Chromatin Assembly and Disassembly

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  Subject Areas on Research

  • A cis-regulatory map of the Drosophila genome. 
  • A dynamic H3K27ac signature identifies VEGFA-stimulated endothelial enhancers and requires EP300 activity. 
  • A genome-wide analysis of open chromatin in human epididymis epithelial cells reveals candidate regulatory elements for genes coordinating epididymal function. 
  • A heterochromatin barrier partitions the fission yeast centromere into discrete chromatin domains. 
  • A structural perspective on the where, how, why, and what of nucleosome positioning. 
  • Altered telomeres in tumors with ATRX and DAXX mutations. 
  • Biochemical Methods To Investigate lncRNA and the Influence of lncRNA:Protein Complexes on Chromatin. 
  • Chromatin Dynamics and the Development of the TCRα and TCRδ Repertoires. 
  • Chromatin and DNA replication. 
  • Chromatin architecture reorganization during stem cell differentiation. 
  • Chromatin conformation and transcriptional activity are permissive regulators of DNA replication initiation in Drosophila. 
  • Chromatin signatures of the Drosophila replication program. 
  • Comparative analysis of metazoan chromatin organization. 
  • Deciphering the molecular machinery of stem cells: a look at the neoblast gene expression profile. 
  • Dynamic exchange at regulatory elements during chromatin remodeling underlies assisted loading mechanism. 
  • Dynamics of the epigenetic landscape during erythroid differentiation after GATA1 restoration. 
  • Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes. 
  • Functional epialleles at an endogenous human centromere. 
  • Genes with high penetrance for syndromic and non-syndromic autism typically function within the nucleus and regulate gene expression. 
  • Genome accessibility is widely preserved and locally modulated during mitosis. 
  • Genome-wide chromatin state transitions associated with developmental and environmental cues. 
  • Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators. 
  • Haploinsufficiency of the Chromatin Remodeler BPTF Causes Syndromic Developmental and Speech Delay, Postnatal Microcephaly, and Dysmorphic Features. 
  • Histone Deacetylase Inhibitors: An Attractive Therapeutic Strategy Against Breast Cancer. 
  • Incomplete MyoD-induced transdifferentiation is associated with chromatin remodeling deficiencies. 
  • Ligand-specific dynamics of the androgen receptor at its response element in living cells. 
  • Mechanisms of Chromatin Remodeling and Repurposing During Extracellular Translocation. 
  • Microbiota modulate transcription in the intestinal epithelium without remodeling the accessible chromatin landscape. 
  • Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuli. 
  • Modulation of tissue repair by regeneration enhancer elements. 
  • Neocentromeres: a place for everything and everything in its place. 
  • Open chromatin mapping identifies transcriptional networks regulating human epididymis epithelial function. 
  • Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. 
  • Predicting cell-type-specific gene expression from regions of open chromatin. 
  • Regulation of T cell receptor-alpha gene recombination by transcription. 
  • Regulation of TCR delta and alpha repertoires by local and long-distance control of variable gene segment chromatin structure. 
  • Role of thyroid hormone in hepatic gene regulation, chromatin remodeling, and autophagy. 
  • Social status alters chromatin accessibility and the gene regulatory response to glucocorticoid stimulation in rhesus macaques. 
  • Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types. 
  • Synaptic, transcriptional and chromatin genes disrupted in autism. 
  • The Cryptococcus neoformans capsule: a sword and a shield. 
  • The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. 
  • The forkhead transcription factor FoxI1 remains bound to condensed mitotic chromosomes and stably remodels chromatin structure. 
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  Keywords of People

  • Krangel, Michael S., Mary Bernheim Professor of Immunology, Immunology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Yan, Hai, Henry S. Friedman Professor of Neuro-Oncology in the School of Medicine, Pathology