cell sorting in plant developmental biology. 
  • Fluorescent-Linked Enzyme Chemoproteomic Strategy (FLECS) for Identifying HSP70 Inhibitors. 
  • Functional nanostructures from surface chemistry patterning. 
  • Functional screen identifies kinases driving prostate cancer visceral and bone metastasis. 
  • Functional specialization of beta-arrestin interactions revealed by proteomic analysis. 
  • Fungal diagnostics in pneumonia. 
  • G Protein-Coupled Receptor Endocytosis Confers Uniformity in Responses to Chemically Distinct Ligands. 
  • GABA signaling triggered by TMC-1/Tmc delays neuronal aging by inhibiting the PKC pathway in C. elegans. 
  • Gene expression profiles for the prediction of progression-free survival in diffuse large B cell lymphoma: results of a DASL assay. 
  • Generating mammalian sirtuin tools for protein-interaction analysis. 
  • Genetic Subtyping and Phenotypic Characterization of the Immune Microenvironment and MYC/BCL2 Double Expression Reveal Heterogeneity in Diffuse Large B-cell Lymphoma. 
  • Genetic markers: progress and potential for cardiovascular disease. 
  • Genome-wide association study reveals novel genetic loci: a new polygenic risk score for mitral valve prolapse. 
  • Genome-wide high-resolution mapping of exosome substrates reveals hidden features in the Arabidopsis transcriptome. 
  • Genomic convergence to identify candidate genes for Parkinson disease: SAGE analysis of the substantia nigra. 
  • Genomics and clinical medicine: rationale for creating and effectively evaluating animal models. 
  • Global Identification of Small Ubiquitin-related Modifier (SUMO) Substrates Reveals Crosstalk between SUMOylation and Phosphorylation Promotes Cell Migration. 
  • Global analysis of protein folding thermodynamics for disease state characterization. 
  • Global transcriptional and proteomic analysis of the Sig1 heat shock regulon of Deinococcus radiodurans. 
  • Global whole-cell FTICR mass spectrometric proteomics analysis of the heat shock response in the radioresistant bacterium Deinococcus radiodurans. 
  • Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer. 
  • Glycosylation site-specific analysis of clade C HIV-1 envelope proteins. 
  • Guidelines for Genome-Scale Analysis of Biological Rhythms. 
  • HPLC enrichment/isolation of proteins for post-translational modification studies from complex mixtures. 
  • High predictive accuracy of an unbiased proteomic profile for sustained virologic response in chronic hepatitis C patients. 
  • High spatial resolution proteomic comparison of the brain in humans and chimpanzees. 
  • High-Resolution Expression Map of the Arabidopsis Root Reveals Alternative Splicing and lincRNA Regulation. 
  • High-throughput identification of IMCD proteins using LC-MS/MS. 
  • High-throughput targeted proteomics discovery approach and spontaneous reperfusion in ST-segment elevation myocardial infarction. 
  • Host-Based Diagnostics for Acute Respiratory Infections. 
  • Hypophosphorylation of the architectural chromatin protein DEK in death-receptor-induced apoptosis revealed by the isotope coded protein label proteomic platform. 
  • IRF8 is a transcriptional activator of CD37 expression in diffuse large B-cell lymphoma. 
  • Identification and Quantitation of Coding Variants and Isoforms of Pulmonary Surfactant Protein A. 
  • Identification and targeting of a HES1-YAP1-CDKN1C functional interaction in fusion-negative rhabdomyosarcoma. 
  • Identification of Protease Specificity by Combining Proteome-Derived Peptide Libraries and Quantitative Proteomics. 
  • Identification of S-nitrosylated targets of thioredoxin using a quantitative proteomic approach. 
  • Identification of a protective proteomic signature and a potential therapeutic target in diabetic nephropathy. 
  • Identification of proteins and cellular pathways targeted by 2-nitroimidazole hypoxic cytotoxins. 
  • In situ transformation of ethoxylate and glycol surfactants by shale-colonizing microorganisms during hydraulic fracturing. 
  • In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation. 
  • Inflammatory Protein Profiles in Plasma of Candidaemia Patients and the Contribution of Host Genetics to Their Variability. 
  • Insulin Growth Factor Phenotypes in Heart Failure With Preserved Ejection Fraction, an INSPIRE Registry and CATHGEN Study. 
  • Integrated omics networks reveal the temporal signaling events of brassinosteroid response in Arabidopsis. 
