NIH 3T3 Cells

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  Subject Areas on Research

  • 3D printing of high-strength, porous, elastomeric structures to promote tissue integration of implants. 
  • 58-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway. 
  • A Period2 Phosphoswitch Regulates and Temperature Compensates Circadian Period. 
  • A controlled-release strategy for the generation of cross-linked hydrogel microstructures. 
  • A novel EGFR isoform confers increased invasiveness to cancer cells. 
  • A proteomic approach for dissecting H-Ras signaling networks in NIH/3T3 mouse embryonic fibroblast cells. 
  • A proteomic approach for unraveling the oncogenic H-Ras protein networks in NIH/3T3 mouse embryonic fibroblast cells. 
  • Abl interactor 1 (Abi-1) wave-binding and SNARE domains regulate its nucleocytoplasmic shuttling, lamellipodium localization, and wave-1 levels. 
  • Abl kinases are required for invadopodia formation and chemokine-induced invasion. 
  • Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motility. 
  • An Evolutionary Insertion in the Mxra8 Receptor-Binding Site Confers Resistance to Alphavirus Infection and Pathogenesis. 
  • An alternative splice form of Mdm2 induces p53-independent cell growth and tumorigenesis. 
  • An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles. 
  • An opposite role for tau in circadian rhythms revealed by mathematical modeling. 
  • Analysis of long range correlations due to coherent light scattering from in-vitro cell arrays using angle-resolved low coherence interferometry. 
  • Analysis of mRNA partitioning between the cytosol and endoplasmic reticulum compartments of mammalian cells. 
  • Architectural Modification of Conformal PEG-Bottlebrush Coatings Minimizes Anti-PEG Antigenicity While Preserving Stealth Properties. 
  • BCL2 inhibits cell adhesion, spreading, and motility by enhancing actin polymerization. 
  • Beta-arrestin-mediated localization of smoothened to the primary cilium. 
  • Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor. 
  • Biomaterial-mediated retroviral gene transfer using self-assembled monolayers. 
  • CCL5-mediated endogenous antitumor immunity elicited by adoptively transferred lymphocytes and dendritic cell depletion. 
  • CERKL interacts with mitochondrial TRX2 and protects retinal cells from oxidative stress-induced apoptosis. 
  • CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis. 
  • CK1epsilon is required for breast cancers dependent on beta-catenin activity. 
  • Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells. 
  • Cell-Compatible, Site-Specific Covalent Modification of Hydrogel Scaffolds Enables User-Defined Control over Cell-Material Interactions. 
  • Cilia loss sensitizes cells to transformation by activating the mevalonate pathway. 
  • Clustered Arg–Gly–Asp peptides enhances tumor targeting of nonviral vectors 
  • Constitutive Stat3 activation alters behavior of hair follicle stem and progenitor cell populations. 
  • Crosslinked hyaluronic acid hydrogels: a strategy to functionalize and pattern 
  • DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling. 
  • DNA delivery from hyaluronic acid-collagen hydrogels via a substrate-mediated approach 
  • Decreased S -Nitrosylation of Tissue Transglutaminase Contributes to Age-Related Increases in Vascular Stiffness 
  • Development of bioactive photocrosslinkable fibrous hydrogels. 
  • Directed intermixing in multicomponent self-assembling biomaterials. 
  • Discovery of an inhibitor of insulin-like growth factor 1 receptor activation: implications for cellular potency and selectivity over insulin receptor. 
  • Discovery of protein- and DNA-imperceptible nanoparticle hard coating using gel-based reaction tuning. 
  • Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control. 
  • Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients. 
  • Esterified Trehalose Analogues Protect Mammalian Cells from Heat Shock. 
  • GQ-16, a novel peroxisome proliferator-activated receptor γ (PPARγ) ligand, promotes insulin sensitization without weight gain. 
  • Gene delivery through cell culture substrate adsorbed DNA complexes 
  • Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma. 
  • Graphene Enhances Actin Filament Assembly Kinetics and Modulates NIH-3T3 Fibroblast Cell Spreading. 
  • HDAC6 modulates cell motility by altering the acetylation level of cortactin. 
  • Heat shock protein 90 suppresses tumor necrosis factor alpha induced apoptosis by preventing the cleavage of Bid in NIH3T3 fibroblasts. 
  • Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production. 
  • Identification of JWA as a novel functional gene responsive to environmental oxidative stress induced by benzo[a]pyrene and hydrogen peroxide. 
  • Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors. 
  • Immune responses of breast cancer patients to mutated epidermal growth factor receptor (EGF-RvIII, Delta EGF-R, and de2-7 EGF-R). 
