Early Diagnosis

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  Subject Areas on Research

  • A Quality Improvement Project to Increase Early Detection of Syphilis Infection or Re-infection in HIV-infected Men Who Have Sex With Men. 
  • A hidden Markov model approach to analyze longitudinal ternary outcomes when some observed states are possibly misclassified. 
  • A prognostic model of Alzheimer's disease relying on multiple longitudinal measures and time-to-event data. 
  • A quarter century of progress on the early detection and treatment of autism spectrum disorder. 
  • A timely investment: coordinated care for depression and anxiety disorders. 
  • ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction--executive summary. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to revise the 1999 guidelines for the management of patients with acute myocardial infarction). 
  • ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction--executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1999 Guidelines for the Management of Patients With Acute Myocardial Infarction). 
  • Adherence to diabetes guidelines for screening, physical activity and medication and onset of complications and death. 
  • Algorithm for the early diagnosis and treatment of patients with cross reactive immunologic material-negative classic infantile pompe disease: a step towards improving the efficacy of ERT. 
  • American Pediatric Society's 2014 John Howland Award acceptance lecture: saving lives through early diagnosis. 
  • Antifibrinolytic use during cardiac and hepatic surgery makes tubular proteinuria-based early biomarkers poor tools to diagnose perioperative acute kidney injury. 
  • Anxiety symptoms in amnestic mild cognitive impairment are associated with medial temporal atrophy and predict conversion to Alzheimer disease. 
  • Approaches to enhancing the early detection of autism spectrum disorders: a systematic review of the literature. 
  • Are obesity and anthropometry risk factors for diabetic retinopathy? The diabetes management project. 
  • Assessment of the Feasibility of Using Noninvasive Wearable Biometric Monitoring Sensors to Detect Influenza and the Common Cold Before Symptom Onset. 
  • Associated symptoms in the ten days before diagnosis of Kawasaki disease. 
  • Association between early echocardiography, therapy for patent ductus arteriosus, and outcomes in very low birth weight infants. 
  • Associations between cardiovascular risk factors and early age-related macular degeneration in a rural Chinese adult population. 
  • Attention problems in very low birth weight preschoolers: are new screening measures needed for this special population? 
  • Aurora-A and p16 polymorphisms contribute to an earlier age at diagnosis of pancreatic cancer in Caucasians. 
  • Autism spectrum disorder screening in primary care. 
  • Biomarkers for early detection and screening in pancreatic cancer. Highlights from the 45th ASCO annual meeting. Orlando, FL, USA. May 29-June 2, 2009. 
  • Biomarkers of Diabetic Retinopathy. 
  • Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness. 
  • Broad spectrum triazoles for invasive mould infections in adults: Which drug and when? 
  • CAP--advancing the evaluation of preclinical Alzheimer disease treatments. 
  • COVID-19: Mobilizing Quickly for a Rapid Response. 
  • Canadian Cardiovascular Society Guidelines for Evaluation and Management of Cardiovascular Complications of Cancer Therapy. 
  • Cancer therapy-induced cardiac toxicity in early breast cancer: addressing the unresolved issues. 
  • Cardiac Dysfunction and Heart Failure in Hematopoietic Cell Transplantation Survivors: Emerging Paradigms in Pathophysiology, Screening, and Prevention. 
  • Caring for survivors of childhood cancer: it takes a village. 
  • Changing Patterns and Factors Associated With Mode of Delivery Among Pregnant Women With Human Immunodeficiency Virus Infection in the United States. 
  • Childhood and adolescent psychiatric disorders as predictors of young adult disorders. 
  • Childhood to Early-Midlife Systolic Blood Pressure Trajectories: Early-Life Predictors, Effect Modifiers, and Adult Cardiovascular Outcomes. 
  • Chronic kidney disease, cardiovascular disease and mortality: A prospective cohort study in a multi-ethnic Asian population. 
  • Clinical characteristics of peanut-allergic children: recent changes. 
  • Clinical evidence of early acute lung injury often precedes the diagnosis of ALI. 
  • Clinical impact of an adaptive statistical iterative reconstruction algorithm for detection of hypervascular liver tumours using a low tube voltage, high tube current MDCT technique. 
  • Clinical risk factors and inflammatory biomarkers of post-traumatic acute kidney injury in combat patients. 
  • Comparison of missed opportunities for earlier HIV diagnosis in 3 geographically proximate emergency departments. 
  • Computed tomography scanning for lung cancer screening: an update. 
  • Computed tomography screening for the early detection of lung cancer. 
  • Congenital Syphilis: A Discussion of Epidemiology, Diagnosis, Management, and Nurses' Role in Early Identification and Treatment. 