  • Integrated proteomic and transcriptomic profiling of mouse lung development and Nmyc target genes. 
  • Integrated proteomics and metabolomics suggests symbiotic metabolism and multimodal regulation in a fungal-endobacterial system. 
  • Integrative Omics: Harnessing the Proteome to Maximize the Potential of the Genome. 
  • Integrative metabolomics-genomics approach reveals key metabolic pathways and regulators of Alzheimer's disease. 
  • Integrative systems biology: an attempt to describe a simple weed. 
  • Interleukin-13 disrupts type 2 pneumocyte stem cell activity. 
  • Intraoperative Complications With Vitreous Biopsy for Molecular Proteomics. 
  • Investigation of phosphoprotein signatures of archived prostate cancer tissue specimens via proteomic analysis. 
  • Irrational exuberance in clinical proteomics. 
  • Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer. 
  • Joint Fluid Proteome after Anterior Cruciate Ligament Rupture Reflects an Acute Posttraumatic Inflammatory and Chondrodegenerative State. 
  • Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury. 
  • Lipid-independent activation of a muscle-specific PKCα splicing variant. 
  • Liquid biopsy proteomics of uveal melanoma reveals biomarkers associated with metastatic risk. 
  • Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19. 
  • Lung cancer staging: proteomics. 
  • LungMAP: The Molecular Atlas of Lung Development Program. 
  • Lysine glutarylation is a protein posttranslational modification regulated by SIRT5. 
  • MDM2 antagonists overcome intrinsic resistance to CDK4/6 inhibition by inducing p21. 
  • MHC class I-presented lung cancer-associated tumor antigens identified by immunoproteomics analysis are targets for cancer-specific T cell response. 
  • MHC class I-presented tumor antigens identified in ovarian cancer by immunoproteomic analysis are targets for T-cell responses against breast and ovarian cancer. 
  • Manganese (III) meso-tetrakis N-ethylpyridinium-2-yl porphyrin acts as a pro-oxidant to inhibit electron transport chain proteins, modulate bioenergetics, and enhance the response to chemotherapy in lymphoma cells. 
  • Manganese porphyrin reduces renal injury and mitochondrial damage during ischemia/reperfusion. 
  • Mapping Angiotensin II Type 1 Receptor-Biased Signaling Using Proximity Labeling and Proteomics Identifies Diverse Actions of Biased Agonists. 
  • Mass Spectrometry-Based Proteomics for Analysis of Hydrophilic Phosphopeptides. 
  • Mass spectrometry- and lysine amidination-based protocol for thermodynamic analysis of protein folding and ligand binding interactions. 
  • Maximum entropy reconstructions of dynamic signaling networks from quantitative proteomics data. 
  • Mechanism of immune response during immunotherapy. 
  • Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype. 
  • Metabolomics Standards Workshop and the development of international standards for reporting metabolomics experimental results. 
  • Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function. 
  • Metaprotein expression modeling for label-free quantitative proteomics. 
  • Methodologies for the characterization, identification and quantification of S-nitrosylated proteins. 
  • MiMeDB: the Human Microbial Metabolome Database. 
  • Microproteomics: quantitative proteomic profiling of small numbers of laser-captured cells. 
  • Mitochondrial Oxidative Phosphorylation Complex Regulates NLRP3 Inflammasome Activation and Predicts Patient Survival in Nasopharyngeal Carcinoma. 
  • Mitotic phosphorylation of eukaryotic initiation factor 4G1 (eIF4G1) at Ser1232 by Cdk1:cyclin B inhibits eIF4A helicase complex binding with RNA. 
  • Molecular and genetic markers in thoracic surgery. 
  • Molecular biomarkers in glaucoma. 
  • Molecular markers for incidence, prognosis, and response to therapy. 
  • Multi-marker strategies in heart failure: clinical and statistical approaches. 
  • Multiplexed protein array platforms for analysis of autoimmune diseases. 
  • Multiscale, multimodal analysis of tumor heterogeneity in IDH1 mutant vs wild-type diffuse gliomas. 
  • Muscle-Specific Overexpression of PGC-1α Does Not Augment Metabolic Improvements in Response to Exercise and Caloric Restriction. 
  • Myocardial Injury Caused by Chronic Alcohol Exposure-A Pilot Study Based on Proteomics. 
  • Nanotechnologies and regenerative medical approaches for space and terrestrial medicine. 
  • National Heart, Lung, And Blood Institute Clinical Proteomics Working Group report. 
