Intracellular Space

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  Subject Areas on Research

  • 2B4 utilizes ITAM-containing receptor complexes to initiate intracellular signaling and cytolysis. 
  • A Bidomain Model for Lens Microcirculation. 
  • A computer model of engineered cardiac monolayers. 
  • Activation of NADPH oxidase 1 increases intracellular calcium and migration of smooth muscle cells. 
  • Activation of the NLRP3 inflammasome by intracellular poly I:C. 
  • Altered intracellular and extracellular signaling leads to impaired T-cell functions in ADA-SCID patients. 
  • An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles. 
  • Antillatoxin, a novel lipopeptide, enhances neurite outgrowth in immature cerebrocortical neurons through activation of voltage-gated sodium channels. 
  • Biomechanical strain as a trigger for pore formation in Schlemm's canal endothelial cells. 
  • Biomechanics of Schlemm's canal endothelium and intraocular pressure reduction. 
  • Combined acetaldehyde and nicotine exposure depresses cardiac contraction in ventricular myocytes: prevention by folic acid. 
  • Delivery systems exploiting natural cell transport processes of macromolecules for intracellular targeting of Auger electron emitters. 
  • Dilated intercellular spaces as a marker of GERD. 
  • Extensive uptake of α-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage. 
  • Feedback-control induced pattern formation in cardiac myocytes: a mathematical modeling study. 
  • Gene expression signatures as a guide to treatment strategies for in-transit metastatic melanoma. 
  • Genetically induced microtubule disruption in the mouse intestine impairs intracellular organization and transport. 
  • Glutathione activates virulence gene expression of an intracellular pathogen. 
  • Heat shock protein 90 (Hsp90): A novel antifungal target against Aspergillus fumigatus. 
  • Increased interstitial loading reduces the effect of microstructural variations in cardiac tissue. 
  • Intracellular CMTM2 negatively regulates human immunodeficiency virus type-1 transcription through targeting the transcription factors AP-1 and CREB. 
  • Intracellular Generation of Superoxide by TiO₂ Nanoparticles Decreases Histone Deacetylase 9 (HDAC9), an Epigenetic Modifier. 
  • Intracellular innate immune cascades and interferon defenses that control hepatitis C virus. 
  • Intracellular osteopontin (iOPN) and immunity. 
  • Long term disease-free survival and T cell and antibody responses in women with high-risk Her2+ breast cancer following vaccination against Her2. 
  • Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure. 
  • Membrane binding of plasmid DNA and endocytic pathways are involved in electrotransfection of mammalian cells. 
  • Mesenchymal Stromal Cells Deficient in Autophagy Proteins Are Susceptible to Oxidative Injury and Mitochondrial Dysfunction. 
  • Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation. 
  • Methylglyoxal augments intracellular oxidative stress in human aortic endothelial cells. 
  • Monitoring intracellular proteins using fluorescence techniques: from protein synthesis and localization to activity. 
  • New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis. 
  • Nicotinamide Phosphoribosyltransferase Deficiency Potentiates the Antiproliferative Activity of Methotrexate through Enhanced Depletion of Intracellular ATP. 
  • Nucleic acid-binding polymers as anti-inflammatory agents. 
  • Preliminary validation of varicella zoster virus thymidine kinase as a novel reporter gene for PET. 
  • Prenylated c17orf37 induces filopodia formation to promote cell migration and metastasis. 
  • Protective role of fructose in the metabolism of astroglial C6 cells exposed to hydrogen peroxide. 
  • Pus: the Rodney Dangerfield of immunology. 
  • Pyroptosis triggers pore-induced intracellular traps (PITs) that capture bacteria and lead to their clearance by efferocytosis. 
  • Pyroptotic cell death defends against intracellular pathogens. 
  • Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis. 
  • Release of intracellular calcium stores facilitates coxsackievirus entry into polarized endothelial cells. 
  • Salmonella Activation of STAT3 Signaling by SarA Effector Promotes Intracellular Replication and Production of IL-10. 
  • Subcellular Localization of Pseudomonas syringae pv. tomato Effector Proteins in Plants. 
  • The Chlamydia type III secretion system C-ring engages a chaperone-effector protein complex. 
  • The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis. 
  • The manganese(III) porphyrin MnTnHex-2-PyP5+ modulates intracellular ROS and breast cancer cell migration: Impact on doxorubicin-treated cells. 
  • Ubiquitination of Innate Immune Regulator TRAF3 Orchestrates Expulsion of Intracellular Bacteria by Exocyst Complex. 
  • Unified biophysical mechanism for cell-shape oscillations and cell ingression. 
  • c-FLIP protects T lymphocytes from apoptosis in the intrinsic pathway. 
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  Keywords of People

  • Chitneni, Satish K., Associate Professor in Radiology, Radiology
  • Henriquez, Craig S., Professor of Biomedical Engineering, Pratt School of Engineering
  • Shinohara, Mari L., Associate Professor of Immunology, Immunology