  • Contemporary Patterns of Early Coronary Angiography Use in Patients With Non-ST-Segment Elevation Myocardial Infarction in the United States: Insights From the National Cardiovascular Data Registry Acute Coronary Treatment and Intervention Outcomes Network Registry. 
  • Contributions to early HIV diagnosis among patients linked to care vary by testing venue. 
  • Copeptin helps in the early detection of patients with acute myocardial infarction: primary results of the CHOPIN trial (Copeptin Helps in the early detection Of Patients with acute myocardial INfarction). 
  • Costs and consequences of universal sibling screening for vesicoureteral reflux: decision analysis. 
  • Current epidemiology of diabetic retinopathy and diabetic macular edema. 
  • Defining and applying a method for improving the sensitivity and specificity of an emergency department early event detection system. 
  • Defining early mycosis fungoides. 
  • Delayed-onset adenosine deaminase deficiency: strategies for an early diagnosis. 
  • Delirium Screening and Management in Inpatient Rehabilitation Facilities. 
  • Determination of human platelet antigen typing by molecular methods: Importance in diagnosis and early treatment of neonatal alloimmune thrombocytopenia. 
  • Developing an Algorithm to Detect Early Childhood Obesity in Two Tertiary Pediatric Medical Centers. 
  • Development and validation of a prioritization rule for obtaining an immediate 12-lead electrocardiogram in the emergency department to identify ST-elevation myocardial infarction. 
  • Diagnosing HIV infection in primary care settings: missed opportunities. 
  • Diagnosis and outcome of early pleural space infection following lung transplantation. 
  • Diagnostic challenges for Pompe disease: an under-recognized cause of floppy baby syndrome. 
  • Differences in short-term versus long-term outcomes of older black versus white patients with myocardial infarction: findings from the Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes with Early Implementation of American College of Cardiology/American Heart Association Guidelines (CRUSADE). 
  • Differential volatile signatures from skin, naevi and melanoma: a novel approach to detect a pathological process. 
  • Disease progression in hemodynamically stable patients presenting to the emergency department with sepsis. 
  • Disordered FGF23 and mineral metabolism in children with CKD. 
  • Does Early Prostate Specific Antigen Doubling Time after Radical Prostatectomy, Calculated Prior to Prostate Specific Antigen Recurrence, Correlate with Prostate Cancer Outcomes? A Report from the SEARCH Database Group. 
  • Does the interval of screening endoscopy affect survival in gastric cancer patients?: A cross-sectional study. 
  • Dynamic contrast-enhanced MRI promotes early detection of toxin-induced acute kidney injury. 
  • Early Antiretroviral Therapy Initiation and Mortality Among Infants Diagnosed With HIV in the First 12 Weeks of Life: Experiences From Kinshasa, DR Congo and Blantyre, Malawi. 
  • Early Detection and Prevention of Mental Health Problems: Developmental Epidemiology and Systems of Support. 
  • Early Detection of Alzheimer's Disease Benefits Research, Quality of Life, and End-of-Life Planning. 
  • Early Detection of Mild Cognitive Impairment (MCI) in an At-Home Setting. 
  • Early Determination of Prognosis in Neonatal Moderate or Severe Hypoxic-Ischemic Encephalopathy. 
  • Early MRI Detection and Closed Bone Graft Epiphysiodesis May Alter the Course of Avascular Necrosis Following Unstable Slipped Capital Femoral Epiphysis. 
  • Early acute lung injury: criteria for identifying lung injury prior to the need for positive pressure ventilation*. 
  • Early behavioral intervention, brain plasticity, and the prevention of autism spectrum disorder. 
  • Early change in ferumoxytol-enhanced magnetic resonance imaging signal suggests unstable human cerebral aneurysm: a pilot study. 
  • Early detection and measurement of urothelial tumors in mice. 
  • Early management of atrial fibrillation to prevent cardiovascular complications. 
  • Early prostate cancer: prevention, treatment modalities, and quality of life issues. 
  • Early signs of exudative age-related macular degeneration in Asians. 
  • Early trauma induced coagulopathy (ETIC): prevalence across the injury spectrum. 
  • Early treatment of candidemia in adults: a review. 
  • Echocardiographic risk stratification for early surgery with endocarditis: a cost-effectiveness analysis. 
  • Effect of a deep-learning computer-aided detection system on adenoma detection during colonoscopy (CADe-DB trial): a double-blind randomised study. 
  • Elevation of guanidinoacetate in newborn dried blood spots and impact of early treatment in GAMT deficiency. 