  • New Insight of Common Regulatory Pathways in Human Trabecular Meshwork Cells in Response to Dexamethasone and Prednisolone Using an Integrated Quantitative Proteomics: SWATH and MRM-HR Mass Spectrometry. 
  • New Strategies and Challenges in Lung Proteomics and Metabolomics. An Official American Thoracic Society Workshop Report. 
  • New developments in proteomics. 
  • Nitric oxide and redox regulation in the liver: part II. Redox biology in pathologic hepatocytes and implications for intervention. 
  • Novel breast cancer biomarkers identified by integrative proteomic and gene expression mapping. 
  • Novel multi-marker proteomics in phenotypically matched patients with ST-segment myocardial infarction: association with clinical outcomes. 
  • Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression. 
  • Opportunities-and hard work-ahead. 
  • Optimized mixed Markov models for motif identification. 
  • Outcomes of COPD Patients with Flame Burn and Inhalation Injuries at a Single Institution. 
  • Overexpression of cell surface cytokeratin 8 in multidrug-resistant MCF-7/MX cells enhances cell adhesion to the extracellular matrix. 
  • Oxidase Activity of the Barnacle Adhesive Interface Involves Peroxide-Dependent Catechol Oxidase and Lysyl Oxidase Enzymes. 
  • Oxidative stress and covalent modification of protein with bioactive aldehydes. 
  • Pacemaker-induced transient asynchrony suppresses heart failure progression. 
  • Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas. 
  • Parallel Multi-Omics in High-Risk Subjects for the Identification of Integrated Biomarker Signatures of Type 1 Diabetes. 
  • Parallel assay of oxygen equilibria of hemoglobin. 
  • Pathophysiology of the blood-brain barrier: animal models and methods. 
  • Paying Homage to the Power of Proteomics: Insights Into Obesity and Heart Failure From the HOMAGE Trial. 
  • Peptide array X-linking (PAX): a new peptide-protein identification approach. 
  • Performance of a proteomic preterm delivery predictor in a large independent prospective cohort. 
  • Peripheral blood proteomic profiling of idiopathic pulmonary fibrosis biomarkers in the multicentre IPF-PRO Registry. 
  • Pharmacokinetic Analysis of a Novel Human EGFRvIII:CD3 Bispecific Antibody in Plasma and Whole Blood Using a High-Resolution Targeted Mass Spectrometry Approach. 
  • Phosphoproteome analysis reveals regulatory sites in major pathways of cardiac mitochondria. 
  • Phosphoproteomic analysis of human mesenchymal stromal cells during osteogenic differentiation. 
  • Phosphoproteomic profiling of human myocardial tissues distinguishes ischemic from non-ischemic end stage heart failure. 
  • Phosphoproteomics for the masses. 
  • Pilot and feasibility study: prospective proteomic profiling of mammary epithelial cells from high-risk women provides evidence of activation of pro-survival pathways. 
  • Plant transcription factors - being in the right place with the right company. 
  • Plasma kallikrein predicts primary graft dysfunction after heart transplant. 
  • Plasma proteomics of patients with non-valvular atrial fibrillation on chronic anti-coagulation with warfarin or a direct factor Xa inhibitor. 
  • Platelets from genome to proteome and beyond. 
  • Platelets: developmental biology, physiology, and translatable platforms for preclinical investigation and drug development. 
  • Plug-and-Play Protein Modification Using Homology-Independent Universal Genome Engineering. 
  • Polyreactive IgM initiates complement activation by PF4/heparin complexes through the classical pathway. 
  • Polyubiquitin Chains Linked by Lysine Residue 48 (K48) Selectively Target Oxidized Proteins In Vivo. 
  • Post-translational regulation of calsarcin-1 during pressure overload-induced cardiac hypertrophy. 
  • Posttranslational, translational, and transcriptional responses to nitric oxide stress in Cryptococcus neoformans: implications for virulence. 
  • Pregnancy and Smoothelin-like Protein 1 (SMTNL1) Deletion Promote the Switching of Skeletal Muscle to a Glycolytic Phenotype in Human and Mice. 
  • Preoteomics, metabolomics and circulating endothelial progenitor cells in acute coronary syndromes. 
  • Preoteomics, metabolomics and progenitor cells in acute coronary syndromes. 
  • Profiling of experience-regulated proteins in the songbird auditory forebrain using quantitative proteomics. 
  • Protein fragment domains identified using 2D gel electrophoresis/MALDI-TOF. 
  • Protein microarray signature of autoantibody biomarkers for the early detection of breast cancer. 
