Genomic Instability
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Subject Areas on Research
- A longitudinal study of epigenetic variation in twins.
- A role for mitochondrial dysfunction in perpetuating radiation-induced genomic instability.
- Caspase-3 promotes genetic instability and carcinogenesis.
- Centromeric barrier disruption leads to mitotic defects in Schizosaccharomyces pombe.
- Chromosome rearrangements via template switching between diverged repeated sequences.
- Damage Control in the Developing Brain: Tradeoffs and Consequences.
- Defining the replication program through the chromatin landscape.
- Effects of camptothecin or TOP1 overexpression on genetic stability in Saccharomyces cerevisiae.
- Elevated Genome-Wide Instability in Yeast Mutants Lacking RNase H Activity.
- Endoreplication and polyploidy: insights into development and disease.
- Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage.
- Essential roles of Caspase-3 in facilitating Myc-induced genetic instability and carcinogenesis.
- Functionality of the TOL plasmid under varying environmental conditions following conjugal transfer.
- Gene expression profiling of microsatellite unstable and microsatellite stable endometrial cancers indicates distinct pathways of aberrant signaling.
- Genetic Control of Genomic Alterations Induced in Yeast by Interstitial Telomeric Sequences.
- Genome rearrangements caused by interstitial telomeric sequences in yeast.
- Genome-destabilizing effects associated with top1 loss or accumulation of top1 cleavage complexes in yeast.
- Genome-wide analysis of genomic alterations induced by oxidative DNA damage in yeast.
- Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO.
- Genomic and functional variation of human centromeres.
- Genomic variation within alpha satellite DNA influences centromere location on human chromosomes with metastable epialleles.
- Global analysis of genomic instability caused by DNA replication stress in Saccharomyces cerevisiae.
- Guanine repeat-containing sequences confer transcription-dependent instability in an orientation-specific manner in yeast.
- Inner nuclear envelope proteins SUN1 and SUN2 play a prominent role in the DNA damage response.
- Inositol phosphate synthesis and the nuclear processes they affect.
- Inverted DNA repeats channel repair of distant double-strand breaks into chromatid fusions and chromosomal rearrangements.
- Lineage Switch Between B-Lymphoblastic Leukemia and Acute Myeloid Leukemia Intermediated by "Occult" Myelodysplastic Neoplasm: Two Cases of Adult Patients With Evidence of Genomic Instability and Clonal Selection by Chemotherapy.
- Methylation of histone H4 lysine 20 by PR-Set7 ensures the integrity of late replicating sequence domains in Drosophila.
- Mitochondrial dysfunction, persistently elevated levels of reactive oxygen species and radiation-induced genomic instability: a review.
- Mitotic Recombination and Adaptive Genomic Changes in Human Pathogenic Fungi.
- Mre11-Sae2 and RPA Collaborate to Prevent Palindromic Gene Amplification.
- Msh6 protects mature B cells from lymphoma by preserving genomic stability.
- Multiple roles of ATM in monitoring and maintaining DNA integrity.
- Mutant allele quantification reveals a genetic basis for TP53 mutation-driven castration resistance in prostate cancer cells.
- Mutational landscape in genetically engineered, carcinogen-induced, and radiation-induced mouse sarcoma.
- NADPH oxidase inhibition attenuates total body irradiation-induced haematopoietic genomic instability.
- PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance.
- Paradoxical relationship between chromosomal instability and survival outcome in cancer.
- Protein tyrosine phosphatase (PTP) inhibition enhances chromosomal stability after genotoxic stress: decreased chromosomal instability (CIN) at the expense of enhanced genomic instability (GIN)?
- REV3L 3'UTR 460 T>C polymorphism in microRNA target sites contributes to lung cancer susceptibility.
- Reciprocal uniparental disomy in yeast.
- Recombination between retrotransposons as a source of chromosome rearrangements in the yeast Saccharomyces cerevisiae.
- Replication of the Escherichia coli chromosome in RNase HI-deficient cells: multiple initiation regions and fork dynamics.
- Stable Expression of Lentiviral Antigens by Quality-Controlled Recombinant Mycobacterium bovis BCG Vectors.
- The Top1 paradox: Friend and foe of the eukaryotic genome.
- The Transient Inactivation of the Master Cell Cycle Phosphatase Cdc14 Causes Genomic Instability in Diploid Cells of Saccharomyces cerevisiae.
- The loss of PIN1 deregulates cyclin E and sensitizes mouse embryo fibroblasts to genomic instability.
- Topoisomerase I and Genome Stability: The Good and the Bad.
- Topoisomerase I plays a critical role in suppressing genome instability at a highly transcribed G-quadruplex-forming sequence.
- Transcription as a source of genome instability.
- Transcription-associated mutagenesis in yeast is directly proportional to the level of gene expression and influenced by the direction of DNA replication.
- Yeast screens identify the RNA polymerase II CTD and SPT5 as relevant targets of BRCA1 interaction.
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Keywords of People
- Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
- Fox, Donald T, Associate Professor of Pharmacology & Cancer Biology, Duke Science & Society