  • Endoscopic approaches for early-stage esophageal cancer: current options. 
  • Eradicating the Burden of Atherosclerotic Cardiovascular Disease by Lowering Apolipoprotein B Lipoproteins Earlier in Life. 
  • Evaluation of Modified 2-Tiered Serodiagnostic Testing Algorithms for Early Lyme Disease. 
  • Evidence of early retinal microvascular changes in patients with type 2 diabetes and depression. 
  • Examination of acetabular labral tear: a continued diagnostic challenge. 
  • Factors associated with patient, and diagnostic delays in Chinese TB patients: a systematic review and meta-analysis. 
  • Failures in learning-dependent predictive perception as the key cognitive vulnerability to psychosis in schizophrenia. 
  • Feasibility and yield of screening in relatives from familial pancreatic cancer families. 
  • Fiscal implications of newborn screening in the diagnosis of severe combined immunodeficiency. 
  • Functional MRI in the early diagnosis of Alzheimer's disease: is it time to refocus? 
  • Gastroschisis in Uganda: Opportunities for improved survival. 
  • Genetic susceptibility for lung cancer: interactions with gender and smoking history and impact on early detection policies. 
  • Glucose-6-Phosphate Dehydrogenase Deficiency and the Benefits of Early Screening. 
  • Glycohemoglobin not as predictive as fasting glucose as a measure of prediabetes in predicting proteinuria. 
  • Good problems to have? Policy and societal implications of a disease-modifying therapy for presymptomatic late-onset Alzheimer's disease. 
  • HIV testing and engagement with the HIV treatment cascade among men who have sex with men in Africa: a systematic review and meta-analysis. 
  • Hepatocyte paraffin 1 antigen as a biomarker for early diagnosis of Barrett esophagus. 
  • Hereditary Spherocytosis in the Neonatal Period: A Case Report. 
  • How can we optimize the processes of care for acute coronary syndromes to improve outcomes? 
  • ICON: the early diagnosis of congenital immunodeficiencies. 
  • Identifying depression early in adolescence. 
  • Impact of automated reporting of estimated glomerular filtration rate in the veterans health administration. 
  • Impact of glaucoma severity and laterality on vision-specific functioning: the Singapore Malay eye study. 
  • Impact of multiple policy interventions on the screening and diagnosis of drug-resistant tuberculosis patients: a cascade analysis on six prefectures in China. 
  • Impact of the fast track prevention program on health services use by conduct-problem youth. 
  • Implantable Cardiac Alert System for Early Recognition of ST-Segment Elevation Myocardial Infarction. 
  • Implications of early and guideline adherent physical therapy for low back pain on utilization and costs. 
  • Improving Care of Skilled Nursing Patients: Implementation of Early Sepsis Recognition. 
  • Increased prevalence of advanced tuberculosis in rural low tuberculosis caseload counties in North Carolina. 
  • Infrared imaging of trauma patients for detection of acute compartment syndrome of the leg. 
  • Insight into the phenotype of infants with Pompe disease identified by newborn screening with the common c.-32-13T>G "late-onset" GAA variant. 
  • Integrating carthage-specific T1rho MRI into knee clinic diagnostic imaging. 
  • Integrating depression management into HIV primary care in central Malawi: the implementation of a pilot capacity building program. 
  • Integrative "omic" analysis of experimental bacteremia identifies a metabolic signature that distinguishes human sepsis from systemic inflammatory response syndromes. 
  • Intussusception in the Neonate: A Case Study. 
  • Long-Term Blood Pressure Variability, New-Onset Diabetes Mellitus, and New-Onset Chronic Kidney Disease in the Japanese General Population. 
  • Longitudinal evidence that psychopathy scores in early adolescence predict adult psychopathy. 
  • Longitudinal measurement and hierarchical classification framework for the prediction of Alzheimer's disease. 
  • Lower extremity amputation in peripheral artery disease: improving patient outcomes. 
  • Markers of cardiac ischemia and inflammation. 
  • Meta-analysis of studies with bivariate binary outcomes: a marginal beta-binomial model approach. 
  • Metabolic myopathies: clinical features and diagnostic approach. 
  • MicroRNAs relate to early worsening of renal function in patients with acute heart failure. 
  • Minimal Impact of Implemented Early Warning Score and Best Practice Alert for Patient Deterioration. 
  • Morphometry Predicts Early GFR Change in Primary Proteinuric Glomerulopathies: A Longitudinal Cohort Study Using Generalized Estimating Equations. 
  • Multimodal and Multiscale Deep Neural Networks for the Early Diagnosis of Alzheimer's Disease using structural MR and FDG-PET images. 