  • Protein-Protein Docking Benchmark 2.0: an update. 
  • Proteome analysis by mass spectrometry. 
  • Proteome analysis of the rat cornea during angiogenesis. 
  • Proteome-Wide Structural Biology: An Emerging Field for the Structural Analysis of Proteins on the Proteomic Scale. 
  • Proteome-wide analysis reveals widespread lysine acetylation of major protein complexes in the malaria parasite. 
  • Proteomic Analysis of Infants Undergoing Cardiopulmonary Bypass Using Contemporary Ontological Tools. 
  • Proteomic Architecture of Human Coronary and Aortic Atherosclerosis. 
  • Proteomic Profiling Reveals Adaptive Responses to Surgical Myocardial Ischemia-Reperfusion in Hibernating Arctic Ground Squirrels Compared to Rats. 
  • Proteomic Profiling of Human Hepatic Stellate Cell Line LX2 Responses to Irradiation and TGF-β1. 
  • Proteomic Signature of Subclinical Coronary Artery Disease in People With HIV: Analysis of the REPRIEVE Mechanistic Substudy. 
  • Proteomic analysis of S-nitrosylation and denitrosylation by resin-assisted capture. 
  • Proteomic analysis of an unculturable bacterial endosymbiont (Blochmannia) reveals high abundance of chaperonins and biosynthetic enzymes. 
  • Proteomic analysis of calcium/calmodulin-dependent protein kinase I and IV in vitro substrates reveals distinct catalytic preferences. 
  • Proteomic analysis of desmosomes reveals novel components required for epidermal integrity. 
  • Proteomic analysis of human bronchoalveolar lavage fluid after subsgemental exposure. 
  • Proteomic analysis of mitotic RNA polymerase II reveals novel interactors and association with proteins dysfunctional in disease. 
  • Proteomic analysis of proteins related to rice grain chalkiness using iTRAQ and a novel comparison system based on a notched-belly mutant with white-belly. 
  • Proteomic analysis of regenerated rabbit lenses reveal crystallin expression characteristic of adult rabbits. 
  • Proteomic analysis of stage I endometrial cancer tissue: identification of proteins associated with oxidative processes and inflammation. 
  • Proteomic analysis of the NOS2 interactome in human airway epithelial cells. 
  • Proteomic analysis of the luteal endometrial secretome. 
  • Proteomic analysis of urinary extracellular vesicles reveal biomarkers for neurologic disease. 
  • Proteomic biomarker discovery in cerebrospinal fluid for cerebral vasospasm following subarachnoid hemorrhage. 
  • Proteomic biomarkers of intra-amniotic inflammation: relationship with funisitis and early-onset sepsis in the premature neonate. 
  • Proteomic differences among patients with heart failure taking furosemide or torsemide. 
  • Proteomic dissection of LPS-inducible, PHF8-dependent secretome reveals novel roles of PHF8 in TLR4-induced acute inflammation and T cell proliferation. 
  • Proteomic identification and functional characterization of MYH9, Hsc70, and DNAJA1 as novel substrates of HDAC6 deacetylase activity. 
  • Proteomic identification of specific oxidized proteins in ApoE-knockout mice: relevance to Alzheimer's disease. 
  • Proteomic identification of the cerebral cavernous malformation signaling complex. 
  • Proteomic identification of unique photoreceptor disc components reveals the presence of PRCD, a protein linked to retinal degeneration. 
  • Proteomic profiling identifies CLEC4C expression as a novel biomarker of primary graft dysfunction after heart transplantation. 
  • Proteomic profiling of a layered tissue reveals unique glycolytic specializations of photoreceptor cells. 
  • Proteomic profiling of nuclei from native renal inner medullary collecting duct cells using LC-MS/MS. 
  • Proteomic profiling of patient-derived glioblastoma xenografts identifies a subset with activated EGFR: implications for drug development. 
  • Proteomics and immunohistochemistry identify the expression of α-cardiac myosin heavy chain in the jaw-closing muscles of sooty mangabeys (order Primates). 
  • Proteomics characterization of cell membrane blebs in human retinal pigment epithelium cells. 
  • Proteomics for monitoring immune responses to cancer vaccines. 
  • Proteomics in prostate cancer. 
  • Proteomics in uveal melanoma. 
  • Proteomics of cerebral injury in a neonatal model of cardiopulmonary bypass with deep hypothermic circulatory arrest. 
  • Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane. 
