Genomic Instability

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  Subject Areas on Research

  • A longitudinal study of epigenetic variation in twins. 
  • A role for mitochondrial dysfunction in perpetuating radiation-induced genomic instability. 
  • Caspase-3 promotes genetic instability and carcinogenesis. 
  • Centromeric barrier disruption leads to mitotic defects in Schizosaccharomyces pombe. 
  • Chromosome rearrangements via template switching between diverged repeated sequences. 
  • Damage Control in the Developing Brain: Tradeoffs and Consequences. 
  • Defining the replication program through the chromatin landscape. 
  • Effects of camptothecin or TOP1 overexpression on genetic stability in Saccharomyces cerevisiae. 
  • Elevated Genome-Wide Instability in Yeast Mutants Lacking RNase H Activity. 
  • Endoreplication and polyploidy: insights into development and disease. 
  • Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage. 
  • Essential roles of Caspase-3 in facilitating Myc-induced genetic instability and carcinogenesis. 
  • Functionality of the TOL plasmid under varying environmental conditions following conjugal transfer. 
  • Gene expression profiling of microsatellite unstable and microsatellite stable endometrial cancers indicates distinct pathways of aberrant signaling. 
  • Genetic Control of Genomic Alterations Induced in Yeast by Interstitial Telomeric Sequences. 
  • Genome rearrangements caused by interstitial telomeric sequences in yeast. 
  • Genome-destabilizing effects associated with top1 loss or accumulation of top1 cleavage complexes in yeast. 
  • Genome-wide analysis of genomic alterations induced by oxidative DNA damage in yeast. 
  • Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO. 
  • Genomic and functional variation of human centromeres. 
  • Genomic variation within alpha satellite DNA influences centromere location on human chromosomes with metastable epialleles. 
  • Global analysis of genomic instability caused by DNA replication stress in Saccharomyces cerevisiae. 
  • Guanine repeat-containing sequences confer transcription-dependent instability in an orientation-specific manner in yeast. 
  • Inner nuclear envelope proteins SUN1 and SUN2 play a prominent role in the DNA damage response. 
  • Inositol phosphate synthesis and the nuclear processes they affect. 
  • Inverted DNA repeats channel repair of distant double-strand breaks into chromatid fusions and chromosomal rearrangements. 
  • Lineage Switch Between B-Lymphoblastic Leukemia and Acute Myeloid Leukemia Intermediated by "Occult" Myelodysplastic Neoplasm: Two Cases of Adult Patients With Evidence of Genomic Instability and Clonal Selection by Chemotherapy. 
  • Methylation of histone H4 lysine 20 by PR-Set7 ensures the integrity of late replicating sequence domains in Drosophila. 
  • Mitochondrial dysfunction, persistently elevated levels of reactive oxygen species and radiation-induced genomic instability: a review. 
  • Mitotic Recombination and Adaptive Genomic Changes in Human Pathogenic Fungi. 
  • Mre11-Sae2 and RPA Collaborate to Prevent Palindromic Gene Amplification. 
  • Msh6 protects mature B cells from lymphoma by preserving genomic stability. 
  • Multiple roles of ATM in monitoring and maintaining DNA integrity. 
  • Mutant allele quantification reveals a genetic basis for TP53 mutation-driven castration resistance in prostate cancer cells. 
  • Mutational landscape in genetically engineered, carcinogen-induced, and radiation-induced mouse sarcoma. 
  • NADPH oxidase inhibition attenuates total body irradiation-induced haematopoietic genomic instability. 
  • PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance. 
  • Paradoxical relationship between chromosomal instability and survival outcome in cancer. 
  • Protein tyrosine phosphatase (PTP) inhibition enhances chromosomal stability after genotoxic stress: decreased chromosomal instability (CIN) at the expense of enhanced genomic instability (GIN)? 
  • REV3L 3'UTR 460 T>C polymorphism in microRNA target sites contributes to lung cancer susceptibility. 
  • Reciprocal uniparental disomy in yeast. 
  • Recombination between retrotransposons as a source of chromosome rearrangements in the yeast Saccharomyces cerevisiae. 
  • Replication of the Escherichia coli chromosome in RNase HI-deficient cells: multiple initiation regions and fork dynamics. 
  • Stable Expression of Lentiviral Antigens by Quality-Controlled Recombinant Mycobacterium bovis BCG Vectors. 
  • The Top1 paradox: Friend and foe of the eukaryotic genome. 
  • The Transient Inactivation of the Master Cell Cycle Phosphatase Cdc14 Causes Genomic Instability in Diploid Cells of Saccharomyces cerevisiae. 
  • The loss of PIN1 deregulates cyclin E and sensitizes mouse embryo fibroblasts to genomic instability. 
  • Topoisomerase I and Genome Stability: The Good and the Bad. 
  • Topoisomerase I plays a critical role in suppressing genome instability at a highly transcribed G-quadruplex-forming sequence. 
  • Transcription as a source of genome instability. 
  • Transcription-associated mutagenesis in yeast is directly proportional to the level of gene expression and influenced by the direction of DNA replication. 
  • Yeast screens identify the RNA polymerase II CTD and SPT5 as relevant targets of BRCA1 interaction. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Fox, Donald T, Associate Professor of Pharmacology & Cancer Biology, Duke Science & Society