  • Multiparametric Early Detection and Prediction of Cardiotoxicity Using Myocardial Strain, T1 and T2 Mapping, and Biochemical Markers: A Longitudinal Cardiac Resonance Imaging Study During 2 Years of Follow-Up. 
  • Multiple perspectives on diagnosis delay for tuberculosis from key stakeholders in poor rural China: case study in four provinces. 
  • NCCN clinical practice guidelines in oncology: prostate cancer. 
  • National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IIa. The 2020 Clinical Implementation and Early Diagnosis Working Group Report. 
  • Necessity of hospitalization and stress testing in low risk chest pain patients. 
  • Neurodevelopmental outcomes in children with congenital heart disease: evaluation and management: a scientific statement from the American Heart Association. 
  • Neuropsychology of the prodrome to psychosis in the NAPLS consortium: relationship to family history and conversion to psychosis. 
  • Newborn, carrier, and early childhood screening recommendations for fragile X. 
  • Newly Proposed Sepsis-Induced Coagulopathy Precedes International Society on Thrombosis and Haemostasis Overt-Disseminated Intravascular Coagulation and Predicts High Mortality. 
  • OCT Signs of Early Atrophy in Age-Related Macular Degeneration: Interreader Agreement: Classification of Atrophy Meetings Report 6. 
  • Opportunities for earlier HIV diagnosis in a pediatric ED. 
  • Optimizing SARS-CoV-2 Surveillance in the United States: Insights From the National Football League Occupational Health Program. 
  • Optimizing outcome with antipsychotic treatment in first-episode schizophrenia: balancing efficacy and side effects. 
  • Orbital granulomatosis with polyangiitis (Wegener granulomatosis): clinical and pathologic findings. 
  • Orthopaedic trauma for the general orthopaedist: avoiding problems and pitfalls in treatment. 
  • Osteoarthritis: From Palliation to Prevention: AOA Critical Issues. 
  • PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease. 
  • Patterns of transfer for patients with non-ST-segment elevation acute coronary syndrome from community to tertiary care hospitals. 
  • Performance of HIV Rapid Tests Among Breastfeeding, Malawian Infants. 
  • Performance of kidney injury molecule-1 and liver fatty acid-binding protein and combined biomarkers of AKI after cardiac surgery. 
  • Personal Omics for Precision Health 
  • Plasma N-terminal fragment of the prohormone B-type natriuretic peptide concentrations in relation to time to treatment and Thrombolysis in Myocardial Infarction (TIMI) flow: a substudy of the Assessment of the Safety and Efficacy of a New Treatment Strategy with Percutaneous Coronary Intervention (ASSENT IV-PCI) trial. 
  • Plasma miRNAs as early biomarkers for detecting hepatocellular carcinoma. 
  • Potential Cost-effectiveness of Early Identification of Hospital-acquired Infection in Critically Ill Patients. 
  • Predicting gestational diabetes: choosing the optimal early serum marker. 
  • Predictors of vertigo in the emergency department: The preved study. 
  • Predisease: when does it make sense? 
  • Principles of screening for chronic kidney disease. 
  • Proposal of a two-step process for the diagnosis of sepsis-induced disseminated intravascular coagulation. 
  • Prostate cancer early detection. Clinical practice guidelines in oncology. 
  • Prostate cancer: the new landscape. 
  • Prostate-specific antigen (PSA) and PSA velocity for prostate cancer detection in men aged <50 years. 
  • Providing early detection and early intervention for autism spectrum disorder in South Africa: stakeholder perspectives from the Western Cape province. 
  • Public health and clinical impact of increasing emergency department-based HIV testing: perspectives from the 2007 conference of the National Emergency Department HIV Testing Consortium. 
  • Randomized comparison of universal and targeted HIV screening in the emergency department. 
  • Randomized, controlled trial of an intervention for toddlers with autism: the Early Start Denver Model. 
  • Rankin scale as a potential measure of global disability in early Parkinson's disease. 
  • Rationale for Early Diagnosis of Mild Cognitive Impairment (MCI) Supported by Emerging Digital Technologies. 
  • Recent advances in research on early detection, causes, biology, and treatment of autism spectrum disorders. 
  • Recent advances in the research and management of sepsis-associated DIC. 
  • Recognition of CKD after the introduction of automated reporting of estimated GFR in the Veterans Health Administration. 
  • Red flags in cardiac amyloidosis. 
  • Renal Angina Is a Sensitive, but Nonspecific Identifier of Postcardiac Surgery Acute Kidney Injury. 
  • Retinal pathology as biomarker for cognitive impairment and Alzheimer's disease. 