  • Quantitative label-free phosphoproteomics strategy for multifaceted experimental designs. 
  • Quantitative proteomics approach for identifying protein-drug interactions in complex mixtures using protein stability measurements. 
  • Quantitative proteomics of bronchoalveolar lavage fluid in idiopathic pulmonary fibrosis. 
  • ROCK1 phosphorylates and activates zipper-interacting protein kinase. 
  • Rationale and design of the Kidney Precision Medicine Project. 
  • Real-time in vivo proteomic identification of novel kinase substrates in smooth muscle. 
  • Recent advances for measurement of protein synthesis rates, use of the 'Virtual Biopsy' approach, and measurement of muscle mass. 
  • Redox proteomic identification of HNE-bound mitochondrial proteins in cardiac tissues reveals a systemic effect on energy metabolism after doxorubicin treatment. 
  • Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation. 
  • Renal systems biology of patients with systemic inflammatory response syndrome. 
  • Right ventricular hypertrophy with early dysfunction: A proteomics study in a neonatal model. 
  • SH3 domain-based phototrapping in living cells reveals Rho family GAP signaling complexes. 
  • SILAC-pulse proteolysis: A mass spectrometry-based method for discovery and cross-validation in proteome-wide studies of ligand binding. 
  • SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease. 
  • SUMO proteomics to decipher the SUMO-modified proteome regulated by various diseases. 
  • Scanning Quadrupole Data-Independent Acquisition, Part A: Qualitative and Quantitative Characterization. 
  • Secrets of the perioptome: new tools for a new concept. 
  • Selenocysteine substitutions in thiyl radical enzymes. 
  • Sequence basis of Barnacle Cement Nanostructure is Defined by Proteins with Silk Homology. 
  • Serum proteomic analysis focused on fibrosis in patients with hepatitis C virus infection. 
  • Sex Differences in Gene and Protein Expression After Intracerebral Hemorrhage in Mice. 
  • Simultaneous proteomic profiling of four different growth states of human fibroblasts, using amine-reactive isobaric tagging reagents and tandem mass spectrometry. 
  • Single-cell profiling of the antigen-specific response to BNT162b2 SARS-CoV-2 RNA vaccine. 
  • Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade serous ovarian cancer. 
  • Site-Specific K63 Ubiquitinomics Provides Insights into Translation Regulation under Stress. 
  • Skyline for Small Molecules: A Unifying Software Package for Quantitative Metabolomics. 
  • Small but Mighty: Functional Peptides Encoded by Small ORFs in Plants. 
  • Small ubiquitin-like modifier 3-modified proteome regulated by brain ischemia in novel small ubiquitin-like modifier transgenic mice: putative protective proteins/pathways. 
  • Space flight alters bacterial gene expression and virulence and reveals a role for global regulator Hfq. 
  • Strategic Therapeutic Targeting to Overcome Venetoclax Resistance in Aggressive B-cell Lymphomas. 
  • Stroke Proteomics: From Discovery to Diagnostic and Therapeutic Applications. 
  • Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins. 
  • Subtyping of common complex diseases and disorders by integrating heterogeneous data. Identifying clusters among women with lower urinary tract symptoms in the LURN study. 
  • Surrogate markers for late cardiac allograft survival. 
  • Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1. 
  • Systems proteomics of cardiac chromatin identifies nucleolin as a regulator of growth and cellular plasticity in cardiomyocytes. 
  • Tandem Mass Tag Labeling Facilitates Reversed-Phase Liquid Chromatography-Mass Spectrometry Analysis of Hydrophilic Phosphopeptides. 
  • Targeted Proteomics of Human Metapneumovirus in Clinical Samples and Viral Cultures. 
  • Targeting RET Kinase in Neuroendocrine Prostate Cancer. 
  • Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection. 
  • Techniques for quantifying phytoplankton biodiversity. 
  • The 2012/2013 ABRF Proteomic Research Group Study: Assessing Longitudinal Intralaboratory Variability in Routine Peptide Liquid Chromatography Tandem Mass Spectrometry Analyses. 
  • The Diacetyl-Exposed Human Airway Epithelial Secretome: New Insights into Flavoring-Induced Airways Disease. 
  • The Ephrin B2 Receptor Tyrosine Kinase Is a Regulator of Proto-oncogene MYC and Molecular Programs Central to Barrett's Neoplasia. 
  • The Expressed Genome in Cardiovascular Diseases and Stroke: Refinement, Diagnosis, and Prediction: A Scientific Statement From the American Heart Association. 