  • Immunogenic cancer cell death selectively induced by near infrared photoimmunotherapy initiates host tumor immunity. 
  • Impact of synchronized anti-PD-1 with Ad-CEA vaccination on inhibition of colon cancer growth. 
  • In vitro pharmacology of clinically used central nervous system-active drugs as inverse H(1) receptor agonists. 
  • Increased immunogenicity of a DNA-launched Venezuelan equine encephalitis virus-based replicon DNA vaccine. 
  • JAK2-binding long noncoding RNA promotes breast cancer brain metastasis. 
  • Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2. 
  • Merlin facilitates ubiquitination and degradation of transactivation-responsive RNA-binding protein. 
  • Mitochondrial GLUT10 facilitates dehydroascorbic acid import and protects cells against oxidative stress: mechanistic insight into arterial tortuosity syndrome. 
  • Molecular interactions of B-CAM (basal-cell adhesion molecule) and laminin in epithelial skin cancer. 
  • Mouse translation elongation factor eEF1A-2 interacts with Prdx-I to protect cells against apoptotic death induced by oxidative stress. 
  • Multi-resolution 3D visualization of the early stages of cellular uptake of peptide-coated nanoparticles. 
  • Multilayer microfluidic PEGDA hydrogels. 
  • Novel aminoalkyl tris-cyclometalated iridium complexes as cellular stains. 
  • Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants. 
  • PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity. 
  • Patterning cells in highly deformable microstructures: effect of plastic deformation of substrate on cellular phenotype and gene expression. 
  • Phosphorylation of PDZ1 domain attenuates NHERF-1 binding to cellular targets. 
  • Piezo proteins are pore-forming subunits of mechanically activated channels. 
  • Post-fabrication QAC-functionalized thermoplastic polyurethane for contact-killing catheter applications. 
  • Prenylated c17orf37 induces filopodia formation to promote cell migration and metastasis. 
  • Probing the folded state of fibronectin type III domains in stretched fibrils by measuring buried cysteine accessibility. 
  • RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation. 
  • RIP3 induces apoptosis independent of pronecrotic kinase activity. 
  • Radiopaque, iodine functionalized, phenylalanine-based poly(ester urea)s. 
  • Rapid and orthogonal logic gating with a gibberellin-induced dimerization system. 
  • Rapid cross-linking of elastin-like polypeptides with (hydroxymethyl)phosphines in aqueous solution. 
  • Recognition of glioma stem cells by genetically modified T cells targeting EGFRvIII and development of adoptive cell therapy for glioma. 
  • Regulation of Rac1 translocation and activation by membrane domains and their boundaries. 
  • Regulation of hedgehog signaling by Myc-interacting zinc finger protein 1, Miz1. 
  • Reversibly switchable fluorescence microscopy with enhanced resolution and image contrast. 
  • Revisiting the mystery of fibronectin multimers: the fibronectin matrix is composed of fibronectin dimers cross-linked by non-covalent bonds. 
  • SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis. 
  • Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor. 
  • Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells. 
  • TGF-β signalling is required for CD4⁺ T cell homeostasis but dispensable for regulatory T cell function. 
  • The CapZ interacting protein Rcsd1 is required for cardiogenesis downstream of Wnt11a in Xenopus laevis. 
  • The MicroRNA miR-191 Supports T Cell Survival Following Common γ Chain Signaling. 
  • The N- and C-terminal peptides of hIL8/CXCL8 are ligands for hCXCR1 and hCXCR2. 
  • The autophagic protein LC3 translocates to the nucleus and localizes in the nucleolus associated to NUFIP1 in response to cyclic mechanical stress. 
  • The double-stranded RNA-activated protein kinase mediates viral-induced encephalitis. 
  • The effect of charge-reversal amphiphile spacer composition on DNA and siRNA delivery. 
  • The release of microparticles by apoptotic cells and their effects on macrophages. 
  • The structure of helical lipoprotein lipase reveals an unexpected twist in lipase storage. 
  • The synergistic combination of the farnesyl transferase inhibitor lonafarnib and paclitaxel enhances tubulin acetylation and requires a functional tubulin deacetylase. 
  • Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming. 
  • Transcriptional control of preadipocyte determination by Zfp423. 
  • VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling. 
  • [IL-21 induces regulatory B cell differentiation and immunosuppressive effect through cognate interaction with T cells]. 
  • miR-181a is an intrinsic modulator of T cell sensitivity and selection. 
  • miR-19 is a key oncogenic component of mir-17-92.