  • Risk score to predict serious bleeding in stable outpatients with or at risk of atherothrombosis. 
  • Role of allogeneic transplantation for FLT3/ITD acute myeloid leukemia: outcomes from 133 consecutive newly diagnosed patients from a single institution. 
  • Screening for Obstructive Sleep Apnea in Adults: US Preventive Services Task Force Recommendation Statement. 
  • Screening for metabolic and reproductive complications in obese children and adolescents. 
  • Screening for postnatal depression in Chinese-speaking women using the Hong Kong translated version of the Edinburgh Postnatal Depression Scale. 
  • Screening instruments for substance use and brief interventions targeting adolescents in primary care: a literature review. 
  • Sepsis Subclasses: A Framework for Development and Interpretation. 
  • Sepsis in Pregnancy: Identification and Management. 
  • Sex differences in patients seeking medical attention for prodromal symptoms before an acute coronary event. 
  • Snakebite Envenoming Diagnosis and Diagnostics. 
  • Staying ahead of pertussis. 
  • Strategies used in the detection of acute/early HIV infections. The NIMH Multisite Acute HIV Infection Study: I. 
  • Symptoms of Women With High-Risk Early-Stage Ovarian Cancer. 
  • Systematic review of the use of dried blood spots for monitoring HIV viral load and for early infant diagnosis. 
  • Systems modelling as an approach for understanding and building consensus on non-communicable diseases (NCD) management in Cambodia. 
  • The (1,3){beta}-D-glucan test as an aid to early diagnosis of invasive fungal infections following lung transplantation. 
  • The National Lung Screening Trial: overview and study design. 
  • The Role of Chest Imaging in Patient Management During the COVID-19 Pandemic: A Multinational Consensus Statement From the Fleischner Society. 
  • The benefit of prevention: engaging the public through strategic collaborations. 
  • The burden of hypertension in the emergency department and linkage to care: A prospective cohort study in Tanzania. 
  • The clinical and prognostic importance of positive blood cultures in adults. 
  • The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. 
  • The importance of early treatment of schizophrenia. 
  • The importance of preclinical diagnostics in Parkinson disease. 
  • The influence of statin medications on prostate-specific antigen levels. 
  • The influence of various patient characteristics on D-dimer concentration in critically ill patients and its role as a prognostic indicator in the intensive care unit setting. 
  • The long quest for neonatal screening for severe combined immunodeficiency. 
  • The modified checklist for autism in toddlers: reliability in a diverse rural American sample. 
  • The value of muscle biopsies in Pompe disease: identifying lipofuscin inclusions in juvenile- and adult-onset patients. 
  • Thresholds and accuracy in screening tools for early detection of psychopathology. 
  • Thrombogenicity markers for early diagnosis and prognosis in COVID-19: a change from the current paradigm? 
  • Treatment Gaps in Adults With Heterozygous Familial Hypercholesterolemia in the United States: Data From the CASCADE-FH Registry. 
  • Treatment outcomes of necrotizing enterocolitis for preterm infants. 
  • Trimethoprim-sulfamethoxazole-induced hepatotoxicity in a pediatric patient. 
  • Ultrasound for screening and management of developmental dysplasia of the hip. 
  • Use of a Digital Modified Checklist for Autism in Toddlers - Revised with Follow-up to Improve Quality of Screening for Autism. 
  • Use of a Novel Electronic Maternal Surveillance System and the Maternal Early Warning Criteria to Detect Severe Postpartum Hemorrhage. 
  • What exactly is endometrial receptivity? 
  • What was old is new again: using the host response to diagnose infectious disease. 
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  Keywords of People

  • Colsher, James George, Adjunct Assistant Professor in the Department of Radiology, Radiology
  • Dodge, Kenneth A., William McDougall Distinguished Professor of Public Policy Studies, Duke Science & Society
  • Levy, Jerrold Henry, Professor of Anesthesiology, Anesthesiology, Cardiothoracic
  • Limkakeng Jr., Alexander Tan, Professor of Emergency Medicine, Emergency Medicine
  • Patel, Uptal Dinesh, Adjunct Professor in the Department of Medicine, Medicine, Nephrology
  • Patz Jr., Edward F., James and Alice Chen Distinguished Professor of Radiology, Pathology
  • Routh, Jonathan Charles, Paul H. Sherman, M.D. Distinguished Associate Professor of Surgery, Pediatrics
  • Sullivan, Daniel Carl, Professor Emeritus of Radiology, Radiology
  • Tsalik, Ephraim, Adjunct Associate Professor in the Department of Medicine, Medicine, Infectious Diseases