  • The G Protein-Coupled Estrogen Receptor Agonist G-1 Inhibits Nuclear Estrogen Receptor Activity and Stimulates Novel Phosphoproteomic Signatures. 
  • The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis. 
  • The Phenix software for automated determination of macromolecular structures. 
  • The Protein Kinase A-Dependent Phosphoproteome of the Human Pathogen Aspergillus fumigatus Reveals Diverse Virulence-Associated Kinase Targets. 
  • The binding of SLE autoantibodies to mitochondria. 
  • The chromatin-binding protein Smyd1 restricts adult mammalian heart growth. 
  • The current epidemiology and clinical decisions surrounding acute respiratory infections. 
  • The metabolomics standards initiative. 
  • The performance of ZDOCK and ZRANK in rounds 6-11 of CAPRI. 
  • The protein expression landscape of the Arabidopsis root. 
  • Therapeutic Targets for Heart Failure Identified Using Proteomics and Mendelian Randomization. 
  • Thermodynamic Analysis of the Geldanamycin-Hsp90 Interaction in a Whole Cell Lysate Using a Mass Spectrometry-Based Proteomics Approach. 
  • Thermodynamic analysis of protein folding and stability using a tryptophan modification protocol. 
  • Thermodynamic analysis of protein-ligand binding interactions in complex biological mixtures using the stability of proteins from rates of oxidation. 
  • Three biomarkers identified from serum proteomic analysis for the detection of early stage ovarian cancer. 
  • Thrombospondin-1 mediates Rho-kinase inhibitor-induced increase in outflow-facility. 
  • Top-down quantitative proteomics identified phosphorylation of cardiac troponin I as a candidate biomarker for chronic heart failure. 
  • Toxin-based targeted therapy for malignant brain tumors. 
  • Transcriptional profiling of whole blood and serum protein analysis of mice exposed to the neurotoxin Pacific Ciguatoxin-1. 
  • Transcriptomic and Proteomic Analysis of Clear Cell Foci (CCF) in the Human Non-Cirrhotic Liver Identifies Several Differentially Expressed Genes and Proteins with Functions in Cancer Cell Biology and Glycogen Metabolism. 
  • Transformative Impact of Proteomics on Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association. 
  • Tripartite synaptomics: Cell-surface proximity labeling in vivo. 
  • Tumor cell sensitivity to vemurafenib can be predicted from protein expression in a BRAF-V600E basket trial setting. 
  • Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart Injury. 
  • UBE2N Promotes Melanoma Growth via MEK/FRA1/SOX10 Signaling. 
  • Update on the genetics of primary open-angle glaucoma. 
  • Urine proteomics in kidney transplantation. 
  • Usefulness of material recovered from distal embolic protection devices after carotid angioplasty: too little, too late? 
  • Using Stepwise Pharmacogenomics and Proteomics to Predict Hepatitis C Treatment Response in Difficult to Treat Patient Populations. 
  • Utility of discovery approach using proteomics to create a biomarker profile for coronary microvascular dysfunction. 
  • Verification of systems biology research in the age of collaborative competition. 
  • Visual annotation of the gene database. 
  • What is mzXML good for? 
  • What was old is new again: using the host response to diagnose infectious disease. 
  • Whole-Slide Cytometric Feature Mapping for Distinguishing Tumor Genomic Subtypes in Head and Neck Squamous Cell Carcinoma Whole-Slide Images. 
  • Workshop on cancer biometrics: identifying biomarkers and surrogates of cancer in patients: a meeting held at the Masur Auditorium, National Institutes of Health. 
  • XPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A. 
  • YbiV from Escherichia coli K12 is a HAD phosphatase. 
  • ZDOCK and RDOCK performance in CAPRI rounds 3, 4, and 5. 
• 

  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Courtland, Jamie, House Staff, Neurobiology
  • Granger, Christopher Bull, Professor of Medicine, School of Nursing
  • Grimsrud, Paul, Assistant Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition
  • Hartemink, Alexander J., Professor in the Department of Computer Science, Biology
  • Milano, Carmelo Alessio, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering
  • Soderling, Scott Haydn, George Barth Geller Distinguished Professor of Molecular Biology, Cell Biology
  • Tsalik, Ephraim, Adjunct Associate Professor in the Department of Medicine, Medicine, Infectious Diseases
  • Wernegreen, Jennifer Jo, Lee Hill Snowdon Associate Professor, Environmental Sciences and Policy