Chromatin Assembly and Disassembly

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  Subject Areas on Research

  • A cis-regulatory map of the Drosophila genome. 
  • A dynamic H3K27ac signature identifies VEGFA-stimulated endothelial enhancers and requires EP300 activity. 
  • A genome-wide analysis of open chromatin in human epididymis epithelial cells reveals candidate regulatory elements for genes coordinating epididymal function. 
  • A structural perspective on the where, how, why, and what of nucleosome positioning. 
  • Altered telomeres in tumors with ATRX and DAXX mutations. 
  • Antisense oligonucleotides targeting mutant Ataxin-7 restore visual function in a mouse model of spinocerebellar ataxia type 7. 
  • Biochemical Methods To Investigate lncRNA and the Influence of lncRNA:Protein Complexes on Chromatin. 
  • Cell surface GRP78 signaling: An emerging role as a transcriptional modulator in cancer. 
  • Chromatin Dynamics and the Development of the TCRα and TCRδ Repertoires. 
  • Chromatin Remodeling of Colorectal Cancer Liver Metastasis is Mediated by an HGF-PU.1-DPP4 Axis. 
  • Chromatin and DNA replication. 
  • Chromatin architecture reorganization during stem cell differentiation. 
  • Chromatin conformation and transcriptional activity are permissive regulators of DNA replication initiation in Drosophila. 
  • Chromatin signatures of the Drosophila replication program. 
  • Comparative analysis of metazoan chromatin organization. 
  • DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. 
  • Deciphering the molecular machinery of stem cells: a look at the neoblast gene expression profile. 
  • Dynamic exchange at regulatory elements during chromatin remodeling underlies assisted loading mechanism. 
  • Dynamics of the epigenetic landscape during erythroid differentiation after GATA1 restoration. 
  • Early adaptive chromatin remodeling events precede pathologic phenotypes and are reinforced in the failing heart. 
  • Epigenomic regulation of heart failure: integrating histone marks, long noncoding RNAs, and chromatin architecture. 
  • Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes. 
  • Foreword: the centromere and kinetochore in creatures great and small. 
  • Functional epialleles at an endogenous human centromere. 
  • Genes with high penetrance for syndromic and non-syndromic autism typically function within the nucleus and regulate gene expression. 
  • Genome accessibility is widely preserved and locally modulated during mitosis. 
  • Genome-scale screens identify factors regulating tumor cell responses to natural killer cells. 
  • Genome-wide analysis reveals positional-nucleosome-oriented binding pattern of pioneer factor FOXA1. 
  • Genome-wide chromatin state transitions associated with developmental and environmental cues. 
  • Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators. 
  • High-Resolution Mapping of Chromatin Conformation in Cardiac Myocytes Reveals Structural Remodeling of the Epigenome in Heart Failure. 
  • Histone Deacetylase Inhibitors: An Attractive Therapeutic Strategy Against Breast Cancer. 
  • Identification and requirements of enhancers that direct gene expression during zebrafish fin regeneration. 
  • Incomplete MyoD-induced transdifferentiation is associated with chromatin remodeling deficiencies. 
  • Integrative QTL analysis of gene expression and chromatin accessibility identifies multi-tissue patterns of genetic regulation. 
  • Leveraging chromatin accessibility for transcriptional regulatory network inference in T Helper 17 Cells. 
  • Ligand-specific dynamics of the androgen receptor at its response element in living cells. 
  • Mechanisms of Chromatin Remodeling and Repurposing During Extracellular Translocation. 
  • Microbiota modulate transcription in the intestinal epithelium without remodeling the accessible chromatin landscape. 
  • Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuli. 
  • Modulation of tissue repair by regeneration enhancer elements. 
  • NIP45 controls the magnitude of the type 2 T helper cell response. 
  • Nascent chromatin occupancy profiling reveals locus- and factor-specific chromatin maturation dynamics behind the DNA replication fork. 
  • Neocentromeres: a place for everything and everything in its place. 
  • Open chromatin mapping identifies transcriptional networks regulating human epididymis epithelial function. 
  • Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. 
  • Predicting cell-type-specific gene expression from regions of open chromatin. 
  • Quantitative analysis of the chromatin proteome in disease reveals remodeling principles and identifies high mobility group protein B2 as a regulator of hypertrophic growth. 
  • Radiation-Induced Phosphorylation of a Prion-Like Domain Regulates Transformation by FUS-CHOP. 
  • Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles. 
  • Regulation of T cell receptor-alpha gene recombination by transcription. 
  • Regulation of TCR delta and alpha repertoires by local and long-distance control of variable gene segment chromatin structure. 
  • Role of thyroid hormone in hepatic gene regulation, chromatin remodeling, and autophagy. 
  • Shaping Chromatin States in Prostate Cancer by Pioneer Transcription Factors. 
  • Social status alters chromatin accessibility and the gene regulatory response to glucocorticoid stimulation in rhesus macaques. 
  • Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types. 
  • Synaptic, transcriptional and chromatin genes disrupted in autism. 
  • Systems proteomics of cardiac chromatin identifies nucleolin as a regulator of growth and cellular plasticity in cardiomyocytes. 
  • Techniques used to study transcription on chromatin templates. 
  • The Cryptococcus neoformans capsule: a sword and a shield. 
  • The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. 
  • The chromatin-binding protein Smyd1 restricts adult mammalian heart growth. 
  • The forkhead transcription factor FoxI1 remains bound to condensed mitotic chromosomes and stably remodels chromatin structure. 
  • Transcription Factor-Directed Re-wiring of Chromatin Architecture for Somatic Cell Nuclear Reprogramming toward trans-Differentiation. 
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  Keywords of People

  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Immunology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Yan, Hai, Adjunct Professor of Pathology, Pathology