Angiopoietin-2

• 

  Subject Areas on Research

  • A Phase I, First-in-Human Study of AMG 780, an Angiopoietin-1 and -2 Inhibitor, in Patients with Advanced Solid Tumors. 
  • Angiopoietin-1 enhances skeletal muscle regeneration in mice. 
  • Angiopoietin-2 confers Atheroprotection in apoE-/- mice by inhibiting LDL oxidation via nitric oxide. 
  • Angiotensin II promotes development of the renal microcirculation through AT1 receptors. 
  • Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2. 
  • Circulating angiopoietin-2 as a biomarker in ANCA-associated vasculitis. 
  • Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP. 
  • Cross-talk between endothelial and breast cancer cells regulates reciprocal expression of angiogenic factors in vitro. 
  • Early Endothelial Activation Precedes Glycocalyx Degradation and Microvascular Dysfunction in Experimentally Induced Plasmodium falciparum and Plasmodium vivax Infection. 
  • Efficacy of bevacizumab plus erlotinib for advanced hepatocellular carcinoma and predictors of outcome: final results of a phase II trial. 
  • Efficacy, durability, and safety of intravitreal faricimab up to every 16 weeks for neovascular age-related macular degeneration (TENAYA and LUCERNE): two randomised, double-masked, phase 3, non-inferiority trials. 
  • Efficacy, durability, and safety of intravitreal faricimab with extended dosing up to every 16 weeks in patients with diabetic macular oedema (YOSEMITE and RHINE): two randomised, double-masked, phase 3 trials. 
  • Elevated plasma angiopoietin-2 levels and primary graft dysfunction after lung transplantation. 
  • Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. 
  • Infection-Induced Vascular Permeability Aids Mycobacterial Growth. 
  • Inhibition of in vivo tumor angiogenesis and growth via systemic delivery of an angiopoietin 2-specific RNA aptamer. 
  • Inhibition of rat corneal angiogenesis by a nuclease-resistant RNA aptamer specific for angiopoietin-2. 
  • Plasma levels of VEGF-A and VCAM-1 as predictors of drug-induced hypertension in patients treated with VEGF pathway inhibitors. 
  • Plasma levels of angiopoietin-2, VEGF-A, and VCAM-1 as markers of bevacizumab-induced hypertension: CALGB 80303 and 90401 (Alliance). 
  • Plasma levels of soluble Tie2 and vascular endothelial growth factor distinguish critical limb ischemia from intermittent claudication in patients with peripheral arterial disease. 
  • Salivary levels of angiopoietin-2 in infants with infantile haemangiomas treated with and without systemic propranolol. 
  • Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression and inhibits angiogenesis and tumor growth. 
  • Tie1: an orphan receptor provides context for angiopoietin-2/Tie2 signaling. 
  • VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling. 
  • Variants in angiopoietin-2 (ANGPT2) contribute to variation in nocturnal oxyhaemoglobin saturation level.