Histone Code

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  Subject Areas on Research

  • An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation. 
  • Caenorhabditis elegans as an emerging model system in environmental epigenetics. 
  • DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions. 
  • Editing the Epigenome: Reshaping the Genomic Landscape. 
  • Evidence for sequence biases associated with patterns of histone methylation. 
  • Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells. 
  • Glucocorticoid receptor recruits to enhancers and drives activation by motif-directed binding. 
  • Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis. 
  • Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width. 
  • Site-specific silencing of regulatory elements as a mechanism of X inactivation. 
  • SnapShot: Origins of DNA replication. 
  • Stromal cues regulate the pancreatic cancer epigenome and metabolome. 
  • Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation. 
  • Targeting the histone methyltransferase G9a activates imprinted genes and improves survival of a mouse model of Prader-Willi syndrome. 
  • Temporal association of ORCA/LRWD1 to late-firing origins during G1 dictates heterochromatin replication and organization. 
  • The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery. 
  • Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms. 
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  Keywords of People

  • Sullivan, Beth Ann, Associate Professor of Molecular Genetics and Microbiology, Duke Science & Society