Angiopoietin-1
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Subject Areas on Research
- A Phase I, First-in-Human Study of AMG 780, an Angiopoietin-1 and -2 Inhibitor, in Patients with Advanced Solid Tumors.
- A nuclease-resistant RNA aptamer specifically inhibits angiopoietin-1-mediated Tie2 activation and function.
- Abl kinases are required for vascular function, Tie2 expression, and angiopoietin-1-mediated survival.
- An Engineered Optogenetic Switch for Spatiotemporal Control of Gene Expression, Cell Differentiation, and Tissue Morphogenesis.
- Angiogenic growth factors in the pathophysiology of a murine model of acute lung injury.
- Angiopoietin-1 enhances skeletal muscle regeneration in mice.
- Angiopoietin-1 is required for Schlemm's canal development in mice and humans.
- Angiopoietin-1 promotes atherosclerosis by increasing the proportion of circulating Gr1+ monocytes.
- Angiotensin II promotes development of the renal microcirculation through AT1 receptors.
- Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2.
- Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies.
- Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP.
- MiR-21 alleviates secondary blood-brain barrier damage after traumatic brain injury in rats.
- Pericyte requirement for anti-leak action of angiopoietin-1 and vascular remodeling in sustained inflammation.
- Phosphorylation of Threonine 794 on Tie1 by Rac1/PAK1 Reveals a Novel Angiogenesis Regulatory Pathway.
- Targeting the vascular-specific phosphatase PTPRB protects against retinal ganglion cell loss in a pre-clinical model of glaucoma.
- Tie1: an orphan receptor provides context for angiopoietin-2/Tie2 signaling.
- Tie2 (to) Abl: Signaling to endothelial cell survival.
- VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling.